ULK-101_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in AN3 CA cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ULK-101_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I 0.0867294
HMGA2 high mobility group AT-hook 2 0.0770707
MYOF myoferlin 0.0739587
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.073663
CADM2 cell adhesion molecule 2 0.0605694
EGFR epidermal growth factor receptor 0.0602929
TRIO trio Rho guanine nucleotide exchange factor 0.0576
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0546662
SOX4 SRY (sex determining region Y)-box 4 0.0452089
FGFR1 fibroblast growth factor receptor 1 0.0446411
RAB7A RAB7A, member RAS oncogene family 0.044003
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0438455
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0428299
VIM vimentin 0.0420563
AFF4 AF4/FMR2 family, member 4 0.0419452
FLNB filamin B, beta 0.0418036
CSNK1A1 casein kinase 1, alpha 1 0.0413385
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0413115
DDIT4 DNA-damage-inducible transcript 4 0.0383449
FNIP1 folliculin interacting protein 1 0.0373814
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0371431
SIK3 SIK family kinase 3 0.0353065
LPP LIM domain containing preferred translocation partner in lipoma 0.0346436
TSHZ2 teashirt zinc finger homeobox 2 0.0345116
TSC22D1 TSC22 domain family, member 1 0.0339932
JMJD1C jumonji domain containing 1C 0.0336199
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0315916
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0313597
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0311354
SKIL SKI-like proto-oncogene 0.0308731
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0302336
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0296718
MICU1 mitochondrial calcium uptake 1 0.0291142
ATP11A ATPase, class VI, type 11A 0.028887
TULP4 tubby like protein 4 0.0288132
UTRN utrophin 0.0284591
KDM5B lysine (K)-specific demethylase 5B 0.0281572
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0281531
ATXN2 ataxin 2 0.0280076
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0273213
MGP matrix Gla protein 0.0272393
RAD51B RAD51 paralog B 0.0271591
GMDS GDP-mannose 4,6-dehydratase 0.0269254
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0266117
FRMD6 FERM domain containing 6 0.0266079
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0263275
COL5A2 collagen, type V, alpha 2 0.0253994
FAF1 Fas (TNFRSF6) associated factor 1 0.0249068
LINGO2 leucine rich repeat and Ig domain containing 2 0.0247384
MSRB3 methionine sulfoxide reductase B3 0.024424
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0244058
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0234741
EGR1 early growth response 1 0.0233586
ANO6 anoctamin 6 0.0233453
NAV2 neuron navigator 2 0.0229486
SPIDR scaffolding protein involved in DNA repair 0.0228185
ATOSA atos homolog A 0.0227593
LMO7 LIM domain 7 0.0226026
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0224498
STAG2 stromal antigen 2 0.0224361
RACK1 receptor for activated C kinase 1 0.0224022
HOXC10 homeobox C10 0.022369
HMGA1 high mobility group AT-hook 1 0.0223342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0220307
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0219259
SAMD4A sterile alpha motif domain containing 4A 0.0217695
SCAPER S-phase cyclin A-associated protein in the ER 0.021732
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0214481
GTF2IRD1 GTF2I repeat domain containing 1 0.0213732
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0210025
PARD3 par-3 family cell polarity regulator 0.0206614
NGLY1 N-glycanase 1 0.0204869
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0204192
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0201626
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0201565
TPST1 tyrosylprotein sulfotransferase 1 0.0201204
MTUS1 microtubule associated tumor suppressor 1 0.0196232
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0194457
HSPH1 heat shock 105kDa/110kDa protein 1 0.0194061
RAI1 retinoic acid induced 1 0.0193729
ERRFI1 ERBB receptor feedback inhibitor 1 0.0192284
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0191767
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0191622
DENND4A DENN/MADD domain containing 4A 0.0191128
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0190311
RCOR1 REST corepressor 1 0.0186034
CLTC clathrin, heavy chain (Hc) 0.0186016
SKAP2 src kinase associated phosphoprotein 2 0.0185062
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.018475
PDE4B phosphodiesterase 4B, cAMP-specific 0.0184547
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0184048
VCL vinculin 0.0183541
SQSTM1 sequestosome 1 0.0182116
NRF1 nuclear respiratory factor 1 0.0182035
SMC3 structural maintenance of chromosomes 3 0.0181833
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0181625
KDM5A lysine (K)-specific demethylase 5A 0.0181192
