UHRF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase|This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 115426)
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Genes

358 genes differentially expressed following the UHRF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPINK4 serine peptidase inhibitor, Kazal type 4 4.23322
DIRAS2 DIRAS family, GTP-binding RAS-like 2 4.23322
GPR26 G protein-coupled receptor 26 4.23322
GPR22 G protein-coupled receptor 22 4.23322
SPINT3 serine peptidase inhibitor, Kunitz type, 3 4.23322
SERF1A small EDRK-rich factor 1A (telomeric) 4.23322
RFPL3 ret finger protein-like 3 4.23322
UBE2U ubiquitin-conjugating enzyme E2U (putative) 4.23322
TRPV5 transient receptor potential cation channel, subfamily V, member 5 4.23322
ADAMTSL5 ADAMTS-like 5 4.23322
TPSD1 tryptase delta 1 4.23322
BSX brain-specific homeobox 4.23322
SSTR5 somatostatin receptor 5 4.23322
ASB17 ankyrin repeat and SOCS box containing 17 4.23322
PRELP proline/arginine-rich end leucine-rich repeat protein 4.23322
MGAM2 maltase-glucoamylase 2 (putative) 4.23322
CELA3A chymotrypsin-like elastase family, member 3A 4.23322
CAPNS2 calpain, small subunit 2 4.23322
SIRPB2 signal-regulatory protein beta 2 4.23322
EPB42 erythrocyte membrane protein band 4.2 4.23322
CCL5 chemokine (C-C motif) ligand 5 4.23322
GJB3 gap junction protein, beta 3, 31kDa 4.23322
HBA1 hemoglobin, alpha 1 4.23322
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 4.23322
PAX4 paired box 4 4.23322
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 4.23322
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 4.23322
PCDH8 protocadherin 8 4.23322
HAND1 heart and neural crest derivatives expressed 1 4.23322
PRDM1 PR domain containing 1, with ZNF domain 4.23322
ARSH arylsulfatase family, member H 4.23322
EMCN endomucin 4.23322
FGF7 fibroblast growth factor 7 4.23322
FAM81B family with sequence similarity 81, member B 4.23322
TSSK1B testis-specific serine kinase 1B 4.23322
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 4.23322
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 4.23322
LOXL4 lysyl oxidase-like 4 4.23322
ASCL1 achaete-scute family bHLH transcription factor 1 4.23322
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 4.23322
LOC105378220 macrophage receptor MARCO-like 4.23322
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 4.23322
TDRD9 tudor domain containing 9 4.23322
DPPA3 developmental pluripotency associated 3 4.23322
MAGED4 melanoma antigen family D4 4.23322
SHE Src homology 2 domain containing E 4.23322
LRRC61 leucine rich repeat containing 61 4.23322
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 4.23322
MMP20 matrix metallopeptidase 20 4.23322
ZNF705D zinc finger protein 705D 4.23322
IL2RA interleukin 2 receptor, alpha 4.23322
GALR3 galanin receptor 3 4.23322
ASCL2 achaete-scute family bHLH transcription factor 2 4.23322
CIMIP1 ciliary microtubule inner protein 1 4.23322
CD300LF CD300 molecule-like family member f 4.23322
MYH7 myosin, heavy chain 7, cardiac muscle, beta 4.23322
FRG2C FSHD region gene 2 family, member C 4.23322
KRT83 keratin 83, type II 4.23322
FIMP1 fertilization-influencing membrane protein 1 4.23322
FMOD fibromodulin 4.23322
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 4.23322
BDKRB2 bradykinin receptor B2 4.23322
GCSAM germinal center-associated, signaling and motility 4.23322
SELL selectin L 4.23322
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 4.23322
MCHR1 melanin-concentrating hormone receptor 1 4.23322
PTH1R parathyroid hormone 1 receptor 4.23322
EPCIP exosomal polycystin 1 interacting protein 4.23322
TEX53 testis expressed 53 4.23322
IRF2-DT IRF2 divergent transcript 4.23322
TMEM225B transmembrane protein 225B 4.23322
GARIN4 golgi associated RAB2 interactor family member 4 4.23322
CABCOCO1 ciliary associated calcium binding coiled-coil 1 4.23322
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 4.23322
CBLIF cobalamin binding intrinsic factor 4.23322
ASDURF ASNSD1 upstream open reading frame 4.23322
SEPTIN14 septin 14 4.23322
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 4.23322
LEKR1 leucine, glutamate and lysine rich 1 4.23322
KL klotho 4.23322
MLANA melan-A 4.23322
GOLGA6L4 golgin A6 family-like 4 4.23322
LIPF lipase, gastric 4.23322
PVRIG poliovirus receptor related immunoglobulin domain containing 4.23322
HHEX hematopoietically expressed homeobox 4.23322
