UBE2N Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ubiquitin-conjugating enzyme E2N|The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7334)
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Genes

338 genes differentially expressed following the UBE2N gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.33787
C6 complement component 6 3.33787
SAMD11 sterile alpha motif domain containing 11 3.33787
SP5 Sp5 transcription factor 3.33787
FGFBP1 fibroblast growth factor binding protein 1 3.33787
NMUR2 neuromedin U receptor 2 3.33787
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.33787
TDO2 tryptophan 2,3-dioxygenase 3.33787
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.33787
PRDM13 PR domain containing 13 3.33787
MPO myeloperoxidase 3.33787
UTS2 urotensin 2 3.33787
GYPB glycophorin B (MNS blood group) 3.33787
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.33787
BSX brain-specific homeobox 3.33787
LRRC10B leucine rich repeat containing 10B 3.33787
CDKN2A cyclin-dependent kinase inhibitor 2A 3.33787
CELA1 chymotrypsin-like elastase family, member 1 3.33787
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.33787
TRPC5OS TRPC5 opposite strand 3.33787
KRTAP5-9 keratin associated protein 5-9 3.33787
ASIC3 acid sensing (proton gated) ion channel 3 3.33787
TMPRSS7 transmembrane protease, serine 7 3.33787
GPRC5A G protein-coupled receptor, class C, group 5, member A 3.33787
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.33787
SLC38A11 solute carrier family 38, member 11 3.33787
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.33787
ADAM29 ADAM metallopeptidase domain 29 3.33787
PF4V1 platelet factor 4 variant 1 3.33787
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.33787
GCSAM germinal center-associated, signaling and motility 3.33787
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.33787
ASCL5 achaete-scute family bHLH transcription factor 5 3.33787
CCDC87 coiled-coil domain containing 87 3.33787
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.33787
PRSS22 protease, serine, 22 3.33787
AMIGO3 adhesion molecule with Ig-like domain 3 3.33787
NFE2 nuclear factor, erythroid 2 3.33787
CD33 CD33 molecule 3.33787
ANKRD30A ankyrin repeat domain 30A 3.33787
CLEC6A C-type lectin domain family 6, member A 3.33787
TEX35 testis expressed 35 3.33787
NKX2-6 NK2 homeobox 6 3.33787
SOX1 SRY (sex determining region Y)-box 1 3.33787
LRRD1 leucine-rich repeats and death domain containing 1 3.33787
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 3.33787
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.33787
SCG2 secretogranin II 3.33787
CTRL chymotrypsin-like 3.33787
EGFL6 EGF-like-domain, multiple 6 3.33787
PLIN1 perilipin 1 3.33787
LAPTM5 lysosomal protein transmembrane 5 3.33787
CLEC3A C-type lectin domain family 3, member A 3.33787
TEX101 testis expressed 101 3.33787
PCDHA7 protocadherin alpha 7 3.33787
HDC histidine decarboxylase 3.33787
CD300LG CD300 molecule-like family member g 3.33787
FAM153A family with sequence similarity 153, member A 3.33787
HBA2 hemoglobin, alpha 2 3.33787
SLC22A14 solute carrier family 22, member 14 3.33787
IRF5 interferon regulatory factor 5 3.33787
CFHR3 complement factor H-related 3 3.33787
SPINK4 serine peptidase inhibitor, Kazal type 4 3.33787
FABP1 fatty acid binding protein 1, liver 3.33787
BMP8B bone morphogenetic protein 8b 3.33787
BMP8A bone morphogenetic protein 8a 3.33787
OVOL3 ovo-like zinc finger 3 3.33787
ASB12 ankyrin repeat and SOCS box containing 12 3.33787
SLAMF1 signaling lymphocytic activation molecule family member 1 3.33787
RSPO1 R-spondin 1 3.33787
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.33787
SSTR5 somatostatin receptor 5 3.33787
PAX3 paired box 3 3.33787
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.33787
CD48 CD48 molecule 3.33787
TRIM17 tripartite motif containing 17 3.33787
ADIPOQ adiponectin, C1Q and collagen domain containing 3.33787
SOX18 SRY (sex determining region Y)-box 18 3.33787
TCHH trichohyalin 3.33787
ZSWIM2 zinc finger, SWIM-type containing 2 3.33787
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.33787
SLC25A41 solute carrier family 25, member 41 3.33787