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0181019
TMEM41B transmembrane protein 41B 0.0179452
LOXL2 lysyl oxidase-like 2 0.0179011

decreased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript -0.170056
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0875587
PEG10 paternally expressed 10 -0.0852134
PTMA prothymosin, alpha -0.0679264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0630356
HMGB2 high mobility group box 2 -0.0555516
CALR calreticulin -0.0543674
UBC ubiquitin C -0.0530658
PRELID2 PRELI domain containing 2 -0.0496051
RPS27A ribosomal protein S27a -0.0470514
TMSB10 thymosin beta 10 -0.0461264
MT2A metallothionein 2A -0.0460034
EEF2 eukaryotic translation elongation factor 2 -0.0432463
RPS6 ribosomal protein S6 -0.0423481
PDE4D phosphodiesterase 4D, cAMP-specific -0.0409943
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0392288
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0390705
BCOR BCL6 corepressor -0.0383764
TMSB4X thymosin beta 4, X-linked -0.0377714
RPL26 ribosomal protein L26 -0.0369549
YBX1 Y box binding protein 1 -0.0367949
PDIA3 protein disulfide isomerase family A, member 3 -0.0325666
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0325346
PDIA6 protein disulfide isomerase family A, member 6 -0.0319679
RPL37A ribosomal protein L37a -0.0316776
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0316289
CANX calnexin -0.0314186
MKI67 marker of proliferation Ki-67 -0.0310506
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0306785
KIF11 kinesin family member 11 -0.0306285
RAD21 RAD21 homolog (S. pombe) -0.0304301
RPS3 ribosomal protein S3 -0.0296063
BTBD3 BTB (POZ) domain containing 3 -0.0284996
CENPF centromere protein F, 350/400kDa -0.0284766
RPS19 ribosomal protein S19 -0.0276926
CSDE1 cold shock domain containing E1, RNA-binding -0.0273486
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0270798
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.027065
ZNF292 zinc finger protein 292 -0.0268287
CKAP5 cytoskeleton associated protein 5 -0.0268228
TM9SF3 transmembrane 9 superfamily member 3 -0.0265931
RPL38 ribosomal protein L38 -0.026099
NFIA nuclear factor I/A -0.025918
DLG1 discs, large homolog 1 (Drosophila) -0.0258999
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0257612
CENPE centromere protein E, 312kDa -0.0250881
RTN4 reticulon 4 -0.0249553
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0246467
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0246408
APP amyloid beta (A4) precursor protein -0.0246292
RPS12 ribosomal protein S12 -0.0244395
ZYG11B zyg-11 family member B, cell cycle regulator -0.0238505
SMC1A structural maintenance of chromosomes 1A -0.0234115
CCNB1 cyclin B1 -0.0233222
RPLP2 ribosomal protein, large, P2 -0.0231205
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0229859
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0227564
MYH9 myosin, heavy chain 9, non-muscle -0.0225793
ENO1 enolase 1, (alpha) -0.0223838
RPS21 ribosomal protein S21 -0.0223733
SET SET nuclear proto-oncogene -0.0222673
SRPK2 SRSF protein kinase 2 -0.022181
TFG TRK-fused gene -0.0219215
RPL23 ribosomal protein L23 -0.0219118
HOXA3 homeobox A3 -0.0218814
AKAP9 A kinase (PRKA) anchor protein 9 -0.0218582
DEK DEK proto-oncogene -0.0217754
LDHA lactate dehydrogenase A -0.0217512
CD44 CD44 molecule (Indian blood group) -0.0215047
STRN3 striatin, calmodulin binding protein 3 -0.0214642
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0213175
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0213136
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.02107
MED13L mediator complex subunit 13-like -0.0209838
GSTP1 glutathione S-transferase pi 1 -0.0207301
RBM39 RNA binding motif protein 39 -0.0204256
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0202285
PTEN phosphatase and tensin homolog -0.0201952
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0201656
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0201209
ARHGAP35 Rho GTPase activating protein 35 -0.020098
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0200797
DEPDC1B DEP domain containing 1B -0.0200251
GSE1 Gse1 coiled-coil protein -0.0200061
CEP192 centrosomal protein 192kDa -0.019996
LOC112694756 uncharaterized LOC112694756 -0.0197866
PHF21A PHD finger protein 21A -0.0195996
RRBP1 ribosome binding protein 1 -0.0195582
POM121 POM121 transmembrane nucleoporin -0.0195514
RPL34 ribosomal protein L34 -0.0195325
RBM5 RNA binding motif protein 5 -0.0194772
RPL10A ribosomal protein L10a -0.0192949
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.0192456
PDIA4 protein disulfide isomerase family A, member 4 -0.0192229
TPX2 TPX2, microtubule-associated -0.0191506
WDR11 WD repeat domain 11 -0.0189785
RPL8 ribosomal protein L8 -0.0188687
CELF1 CUGBP, Elav-like family member 1 -0.0188306
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0188189
CKAP2 cytoskeleton associated protein 2 -0.0187637