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 4.23322
GJA4 gap junction protein, alpha 4, 37kDa 4.23322
TMPRSS11D transmembrane protease, serine 11D 4.23322
LY86 lymphocyte antigen 86 4.23322
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 4.23322
ZNF503 zinc finger protein 503 4.23322
CDH5 cadherin 5, type 2 (vascular endothelium) 4.23322
C10ORF67 chromosome 10 open reading frame 67 4.23322
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 4.23322
LTK leukocyte receptor tyrosine kinase 4.23322
GPR85 G protein-coupled receptor 85 4.23322
TAS1R1 taste receptor, type 1, member 1 4.23322
FGFBP1 fibroblast growth factor binding protein 1 4.23322
ARHGAP15 Rho GTPase activating protein 15 4.23322
LRRC3C leucine rich repeat containing 3C 4.23322
SAA1 serum amyloid A1 4.23322
S100G S100 calcium binding protein G 4.23322
PRR18 proline rich 18 4.23322
C1QL2 complement component 1, q subcomponent-like 2 4.23322
IL5 interleukin 5 4.23322
IGFL3 IGF-like family member 3 4.23322
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 4.23322
TRADD TNFRSF1A-associated via death domain 4.23322
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 4.23322
TRIM55 tripartite motif containing 55 4.23322
POU2AF1 POU class 2 associating factor 1 4.23322
RANBP3L RAN binding protein 3-like 4.23322
NUPR1 nuclear protein, transcriptional regulator, 1 4.23322
LMOD2 leiomodin 2 (cardiac) 4.23322
LMOD3 leiomodin 3 (fetal) 4.23322
TAT tyrosine aminotransferase 4.23322
IL1A interleukin 1, alpha 4.23322
TEKT5 tektin 5 4.23322
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 4.23322
ERICH6B glutamate-rich 6B 4.23322
LCN1 lipocalin 1 4.23322
IGFBP1 insulin-like growth factor binding protein 1 4.23322
RNF112 ring finger protein 112 4.23322
GPR12 G protein-coupled receptor 12 4.23322
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 4.23322
S100A14 S100 calcium binding protein A14 4.23322
SPANXD SPANX family, member D 4.23322
ETNPPL ethanolamine-phosphate phospho-lyase 4.23322
CLRN1 clarin 1 4.23322
ANKRD60 ankyrin repeat domain 60 4.23322
ANKRD63 ankyrin repeat domain 63 4.23322
DGCR6 DiGeorge syndrome critical region gene 6 4.23322
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 4.23322
PCDH19 protocadherin 19 4.23322
TRIM7 tripartite motif containing 7 4.23322
LRRC25 leucine rich repeat containing 25 4.23322
NYX nyctalopin 4.23322
DEFB136 defensin, beta 136 4.23322
TM4SF19 transmembrane 4 L six family member 19 4.23322
WNT2 wingless-type MMTV integration site family member 2 4.23322
CLEC18B C-type lectin domain family 18, member B 4.23322
CXORF58 chromosome X open reading frame 58 4.23322
SFTA2 surfactant associated 2 4.23322
DRC1 dynein regulatory complex subunit 1 4.23322
LY6G6C lymphocyte antigen 6 complex, locus G6C 4.23322
SOSTDC1 sclerostin domain containing 1 4.23322
DAW1 dynein assembly factor with WDR repeat domains 1 4.23322
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 4.23322
RGCC regulator of cell cycle 4.23322
HRCT1 histidine rich carboxyl terminus 1 4.23322
CNGB3 cyclic nucleotide gated channel beta 3 4.23322
PLA1A phospholipase A1 member A 4.23322
LY96 lymphocyte antigen 96 4.23322
CD200R1 CD200 receptor 1 4.23322
NT5DC4 5'-nucleotidase domain containing 4 4.23322
GFRAL GDNF family receptor alpha like 4.23322
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 4.23322
SYNGR4 synaptogyrin 4 4.23322
NR5A1 nuclear receptor subfamily 5, group A, member 1 4.23322
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 4.23322
CHRM1 cholinergic receptor, muscarinic 1 4.23322
PLA2G4D phospholipase A2, group IVD (cytosolic) 4.23322
OR8H1 olfactory receptor, family 8, subfamily H, member 1 4.23322
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 4.23322
ZBED6 zinc finger, BED-type containing 6 4.23322
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 4.23322
TBC1D28 TBC1 domain family, member 28 4.23322
GLRA1 glycine receptor, alpha 1 4.23322
SUN3 Sad1 and UNC84 domain containing 3 4.23322
CETP cholesteryl ester transfer protein, plasma 4.23322
OR11G2 olfactory receptor, family 11, subfamily G, member 2 4.23322
RNF224 ring finger protein 224 4.23322
RGR retinal G protein coupled receptor 4.23322
EPO erythropoietin 4.23322
PSORS1C2 psoriasis susceptibility 1 candidate 2 4.23322
SCN3B sodium channel, voltage gated, type III beta subunit 4.23322
GH1 growth hormone 1 4.23322
TSKS testis-specific serine kinase substrate 4.23322
