| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/10026128 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Turofexorate relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 1.85 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.45 |
| RPS26 | ribosomal protein S26 | 1.39 |
| KLHL24 | kelch-like family member 24 | 1.17 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.15 |
| MIGA2 | mitoguardin 2 | 1.09 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 0.87 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.8 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.71 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.69 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.67 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.62 |
| RPLP1 | ribosomal protein, large, P1 | 0.6 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.6 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.6 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.6 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.59 |
| MEX3C | mex-3 RNA binding family member C | 0.57 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.56 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.54 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | 0.51 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.51 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.5 |
| SLC38A2 | solute carrier family 38, member 2 | 0.5 |
| TOX2 | TOX high mobility group box family member 2 | 0.5 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.49 |
| SP100 | SP100 nuclear antigen | 0.49 |
| RNF185 | ring finger protein 185 | 0.48 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.47 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.47 |
| SET | SET nuclear proto-oncogene | 0.47 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.47 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.47 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.46 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.44 |
| RPL10A | ribosomal protein L10a | 0.44 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.44 |
| PTEN | phosphatase and tensin homolog | 0.43 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.43 |
| ARSD | arylsulfatase D | 0.43 |
| CLTA | clathrin, light chain A | 0.42 |
| MAGEA2 | melanoma antigen family A2 | 0.42 |
| MYCBP | MYC binding protein | 0.41 |
| YAP1 | Yes-associated protein 1 | 0.41 |
| FAM8A1 | family with sequence similarity 8, member A1 | 0.41 |
| TNS2 | tensin 2 | 0.41 |
| RBM33 | RNA binding motif protein 33 | 0.4 |
| MYO9A | myosin IXA | 0.4 |
| COX5A | cytochrome c oxidase subunit Va | 0.4 |
| HYKK | hydroxylysine kinase | 0.39 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.39 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.39 |
| LDHA | lactate dehydrogenase A | 0.39 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.39 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.39 |
| FRK | fyn-related Src family tyrosine kinase | 0.38 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.38 |
| MYH16 | myosin, heavy chain 16 pseudogene | 0.38 |
| NUCB1 | nucleobindin 1 | 0.38 |
| TEP1 | telomerase-associated protein 1 | 0.38 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.38 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.38 |
| TMSB10 | thymosin beta 10 | 0.38 |
| CNPY2 | canopy FGF signaling regulator 2 | 0.37 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.37 |
| RPS25 | ribosomal protein S25 | 0.37 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.36 |
| ZNF672 | zinc finger protein 672 | 0.36 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | 0.36 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.36 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.36 |
| H1-2 | H1.2 linker histone, cluster member | 0.35 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.35 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.35 |
| HMBOX1 | homeobox containing 1 | 0.35 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.34 |
| RCAN3 | RCAN family member 3 | 0.34 |
| TRIM2 | tripartite motif containing 2 | 0.34 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.34 |
| CHPF2 | chondroitin polymerizing factor 2 | 0.34 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.34 |
| LOXL2 | lysyl oxidase-like 2 | 0.34 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.34 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | 0.33 |
| HSPA8 | heat shock 70kDa protein 8 | 0.33 |
| GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 0.33 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.33 |
| MSX1 | msh homeobox 1 | 0.33 |
| CAMKK1 | calcium/calmodulin-dependent protein kinase kinase 1, alpha | 0.33 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.33 |
| H1-3 | H1.3 linker histone, cluster member | 0.32 |
| RPL12 | ribosomal protein L12 | 0.32 |
| ALDOA | aldolase A, fructose-bisphosphate | 0.32 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 0.32 |
| TUBB3 | tubulin, beta 3 class III | 0.32 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.32 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | 0.32 |
| ZBTB24 | zinc finger and BTB domain containing 24 | 0.32 |
| RPS27L | ribosomal protein S27-like | 0.32 |
