ULK-101_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ULK-101_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.120827
FMN1 formin 1 0.0945981
AKAP12 A kinase (PRKA) anchor protein 12 0.0760225
ZSWIM6 zinc finger, SWIM-type containing 6 0.0697356
VMP1 vacuole membrane protein 1 0.0649396
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0619533
TLE4 transducin-like enhancer of split 4 0.0537394
FNDC3A fibronectin type III domain containing 3A 0.0528884
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0498219
CEMIP cell migration inducing protein, hyaluronan binding 0.0484795
TPST1 tyrosylprotein sulfotransferase 1 0.0448361
SLIT2 slit homolog 2 (Drosophila) 0.0376633
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0367906
COL4A1 collagen, type IV, alpha 1 0.0362205
DPH6 diphthamine biosynthesis 6 0.0339589
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0333353
DGKH diacylglycerol kinase, eta 0.0330389
HOMER1 homer scaffolding protein 1 0.032467
FAM107B family with sequence similarity 107, member B 0.0323922
FRMD4A FERM domain containing 4A 0.0316518
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0314507
CHD9 chromodomain helicase DNA binding protein 9 0.0309789
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0307672
EXT1 exostosin glycosyltransferase 1 0.0295056
TIMP3 TIMP metallopeptidase inhibitor 3 0.0289535
INTS6 integrator complex subunit 6 0.0288327
SIK2 salt-inducible kinase 2 0.0275991
EGR1 early growth response 1 0.0274546
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0269443
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0258935
SPAG9 sperm associated antigen 9 0.0250588
SEC31A SEC31 homolog A (S. cerevisiae) 0.0249134
TRIO trio Rho guanine nucleotide exchange factor 0.0247062
MYO1E myosin IE 0.0244623
ANTXR1 anthrax toxin receptor 1 0.0243612
UBAP2 ubiquitin associated protein 2 0.0240375
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0239787
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0238313
PLAT plasminogen activator, tissue 0.023658
MACF1 microtubule-actin crosslinking factor 1 0.023514
ARHGAP9 Rho GTPase activating protein 9 0.0234163
PLPP1 phospholipid phosphatase 1 0.0226301
GLCCI1 glucocorticoid induced 1 0.0225081
SLITRK6 SLIT and NTRK-like family, member 6 0.0221012
PTPRM protein tyrosine phosphatase, receptor type, M 0.0220733
FLNB filamin B, beta 0.0217984
PALLD palladin, cytoskeletal associated protein 0.0217816
HELZ helicase with zinc finger 0.0215913
FLT1 fms-related tyrosine kinase 1 0.0214134
GPBP1 GC-rich promoter binding protein 1 0.0214113
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0209121
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0208112
PCBP2 poly(rC) binding protein 2 0.0206138
COL4A5 collagen, type IV, alpha 5 0.0206108
AHR aryl hydrocarbon receptor 0.0205895
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0205553
FERMT2 fermitin family member 2 0.0204739
MBNL2 muscleblind-like splicing regulator 2 0.0203862
PTPRE protein tyrosine phosphatase, receptor type, E 0.0201249
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0200748
LIMA1 LIM domain and actin binding 1 0.0199198
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0197986
EXOC4 exocyst complex component 4 0.0197921
PTEN phosphatase and tensin homolog 0.0197885
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0197397
LPP LIM domain containing preferred translocation partner in lipoma 0.0196556
MCL1 myeloid cell leukemia 1 0.0194528
ZFAND3 zinc finger, AN1-type domain 3 0.0194218
FNIP1 folliculin interacting protein 1 0.0192701
APLP2 amyloid beta (A4) precursor-like protein 2 0.0189352
TENM3 teneurin transmembrane protein 3 0.0187
MBTD1 mbt domain containing 1 0.0186611
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.018413
RARA retinoic acid receptor, alpha 0.0183099
TOR1AIP2 torsin A interacting protein 2 0.0181981
ITGA1 integrin, alpha 1 0.0180718
SIK3 SIK family kinase 3 0.0180686
B2M beta-2-microglobulin 0.0180619
IGFBP5 insulin-like growth factor binding protein 5 0.0180397
PCBP3 poly(rC) binding protein 3 0.0179292
SOD2 superoxide dismutase 2, mitochondrial 0.0177977
TBL1X transducin (beta)-like 1X-linked 0.0176249
NBEAL1 neurobeachin-like 1 0.0175398
NPAS2 neuronal PAS domain protein 2 0.0174943
SETX senataxin 0.017281
CA12 carbonic anhydrase XII 0.0172809
PACS1 phosphofurin acidic cluster sorting protein 1 0.0168742
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0168533
CTNND1 catenin (cadherin-associated protein), delta 1 0.0168329
LIMCH1 LIM and calponin homology domains 1 0.0167637
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0165173
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0164849
KTN1 kinectin 1 (kinesin receptor) 0.0164528
ASL argininosuccinate lyase 0.0164079
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0162131
PARD3 par-3 family cell polarity regulator 0.0161315
