U-118-MG Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human neuronal glioblastoma (grade III) cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004605)
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Genes

319 genes with high or low expression in U-118-MG relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 3.09046
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.99795
COLEC12 collectin sub-family member 12 2.89453
SYNC syncoilin, intermediate filament protein 2.76924
FOXF2 forkhead box F2 2.68875
CEP250 centrosomal protein 250kDa 2.68515
CSN1S1 casein alpha s1 2.64888
AJAP1 adherens junctions associated protein 1 2.59901
PPAP2B phosphatidic acid phosphatase type 2B 2.55748
LUZP2 leucine zipper protein 2 2.51984
TPM4 tropomyosin 4 2.51589
NT5E 5'-nucleotidase, ecto (CD73) 2.47838
LTBP1 latent transforming growth factor beta binding protein 1 2.43434
KIAA1644 KIAA1644 2.3471
ACO1 aconitase 1, soluble 2.30489
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.29609
FST follistatin 2.24706
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.20719
EML1 echinoderm microtubule associated protein like 1 2.20153
FBN1 fibrillin 1 2.16344
GDF5 growth differentiation factor 5 2.1533
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 2.13601
RBPJ recombination signal binding protein for immunoglobulin kappa J region 2.13338
CDC42 cell division cycle 42 2.06389
CREB5 cAMP responsive element binding protein 5 2.02678
RGS3 regulator of G-protein signaling 3 2.02153
CCDC92 coiled-coil domain containing 92 2.00017
TBC1D19 TBC1 domain family, member 19 1.97078
HCFC2 host cell factor C2 1.94995
HRH1 histamine receptor H1 1.93946
EDNRA endothelin receptor type A 1.92682
CCDC53 coiled-coil domain containing 53 1.9184
DDB2 damage-specific DNA binding protein 2, 48kDa 1.91362
TSPAN5 tetraspanin 5 1.90798
MOCS2 molybdenum cofactor synthesis 2 1.9064
COL14A1 collagen, type XIV, alpha 1 1.90399
ADCY8 adenylate cyclase 8 (brain) 1.89808
LRRC15 leucine rich repeat containing 15 1.87458
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 1.87274
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 1.87028
GLIPR1 GLI pathogenesis-related 1 1.85983
MN1 meningioma (disrupted in balanced translocation) 1 1.84265
IRAK4 interleukin-1 receptor-associated kinase 4 1.83916
DCN decorin 1.81634
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.80799
TMEM158 transmembrane protein 158 (gene/pseudogene) 1.80144
PTX3 pentraxin 3, long 1.80141
CENPB centromere protein B, 80kDa 1.79732
FAM107A family with sequence similarity 107, member A 1.79329
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.79202
FOXC2 forkhead box C2 1.78621
CPZ carboxypeptidase Z 1.77747
TRAM2 translocation associated membrane protein 2 1.77555
FABP3 fatty acid binding protein 3, muscle and heart 1.77216
CMKLR1 chemerin chemokine-like receptor 1 1.77121
DOK5 docking protein 5 1.76391
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 1.75977
ARHGAP22 Rho GTPase activating protein 22 1.74974
HAS2 hyaluronan synthase 2 1.74083
TMPRSS15 transmembrane protease, serine 15 1.73224
ZNF385D zinc finger protein 385D 1.7313
SACS sacsin molecular chaperone 1.72873
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.72203
CORO2B coronin, actin binding protein, 2B 1.71126
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 1.71099
LOXL1 lysyl oxidase-like 1 1.69997
MMP3 matrix metallopeptidase 3 1.68762
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 1.6867
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.68398
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 1.67951
NCAM2 neural cell adhesion molecule 2 1.67528
PSD3 pleckstrin and Sec7 domain containing 3 1.6642
THY1 Thy-1 cell surface antigen 1.66418
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.66077
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 1.65434
COL15A1 collagen, type XV, alpha 1 1.64729
NPTX1 neuronal pentraxin I 1.64627
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.63889