SH2D7 SH2 domain containing 7 3.33787
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.33787
RPS24 ribosomal protein S24 3.33787
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.33787
CIMIP3 ciliary microtubule inner protein 3 3.33787
SPATA31H1 SPATA31 subfamily H member 1 3.33787
DLX3 distal-less homeobox 3 3.33787
IRF2-DT IRF2 divergent transcript 3.33787
DND1 DND microRNA-mediated repression inhibitor 1 3.33787
CTRB1 chymotrypsinogen B1 3.33787
FAM240A family with sequence similarity 240 member A 3.33787
FSHR follicle stimulating hormone receptor 3.33787
LOC124903372 uncharacterized LOC124903372 3.33787
FAM135B family with sequence similarity 135, member B 3.33787
PCDHGA4 protocadherin gamma subfamily A, 4 3.33787
CLEC18C C-type lectin domain family 18, member C 3.33787
PPP1R2C PPP1R2C family member C 3.33787
TERB2 telomere repeat binding bouquet formation protein 2 3.33787
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.33787
MDFIC2 MyoD family inhibitor domain containing 2 3.33787
TTC16 tetratricopeptide repeat domain 16 3.33787
FBXL22 F-box and leucine-rich repeat protein 22 3.33787
CD28 CD28 molecule 3.33787
RGS8 regulator of G-protein signaling 8 3.33787
EOMES eomesodermin 3.33787
TTC24 tetratricopeptide repeat domain 24 3.33787
ZPBP zona pellucida binding protein 3.33787
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.33787
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.33787
PHACTR3 phosphatase and actin regulator 3 3.33787
CFP complement factor properdin 3.33787
CFH complement factor H 3.33787
CNGB1 cyclic nucleotide gated channel beta 1 3.33787
CCDC70 coiled-coil domain containing 70 3.33787
FKBP1C FK506 binding protein 1C 3.33787
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.33787
HMGB4 high mobility group box 4 3.33787
CAPSL calcyphosine-like 3.33787
TYR tyrosinase 3.33787
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.33787
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.33787
TEX53 testis expressed 53 3.33787
LMX1A LIM homeobox transcription factor 1, alpha 3.33787
ITGA8 integrin, alpha 8 3.33787
LMNTD1 lamin tail domain containing 1 3.33787
OTOS otospiralin 3.33787
SPATS1 spermatogenesis associated, serine-rich 1 3.33787
GOLGA6L7 golgin A6 family like 7 3.33787
APOH apolipoprotein H (beta-2-glycoprotein I) 3.33787
PCDHGB5 protocadherin gamma subfamily B, 5 3.33787
PCDHGB1 protocadherin gamma subfamily B, 1 3.33787
MAGEA2B melanoma antigen family A2B 3.33787
LRRC4C leucine rich repeat containing 4C 3.33787
TCF21 transcription factor 21 3.33787
SPRR2F small proline-rich protein 2F 3.33787
PRR15L proline rich 15-like 3.33787
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.33787
LAMP3 lysosomal-associated membrane protein 3 3.33787
CLCA1 chloride channel accessory 1 3.33787
SPRR2G small proline-rich protein 2G 3.33787
MT1M metallothionein 1M 3.33787
POTEJ POTE ankyrin domain family, member J 3.33787
AMER2 APC membrane recruitment protein 2 3.33787
ACKR2 atypical chemokine receptor 2 3.33787
FNDC1 fibronectin type III domain containing 1 3.33787
GNA14 guanine nucleotide binding protein (G protein), alpha 14 3.33787
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.33787
BPIFB3 BPI fold containing family B, member 3 3.33787
TBC1D10C TBC1 domain family, member 10C 3.33787
DIPK1C divergent protein kinase domain 1C 3.33787
NPFFR1 neuropeptide FF receptor 1 3.33787
SOFU1 sperm-oocyte fusion factor 1 3.33787
TRIM55 tripartite motif containing 55 3.33787
RANBP3L RAN binding protein 3-like 3.33787
LORICRIN loricrin cornified envelope precursor protein 3.33787
DRD5 dopamine receptor D5 3.33787
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.33787
SQOR sulfide quinone oxidoreductase 3.33787
NOG noggin 3.33787
H3-5 H3.5 histone 3.33787
OPRK1 opioid receptor, kappa 1 3.33787
H1-3 H1.3 linker histone, cluster member 3.33787
CTAGE15 CTAGE family, member 15 3.33787
VNN1 vanin 1 3.33787
ESYT1 extended synaptotagmin-like protein 1 3.16179
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.93202
TEN1 TEN1 CST complex subunit 2.76372
ATXN1 ataxin 1 2.5847
RPL6 ribosomal protein L6 2.57927
