Type 1 diabetes mellitus_Muscle - Striated (Skeletal) (MMHCC)_GSE1659 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1659
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Genes

600 genes differentially expressed during Type 1 diabetes mellitus_Muscle - Striated (Skeletal) (MMHCC)_GSE1659 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
TBC1D20 TBC1 domain family, member 20 4.24036
RALBP1 ralA binding protein 1 3.93004
RABAC1 Rab acceptor 1 (prenylated) 3.45998
BCL2L13 BCL2-like 13 (apoptosis facilitator) 3.2745
CLTB clathrin, light chain B 3.1651
RPLP0 ribosomal protein, large, P0 3.10671
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 3.00132
B2M beta-2-microglobulin 2.97617
EEF2 eukaryotic translation elongation factor 2 2.90965
TMEM38B transmembrane protein 38B 2.88289
ITGB1BP1 integrin beta 1 binding protein 1 2.8783
RPL18 ribosomal protein L18 2.86978
KDM3B lysine (K)-specific demethylase 3B 2.8448
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.81567
STK38 serine/threonine kinase 38 2.70995
KCMF1 potassium channel modulatory factor 1 2.70786
RPS23 ribosomal protein S23 2.68991
FKBP5 FK506 binding protein 5 2.66221
SUMO3 small ubiquitin-like modifier 3 2.64381
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.63972
RPS19 ribosomal protein S19 2.63706
ODC1 ornithine decarboxylase 1 2.6186
PQLC1 PQ loop repeat containing 1 2.6026
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.53999
LOX lysyl oxidase 2.52852
GOLGA4 golgin A4 2.52846
KLF9 Kruppel-like factor 9 2.50627
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.47966
PKP4 plakophilin 4 2.46405
RAB7A RAB7A, member RAS oncogene family 2.43175
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.42418
FOXO3 forkhead box O3 2.42407
STX12 syntaxin 12 2.4162
EIF3K eukaryotic translation initiation factor 3, subunit K 2.41562
PRMT3 protein arginine methyltransferase 3 2.3991
RPL6 ribosomal protein L6 2.39234
WDR43 WD repeat domain 43 2.38263
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.37723
LIFR leukemia inhibitory factor receptor alpha 2.36564
ZNF274 zinc finger protein 274 2.36433
RPL10 ribosomal protein L10 2.35897
NPEPL1 aminopeptidase-like 1 2.34598
FAM134B family with sequence similarity 134, member B 2.31993
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.31254
APP amyloid beta (A4) precursor protein 2.27947
ARGLU1 arginine and glutamate rich 1 2.27148
SAR1A secretion associated, Ras related GTPase 1A 2.23466
C5ORF15 chromosome 5 open reading frame 15 2.22217
NCKAP1 NCK-associated protein 1 2.22145
ETF1 eukaryotic translation termination factor 1 2.21325
SYF2 SYF2 pre-mRNA-splicing factor 2.20988
GABARAPL1 GABA(A) receptor-associated protein like 1 2.20796
RPS10 ribosomal protein S10 2.18775
SMYD2 SET and MYND domain containing 2 2.17375
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.17154
RPL8 ribosomal protein L8 2.17009
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2.16922
WDR7 WD repeat domain 7 2.16388
TRAF3IP2 TRAF3 interacting protein 2 2.16333
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.15108
CUL4A cullin 4A 2.14095
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.1387
SEC13 SEC13 homolog (S. cerevisiae) 2.13461
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.13118
MTMR1 myotubularin related protein 1 2.13042
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.12469
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.12108
CUL1 cullin 1 2.12056
LRRC59 leucine rich repeat containing 59 2.11916
CD63 CD63 molecule 2.10614
ECH1 enoyl CoA hydratase 1, peroxisomal 2.09229
LDHAL6A lactate dehydrogenase A-like 6A 2.0905
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 2.08262
GFER growth factor, augmenter of liver regeneration 2.07703
MXI1 MAX interactor 1, dimerization protein 2.07051
ACP1 acid phosphatase 1, soluble 2.06753
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.06597
ACOT9 acyl-CoA thioesterase 9 2.05942
IGBP1 immunoglobulin (CD79A) binding protein 1 2.04236
ZFP37 ZFP37 zinc finger protein 2.03635
LMNA lamin A/C 2.01357
KIF1C kinesin family member 1C 2.00895
CDV3 CDV3 homolog (mouse) 2.00778
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.00341
GLUL glutamate-ammonia ligase 2.0018
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.00053
