ULK-101_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in BT-474 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ULK-101_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.102483
RPL23 ribosomal protein L23 0.0631751
NCOA3 nuclear receptor coactivator 3 0.0436763
FBXL20 F-box and leucine-rich repeat protein 20 0.040436
PDLIM5 PDZ and LIM domain 5 0.0381031
PTMA prothymosin, alpha 0.0360988
FNDC3A fibronectin type III domain containing 3A 0.0350495
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0347431
ITCH itchy E3 ubiquitin protein ligase 0.0335347
SLC38A1 solute carrier family 38, member 1 0.0333074
EXT1 exostosin glycosyltransferase 1 0.0309932
ACTG1 actin gamma 1 0.0303617
INSR insulin receptor 0.0287065
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0283997
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0277098
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0274722
GRB7 growth factor receptor-bound protein 7 0.0273287
NRIP1 nuclear receptor interacting protein 1 0.0268887
CCNI cyclin I 0.0256203
CREB5 cAMP responsive element binding protein 5 0.02556
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0250677
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0249597
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0245401
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0244561
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0243282
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0242967
RPL19 ribosomal protein L19 0.0242533
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0233041
IGFBP5 insulin-like growth factor binding protein 5 0.0230916
ZNFX1 zinc finger, NFX1-type containing 1 0.022988
TPT1 tumor protein, translationally-controlled 1 0.0228599
SERINC3 serine incorporator 3 0.0223895
PAWR PRKC, apoptosis, WT1, regulator 0.0209273
EGR1 early growth response 1 0.0208859
RAD21 RAD21 homolog (S. pombe) 0.0208635
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.019907
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0194049
PTPRK protein tyrosine phosphatase, receptor type, K 0.0193815
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0192403
TRIO trio Rho guanine nucleotide exchange factor 0.0191159
UBAP1 ubiquitin associated protein 1 0.0187929
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0187821
KTN1 kinectin 1 (kinesin receptor) 0.0186548
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0186521
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0185484
TRA2A transformer 2 alpha homolog (Drosophila) 0.0185004
CDK12 cyclin-dependent kinase 12 0.0182779
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0179414
TPM4 tropomyosin 4 0.0173816
JMJD1C jumonji domain containing 1C 0.0173651
UBE2H ubiquitin-conjugating enzyme E2H 0.0172422
ZBTB10 zinc finger and BTB domain containing 10 0.0171571
CXCL8 chemokine (C-X-C motif) ligand 8 0.0170485
LPP LIM domain containing preferred translocation partner in lipoma 0.0167939
IQGAP1 IQ motif containing GTPase activating protein 1 0.0166025
MYOF myoferlin 0.0165343
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.016499
ELOVL5 ELOVL fatty acid elongase 5 0.0163742
RAB22A RAB22A, member RAS oncogene family 0.0163389
RPL34 ribosomal protein L34 0.0163241
FTH1 ferritin, heavy polypeptide 1 0.0162208
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.016037
SMAD3 SMAD family member 3 0.0158761
RPL12 ribosomal protein L12 0.0157914
FNBP1 formin binding protein 1 0.0156714
CCNL1 cyclin L1 0.0154078
NTN4 netrin 4 0.0153398
PRR11 proline rich 11 0.0153274
SET SET nuclear proto-oncogene 0.0152079
RAB7A RAB7A, member RAS oncogene family 0.0150873
MSI2 musashi RNA-binding protein 2 0.0149199
SMYD3 SET and MYND domain containing 3 0.0148916
SETX senataxin 0.0148119
SP100 SP100 nuclear antigen 0.0147854
KDM3A lysine (K)-specific demethylase 3A 0.0146777
ABI1 abl-interactor 1 0.0144992
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0143706
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0143469
B2M beta-2-microglobulin 0.0143192
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0142956
DUSP16 dual specificity phosphatase 16 0.0142409
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0142187
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0142138
DOCK5 dedicator of cytokinesis 5 0.0142081
MYO10 myosin X 0.014207
CCND1 cyclin D1 0.0141994
RPS8 ribosomal protein S8 0.0141654
VCL vinculin 0.0141551
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0141495
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0140294
RPS24 ribosomal protein S24 0.0139342
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0139163
STRN3 striatin, calmodulin binding protein 3 0.0139147
KMT2E lysine (K)-specific methyltransferase 2E 0.0138143
RIOK3 RIO kinase 3 0.01379
NCOA7 nuclear receptor coactivator 7 0.0137313
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.013616
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0135548
SQSTM1 sequestosome 1 0.0135299
THSD4 thrombospondin, type I, domain containing 4 0.0134612

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.0547015
CEP250 centrosomal protein 250kDa -0.0404769