| ALKBH6 | alkB, alkylation repair homolog 6 (E. coli) | 0.31 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM241B | family with sequence similarity 241 member B | -0.88 |
| BET1L | Bet1 golgi vesicular membrane trafficking protein-like | -0.83 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.74 |
| TSPAN5 | tetraspanin 5 | -0.73 |
| VAMP7 | vesicle-associated membrane protein 7 | -0.73 |
| UPP1 | uridine phosphorylase 1 | -0.72 |
| FAM241A | family with sequence similarity 241 member A | -0.7 |
| AKNA | AT-hook transcription factor | -0.69 |
| PREB | prolactin regulatory element binding | -0.68 |
| UNC13C | unc-13 homolog C (C. elegans) | -0.67 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | -0.66 |
| SLC38A7 | solute carrier family 38, member 7 | -0.66 |
| PLIN2 | perilipin 2 | -0.65 |
| TDG | thymine-DNA glycosylase | -0.65 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.64 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.63 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.62 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.6 |
| STC2 | stanniocalcin 2 | -0.58 |
| ODC1 | ornithine decarboxylase 1 | -0.58 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | -0.56 |
| ZFPL1 | zinc finger protein-like 1 | -0.53 |
| ZNF92 | zinc finger protein 92 | -0.51 |
| STX12 | syntaxin 12 | -0.51 |
| GOLGA5 | golgin A5 | -0.51 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | -0.51 |
| TRIM41 | tripartite motif containing 41 | -0.51 |
| USE1 | unconventional SNARE in the ER 1 homolog (S. cerevisiae) | -0.51 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.49 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.48 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.48 |
| SP110 | SP110 nuclear body protein | -0.47 |
| DENND4A | DENN/MADD domain containing 4A | -0.46 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.46 |
| ZNF317 | zinc finger protein 317 | -0.46 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | -0.46 |
| SELENOT | selenoprotein T | -0.45 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | -0.45 |
| SESN2 | sestrin 2 | -0.44 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | -0.44 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.44 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.44 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.43 |
| SPATA2 | spermatogenesis associated 2 | -0.43 |
| TAZ | tafazzin | -0.43 |
| DYSF | dysferlin | -0.43 |
| TRMT44 | tRNA methyltransferase 44 homolog (S. cerevisiae) | -0.43 |
| FAM102B | family with sequence similarity 102, member B | -0.43 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.43 |
| BAG1 | BCL2-associated athanogene | -0.43 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.42 |
| FAT4 | FAT atypical cadherin 4 | -0.42 |
| RNFT2 | ring finger protein, transmembrane 2 | -0.41 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.41 |
| LMO4 | LIM domain only 4 | -0.41 |
| JUN | jun proto-oncogene | -0.41 |
| PIGA | phosphatidylinositol glycan anchor biosynthesis, class A | -0.41 |
| FER1L5 | fer-1-like family member 5 | -0.4 |
| CUX1 | cut-like homeobox 1 | -0.4 |
| RAET1G | retinoic acid early transcript 1G | -0.4 |
| IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | -0.39 |
| SLC25A17 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | -0.39 |
| MTFP1 | mitochondrial fission process 1 | -0.39 |
| ANKRD46 | ankyrin repeat domain 46 | -0.39 |
| IRF5 | interferon regulatory factor 5 | -0.39 |
| TXNL4B | thioredoxin-like 4B | -0.39 |
| ADIPOR1 | adiponectin receptor 1 | -0.38 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | -0.38 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.38 |
| RILPL1 | Rab interacting lysosomal protein-like 1 | -0.38 |
| PTK2B | protein tyrosine kinase 2 beta | -0.38 |
| WASHC3 | WASH complex subunit 3 | -0.38 |
| MYOF | myoferlin | -0.37 |
| RWDD2B | RWD domain containing 2B | -0.37 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | -0.37 |
| ZNF581 | zinc finger protein 581 | -0.37 |
| B3GALT6 | UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 | -0.37 |
| TPM4 | tropomyosin 4 | -0.35 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -0.35 |
| GPRIN1 | G protein regulated inducer of neurite outgrowth 1 | -0.35 |
| RNPEPL1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | -0.34 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.34 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.34 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -0.34 |
| KLK6 | kallikrein-related peptidase 6 | -0.33 |
| MB21D2 | Mab-21 domain containing 2 | -0.33 |
| LRRC28 | leucine rich repeat containing 28 | -0.33 |
| DENND3 | DENN/MADD domain containing 3 | -0.33 |
| SFR1 | SWI5-dependent recombination repair 1 | -0.33 |
| POLG | polymerase (DNA directed), gamma | -0.33 |
| UBXN2B | UBX domain protein 2B | -0.33 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | -0.33 |
| PRELID1 | PRELI domain containing 1 | -0.33 |
| SMPD4 | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) | -0.33 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.32 |
| ALAS1 | 5'-aminolevulinate synthase 1 | -0.32 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.32 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.32 |
| CDC20 | cell division cycle 20 | -0.32 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.32 |
