Tularemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted_by dog tick bite (Dermacentor variabilis), transmitted_by deer flies (Chrysops sp) or transmitted_by contact with infected animal tissues. (Human Disease Ontology, DOID_2123)
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Genes

169 genes co-occuring with the disease Tularemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
FTL ferritin, light polypeptide 2.587
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.475
IFNG interferon, gamma 2.446
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 2.373
TLR2 toll-like receptor 2 2.319
AIM2 absent in melanoma 2 2.216
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.213
SCGB1D1 secretoglobin, family 1D, member 1 2.153
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.132
CD4 CD4 molecule 2.101
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.071
CD8A CD8a molecule 2.04
TLR4 toll-like receptor 4 2.035
TNF tumor necrosis factor 2.033
IL1B interleukin 1, beta 2.022
IL17A interleukin 17A 1.956
HSPE1 heat shock 10kDa protein 1 1.932
LAMP1 lysosomal-associated membrane protein 1 1.907
IL6 interleukin 6 1.894
MYD88 myeloid differentiation primary response 88 1.867
NLRC4 NLR family, CARD domain containing 4 1.859
IL10 interleukin 10 1.832
IL18 interleukin 18 1.818
PIGR polymeric immunoglobulin receptor 1.764
GBP5 guanylate binding protein 5 1.718
EEA1 early endosome antigen 1 1.706
R3HCC1L R3H domain and coiled-coil containing 1-like 1.697
LY96 lymphocyte antigen 96 1.688
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 1.68
IFNB1 interferon, beta 1, fibroblast 1.649
MARK3 MAP/microtubule affinity-regulating kinase 3 1.648
ALB albumin 1.625
IL4 interleukin 4 1.624
CCL2 chemokine (C-C motif) ligand 2 1.619
CCDC85B coiled-coil domain containing 85B 1.616
IL2 interleukin 2 1.614
EPHB2 EPH receptor B2 1.611
ERVW-1 endogenous retrovirus group W, member 1 1.609
CTSD cathepsin D 1.606
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.602
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.599
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 1.587
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.571
ERV3-1 endogenous retrovirus group 3, member 1 1.571
CRP C-reactive protein, pentraxin-related 1.561
TLR5 toll-like receptor 5 1.556
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.555
TLR1 toll-like receptor 1 1.543
IL12RB2 interleukin 12 receptor, beta 2 1.537
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.53
GBP2 guanylate binding protein 2, interferon-inducible 1.512
IRF3 interferon regulatory factor 3 1.495
TLR9 toll-like receptor 9 1.484
TLR6 toll-like receptor 6 1.474
KCMF1 potassium channel modulatory factor 1 1.47
CLEC7A C-type lectin domain family 7, member A 1.47
CCL4 chemokine (C-C motif) ligand 4 1.461
CCL5 chemokine (C-C motif) ligand 5 1.451
TLR3 toll-like receptor 3 1.447
NOD1 nucleotide-binding oligomerization domain containing 1 1.434
IL22 interleukin 22 1.43
NOD2 nucleotide-binding oligomerization domain containing 2 1.424
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.412
FNTB farnesyltransferase, CAAX box, beta 1.401
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.395
IL5 interleukin 5 1.393
HABP2 hyaluronan binding protein 2 1.39
STX8 syntaxin 8 1.381
GBP1 guanylate binding protein 1, interferon-inducible 1.378
IL1A interleukin 1, alpha 1.376
CXCL10 chemokine (C-X-C motif) ligand 10 1.36
CXCR3 chemokine (C-X-C motif) receptor 3 1.358
CD86 CD86 molecule 1.354
PXDNL peroxidasin-like 1.353
PXDN peroxidasin 1.352
CD69 CD69 molecule 1.351
CAMP cathelicidin antimicrobial peptide 1.34
TLR7 toll-like receptor 7 1.336
CST9 cystatin 9 (testatin) 1.326
CSF3 colony stimulating factor 3 (granulocyte) 1.325
TBX21 T-box 21 1.318
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.312