COPZ2 coatomer protein complex, subunit zeta 2 1.63736
KIF13A kinesin family member 13A 1.62607
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 1.62133
GOLIM4 golgi integral membrane protein 4 1.62128
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 1.61573
NDP Norrie disease (pseudoglioma) 1.61114
ITGA8 integrin, alpha 8 1.60817
SOX5 SRY (sex determining region Y)-box 5 1.5982
PCOLCE2 procollagen C-endopeptidase enhancer 2 1.59752
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.59142
SH3GL1 SH3-domain GRB2-like 1 1.5829
PLN phospholamban 1.58246
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 1.57855
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.57165
ROM1 retinal outer segment membrane protein 1 1.56742
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.5664
PHLDA1 pleckstrin homology-like domain, family A, member 1 1.56171
RORB RAR-related orphan receptor B 1.56171
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.56159
LUM lumican 1.56145
NID2 nidogen 2 (osteonidogen) 1.56086
MEOX2 mesenchyme homeobox 2 1.56077
RNH1 ribonuclease/angiogenin inhibitor 1 1.55901
FKBP14 FK506 binding protein 14, 22 kDa 1.55066
BBS9 Bardet-Biedl syndrome 9 1.54785
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 1.54578
SPA17 sperm autoantigenic protein 17 1.54277
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 1.53524
PLIN3 perilipin 3 1.52848
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 1.52846
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 1.52695
AK1 adenylate kinase 1 1.52691
POSTN periostin, osteoblast specific factor 1.5217
CLEC3B C-type lectin domain family 3, member B 1.51876
RAB11FIP5 RAB11 family interacting protein 5 (class I) 1.51043
PPAP2A phosphatidic acid phosphatase type 2A 1.50928
VCL vinculin 1.50756
RECK reversion-inducing-cysteine-rich protein with kazal motifs 1.50614
RIN1 Ras and Rab interactor 1 1.50552
DENND2A DENN/MADD domain containing 2A 1.50392
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 1.49034
CA5B carbonic anhydrase VB, mitochondrial 1.48971
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.48384
CH25H cholesterol 25-hydroxylase 1.4758
HSPB6 heat shock protein, alpha-crystallin-related, B6 1.47103
NRIP3 nuclear receptor interacting protein 3 1.46529
CROT carnitine O-octanoyltransferase 1.46282
SFRP4 secreted frizzled-related protein 4 1.45678
MVP major vault protein 1.4503
DAP death-associated protein 1.44946
RAB31 RAB31, member RAS oncogene family 1.44634
SNX9 sorting nexin 9 1.43672
IGFBP4 insulin-like growth factor binding protein 4 1.43252
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 1.43062
RGS17 regulator of G-protein signaling 17 1.42599
SOD3 superoxide dismutase 3, extracellular 1.41746

low expression

Symbol Name Standardized Value
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -3.42303
CTSH cathepsin H -2.91692
CAMK2B calcium/calmodulin-dependent protein kinase II beta -2.84476
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -2.8008
EXOC6B exocyst complex component 6B -2.79961
IL22 interleukin 22 -2.79138
OPHN1 oligophrenin 1 -2.68185
PSG4 pregnancy specific beta-1-glycoprotein 4 -2.58381
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.58364
NEUROD4 neuronal differentiation 4 -2.54715
RPP38 ribonuclease P/MRP 38kDa subunit -2.53783
RBM7 RNA binding motif protein 7 -2.5226
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.51951
POU4F2 POU class 4 homeobox 2 -2.46568
TSNAXIP1 translin-associated factor X interacting protein 1 -2.38669
CREG1 cellular repressor of E1A-stimulated genes 1 -2.31686
RFPL3 ret finger protein-like 3 -2.3166
FAM60A family with sequence similarity 60, member A -2.31077
FLJ42627 uncharacterized LOC645644 -2.30331
INADL InaD-like (Drosophila) -2.29211
RNF44 ring finger protein 44 -2.2724
FYB FYN binding protein -2.26917
FPGT fucose-1-phosphate guanylyltransferase -2.26759
CRYZ crystallin, zeta (quinone reductase) -2.25965