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 1.99537
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 1.99033
CLK1 CDC-like kinase 1 1.9899
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.97494
XPO7 exportin 7 1.95111
RPL13 ribosomal protein L13 1.94674
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 1.94435
MAPK14 mitogen-activated protein kinase 14 1.94402
EMG1 EMG1 N1-specific pseudouridine methyltransferase 1.94234
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 1.93358
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 1.93198
SELK selenoprotein K 1.9293
NDE1 nudE neurodevelopment protein 1 1.92852
PUM2 pumilio RNA-binding family member 2 1.91874
EPB41 erythrocyte membrane protein band 4.1 1.9096
SBF2 SET binding factor 2 1.90734
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.90519
C20ORF24 chromosome 20 open reading frame 24 1.90372
RAD23B RAD23 homolog B (S. cerevisiae) 1.90293
FKBP1A FK506 binding protein 1A, 12kDa 1.89956
LSP1 lymphocyte-specific protein 1 1.89798
GABARAP GABA(A) receptor-associated protein 1.89684
TUBB3 tubulin, beta 3 class III 1.88883
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1.88751
ZNF598 zinc finger protein 598 1.88667
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 1.88448
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 1.8827
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 1.88195
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.87147
GINM1 glycoprotein integral membrane 1 1.87039
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 1.86734
RPL7 ribosomal protein L7 1.86556
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 1.86128
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 1.84674
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 1.84573
ITCH itchy E3 ubiquitin protein ligase 1.84228
PLIN4 perilipin 4 1.84146
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 1.84061
CD99L2 CD99 molecule-like 2 1.82608
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 1.82382
CA14 carbonic anhydrase XIV 1.81688
RORC RAR-related orphan receptor C 1.81369
RPL5 ribosomal protein L5 1.81301
SESN1 sestrin 1 1.80618
MYF6 myogenic factor 6 (herculin) 1.79479
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.78897
DRG1 developmentally regulated GTP binding protein 1 1.76691
JAGN1 jagunal homolog 1 (Drosophila) 1.75789
BCL10 B-cell CLL/lymphoma 10 1.75457
EPRS glutamyl-prolyl-tRNA synthetase 1.75092
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 1.74333
DPP8 dipeptidyl-peptidase 8 1.74027
REXO2 RNA exonuclease 2 1.73734
OSBPL5 oxysterol binding protein-like 5 1.73269
DUSP1 dual specificity phosphatase 1 1.73091
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 1.72933
LRRC58 leucine rich repeat containing 58 1.72163
ANAPC16 anaphase promoting complex subunit 16 1.71894
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 1.7093
RPL3 ribosomal protein L3 1.70117
IPO4 importin 4 1.69878
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 1.69729
CKAP2 cytoskeleton associated protein 2 1.69726
MORF4L1 mortality factor 4 like 1 1.69494
ACSS1 acyl-CoA synthetase short-chain family member 1 1.6917
AGRP agouti related neuropeptide 1.68703
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 1.68599
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 1.68315
SF3B3 splicing factor 3b, subunit 3, 130kDa 1.683
CHD7 chromodomain helicase DNA binding protein 7 1.67759
SIN3B SIN3 transcription regulator family member B 1.67528
SMAD4 SMAD family member 4 1.67345
CTRB2 chymotrypsinogen B2 1.66828
GTPBP4 GTP binding protein 4 1.66628
ZFYVE19 zinc finger, FYVE domain containing 19 1.66532
RIOK3 RIO kinase 3 1.66375
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.6539
USF2 upstream transcription factor 2, c-fos interacting 1.65182
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.6477
CAT catalase 1.64689
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.64424
EIF3C eukaryotic translation initiation factor 3, subunit C 1.63885
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.63643
MECP2 methyl CpG binding protein 2 1.63459
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 1.63359
CTSV cathepsin V 1.63242
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.63031