GRAP2 GRB2-related adaptor protein 2 4.23322
VHLL von Hippel-Lindau tumor suppressor-like 4.23322
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 4.23322
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 4.23322
VWC2L von Willebrand factor C domain containing protein 2-like 4.23322
RPA4 replication protein A4, 30kDa 4.23322
TEX35 testis expressed 35 4.23322
GYPB glycophorin B (MNS blood group) 4.23322
PATE2 prostate and testis expressed 2 4.23322
BMX BMX non-receptor tyrosine kinase 4.23322
PTPN7 protein tyrosine phosphatase, non-receptor type 7 4.23322
PPP1R3C protein phosphatase 1, regulatory subunit 3C 4.11541
EFNB1 ephrin-B1 4.11541
DPEP1 dipeptidase 1 (renal) 4.11541
PCDHGB7 protocadherin gamma subfamily B, 7 4.11541
COG3 component of oligomeric golgi complex 3 4.09134
LRRC39 leucine rich repeat containing 39 3.54248
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 3.53169
OXR1 oxidation resistance 1 3.46171
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 3.13221
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 3.1137
ARHGAP22 Rho GTPase activating protein 22 3.09954
KIAA0319 KIAA0319 3.06998
SLC43A3 solute carrier family 43, member 3 2.99115
OXTR oxytocin receptor 2.97927
GLRB glycine receptor, beta 2.94611
CD86 CD86 molecule 2.94611
SPMIP2 sperm microtubule inner protein 2 2.94611
PODNL1 podocan-like 1 2.84158
CST3 cystatin C 2.8412
GSR glutathione reductase 2.72252
BIRC2 baculoviral IAP repeat containing 2 2.70671
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.57297
GREB1 growth regulation by estrogen in breast cancer 1 2.53732
UQCC4 ubiquinol-cytochrome c reductase complex assembly factor 4 2.48481
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.47037
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.40913
EIF2D eukaryotic translation initiation factor 2D 2.33634
ATP5F1D ATP synthase F1 subunit delta 2.33194
CLEC19A C-type lectin domain family 19, member A 2.3261
GPR27 G protein-coupled receptor 27 2.29501
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.2763
BTC betacellulin 2.2763
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.2763
RBPMS RNA binding protein with multiple splicing 2.2763
TSNARE1 t-SNARE domain containing 1 2.26799
LRRC4B leucine rich repeat containing 4B 2.26295
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.2565
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 2.24754
APOL2 apolipoprotein L, 2 2.24628
TGFB1 transforming growth factor, beta 1 2.2454
NTN5 netrin 5 2.23822
ANXA2 annexin A2 2.22745
IFT80 intraflagellar transport 80 2.2257
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.22212
GPRIN3 GPRIN family member 3 2.21439
MAPK8 mitogen-activated protein kinase 8 2.2123
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.20582
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 2.20091
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.18093
SESN3 sestrin 3 2.18093
AK3 adenylate kinase 3 2.15177
SNX29 sorting nexin 29 2.10087
STK38L serine/threonine kinase 38 like 2.09952
LYPD6B LY6/PLAUR domain containing 6B 2.09171
MFN2 mitofusin 2 2.07278
MYO6 myosin VI 2.06715
MOSPD2 motile sperm domain containing 2 2.06682
REL v-rel avian reticuloendotheliosis viral oncogene homolog 2.03405
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.03405
GMEB2 glucocorticoid modulatory element binding protein 2 2.03405
CDK16 cyclin-dependent kinase 16 2.03347
H2AC21 H2A clustered histone 21 2.03019
CCND1 cyclin D1 2.02683
STARD10 StAR-related lipid transfer (START) domain containing 10 2.01776
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.01723

decreased expression

Symbol Name Standardized Value
NPIPA6 nuclear pore complex interacting protein family, member A6 -4.23322
RFPL2 ret finger protein-like 2 -4.23322
WNT3A wingless-type MMTV integration site family, member 3A -4.23322
PTGER3 prostaglandin E receptor 3 (subtype EP3) -4.23322
MPL MPL proto-oncogene, thrombopoietin receptor -4.23322
SERTM1 serine-rich and transmembrane domain containing 1 -4.23322
PRSS27 protease, serine 27 -4.23322
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -4.23322
LKAAEAR1 LKAAEAR motif containing 1 -4.23322
RP1 retinitis pigmentosa 1 (autosomal dominant) -4.23322
C17ORF78 chromosome 17 open reading frame 78 -4.23322
C22ORF23 chromosome 22 open reading frame 23 -4.23322
SP100 SP100 nuclear antigen -4.23322
SH2D6 SH2 domain containing 6 -4.23322