TAMALIN trafficking regulator and scaffold protein tamalin 2.49728
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J 2.46839
PTCHD4 patched domain containing 4 2.45306
PTN pleiotrophin 2.40916
TSPAN5 tetraspanin 5 2.40812
SIMC1 SUMO-interacting motifs containing 1 2.4023
TUBE1 tubulin, epsilon 1 2.38695
GET1 guided entry of tail-anchored proteins factor 1 2.37016
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.36901
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.36901
C2ORF42 chromosome 2 open reading frame 42 2.35752
OPRM1 opioid receptor, mu 1 2.35591
TFEC transcription factor EC 2.35591
CPA2 carboxypeptidase A2 (pancreatic) 2.35591
ADAM12 ADAM metallopeptidase domain 12 2.33954
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.33954
WAS Wiskott-Aldrich syndrome 2.33954
DNAH8 dynein, axonemal, heavy chain 8 2.33954
TIGD6 tigger transposable element derived 6 2.33954
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.33954
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.33954
MEOX2 mesenchyme homeobox 2 2.33954
OCM oncomodulin 2.33539
FAM227B family with sequence similarity 227, member B 2.31234
ZMYND15 zinc finger, MYND-type containing 15 2.28631
HLF hepatic leukemia factor 2.28631
SMIM22 small integral membrane protein 22 2.27075
TEX19 testis expressed 19 2.27075
RAB37 RAB37, member RAS oncogene family 2.2239
LTA4H leukotriene A4 hydrolase 2.21859
LZTS2 leucine zipper, putative tumor suppressor 2 2.21859
TAPT1 transmembrane anterior posterior transformation 1 2.2097
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 2.19061
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.1854
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.18077
GPN3 GPN-loop GTPase 3 2.17586
GSS glutathione synthetase 2.15839
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.15839
MRAP2 melanocortin 2 receptor accessory protein 2 2.14169
TTK TTK protein kinase 2.12309
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.12309
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2.11054
RFLNB refilin B 2.11054
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.0938
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 2.0895
MPI mannose phosphate isomerase 2.08847
LCORL ligand dependent nuclear receptor corepressor-like 2.08847
SFMBT1 Scm-like with four mbt domains 1 2.08151
RPS19BP1 ribosomal protein S19 binding protein 1 2.06624
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.06468
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.0381
DRAM2 DNA-damage regulated autophagy modulator 2 2.0381
FOXO6 forkhead box O6 2.02486
ESRP1 epithelial splicing regulatory protein 1 2.0221
IL34 interleukin 34 2.0192
TSNAX translin-associated factor X 2.0192
AVPI1 arginine vasopressin-induced 1 2.0192
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.01479

decreased expression

Symbol Name Standardized Value
TMEM151A transmembrane protein 151A -3.33787
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -3.33787
TMEM213 transmembrane protein 213 -3.33787
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -3.33787
MFAP4 microfibrillar-associated protein 4 -3.33787
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 -3.33787
APOB apolipoprotein B -3.33787
OR56A4 olfactory receptor, family 56, subfamily A, member 4 -3.33787
STARD6 StAR-related lipid transfer (START) domain containing 6 -3.33787
PRDM7 PR domain containing 7 -3.33787
ZFAND4 zinc finger, AN1-type domain 4 -3.33787
UPK3A uroplakin 3A -3.33787
PNMA5 paraneoplastic Ma antigen family member 5 -3.33787
PROKR1 prokineticin receptor 1 -3.33787
SLC15A5 solute carrier family 15, member 5 -3.33787
PCDHB14 protocadherin beta 14 -3.33787
UBE2N ubiquitin-conjugating enzyme E2N -3.33787
RPL3L ribosomal protein L3-like -3.33787
TDRD7 tudor domain containing 7 -3.33787
C1ORF87 chromosome 1 open reading frame 87 -3.33787
LCN10 lipocalin 10 -3.33787
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -3.33787
BCO1 beta-carotene oxygenase 1 -3.33787
KLK14 kallikrein-related peptidase 14 -3.33787
DENND1C DENN/MADD domain containing 1C -3.33787
LGALS14 lectin, galactoside-binding, soluble, 14 -3.33787
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -3.33787
