ULK-101_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0952596
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0774579
B2M beta-2-microglobulin 0.0615966
APLP2 amyloid beta (A4) precursor-like protein 2 0.0584997
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0546047
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0544647
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0499108
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0496675
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0484276
MCL1 myeloid cell leukemia 1 0.047542
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0453479
PCBP2 poly(rC) binding protein 2 0.0452915
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0452022
LOC102724023 ES1 protein homolog, mitochondrial 0.0451919
LAMA4 laminin, alpha 4 0.0445076
CXCL8 chemokine (C-X-C motif) ligand 8 0.0425588
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0422031
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0416698
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0413783
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0401712
ZSWIM6 zinc finger, SWIM-type containing 6 0.0378258
SGMS2 sphingomyelin synthase 2 0.036857
PKM pyruvate kinase, muscle 0.0360916
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.035805
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.035385
SRP54 signal recognition particle 54kDa 0.0340238
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0336693
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0335764
AKAP12 A kinase (PRKA) anchor protein 12 0.0331607
AKAP13 A kinase (PRKA) anchor protein 13 0.0330552
VMP1 vacuole membrane protein 1 0.0327535
ENO1 enolase 1, (alpha) 0.0313547
JMJD1C jumonji domain containing 1C 0.0310243
PICALM phosphatidylinositol binding clathrin assembly protein 0.0300607
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0299761
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0296458
EREG epiregulin 0.0291363
HMGA1 high mobility group AT-hook 1 0.02875
SPAG9 sperm associated antigen 9 0.0285608
HMGA2 high mobility group AT-hook 2 0.0282952
MACF1 microtubule-actin crosslinking factor 1 0.0276148
RCOR1 REST corepressor 1 0.0274621
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0268104
SFTPA2 surfactant protein A2 0.0258967
GRB10 growth factor receptor-bound protein 10 0.0256662
TSC22D2 TSC22 domain family, member 2 0.0255935
SH3KBP1 SH3-domain kinase binding protein 1 0.0255461
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0254873
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0247556
UBC ubiquitin C 0.0246911
MAML2 mastermind-like 2 (Drosophila) 0.024561
FAM107B family with sequence similarity 107, member B 0.0245338
KRT19 keratin 19, type I 0.0244625
SPDYA speedy/RINGO cell cycle regulator family member A 0.0241327
SEPTIN9 septin 9 0.0240819
HELZ helicase with zinc finger 0.0238317
TXNIP thioredoxin interacting protein 0.0238114
PPARD peroxisome proliferator-activated receptor delta 0.0236387
VEGFA vascular endothelial growth factor A 0.0234212
LDHA lactate dehydrogenase A 0.0234105
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.023301
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0232006
CANX calnexin 0.0231182
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0230095
POTEF POTE ankyrin domain family, member F 0.0228665
EZR ezrin 0.0225017
KYNU kynureninase 0.0224794
RAB7A RAB7A, member RAS oncogene family 0.022457
JUN jun proto-oncogene 0.0223564
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0223179
ZFP36L1 ZFP36 ring finger protein-like 1 0.0220705
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0219844
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0217207
RUNX1 runt-related transcription factor 1 0.0217058
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0216586
MT1E metallothionein 1E 0.0216198
ADAM9 ADAM metallopeptidase domain 9 0.0214959
LAMC2 laminin, gamma 2 0.021338
DTNA dystrobrevin, alpha 0.0212777
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0211197
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0210283
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.020888
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0207958
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0207717
AKAP9 A kinase (PRKA) anchor protein 9 0.0207077
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0206584
MYO1E myosin IE 0.0206556
FOSL1 FOS-like antigen 1 0.0205224
MYO10 myosin X 0.0203688
CCNL1 cyclin L1 0.0203579
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0203165
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0202435
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0201257
UBA6 ubiquitin-like modifier activating enzyme 6 0.0200849
EIF5 eukaryotic translation initiation factor 5 0.02008
TPM3 tropomyosin 3 0.0199076
MORF4L2 mortality factor 4 like 2 0.0197127
EPAS1 endothelial PAS domain protein 1 0.0196589