TADA2B transcriptional adaptor 2B 1.62994
PSIP1 PC4 and SFRS1 interacting protein 1 1.62318
ADCY2 adenylate cyclase 2 (brain) 1.62155
THBS1 thrombospondin 1 1.62032
HSPA1L heat shock 70kDa protein 1-like 1.61769
PHC1 polyhomeotic homolog 1 (Drosophila) 1.61429
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.61425
APOD apolipoprotein D 1.6098
HOXB2 homeobox B2 1.60395
ARF1 ADP-ribosylation factor 1 1.60248
PCBP2 poly(rC) binding protein 2 1.59709
ERRFI1 ERBB receptor feedback inhibitor 1 1.59617
RRAGC Ras-related GTP binding C 1.59375
UBQLN2 ubiquilin 2 1.59255
C1QC complement component 1, q subcomponent, C chain 1.59135
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 1.58775
ARAF A-Raf proto-oncogene, serine/threonine kinase 1.58572
ZDHHC3 zinc finger, DHHC-type containing 3 1.58339
PADI2 peptidyl arginine deiminase, type II 1.58303
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1.5801
RPS5 ribosomal protein S5 1.57948
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 1.57733
SFR1 SWI5-dependent recombination repair 1 1.57412
GDAP2 ganglioside induced differentiation associated protein 2 1.56922
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 1.56901
SERINC3 serine incorporator 3 1.56773
DAZAP2 DAZ associated protein 2 1.56673
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 1.56667
NCOR1 nuclear receptor corepressor 1 1.56559
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 1.56369
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 1.56318
ZBTB2 zinc finger and BTB domain containing 2 1.55942
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 1.55596
CLPTM1 cleft lip and palate associated transmembrane protein 1 1.55591
SRPX sushi-repeat containing protein, X-linked 1.55555
RPS28 ribosomal protein S28 1.55067
UBE2I ubiquitin-conjugating enzyme E2I 1.5497
GOLGA5 golgin A5 1.54752
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.53778
FAF1 Fas (TNFRSF6) associated factor 1 1.53555
SCARB2 scavenger receptor class B, member 2 1.52487
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 1.52099
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 1.50624
SIVA1 SIVA1, apoptosis-inducing factor 1.49782
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1.49087
ATG13 autophagy related 13 1.48371
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.48261
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 1.47444
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 1.47385
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.46499
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 1.46335
ZNF706 zinc finger protein 706 1.45279
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.44729
RUFY1 RUN and FYVE domain containing 1 1.44722
HLA-A major histocompatibility complex, class I, A 1.44672
IL6ST interleukin 6 signal transducer 1.44532
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.44465
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.44194
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 1.43645
NAPSA napsin A aspartic peptidase 1.43157
PARP6 poly (ADP-ribose) polymerase family, member 6 1.4314
VKORC1 vitamin K epoxide reductase complex, subunit 1 1.4312
LPIN1 lipin 1 1.43085
KAT2B K(lysine) acetyltransferase 2B 1.42874
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 1.42264
HAGH hydroxyacylglutathione hydrolase 1.41746
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.41055
ART3 ADP-ribosyltransferase 3 1.40864
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.40863
PAIP2B poly(A) binding protein interacting protein 2B 1.40714
TTC1 tetratricopeptide repeat domain 1 1.4067
CDKN2AIPNL CDKN2A interacting protein N-terminal like 1.40502
PLBD1 phospholipase B domain containing 1 1.40496
RPL13A ribosomal protein L13a 1.40421
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 1.40405
QRICH1 glutamine-rich 1 1.40401
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 1.40088
RERE arginine-glutamic acid dipeptide (RE) repeats 1.40039
WDR45 WD repeat domain 45 1.39679
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 1.39389
RPL10A ribosomal protein L10a 1.39145
PDE8A phosphodiesterase 8A 1.39085
SEC62 SEC62 homolog (S. cerevisiae) 1.39039
TMEM245 transmembrane protein 245 1.38279
ZNF32 zinc finger protein 32 1.38119
