Tucidinostat_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tucidinostat_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0834115
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0667972
GLIS3 GLIS family zinc finger 3 0.039718
VCL vinculin 0.0396982
NRG1 neuregulin 1 0.0302107
NTN4 netrin 4 0.0286053
SMAD3 SMAD family member 3 0.0281402
PDLIM5 PDZ and LIM domain 5 0.0268237
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0258754
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0255768
SMYD3 SET and MYND domain containing 3 0.0220296
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0211337
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0210659
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0208716
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0205898
JARID2 jumonji, AT rich interactive domain 2 0.0204653
TMEM156 transmembrane protein 156 0.0201527
PALLD palladin, cytoskeletal associated protein 0.019966
LOXL2 lysyl oxidase-like 2 0.0198781
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0197715
EGFR epidermal growth factor receptor 0.0193455
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0192764
BICD1 bicaudal D homolog 1 (Drosophila) 0.0188707
UBASH3B ubiquitin associated and SH3 domain containing B 0.0185326
DNAH14 dynein, axonemal, heavy chain 14 0.0184277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0178883
PRKCA protein kinase C, alpha 0.0177328
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0174473
NPAS2 neuronal PAS domain protein 2 0.0170835
INTS6 integrator complex subunit 6 0.0170797
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0169849
STAU2 staufen double-stranded RNA binding protein 2 0.0168271
FRY furry homolog (Drosophila) 0.0166604
ATXN1 ataxin 1 0.0165292
RUNX2 runt-related transcription factor 2 0.0164418
TTC28 tetratricopeptide repeat domain 28 0.0162042
RAD51B RAD51 paralog B 0.0161756
MBD5 methyl-CpG binding domain protein 5 0.0161751
RANBP17 RAN binding protein 17 0.0160921
EPHA4 EPH receptor A4 0.0160502
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0158624
DST dystonin 0.0155708
NRP1 neuropilin 1 0.0155129
MYH9 myosin, heavy chain 9, non-muscle 0.0154488
PRKG1 protein kinase, cGMP-dependent, type I 0.0153184
SDC2 syndecan 2 0.0153022
FNDC3A fibronectin type III domain containing 3A 0.0152361
BICC1 BicC family RNA binding protein 1 0.0151522
SEPTIN9 septin 9 0.0150085
LRMDA leucine rich melanocyte differentiation associated 0.0149383
TOP1 topoisomerase (DNA) I 0.0148476
PCNX2 pecanex 2 0.0145807
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0145557
TGFB2 transforming growth factor, beta 2 0.0145285
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0144421
HMGA2 high mobility group AT-hook 2 0.0143764
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143207
AEBP2 AE binding protein 2 0.0142114
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0141864
GLCCI1 glucocorticoid induced 1 0.0138517
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0138109
NBEA neurobeachin 0.0135609
ZC3H12C zinc finger CCCH-type containing 12C 0.0133716
DUSP16 dual specificity phosphatase 16 0.0132927
MIPOL1 mirror-image polydactyly 1 0.0132855
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0132748
SLC35F3 solute carrier family 35, member F3 0.0132746
RASAL2 RAS protein activator like 2 0.0131922
TRPS1 trichorhinophalangeal syndrome I 0.0129225
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0128006
NABP1 nucleic acid binding protein 1 0.0127703
HOMER1 homer scaffolding protein 1 0.0127334
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0126885
VEGFC vascular endothelial growth factor C 0.0125939
FMN1 formin 1 0.0122418
RAB10 RAB10, member RAS oncogene family 0.0121237
SAMD4A sterile alpha motif domain containing 4A 0.0120759
SLIT2 slit homolog 2 (Drosophila) 0.0119247
SERTAD2 SERTA domain containing 2 0.0119224
ETV6 ets variant 6 0.0118651
RAB31 RAB31, member RAS oncogene family 0.0118608
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0116551
CAPRIN2 caprin family member 2 0.0116539
NAV1 neuron navigator 1 0.0115747
TUSC3 tumor suppressor candidate 3 0.0115419
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0114799
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0113287
CLIP2 CAP-GLY domain containing linker protein 2 0.0112995
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0112326
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0111597
EHBP1 EH domain binding protein 1 0.0111379
ZNF644 zinc finger protein 644 0.0110982
HIPK2 homeodomain interacting protein kinase 2 0.0110755
WLS wntless Wnt ligand secretion mediator 0.0110398
KSR1 kinase suppressor of ras 1 0.0110341
NALF1 NALCN channel auxiliary factor 1 0.0110128
RABGAP1L RAB GTPase activating protein 1-like 0.0109426
