ULK-101_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.105227
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.092002
AKAP12 A kinase (PRKA) anchor protein 12 0.0911223
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0904498
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0876048
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0817943
EGFR epidermal growth factor receptor 0.0660383
PBX3 pre-B-cell leukemia homeobox 3 0.0634405
AHNAK AHNAK nucleoprotein 0.0556278
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0533851
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0513247
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0450856
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0443146
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0438657
MYOF myoferlin 0.0422698
HDAC9 histone deacetylase 9 0.0404234
EFNA5 ephrin-A5 0.0396747
CDH13 cadherin 13 0.0394827
FNDC3B fibronectin type III domain containing 3B 0.0379193
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0378341
ASPH aspartate beta-hydroxylase 0.0373519
TPM3 tropomyosin 3 0.0364104
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0358331
KLF7 Kruppel-like factor 7 (ubiquitous) 0.035539
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0351546
FLNB filamin B, beta 0.0349189
ELL2 elongation factor, RNA polymerase II, 2 0.0335804
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0331302
CANX calnexin 0.0318088
CD44 CD44 molecule (Indian blood group) 0.0317269
RND3 Rho family GTPase 3 0.03127
NAV2 neuron navigator 2 0.029642
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0292687
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0292654
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0290948
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0284993
NAV1 neuron navigator 1 0.0278991
CENPF centromere protein F, 350/400kDa 0.0278128
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0277929
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0274113
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0273904
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0272164
STC1 stanniocalcin 1 0.0271217
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0268869
ZNF292 zinc finger protein 292 0.0268685
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0266853
FBXL7 F-box and leucine-rich repeat protein 7 0.026113
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0256519
RUNX1 runt-related transcription factor 1 0.0249422
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0247934
E2F7 E2F transcription factor 7 0.0243857
PRELID2 PRELI domain containing 2 0.0243244
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0241418
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0239359
PRKCE protein kinase C, epsilon 0.0237446
MSN moesin 0.023434
ERRFI1 ERBB receptor feedback inhibitor 1 0.0232733
SLFN5 schlafen family member 5 0.0232166
ANKRD11 ankyrin repeat domain 11 0.0231142
SQSTM1 sequestosome 1 0.0229258
RHOBTB3 Rho-related BTB domain containing 3 0.022705
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0221697
IQGAP1 IQ motif containing GTPase activating protein 1 0.022105
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.022066
BACE2 beta-site APP-cleaving enzyme 2 0.0220475
ANO6 anoctamin 6 0.0214481
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0213693
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0209902
SON SON DNA binding protein 0.0203967
AHNAK2 AHNAK nucleoprotein 2 0.0202901
SMAD3 SMAD family member 3 0.020252
USP34 ubiquitin specific peptidase 34 0.0201361
ZEB1 zinc finger E-box binding homeobox 1 0.0200303
LIMCH1 LIM and calponin homology domains 1 0.0200204
JMJD1C jumonji domain containing 1C 0.0199697
ENO1 enolase 1, (alpha) 0.0197459
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0196687
OSBPL8 oxysterol binding protein-like 8 0.019663
TM4SF19 transmembrane 4 L six family member 19 0.0196158
FNIP1 folliculin interacting protein 1 0.0195294
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0194769
RABGAP1L RAB GTPase activating protein 1-like 0.0190649
ACER3 alkaline ceramidase 3 0.0189744
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0189606
SEPTIN9 septin 9 0.0188548
IL6ST interleukin 6 signal transducer 0.0188252
CCDC88A coiled-coil domain containing 88A 0.0187824
CCND1 cyclin D1 0.0187172
FAM107B family with sequence similarity 107, member B 0.0187112
PDIA6 protein disulfide isomerase family A, member 6 0.0186529
NBEAL1 neurobeachin-like 1 0.0186356
EZR ezrin 0.0186018
CALR calreticulin 0.0185944
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0185156
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0181901
DSPP dentin sialophosphoprotein 0.018114
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0180854