BTF3 basic transcription factor 3 1.37743
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 1.37701
ZNF639 zinc finger protein 639 1.37605
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 1.37478
NDFIP2 Nedd4 family interacting protein 2 1.37325
C9ORF16 chromosome 9 open reading frame 16 1.37294
PNP purine nucleoside phosphorylase 1.37017
RPL7A ribosomal protein L7a 1.36389
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.36274
SART1 squamous cell carcinoma antigen recognized by T cells 1.36201
KCTD20 potassium channel tetramerization domain containing 20 1.36064
DES desmin 1.35982
LAMP1 lysosomal-associated membrane protein 1 1.35872
PARD3 par-3 family cell polarity regulator 1.35693
HOXC9 homeobox C9 1.35562
TBRG1 transforming growth factor beta regulator 1 1.35476
FBLN1 fibulin 1 1.35374
DYM dymeclin 1.3535
CIRBP cold inducible RNA binding protein 1.3466
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.34605
BAK1 BCL2-antagonist/killer 1 1.3447
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 1.34389
LARS leucyl-tRNA synthetase 1.34345
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.34094
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 1.34071
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 1.33616
ANKRD17 ankyrin repeat domain 17 1.3359
AEBP2 AE binding protein 2 1.33449
CXCL14 chemokine (C-X-C motif) ligand 14 1.33278
BTG2 BTG family, member 2 1.33073
GAB1 GRB2-associated binding protein 1 1.32808
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 1.32491
CSTB cystatin B (stefin B) 1.32206
SPIN1 spindlin 1 1.32122
RPS2 ribosomal protein S2 1.32092
TPD52 tumor protein D52 1.31826
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.31745
EXOC7 exocyst complex component 7 1.31471
BRAP BRCA1 associated protein 1.31437
CLIP1 CAP-GLY domain containing linker protein 1 1.30959
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.30636
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 1.30367

decreased expression

Symbol Name Standardized Value
HSPA9 heat shock 70kDa protein 9 (mortalin) -3.82378
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -3.68448
LARP4B La ribonucleoprotein domain family, member 4B -3.6527
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -3.43682
STIM1 stromal interaction molecule 1 -3.31201
GSTZ1 glutathione S-transferase zeta 1 -3.26291
DYNLL2 dynein, light chain, LC8-type 2 -3.16856
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -3.11701
ANKH ANKH inorganic pyrophosphate transport regulator -3.09754
COQ9 coenzyme Q9 -3.06117
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -3.05241
MCAM melanoma cell adhesion molecule -3.03113
TRIO trio Rho guanine nucleotide exchange factor -3.02025
NKAIN1 Na+/K+ transporting ATPase interacting 1 -2.9386
ADSSL1 adenylosuccinate synthase like 1 -2.90973
ITM2C integral membrane protein 2C -2.88068
ACTG1 actin gamma 1 -2.84806
LDHA lactate dehydrogenase A -2.7876
OSBPL1A oxysterol binding protein-like 1A -2.73534
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.73425
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -2.69422
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.68365
RNH1 ribonuclease/angiogenin inhibitor 1 -2.67269
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.65283
NFS1 NFS1 cysteine desulfurase -2.6509
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.64986
H1F0 H1 histone family, member 0 -2.64407
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.62858
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -2.6255
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.60944
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.60673
DQX1 DEAQ box RNA-dependent ATPase 1 -2.58687
TPT1 tumor protein, translationally-controlled 1 -2.57564
RASA4 RAS p21 protein activator 4 -2.53748
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.52196
MRPS11 mitochondrial ribosomal protein S11 -2.4803
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.4638
GLRX glutaredoxin (thioltransferase) -2.45647
MLH1 mutL homolog 1 -2.42024
FASN fatty acid synthase -2.41282
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -2.38019
TNNT3 troponin T type 3 (skeletal, fast) -2.3791
TRAPPC5 trafficking protein particle complex 5 -2.37534