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 -2.23059
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.20456
RCOR3 REST corepressor 3 -2.15345
ADCY7 adenylate cyclase 7 -2.13656
RAB4A RAB4A, member RAS oncogene family -2.12939
GCLC glutamate-cysteine ligase, catalytic subunit -2.10187
AEN apoptosis enhancing nuclease -2.09399
PUS1 pseudouridylate synthase 1 -2.07615
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -2.05955
CROCC ciliary rootlet coiled-coil, rootletin -2.05736
AKAP6 A kinase (PRKA) anchor protein 6 -2.05192
SH3BP2 SH3-domain binding protein 2 -2.05094
RAB33B RAB33B, member RAS oncogene family -2.04229
MYH10 myosin, heavy chain 10, non-muscle -2.03835
MOAP1 modulator of apoptosis 1 -2.01737
VRK2 vaccinia related kinase 2 -2.00263
HAUS5 HAUS augmin-like complex, subunit 5 -1.98718
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -1.98062
ENOSF1 enolase superfamily member 1 -1.96129
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -1.95183
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -1.9484
KIAA0040 KIAA0040 -1.9445
CDC42SE1 CDC42 small effector 1 -1.9435
FSCN3 fascin actin-bundling protein 3, testicular -1.94222
TCERG1 transcription elongation regulator 1 -1.93756
ABAT 4-aminobutyrate aminotransferase -1.93269
KDM3B lysine (K)-specific demethylase 3B -1.92754
CYB5A cytochrome b5 type A (microsomal) -1.92529
OFD1 oral-facial-digital syndrome 1 -1.89365
HIST2H2AA3 histone cluster 2, H2aa3 -1.88009
PTAFR platelet-activating factor receptor -1.87532
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -1.85973
CDC23 cell division cycle 23 -1.8541
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -1.84552
MLXIP MLX interacting protein -1.84456
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -1.83415
PROL1 proline rich, lacrimal 1 -1.81726
TMCO6 transmembrane and coiled-coil domains 6 -1.80712
ZNF37BP zinc finger protein 37B, pseudogene -1.80558
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -1.80446
FAM53B family with sequence similarity 53, member B -1.7901
ING1 inhibitor of growth family, member 1 -1.7854
FAM49B family with sequence similarity 49, member B -1.77943
CFAP45 cilia and flagella associated protein 45 -1.77739
RBM23 RNA binding motif protein 23 -1.7735
NFE2L3 nuclear factor, erythroid 2-like 3 -1.76667
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) -1.7629
HIST1H2AE histone cluster 1, H2ae -1.74792
MFSD10 major facilitator superfamily domain containing 10 -1.74599
HRASLS2 HRAS-like suppressor 2 -1.74382
STRN striatin, calmodulin binding protein -1.7389
RAB11FIP1 RAB11 family interacting protein 1 (class I) -1.73485
DOK2 docking protein 2, 56kDa -1.72193
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -1.72182
ECHDC2 enoyl CoA hydratase domain containing 2 -1.7147
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -1.70371
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -1.69481
TMEM168 transmembrane protein 168 -1.69267
PUM2 pumilio RNA-binding family member 2 -1.69074
OVGP1 oviductal glycoprotein 1, 120kDa -1.68778
TAS2R4 taste receptor, type 2, member 4 -1.68022
OSBPL9 oxysterol binding protein-like 9 -1.6798
TGIF2 TGFB-induced factor homeobox 2 -1.67651
ECD ecdysoneless homolog (Drosophila) -1.67325
STOML2 stomatin (EPB72)-like 2 -1.66744
EML2 echinoderm microtubule associated protein like 2 -1.66471
TBC1D4 TBC1 domain family, member 4 -1.66292
SCGB2A2 secretoglobin, family 2A, member 2 -1.6595
MBNL2 muscleblind-like splicing regulator 2 -1.65563
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -1.65507
ARSA arylsulfatase A -1.65264
CARD14 caspase recruitment domain family, member 14 -1.65016
PHF8 PHD finger protein 8 -1.63824
YBX2 Y box binding protein 2 -1.6369
CDH17 cadherin 17, LI cadherin (liver-intestine) -1.63515
FZD3 frizzled class receptor 3 -1.62415
STXBP2 syntaxin binding protein 2 -1.62021
CNOT1 CCR4-NOT transcription complex, subunit 1 -1.61709
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -1.61639