UBASH3B ubiquitin associated and SH3 domain containing B 0.019658
ARL5B ADP-ribosylation factor-like 5B 0.0196008

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0972215
TPT1 tumor protein, translationally-controlled 1 -0.0923775
HLA-B major histocompatibility complex, class I, B -0.075105
LAMB3 laminin, beta 3 -0.0741816
MMP7 matrix metallopeptidase 7 -0.0677227
MT2A metallothionein 2A -0.064555
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0588638
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0574854
ACTG1 actin gamma 1 -0.0495494
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0477365
CP ceruloplasmin (ferroxidase) -0.0469279
RPL35A ribosomal protein L35a -0.043802
FTL ferritin, light polypeptide -0.0437832
RPS29 ribosomal protein S29 -0.0435442
MT1X metallothionein 1X -0.0431976
TM4SF1 transmembrane 4 L six family member 1 -0.0411978
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0350638
BICC1 BicC family RNA binding protein 1 -0.0339885
APOL1 apolipoprotein L, 1 -0.0326124
GCC2 GRIP and coiled-coil domain containing 2 -0.0324473
WSB1 WD repeat and SOCS box containing 1 -0.0282463
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.02791
RRBP1 ribosome binding protein 1 -0.0278656
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0277936
MUC4 mucin 4, cell surface associated -0.0271691
RPL11 ribosomal protein L11 -0.0271539
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0264753
LASP1 LIM and SH3 protein 1 -0.0251678
RPS27A ribosomal protein S27a -0.0242022
PLAU plasminogen activator, urokinase -0.0238705
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0236259
PLAT plasminogen activator, tissue -0.0236056
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0227389
RPLP2 ribosomal protein, large, P2 -0.022375
RPL38 ribosomal protein L38 -0.0223732
FAM162A family with sequence similarity 162, member A -0.0223343
KLF6 Kruppel-like factor 6 -0.022217
RPL37A ribosomal protein L37a -0.0219559
PCDH7 protocadherin 7 -0.0214943
RPLP1 ribosomal protein, large, P1 -0.0213266
RPS6 ribosomal protein S6 -0.0213106
ZMYND8 zinc finger, MYND-type containing 8 -0.0206329
TMSB10 thymosin beta 10 -0.0205279
AHNAK2 AHNAK nucleoprotein 2 -0.0200559
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0198977
TGFB2 transforming growth factor, beta 2 -0.0196856
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0196117
NT5C2 5'-nucleotidase, cytosolic II -0.0195751
RPS25 ribosomal protein S25 -0.0194171
RPL34 ribosomal protein L34 -0.019253
CD2AP CD2-associated protein -0.0192197
RPS19 ribosomal protein S19 -0.0190294
EXT1 exostosin glycosyltransferase 1 -0.0189844
RPS16 ribosomal protein S16 -0.018655
IER3 immediate early response 3 -0.0178513
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0177693
NTN4 netrin 4 -0.0176696
RPS21 ribosomal protein S21 -0.0175983
ANXA4 annexin A4 -0.0175484
FDPS farnesyl diphosphate synthase -0.0174808
SOX4 SRY (sex determining region Y)-box 4 -0.0174254
NCKAP5 NCK-associated protein 5 -0.0174078
FBXO34 F-box protein 34 -0.0169727
RPL36 ribosomal protein L36 -0.0168871
RPL23 ribosomal protein L23 -0.0167938
HLA-C major histocompatibility complex, class I, C -0.0167695
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0164121
RAD51B RAD51 paralog B -0.0163406
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0162975
PTPRK protein tyrosine phosphatase, receptor type, K -0.0161879
NPEPPS aminopeptidase puromycin sensitive -0.0161563
NDRG1 N-myc downstream regulated 1 -0.016147
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0160736
APOL2 apolipoprotein L, 2 -0.0160024
ZBTB20 zinc finger and BTB domain containing 20 -0.0159099
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0158749
NLGN1 neuroligin 1 -0.0157068
EIF5B eukaryotic translation initiation factor 5B -0.0156428
NIPBL Nipped-B homolog (Drosophila) -0.015502
IFI16 interferon, gamma-inducible protein 16 -0.0154596
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0154378
MKI67 marker of proliferation Ki-67 -0.0152775
ADAM8 ADAM metallopeptidase domain 8 -0.0151369
DEK DEK proto-oncogene -0.0150203
HMGB1 high mobility group box 1 -0.0149963
RPL13A ribosomal protein L13a -0.0149408
IFIH1 interferon induced with helicase C domain 1 -0.0149055
XAF1 XIAP associated factor 1 -0.0145971
RPL31 ribosomal protein L31 -0.0143917
TMEM165 transmembrane protein 165 -0.0143627
TMPRSS4 transmembrane protease, serine 4 -0.0142285
CFDP1 craniofacial development protein 1 -0.0142163
KPNB1 karyopherin (importin) beta 1 -0.0141604
CNRIP1 cannabinoid receptor interacting protein 1 -0.0141388
H3-3B H3.3 histone B -0.014059
FUS FUS RNA binding protein -0.0139138
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.0138672
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0138556
EIF1 eukaryotic translation initiation factor 1 -0.0138198
SEC62 SEC62 homolog (S. cerevisiae) -0.0137905