RTN4 reticulon 4 0.0180115
LIMS1 LIM and senescent cell antigen-like domains 1 0.0179069
DPYSL2 dihydropyrimidinase-like 2 0.017851

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.217601
IGFBP3 insulin-like growth factor binding protein 3 -0.0940268
PODXL podocalyxin-like -0.0882222
FBN1 fibrillin 1 -0.0623281
PTMA prothymosin, alpha -0.0428981
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0406518
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0403679
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0399325
FN1 fibronectin 1 -0.038435
SUCNR1 succinate receptor 1 -0.0379393
COL8A1 collagen, type VIII, alpha 1 -0.0332259
TPT1 tumor protein, translationally-controlled 1 -0.0331734
HLA-B major histocompatibility complex, class I, B -0.0328666
PRSS23 protease, serine, 23 -0.0319004
COL1A2 collagen, type I, alpha 2 -0.0307932
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0296322
TTC3 tetratricopeptide repeat domain 3 -0.0288811
SOD2 superoxide dismutase 2, mitochondrial -0.0276835
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0265849
UBC ubiquitin C -0.0255855
PLAT plasminogen activator, tissue -0.0246365
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0242354
CYTH3 cytohesin 3 -0.0241726
FTL ferritin, light polypeptide -0.0228111
LOXL2 lysyl oxidase-like 2 -0.0227874
CAVIN1 caveolae associated protein 1 -0.0226794
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0224322
GNAS GNAS complex locus -0.0223256
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0220449
LMNA lamin A/C -0.0216377
OGA O-GlcNAcase -0.0213396
ADM adrenomedullin -0.0212701
THBS2 thrombospondin 2 -0.0208558
HLA-C major histocompatibility complex, class I, C -0.0204854
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0203226
HIP1 huntingtin interacting protein 1 -0.0182029
LOX lysyl oxidase -0.0181669
ABI3BP ABI family, member 3 (NESH) binding protein -0.0177324
TPM1 tropomyosin 1 (alpha) -0.0175694
TMSB10 thymosin beta 10 -0.0175659
IFITM1 interferon induced transmembrane protein 1 -0.0171231
COL6A1 collagen, type VI, alpha 1 -0.0168915
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0168761
RPL35A ribosomal protein L35a -0.0166953
TUBB tubulin, beta class I -0.0165203
MAP4 microtubule-associated protein 4 -0.0160004
TUBB4B tubulin, beta 4B class IVb -0.0154949
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0152324
FAM162A family with sequence similarity 162, member A -0.0148245
MT2A metallothionein 2A -0.0146889
TNS3 tensin 3 -0.014659
DPYSL3 dihydropyrimidinase-like 3 -0.0146221
TENT4A terminal nucleotidyltransferase 4A -0.0145949
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0144022
PSD3 pleckstrin and Sec7 domain containing 3 -0.0143434
ENO2 enolase 2 (gamma, neuronal) -0.0142343
MEIS2 Meis homeobox 2 -0.0141931
COL5A1 collagen, type V, alpha 1 -0.0141821
RAB1A RAB1A, member RAS oncogene family -0.0139559
ANKRD10 ankyrin repeat domain 10 -0.0135347
HSPB1 heat shock 27kDa protein 1 -0.013285
PXDN peroxidasin -0.0131165
LY6E lymphocyte antigen 6 complex, locus E -0.0130572
CELF1 CUGBP, Elav-like family member 1 -0.0129682
TAGLN2 transgelin 2 -0.0128895
VAT1 vesicle amine transport 1 -0.0128554
WSB1 WD repeat and SOCS box containing 1 -0.012676
LAMB1 laminin, beta 1 -0.012428
RIGI RNA sensor RIG-I -0.0122986
GGNBP2 gametogenetin binding protein 2 -0.012055
ARL15 ADP-ribosylation factor-like 15 -0.012045
ATRN attractin -0.012011
MBNL1 muscleblind-like splicing regulator 1 -0.011997
H3-3B H3.3 histone B -0.0119631
CD63 CD63 molecule -0.0119344
IER3 immediate early response 3 -0.0118803
HMGB2 high mobility group box 2 -0.0117846
PNISR PNN-interacting serine/arginine-rich protein -0.0117122
TMEM263 transmembrane protein 263 -0.011682
COL6A2 collagen, type VI, alpha 2 -0.0115996
SEC11A SEC11 homolog A (S. cerevisiae) -0.011585
GDI1 GDP dissociation inhibitor 1 -0.0115547
FKBP10 FK506 binding protein 10, 65 kDa -0.0115274
RPS25 ribosomal protein S25 -0.01136
TPST1 tyrosylprotein sulfotransferase 1 -0.0113424
HMGB1 high mobility group box 1 -0.0112785
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0112631
PRRX1 paired related homeobox 1 -0.0112274
UBE2I ubiquitin-conjugating enzyme E2I -0.0112221
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.0111455
SAR1A secretion associated, Ras related GTPase 1A -0.0111429
HMGA1 high mobility group AT-hook 1 -0.0110044
COL18A1 collagen, type XVIII, alpha 1 -0.0109627
GOLGA2 golgin A2 -0.010753
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0106739
PKM pyruvate kinase, muscle -0.0106324
LARP1 La ribonucleoprotein domain family, member 1 -0.0105665
OASL 2'-5'-oligoadenylate synthetase-like -0.0105166
LRRC17 leucine rich repeat containing 17 -0.0104201
KRT81 keratin 81, type II -0.0103291