WNT8B wingless-type MMTV integration site family, member 8B -1.61498
COG2 component of oligomeric golgi complex 2 -1.61426
PLAA phospholipase A2-activating protein -1.61318
FOXO1 forkhead box O1 -1.60824
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -1.60773
BCAS3 breast carcinoma amplified sequence 3 -1.60321
ZNF613 zinc finger protein 613 -1.59283
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding) -1.58993
LYN LYN proto-oncogene, Src family tyrosine kinase -1.58702
LARP4B La ribonucleoprotein domain family, member 4B -1.58508
CCDC64 coiled-coil domain containing 64 -1.58436
RPL38 ribosomal protein L38 -1.58086
ITPK1 inositol-tetrakisphosphate 1-kinase -1.57866
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -1.57817
IL5RA interleukin 5 receptor, alpha -1.57038
PRKD1 protein kinase D1 -1.56893
LLGL2 lethal giant larvae homolog 2 (Drosophila) -1.56777
EGLN3 egl-9 family hypoxia-inducible factor 3 -1.56651
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -1.56604
CD226 CD226 molecule -1.55752
EIF4A3 eukaryotic translation initiation factor 4A3 -1.55412
PLAGL2 pleiomorphic adenoma gene-like 2 -1.55372
CA1 carbonic anhydrase I -1.54858
RGS14 regulator of G-protein signaling 14 -1.54738
PRKCB protein kinase C, beta -1.53846
CD40 CD40 molecule, TNF receptor superfamily member 5 -1.53616
NSUN5 NOP2/Sun domain family, member 5 -1.52632
GZMK granzyme K (granzyme 3; tryptase II) -1.52139
GLRA3 glycine receptor, alpha 3 -1.52046
TBL1Y transducin (beta)-like 1, Y-linked -1.51864
IQSEC1 IQ motif and Sec7 domain 1 -1.51588
PUM1 pumilio RNA-binding family member 1 -1.51493
FLAD1 flavin adenine dinucleotide synthetase 1 -1.51334
ZMYM2 zinc finger, MYM-type 2 -1.50593
KRT18 keratin 18, type I -1.50443
TCEAL2 transcription elongation factor A (SII)-like 2 -1.50042
NT5C2 5'-nucleotidase, cytosolic II -1.49428
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -1.4916
SLC41A3 solute carrier family 41, member 3 -1.48665
FAM120C family with sequence similarity 120C -1.48288
PRICKLE3 prickle homolog 3 (Drosophila) -1.47979
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -1.47855
SMYD2 SET and MYND domain containing 2 -1.47797
MTM1 myotubularin 1 -1.47512
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -1.47201
ZCCHC8 zinc finger, CCHC domain containing 8 -1.47066
L1CAM L1 cell adhesion molecule -1.46699
REV1 REV1, polymerase (DNA directed) -1.46675
EPHB1 EPH receptor B1 -1.46634
RPS14 ribosomal protein S14 -1.46493
KRT31 keratin 31, type I -1.46456
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -1.46307
NUP210 nucleoporin 210kDa -1.4629
MARCKSL1 MARCKS-like 1 -1.46238
HNF4G hepatocyte nuclear factor 4, gamma -1.4608
LRP5 low density lipoprotein receptor-related protein 5 -1.45975
PLAC8 placenta-specific 8 -1.45669
GPA33 glycoprotein A33 (transmembrane) -1.45497
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -1.45123
CHST10 carbohydrate sulfotransferase 10 -1.44932
DMP1 dentin matrix acidic phosphoprotein 1 -1.44923
PMPCA peptidase (mitochondrial processing) alpha -1.44834
MTAP methylthioadenosine phosphorylase -1.44721
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -1.44621
FOXI1 forkhead box I1 -1.44338
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2 -1.44108
CCNT2 cyclin T2 -1.43837
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 -1.43763
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -1.43753
LHX6 LIM homeobox 6 -1.43648
TRAF3 TNF receptor-associated factor 3 -1.43177
AHCY adenosylhomocysteinase -1.42892
TPD52 tumor protein D52 -1.42835
LRPPRC leucine-rich pentatricopeptide repeat containing -1.428
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -1.42773
MAP2 microtubule-associated protein 2 -1.42532
PTPRD protein tyrosine phosphatase, receptor type, D -1.42531
MMRN1 multimerin 1 -1.4242
YME1L1 YME1-like 1 ATPase -1.42203
HIST1H3C histone cluster 1, H3c -1.42145
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -1.42048
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -1.41605