PCBP4 poly(rC) binding protein 4 -2.36495
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -2.32399
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -2.31376
PRRC2A proline-rich coiled-coil 2A -2.31242
TBCK TBC1 domain containing kinase -2.29149
C16ORF13 chromosome 16 open reading frame 13 -2.2816
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.27781
ENO3 enolase 3 (beta, muscle) -2.27569
GBAS glioblastoma amplified sequence -2.27313
SPRYD4 SPRY domain containing 4 -2.27304
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.25858
LDOC1L leucine zipper, down-regulated in cancer 1-like -2.24621
SF3A1 splicing factor 3a, subunit 1, 120kDa -2.22263
ALDOA aldolase A, fructose-bisphosphate -2.21885
PRNP prion protein -2.21342
NSUN4 NOP2/Sun domain family, member 4 -2.2052
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -2.19588
TMX2 thioredoxin-related transmembrane protein 2 -2.19497
FRZB frizzled-related protein -2.18629
CLCN3 chloride channel, voltage-sensitive 3 -2.16068
RPL7L1 ribosomal protein L7-like 1 -2.15561
UBXN1 UBX domain protein 1 -2.15384
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.14669
SAMM50 SAMM50 sorting and assembly machinery component -2.12418
PPA1 pyrophosphatase (inorganic) 1 -2.1211
VASP vasodilator-stimulated phosphoprotein -2.11524
PARM1 prostate androgen-regulated mucin-like protein 1 -2.11322
MRPL11 mitochondrial ribosomal protein L11 -2.10776
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.10346
VTA1 vesicle (multivesicular body) trafficking 1 -2.09709
CXCL12 chemokine (C-X-C motif) ligand 12 -2.07915
MAD2L1BP MAD2L1 binding protein -2.07138
HSPB8 heat shock 22kDa protein 8 -2.06916
PGK1 phosphoglycerate kinase 1 -2.06894
OAZ2 ornithine decarboxylase antizyme 2 -2.05965
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.05442
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -2.04527
BCKDK branched chain ketoacid dehydrogenase kinase -2.04445
RNMTL1 RNA methyltransferase like 1 -2.04186
MRPS31 mitochondrial ribosomal protein S31 -2.03995
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.03962
TNNI2 troponin I type 2 (skeletal, fast) -2.03717
SUCLG1 succinate-CoA ligase, alpha subunit -2.0361
PLXND1 plexin D1 -2.03254
SRSF6 serine/arginine-rich splicing factor 6 -2.02962
ACTA1 actin, alpha 1, skeletal muscle -2.02452
RTN3 reticulon 3 -2.01523
EMID1 EMI domain containing 1 -2.00995
ART1 ADP-ribosyltransferase 1 -2.00909
PNKD paroxysmal nonkinesigenic dyskinesia -2.00698
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit -2.00332
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant -1.99719
PKDCC protein kinase domain containing, cytoplasmic -1.9839
PTHLH parathyroid hormone-like hormone -1.98194
CD5 CD5 molecule -1.98048
SP4 Sp4 transcription factor -1.97675
RYR1 ryanodine receptor 1 (skeletal) -1.97511
KIF3C kinesin family member 3C -1.97361
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 -1.97301
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase -1.97077
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.96318
PTPRS protein tyrosine phosphatase, receptor type, S -1.96147
MRPS25 mitochondrial ribosomal protein S25 -1.95028
CCDC28B coiled-coil domain containing 28B -1.95018
PPID peptidylprolyl isomerase D -1.94963
MTIF2 mitochondrial translational initiation factor 2 -1.93975
FH fumarate hydratase -1.9375
MRPL48 mitochondrial ribosomal protein L48 -1.9336
TMED9 transmembrane emp24 protein transport domain containing 9 -1.92732
PDGFA platelet-derived growth factor alpha polypeptide -1.92335
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -1.91768
ALAD aminolevulinate dehydratase -1.9112
RCOR1 REST corepressor 1 -1.90731
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -1.90399
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -1.89833
NRP1 neuropilin 1 -1.8953
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.88981
MAPK6 mitogen-activated protein kinase 6 -1.88681
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -1.8863
DGUOK deoxyguanosine kinase -1.88477
LRPPRC leucine-rich pentatricopeptide repeat containing -1.88457
COL5A1 collagen, type V, alpha 1 -1.87844
PARP1 poly (ADP-ribose) polymerase 1 -1.87378
SPAG7 sperm associated antigen 7 -1.86883
ECI1 enoyl-CoA delta isomerase 1 -1.86744