CCL3 chemokine (C-C motif) ligand 3 1.31
PRF1 perforin 1 (pore forming protein) 1.295
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.295
CD80 CD80 molecule 1.292
STAT1 signal transducer and activator of transcription 1, 91kDa 1.291
RAB5A RAB5A, member RAS oncogene family 1.29
NLRP3 NLR family, pyrin domain containing 3 1.288
IL13 interleukin 13 1.288
IRF1 interferon regulatory factor 1 1.271
CXCL8 chemokine (C-X-C motif) ligand 8 1.271
IL17RA interleukin 17 receptor A 1.269
C3 complement component 3 1.264
PCNP PEST proteolytic signal containing nuclear protein 1.262
IL1R1 interleukin 1 receptor, type I 1.257
IL23A interleukin 23, alpha subunit p19 1.25
ATG5 autophagy related 5 1.247
SYK spleen tyrosine kinase 1.244
EPYC epiphycan 1.239
CGAS cyclic GMP-AMP synthase 1.238
GNG8 guanine nucleotide binding protein (G protein), gamma 8 1.232
LAMP2 lysosomal-associated membrane protein 2 1.231
UBASH3A ubiquitin associated and SH3 domain containing A 1.203
IFNA1 interferon, alpha 1 1.188
GALE UDP-galactose-4-epimerase 1.182
TBL1X transducin (beta)-like 1X-linked 1.175
TGFB1 transforming growth factor, beta 1 1.171
LTF lactotransferrin 1.166
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.165
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 1.164
TEKT5 tektin 5 1.164
IL17F interleukin 17F 1.16
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.159
CD40 CD40 molecule, TNF receptor superfamily member 5 1.153
GBP4 guanylate binding protein 4 1.153
CSF1 colony stimulating factor 1 (macrophage) 1.153
CAST calpastatin 1.146
BPI bactericidal/permeability-increasing protein 1.145
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.144
PYCARD PYD and CARD domain containing 1.142
NUCLEOLIN nucleolin multifunctional protein 1.141
PRTN3 proteinase 3 1.14
CD19 CD19 molecule 1.135
CD1D CD1d molecule 1.135
NLRP1 NLR family, pyrin domain containing 1 1.129
GP5 glycoprotein V (platelet) 1.127
SELL selectin L 1.125
CCR7 chemokine (C-C motif) receptor 7 1.124
ADCY10 adenylate cyclase 10 (soluble) 1.124
PTPRC protein tyrosine phosphatase, receptor type, C 1.123
ACTA1 actin, alpha 1, skeletal muscle 1.122
TLR8 toll-like receptor 8 1.12
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.115
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.113
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.107
MAVS mitochondrial antiviral signaling protein 1.105
GGTLC3 gamma-glutamyltransferase light chain 3 1.098
DUSP1 dual specificity phosphatase 1 1.093
IFIH1 interferon induced with helicase C domain 1 1.089
NOS2 nitric oxide synthase 2, inducible 1.084
CIDEB cell death-inducing DFFA-like effector b 1.081
BTN3A3 butyrophilin, subfamily 3, member A3 1.079
CYBB cytochrome b-245, beta polypeptide 1.077
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 1.075
CNTN3 contactin 3 (plasmacytoma associated) 1.073
IRF7 interferon regulatory factor 7 1.073
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.066
BTNL9 butyrophilin-like 9 1.064
NLRP13 NLR family, pyrin domain containing 13 1.063
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.06
CXCL9 chemokine (C-X-C motif) ligand 9 1.053
ESX1 ESX homeobox 1 1.049
CHIA chitinase, acidic 1.048
IL15 interleukin 15 1.046
IGLL5 immunoglobulin lambda-like polypeptide 5 1.046
CDC27 cell division cycle 27 1.044
INHA inhibin, alpha 1.042
CD63 CD63 molecule 1.033
TTC1 tetratricopeptide repeat domain 1 1.029
BTN2A1 butyrophilin, subfamily 2, member A1 1.026
BTN3A1 butyrophilin, subfamily 3, member A1 1.022
FASLG Fas ligand (TNF superfamily, member 6) 1.02
NAIP NLR family, apoptosis inhibitory protein 1.019
IL3 interleukin 3 1.016
FNTA farnesyltransferase, CAAX box, alpha 1.015
RNF19B ring finger protein 19B 1.011
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 1.005
MAN2B1 mannosidase, alpha, class 2B, member 1 1.001