ATF6 activating transcription factor 6 0.0108848
KLF12 Kruppel-like factor 12 0.0108103
NRIP1 nuclear receptor interacting protein 1 0.0107842

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.382295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.162581
PTMA prothymosin, alpha -0.128473
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11869
MT2A metallothionein 2A -0.102091
SQSTM1 sequestosome 1 -0.09472
AREG amphiregulin -0.0837403
FTL ferritin, light polypeptide -0.082365
TMSB10 thymosin beta 10 -0.0813822
CANX calnexin -0.0790904
VIM vimentin -0.0782886
FTH1 ferritin, heavy polypeptide 1 -0.0741321
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0739438
NAMPT nicotinamide phosphoribosyltransferase -0.073647
HLA-B major histocompatibility complex, class I, B -0.071741
FN1 fibronectin 1 -0.0717255
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0676964
NDRG1 N-myc downstream regulated 1 -0.0611832
S100A6 S100 calcium binding protein A6 -0.0610633
RPS6 ribosomal protein S6 -0.0605667
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0586034
TPT1 tumor protein, translationally-controlled 1 -0.0573569
B2M beta-2-microglobulin -0.0561481
TMSB4X thymosin beta 4, X-linked -0.0543374
RACK1 receptor for activated C kinase 1 -0.0519216
RPL26 ribosomal protein L26 -0.0491261
SFTPA2 surfactant protein A2 -0.048358
IFI27 interferon, alpha-inducible protein 27 -0.0478622
TFPI2 tissue factor pathway inhibitor 2 -0.0469207
RPS27 ribosomal protein S27 -0.0465801
RPLP1 ribosomal protein, large, P1 -0.046262
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0449638
RPL35A ribosomal protein L35a -0.0440295
S100A10 S100 calcium binding protein A10 -0.0429189
RPS19 ribosomal protein S19 -0.0421328
RPL31 ribosomal protein L31 -0.0382243
LMNA lamin A/C -0.0381547
RPS12 ribosomal protein S12 -0.0372102
RPL37 ribosomal protein L37 -0.037101
EIF1 eukaryotic translation initiation factor 1 -0.0366465
RAB1A RAB1A, member RAS oncogene family -0.0365781
RPL37A ribosomal protein L37a -0.036159
GNAS GNAS complex locus -0.0351321
HILPDA hypoxia inducible lipid droplet-associated -0.0345146
RPS8 ribosomal protein S8 -0.0342023
RPS29 ribosomal protein S29 -0.034103
PKM pyruvate kinase, muscle -0.0339283
ENO1 enolase 1, (alpha) -0.0339053
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0333905
RPL34 ribosomal protein L34 -0.0333342
ELL2 elongation factor, RNA polymerase II, 2 -0.0332615
FAM13A family with sequence similarity 13, member A -0.0332224
RPS20 ribosomal protein S20 -0.0331925
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0329329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0328553
RPL12 ribosomal protein L12 -0.0326002
UBC ubiquitin C -0.0321339
RPS24 ribosomal protein S24 -0.0320562
TPI1 triosephosphate isomerase 1 -0.0314867
GOLGA4 golgin A4 -0.0310324
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0308858
ITGA1 integrin, alpha 1 -0.0305503
NAP1L1 nucleosome assembly protein 1-like 1 -0.0303716
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0301052
RPL23 ribosomal protein L23 -0.0299514
LOC112694756 uncharaterized LOC112694756 -0.0295803
RPS21 ribosomal protein S21 -0.0294321
SLC38A1 solute carrier family 38, member 1 -0.0288905
RPS27A ribosomal protein S27a -0.0287494
IER3 immediate early response 3 -0.028742
RPL19 ribosomal protein L19 -0.0286154
RPL11 ribosomal protein L11 -0.0283771
RPS25 ribosomal protein S25 -0.0279943
PRRC2C proline-rich coiled-coil 2C -0.0278895
MARCHF6 membrane associated ring-CH-type finger 6 -0.0278513
PDIA3 protein disulfide isomerase family A, member 3 -0.0278085
TRIO trio Rho guanine nucleotide exchange factor -0.0276139
IFI6 interferon, alpha-inducible protein 6 -0.0275668
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0275608
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0274145
RPL36 ribosomal protein L36 -0.0273226
CALR calreticulin -0.0271156
SOD2 superoxide dismutase 2, mitochondrial -0.027108
RPL28 ribosomal protein L28 -0.0270226
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0266664
RPS16 ribosomal protein S16 -0.0263976
BHLHE40 basic helix-loop-helix family, member e40 -0.0262865
RLF rearranged L-myc fusion -0.0258957
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0258297
RAD21 RAD21 homolog (S. pombe) -0.0257924
RPL38 ribosomal protein L38 -0.0257897
RPL30 ribosomal protein L30 -0.0255316
TXNIP thioredoxin interacting protein -0.0254065
PLIN2 perilipin 2 -0.0253147
RPS5 ribosomal protein S5 -0.0253113
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0252542
LOC102724023 ES1 protein homolog, mitochondrial -0.0252118
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0252043
WDR45B WD repeat domain 45B -0.0244113
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0243605