CDNF cerebral dopamine neurotrophic factor -4.23322
LOC122526780 uncharacterized LOC122526780 -4.23322
NECTIN4 nectin cell adhesion molecule 4 -4.23322
STAT4 signal transducer and activator of transcription 4 -4.23322
MYL10 myosin, light chain 10, regulatory -4.23322
LGSN lengsin, lens protein with glutamine synthetase domain -4.23322
RGS22 regulator of G-protein signaling 22 -4.23322
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -4.23322
TMEM235 transmembrane protein 235 -4.23322
AMBP alpha-1-microglobulin/bikunin precursor -4.23322
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -4.23322
CRLF2 cytokine receptor-like factor 2 -4.23322
GLUD2 glutamate dehydrogenase 2 -4.23322
ACSM1 acyl-CoA synthetase medium-chain family member 1 -4.23322
CAGE1 cancer antigen 1 -4.23322
CDK20 cyclin-dependent kinase 20 -4.23322
KLK14 kallikrein-related peptidase 14 -4.23322
CBX8 chromobox homolog 8 -4.23322
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -4.23322
FAM240C family with sequence similarity 240 member C -4.23322
PCDHA13 protocadherin alpha 13 -4.23322
ANKRD53 ankyrin repeat domain 53 -4.23322
F2RL2 coagulation factor II (thrombin) receptor-like 2 -4.23322
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -4.23322
FBXO43 F-box protein 43 -4.00102
NSF N-ethylmaleimide-sensitive factor -3.68849
PHF20L1 PHD finger protein 20-like 1 -3.6382
PSIP1 PC4 and SFRS1 interacting protein 1 -3.52375
CPED1 cadherin-like and PC-esterase domain containing 1 -3.45875
CUEDC2 CUE domain containing 2 -3.28682
ZNF331 zinc finger protein 331 -3.17285
AMER1 APC membrane recruitment protein 1 -3.06564
MGLL monoglyceride lipase -2.93298
NOL4 nucleolar protein 4 -2.90398
DNAL1 dynein, axonemal, light chain 1 -2.89961
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.85449
PES1 pescadillo ribosomal biogenesis factor 1 -2.84349
G6PC3 glucose 6 phosphatase, catalytic, 3 -2.71952
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -2.63215
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.60991
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.52671
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.51795
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.49327
CD4 CD4 molecule -2.4927
CAPN3 calpain 3, (p94) -2.47766
NCF2 neutrophil cytosolic factor 2 -2.47766
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.47766
ADGRE5 adhesion G protein-coupled receptor E5 -2.46369
DEK DEK proto-oncogene -2.43487
KRTCAP3 keratinocyte associated protein 3 -2.40698
SEC31B SEC31 homolog B (S. cerevisiae) -2.3898
CLIC2 chloride intracellular channel 2 -2.3898
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.3898
MYO15A myosin XVA -2.3898
PNMA6A paraneoplastic Ma antigen family member 6A -2.36183
LGI4 leucine-rich repeat LGI family, member 4 -2.36062
HIST1H2BI histone cluster 1, H2bi -2.36062
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.34862
EDA ectodysplasin A -2.34309
FMNL2 formin-like 2 -2.33634
NEMF nuclear export mediator factor -2.32683
MYO18B myosin XVIIIB -2.28573
WDR72 WD repeat domain 72 -2.28573
ZAN zonadhesin (gene/pseudogene) -2.28573
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -2.26295
LMO3 LIM domain only 3 (rhombotin-like 2) -2.2501
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -2.24754
KATNAL2 katanin p60 subunit A-like 2 -2.23842
SFT2D2 SFT2 domain containing 2 -2.23158
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -2.22734
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -2.22582
ZBTB7A zinc finger and BTB domain containing 7A -2.21692
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -2.21439
RASD1 RAS, dexamethasone-induced 1 -2.19316
PRSS3 protease, serine, 3 -2.19316
DOLPP1 dolichyldiphosphatase 1 -2.19316
GPR137C G protein-coupled receptor 137C -2.19316
SOX4 SRY (sex determining region Y)-box 4 -2.17303
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.16129
RASA4B RAS p21 protein activator 4B -2.14379
SEC14L2 SEC14-like 2 (S. cerevisiae) -2.12818
CETN3 centrin, EF-hand protein, 3 -2.11488
LDAH lipid droplet associated hydrolase -2.08057
SMIM10L2B small integral membrane protein 10 like 2B -2.06891
ZW10 zw10 kinetochore protein -2.06464
LHFPL2 lipoma HMGIC fusion partner-like 2 -2.06059
CXADR coxsackie virus and adenovirus receptor -2.02323
GPC5 glypican 5 -2.02323
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.01052
CRB3 crumbs family member 3 -2.00836