C6ORF89 chromosome 6 open reading frame 89 -1.86501
HNRNPL heterogeneous nuclear ribonucleoprotein L -1.86282
HIGD2A HIG1 hypoxia inducible domain family, member 2A -1.85719
ICT1 immature colon carcinoma transcript 1 -1.85318
SON SON DNA binding protein -1.84924
RBM8A RNA binding motif protein 8A -1.84287
COL18A1 collagen, type XVIII, alpha 1 -1.8318
LIMD1 LIM domains containing 1 -1.83092
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -1.82983
ARID4B AT rich interactive domain 4B (RBP1-like) -1.82326
ATXN2 ataxin 2 -1.81733
ANKRD46 ankyrin repeat domain 46 -1.81663
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -1.80969
C19ORF43 chromosome 19 open reading frame 43 -1.80954
CECR6 cat eye syndrome chromosome region, candidate 6 -1.80879
MRPL28 mitochondrial ribosomal protein L28 -1.80348
LEPROT leptin receptor overlapping transcript -1.8016
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -1.79592
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -1.78662
GFM1 G elongation factor, mitochondrial 1 -1.78645
METAP1 methionyl aminopeptidase 1 -1.78279
LUC7L2 LUC7-like 2 (S. cerevisiae) -1.78112
MYOZ1 myozenin 1 -1.78089
EDF1 endothelial differentiation-related factor 1 -1.78083
MRPS2 mitochondrial ribosomal protein S2 -1.78081
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -1.77947
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -1.77179
STX4 syntaxin 4 -1.76396
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -1.76038
PRDX2 peroxiredoxin 2 -1.75431
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -1.73932
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -1.7355
NICN1 nicolin 1 -1.73349
PHB prohibitin -1.73314
PTCD3 pentatricopeptide repeat domain 3 -1.72727
TMEM150A transmembrane protein 150A -1.7179
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -1.71784
CD59 CD59 molecule, complement regulatory protein -1.71527
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -1.71372
CNN2 calponin 2 -1.70463
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -1.70205
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -1.70051
HMOX2 heme oxygenase 2 -1.69867
SHFM1 split hand/foot malformation (ectrodactyly) type 1 -1.69278
MPDZ multiple PDZ domain protein -1.68959
NTPCR nucleoside-triphosphatase, cancer-related -1.68568
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -1.67477
CAPRIN2 caprin family member 2 -1.66532
GIMAP4 GTPase, IMAP family member 4 -1.65585
FAM192A family with sequence similarity 192, member A -1.65349
TNNT1 troponin T type 1 (skeletal, slow) -1.65074
MRPL24 mitochondrial ribosomal protein L24 -1.64925
HIST1H2BI histone cluster 1, H2bi -1.64753
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit -1.64538
CRNKL1 crooked neck pre-mRNA splicing factor 1 -1.64475
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -1.64423
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -1.64421
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -1.64394
AOX1 aldehyde oxidase 1 -1.64159
PPT2 palmitoyl-protein thioesterase 2 -1.63255
RPN1 ribophorin I -1.63075
PNCK pregnancy up-regulated nonubiquitous CaM kinase -1.62171
CD27 CD27 molecule -1.621
UBE2M ubiquitin-conjugating enzyme E2M -1.61877
MSH2 mutS homolog 2 -1.61753
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -1.61369
PRADC1 protease-associated domain containing 1 -1.61308
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -1.6069
PHYH phytanoyl-CoA 2-hydroxylase -1.60592
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -1.60507
MMP15 matrix metallopeptidase 15 (membrane-inserted) -1.60324
PDHB pyruvate dehydrogenase (lipoamide) beta -1.59625
RPUSD4 RNA pseudouridylate synthase domain containing 4 -1.59253
SETD8 SET domain containing (lysine methyltransferase) 8 -1.5895
CRHR2 corticotropin releasing hormone receptor 2 -1.58795
APIP APAF1 interacting protein -1.58763
FZD9 frizzled class receptor 9 -1.58671
JAK1 Janus kinase 1 -1.58364
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -1.58345
CXXC5 CXXC finger protein 5 -1.58332
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -1.57892
COL4A1 collagen, type IV, alpha 1 -1.56898
CLEC3B C-type lectin domain family 3, member B -1.56861
PVALB parvalbumin -1.56753
PRSS23 protease, serine, 23 -1.56398
SUSD6 sushi domain containing 6 -1.55466