NDRG1 N-myc downstream regulated 1 -0.0387897
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0328855
ASPH aspartate beta-hydroxylase -0.0313431
MMP24OS MMP24 opposite strand -0.0252846
INTS6 integrator complex subunit 6 -0.0233126
EXOC4 exocyst complex component 4 -0.0181237
GMDS GDP-mannose 4,6-dehydratase -0.0178484
RAD51B RAD51 paralog B -0.016919
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0168588
TRPS1 trichorhinophalangeal syndrome I -0.0158958
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0157816
RPL37A ribosomal protein L37a -0.0152155
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0139352
PBX1 pre-B-cell leukemia homeobox 1 -0.0136265
PRELID2 PRELI domain containing 2 -0.0135072
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -0.0133835
GRB10 growth factor receptor-bound protein 10 -0.0126083
CATSPERB catsper channel auxiliary subunit beta -0.0123544
RNF213 ring finger protein 213 -0.0123153
FASN fatty acid synthase -0.0119741
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0115849
NABP1 nucleic acid binding protein 1 -0.0106294
METTL15 methyltransferase like 15 -0.0106236
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0104337
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0102878
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0102789
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0102506
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0102173
KIF16B kinesin family member 16B -0.00996139
EVL Enah/Vasp-like -0.00982154
ZNF638 zinc finger protein 638 -0.00981013
EMSY EMSY transcriptional repressor, BRCA2 interacting -0.00980547
SAMD12 sterile alpha motif domain containing 12 -0.00971655
USO1 USO1 vesicle transport factor -0.00967637
PDIA5 protein disulfide isomerase family A, member 5 -0.00967549
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.00944003
FLNB filamin B, beta -0.00933618
LASP1NB LASP1 neighbor -0.00930501
ZFHX3 zinc finger homeobox 3 -0.00920564
LRRC59 leucine rich repeat containing 59 -0.00907716
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.00890767
ACSF2 acyl-CoA synthetase family member 2 -0.0088998
VEGFA vascular endothelial growth factor A -0.00887864
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.00884669
DYNC2I1 dynein 2 intermediate chain 1 -0.00882831
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.00880201
TENM4 teneurin transmembrane protein 4 -0.00875336
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0087212
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.00871323
GSDMB gasdermin B -0.00856187
LARP1B La ribonucleoprotein domain family, member 1B -0.00853252
LASP1 LIM and SH3 protein 1 -0.00845221
TAS2R14 taste receptor, type 2, member 14 -0.00834898
MIPOL1 mirror-image polydactyly 1 -0.00830617
RCC1 regulator of chromosome condensation 1 -0.00807549
CABIN1 calcineurin binding protein 1 -0.0080721
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00802558
COL13A1 collagen, type XIII, alpha 1 -0.00793409
AHRR aryl-hydrocarbon receptor repressor -0.00783315
SOS1 son of sevenless homolog 1 (Drosophila) -0.00782485
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.00779568
AMPD3 adenosine monophosphate deaminase 3 -0.00771715
YEATS2 YEATS domain containing 2 -0.00760889
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.00758727
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0075833
GPATCH2L G patch domain containing 2-like -0.00755265
RRM2 ribonucleotide reductase M2 -0.00751324
COPA coatomer protein complex, subunit alpha -0.00747141
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.00742218
BACE2 beta-site APP-cleaving enzyme 2 -0.00737913
NCAPG2 non-SMC condensin II complex, subunit G2 -0.00726168
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.00724396
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.00723774
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.00723278
DNAH14 dynein, axonemal, heavy chain 14 -0.00717478
USP37 ubiquitin specific peptidase 37 -0.00713108
DENND1A DENN/MADD domain containing 1A -0.0070414
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.00700042
DICER1 dicer 1, ribonuclease type III -0.00695051
ACLY ATP citrate lyase -0.00687999
TENM2 teneurin transmembrane protein 2 -0.00684369
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00682677
GPATCH2 G patch domain containing 2 -0.00679186
SLC38A2 solute carrier family 38, member 2 -0.00675639
TOX3 TOX high mobility group box family member 3 -0.00675426
KDM4B lysine (K)-specific demethylase 4B -0.00671935
NCOR2 nuclear receptor corepressor 2 -0.00651098
SUMF1 sulfatase modifying factor 1 -0.00650186
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.00650068
XPOT exportin, tRNA -0.00645624
PUDP pseudouridine 5'-phosphatase -0.00640764
ESRRG estrogen-related receptor gamma -0.00640553
ZNF675 zinc finger protein 675 -0.00637826
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00637757
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.00633278
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.00632604
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -0.00632499
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.00629101