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0160692
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0159232
SEC24D SEC24 family member D 0.0157589
COL4A2 collagen, type IV, alpha 2 0.0157441

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.357579
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.169384
PTMA prothymosin, alpha -0.116656
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104888
RPL35A ribosomal protein L35a -0.0755207
RPL34 ribosomal protein L34 -0.0650358
RPS6 ribosomal protein S6 -0.0600082
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0596943
COL1A1 collagen, type I, alpha 1 -0.0586201
SYT1 synaptotagmin I -0.0577405
H3-3B H3.3 histone B -0.0567123
TPT1 tumor protein, translationally-controlled 1 -0.0531209
RPL26 ribosomal protein L26 -0.0484864
MAP1B microtubule-associated protein 1B -0.0478309
RPL19 ribosomal protein L19 -0.045284
RPLP1 ribosomal protein, large, P1 -0.0444876
TMSB10 thymosin beta 10 -0.0435894
RPL38 ribosomal protein L38 -0.0411691
RPL9 ribosomal protein L9 -0.0406916
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0389494
RPL23 ribosomal protein L23 -0.0382134
RPL32 ribosomal protein L32 -0.0363848
PRRC2C proline-rich coiled-coil 2C -0.036098
RPS8 ribosomal protein S8 -0.0339251
VIM vimentin -0.0333999
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0322408
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0318579
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0316905
TRIB2 tribbles pseudokinase 2 -0.031578
S100A6 S100 calcium binding protein A6 -0.0313353
PCDH9 protocadherin 9 -0.0307981
COL3A1 collagen, type III, alpha 1 -0.0301755
S100A9 S100 calcium binding protein A9 -0.0298929
RPL37A ribosomal protein L37a -0.0287003
GOLGA4 golgin A4 -0.0280806
TBX2 T-box 2 -0.0280704
FTL ferritin, light polypeptide -0.0273965
EIF1 eukaryotic translation initiation factor 1 -0.0271084
RPLP0 ribosomal protein, large, P0 -0.0270177
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0269828
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0269761
ZMYM2 zinc finger, MYM-type 2 -0.0263336
PRKCA protein kinase C, alpha -0.0261976
ZNF804A zinc finger protein 804A -0.0257131
RSL1D1 ribosomal L1 domain containing 1 -0.0254628
MTDH metadherin -0.0248068
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0247648
RPL11 ribosomal protein L11 -0.0245935
RBM20 RNA binding motif protein 20 -0.0245404
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0243217
RPS12 ribosomal protein S12 -0.0242779
CCDC47 coiled-coil domain containing 47 -0.0239985
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0239271
CLTC clathrin, heavy chain (Hc) -0.0232428
RPS11 ribosomal protein S11 -0.0229746
RPS21 ribosomal protein S21 -0.0228733
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0228028
ZNF292 zinc finger protein 292 -0.0223358
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0220834
PABPN1 poly(A) binding protein, nuclear 1 -0.0218836
RBM25 RNA binding motif protein 25 -0.0218434
HMGA1 high mobility group AT-hook 1 -0.0218406
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0217182
RPL36 ribosomal protein L36 -0.0216817
RPL30 ribosomal protein L30 -0.0214242
RPL31 ribosomal protein L31 -0.0213878
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0212013
NF1 neurofibromin 1 -0.0211983
VDAC1 voltage-dependent anion channel 1 -0.0210414
WIPF2 WAS/WASL interacting protein family, member 2 -0.0210173
KPNB1 karyopherin (importin) beta 1 -0.0209923
RPL27 ribosomal protein L27 -0.020933
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0206373
NPEPPS aminopeptidase puromycin sensitive -0.0205749
EIF5B eukaryotic translation initiation factor 5B -0.0204406
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.020332
CDK6 cyclin-dependent kinase 6 -0.0202644
RPS24 ribosomal protein S24 -0.020261
RPLP2 ribosomal protein, large, P2 -0.0200059
RPL7A ribosomal protein L7a -0.019758
CADM2 cell adhesion molecule 2 -0.0196456
MAP4 microtubule-associated protein 4 -0.0195353
PFN1 profilin 1 -0.019412
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0193591
NAP1L1 nucleosome assembly protein 1-like 1 -0.0192137
SERF2 small EDRK-rich factor 2 -0.0191766
RAB7A RAB7A, member RAS oncogene family -0.0190358
NCOR1 nuclear receptor corepressor 1 -0.018935
MYO1D myosin ID -0.0189088
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.018552
RPL13A ribosomal protein L13a -0.0184493
BPTF bromodomain PHD finger transcription factor -0.0182734
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0180691
PDE4D phosphodiesterase 4D, cAMP-specific -0.0180519
NKTR natural killer cell triggering receptor -0.0179552
HDAC9 histone deacetylase 9 -0.0179329
ENAH enabled homolog (Drosophila) -0.0177184
WSB1 WD repeat and SOCS box containing 1 -0.017564
GNAS GNAS complex locus -0.0175587
HMGB2 high mobility group box 2 -0.0175349