UHRF2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase|This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 115426)
External Link http://www.ncbi.nlm.nih.gov/gene/115426
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Genes

148 interacting proteins for UHRF2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ATXN1 ataxin 1
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BCL2L1 BCL2-like 1
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
BRD7 bromodomain containing 7
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C4ORF27 chromosome 4 open reading frame 27
CABIN1 calcineurin binding protein 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNE1 cyclin E1
CD27 CD27 molecule
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CHD1 chromodomain helicase DNA binding protein 1
CHRAC1 chromatin accessibility complex 1
CKAP5 cytoskeleton associated protein 5
CLOCK clock circadian regulator
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
E2F1 E2F transcription factor 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ESRRA estrogen-related receptor alpha
FYN FYN proto-oncogene, Src family tyrosine kinase
GTF2I general transcription factor IIi
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIST1H3B histone cluster 1, H3b
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INO80E INO80 complex subunit E
JAK3 Janus kinase 3
KDM5A lysine (K)-specific demethylase 5A
LCK LCK proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MBD2 methyl-CpG binding domain protein 2
MCL1 myeloid cell leukemia 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPG N-methylpurine-DNA glycosylase
MTA3 metastasis associated 1 family, member 3
NAV3 neuron navigator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGEF neuronal guanine nucleotide exchange factor
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PCNP PEST proteolytic signal containing nuclear protein
PHF8 PHD finger protein 8
PKNOX1 PBX/knotted 1 homeobox 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRDM16 PR domain containing 16
PTEN phosphatase and tensin homolog
PTPRC protein tyrosine phosphatase, receptor type, C
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAN RAN, member RAS oncogene family
RB1 retinoblastoma 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
S100A8 S100 calcium binding protein A8
SAP130 Sin3A-associated protein, 130kDa
SIN3B SIN3 transcription regulator family member B
SKP1 S-phase kinase-associated protein 1
SMAD4 SMAD family member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SOGA3 SOGA family member 3
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBP TATA box binding protein
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFCP2 transcription factor CP2
TFCP2L1 transcription factor CP2-like 1
THYN1 thymocyte nuclear protein 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TRIM27 tripartite motif containing 27
TRIM8 tripartite motif containing 8
TTF2 transcription termination factor, RNA polymerase II
TWF2 twinfilin actin binding protein 2
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBE2I ubiquitin-conjugating enzyme E2I
UBE2K ubiquitin-conjugating enzyme E2K
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBP1 upstream binding protein 1 (LBP-1a)
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USF2 upstream transcription factor 2, c-fos interacting
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VRK1 vaccinia related kinase 1
WIZ widely interspaced zinc finger motifs
YEATS2 YEATS domain containing 2
YY1 YY1 transcription factor
ZBTB35 zinc finger and BTB domain containing 35
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF335 zinc finger protein 335
ZNF462 zinc finger protein 462
ZZZ3 zinc finger, ZZ-type containing 3