DVL1 dishevelled segment polarity protein 1 -1.5546
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -1.55266
CHGA chromogranin A -1.55125
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -1.55102
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -1.54984
MRPL43 mitochondrial ribosomal protein L43 -1.54803
KRT17 keratin 17, type I -1.54543
ESYT1 extended synaptotagmin-like protein 1 -1.54404
SRSF2 serine/arginine-rich splicing factor 2 -1.54323
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -1.54136
PFKM phosphofructokinase, muscle -1.54124
FDX1 ferredoxin 1 -1.53401
UROS uroporphyrinogen III synthase -1.5307
TOX4 TOX high mobility group box family member 4 -1.51641
CD6 CD6 molecule -1.51366
ZC3H11A zinc finger CCCH-type containing 11A -1.508
SCN1B sodium channel, voltage gated, type I beta subunit -1.50702
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -1.5063
SATB1 SATB homeobox 1 -1.50512
CKM creatine kinase, muscle -1.50199
PTOV1 prostate tumor overexpressed 1 -1.50086
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -1.49899
TCF15 transcription factor 15 (basic helix-loop-helix) -1.49853
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -1.49834
MRPL12 mitochondrial ribosomal protein L12 -1.49681
COQ10A coenzyme Q10 homolog A (S. cerevisiae) -1.49613
FNTA farnesyltransferase, CAAX box, alpha -1.49557
COQ3 coenzyme Q3 methyltransferase -1.49545
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -1.49525
SIAH2 siah E3 ubiquitin protein ligase 2 -1.49411
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -1.49246
SYNGR1 synaptogyrin 1 -1.49188
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -1.49114
GCSH glycine cleavage system protein H (aminomethyl carrier) -1.4883
MXD1 MAX dimerization protein 1 -1.48683
CALML4 calmodulin-like 4 -1.48549
CR1L complement component (3b/4b) receptor 1-like -1.48295
AK1 adenylate kinase 1 -1.47866
STIP1 stress-induced phosphoprotein 1 -1.47296
ACAA1 acetyl-CoA acyltransferase 1 -1.47144
FAM101B family with sequence similarity 101, member B -1.46619
PDIA4 protein disulfide isomerase family A, member 4 -1.46504
MFSD4 major facilitator superfamily domain containing 4 -1.46359
USP6NL USP6 N-terminal like -1.46163
D2HGDH D-2-hydroxyglutarate dehydrogenase -1.46081
MRPL3 mitochondrial ribosomal protein L3 -1.45719
SOD2 superoxide dismutase 2, mitochondrial -1.45626
PARK7 parkinson protein 7 -1.4526
CA8 carbonic anhydrase VIII -1.45081
PYCRL pyrroline-5-carboxylate reductase-like -1.45028
HMBS hydroxymethylbilane synthase -1.44961
RBM18 RNA binding motif protein 18 -1.44063
BSG basigin (Ok blood group) -1.43586
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -1.42816
COL14A1 collagen, type XIV, alpha 1 -1.42725
MRPL33 mitochondrial ribosomal protein L33 -1.42616
DPY30 dpy-30 homolog (C. elegans) -1.42478
UQCRC1 ubiquinol-cytochrome c reductase core protein I -1.42429
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -1.41864
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -1.41654
MAP2K5 mitogen-activated protein kinase kinase 5 -1.41544
CKAP5 cytoskeleton associated protein 5 -1.41267
OXCT1 3-oxoacid CoA transferase 1 -1.41083
CCND1 cyclin D1 -1.41073
PGM1 phosphoglucomutase 1 -1.40949
PHLDA3 pleckstrin homology-like domain, family A, member 3 -1.40813
TCEA3 transcription elongation factor A (SII), 3 -1.40579
GRPEL2 GrpE-like 2, mitochondrial (E. coli) -1.40224
UQCRC2 ubiquinol-cytochrome c reductase core protein II -1.39944
PHOSPHO1 phosphatase, orphan 1 -1.39427
ACAA2 acetyl-CoA acyltransferase 2 -1.39158
DDAH2 dimethylarginine dimethylaminohydrolase 2 -1.39109
CCDC94 coiled-coil domain containing 94 -1.38947
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -1.38808
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -1.3859
RFC1 replication factor C (activator 1) 1, 145kDa -1.38203
ETV1 ets variant 1 -1.38197
BIN1 bridging integrator 1 -1.38174
STX1A syntaxin 1A (brain) -1.37995
TPI1 triosephosphate isomerase 1 -1.37384
MRPL18 mitochondrial ribosomal protein L18 -1.37272
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -1.37085
RXRG retinoid X receptor, gamma -1.37036
TRAPPC10 trafficking protein particle complex 10 -1.36938
CHRNG cholinergic receptor, nicotinic, gamma (muscle) -1.36913
TUBA1B tubulin, alpha 1b -1.36907
Funding