GPRC6A G protein-coupled receptor, class C, group 6, member A -3.33787
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -3.33787
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -3.33787
CRYBB3 crystallin, beta B3 -3.33787
ARHGAP40 Rho GTPase activating protein 40 -3.33787
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.33787
FAM151A family with sequence similarity 151, member A -3.33787
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -3.324
N4BP2L1 NEDD4 binding protein 2-like 1 -3.29519
ZNF471 zinc finger protein 471 -3.24573
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -3.13634
BRD3 bromodomain containing 3 -3.0613
FAM169A family with sequence similarity 169, member A -3.03923
PELO pelota homolog (Drosophila) -2.93707
MTX3 metaxin 3 -2.92553
TCAIM T cell activation inhibitor, mitochondrial -2.92441
TIGD1 tigger transposable element derived 1 -2.87053
TLN1 talin 1 -2.78668
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 -2.74772
ZNF184 zinc finger protein 184 -2.74102
HEYL hes-related family bHLH transcription factor with YRPW motif-like -2.74102
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.74102
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -2.73385
RAP1B RAP1B, member of RAS oncogene family -2.72073
FES FES proto-oncogene, tyrosine kinase -2.71483
ZNF619 zinc finger protein 619 -2.68166
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.61988
RFC1 replication factor C (activator 1) 1, 145kDa -2.61424
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.60286
BRCA1 breast cancer 1, early onset -2.57927
PASK PAS domain containing serine/threonine kinase -2.55595
FIBP fibroblast growth factor (acidic) intracellular binding protein -2.51265
GRM5 glutamate receptor, metabotropic 5 -2.43364
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.42707
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.38669
OTOA otoancorin -2.37721
FAM53A family with sequence similarity 53, member A -2.37721
C1ORF159 chromosome 1 open reading frame 159 -2.36507
SHROOM4 shroom family member 4 -2.35591
CFDP1 craniofacial development protein 1 -2.33444
MSL2 male-specific lethal 2 homolog (Drosophila) -2.31044
SLMAP sarcolemma associated protein -2.29906
KAT8 K(lysine) acetyltransferase 8 -2.29725
TBK1 TANK-binding kinase 1 -2.2907
ZNF391 zinc finger protein 391 -2.27796
ACACB acetyl-CoA carboxylase beta -2.27008
EID2 EP300 interacting inhibitor of differentiation 2 -2.26262
STAR steroidogenic acute regulatory protein -2.2543
ICOSLG inducible T-cell co-stimulator ligand -2.2543
COMTD1 catechol-O-methyltransferase domain containing 1 -2.23377
PDLIM1 PDZ and LIM domain 1 -2.2239
NPC1 Niemann-Pick disease, type C1 -2.2239
MYO7A myosin VIIA -2.21859
LHX6 LIM homeobox 6 -2.21859
PHYH phytanoyl-CoA 2-hydroxylase -2.19216
VEGFD vascular endothelial growth factor D -2.1854
CISH cytokine inducible SH2-containing protein -2.1854
AP5B1 adaptor-related protein complex 5, beta 1 subunit -2.17586
USP30 ubiquitin specific peptidase 30 -2.17586
PRPF8 pre-mRNA processing factor 8 -2.17586
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.17276
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.16905
ZSCAN22 zinc finger and SCAN domain containing 22 -2.16568
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -2.15839
TCTN3 tectonic family member 3 -2.13992
FRMD1 FERM domain containing 1 -2.12439
CBARP CACN subunit beta associated regulatory protein -2.11673
CUTC cutC copper transporter -2.1101
ISCA2 iron-sulfur cluster assembly 2 -2.10147
TBC1D17 TBC1 domain family, member 17 -2.1012
LOC107985101 uncharacterized LOC107985101 -2.08847
JOSD2 Josephin domain containing 2 -2.08847
COTL1 coactosin-like F-actin binding protein 1 -2.08151
AHDC1 AT hook, DNA binding motif, containing 1 -2.07124
NRBF2 nuclear receptor binding factor 2 -2.06468
LMTK2 lemur tyrosine kinase 2 -2.06204
RPS27L ribosomal protein S27-like -2.04964
H2BC12 H2B clustered histone 12 -2.04665
KLHDC9 kelch domain containing 9 -2.04116
LYSET lysosomal enzyme trafficking factor -2.04007
TNIP2 TNFAIP3 interacting protein 2 -2.03728
MISFA mitochondrial sheath formation associated -2.03273