| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ULK-101 perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ULK-101_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | 0.24988 |
| CD44 | CD44 molecule (Indian blood group) | 0.176893 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.13822 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.133241 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.121561 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.117794 |
| STC1 | stanniocalcin 1 | 0.0959951 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0922206 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0810044 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0776081 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0738714 |
| AHNAK | AHNAK nucleoprotein | 0.0702015 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0678887 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0668711 |
| NAV1 | neuron navigator 1 | 0.0625962 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0585577 |
| EGFR | epidermal growth factor receptor | 0.0583555 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0573192 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0561789 |
| ENO1 | enolase 1, (alpha) | 0.0538225 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0537965 |
| ASPH | aspartate beta-hydroxylase | 0.0525882 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0519418 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0510787 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0508693 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0502146 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0501105 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.049804 |
| DTNA | dystrobrevin, alpha | 0.048781 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0484949 |
| MCL1 | myeloid cell leukemia 1 | 0.0483359 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0467406 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0462497 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0457609 |
| CLMP | CXADR-like membrane protein | 0.0408727 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0407716 |
| SEPTIN9 | septin 9 | 0.0404865 |
| FNIP1 | folliculin interacting protein 1 | 0.0386318 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0385512 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0385216 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0381356 |
| DUSP6 | dual specificity phosphatase 6 | 0.0368804 |
| CDCP1 | CUB domain containing protein 1 | 0.0368043 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0363057 |
| INHBA | inhibin, beta A | 0.0362473 |
| NUMB | numb homolog (Drosophila) | 0.0359732 |
| DOCK5 | dedicator of cytokinesis 5 | 0.035163 |
| NAV2 | neuron navigator 2 | 0.0346838 |
| EFNA5 | ephrin-A5 | 0.0346072 |
| SMYD3 | SET and MYND domain containing 3 | 0.0340399 |
| GPC5 | glypican 5 | 0.0340037 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0333445 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0331292 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0323546 |
| CAPRIN2 | caprin family member 2 | 0.0321592 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.03198 |
| SFTPA2 | surfactant protein A2 | 0.0318535 |
| EMP1 | epithelial membrane protein 1 | 0.031635 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0316123 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0312107 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0309868 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0304664 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0301071 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0300509 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0299818 |
| VMP1 | vacuole membrane protein 1 | 0.0295502 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0291063 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0290053 |
| MYO1D | myosin ID | 0.0288439 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0288228 |
| RCOR1 | REST corepressor 1 | 0.0284229 |
| CLIC4 | chloride intracellular channel 4 | 0.0283903 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0276361 |
| ANGPTL4 | angiopoietin-like 4 | 0.0274556 |
| CANX | calnexin | 0.0271059 |
| PRKCA | protein kinase C, alpha | 0.0265995 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.026262 |
| TBX3 | T-box 3 | 0.0262091 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0260216 |
| LOXL2 | lysyl oxidase-like 2 | 0.025934 |
| HDAC9 | histone deacetylase 9 | 0.0258503 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0255237 |
| MYO10 | myosin X | 0.025494 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0254337 |
| RND3 | Rho family GTPase 3 | 0.0254143 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0253979 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0252214 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.025071 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0250055 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0245789 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0244806 |
| KLF12 | Kruppel-like factor 12 | 0.0244601 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0243586 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0243162 |
| MT1E | metallothionein 1E | 0.024205 |
| ZNF638 | zinc finger protein 638 | 0.0239801 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0239135 |
| FRMD4A | FERM domain containing 4A | 0.0238648 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0236641 |
| RASA2 | RAS p21 protein activator 2 | 0.023612 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.118863 |
| PTMA | prothymosin, alpha | -0.115879 |
| NDRG1 | N-myc downstream regulated 1 | -0.101903 |
| IGF2 | insulin-like growth factor 2 | -0.0935397 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0917759 |
| FN1 | fibronectin 1 | -0.0817871 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0667485 |
| FAM13A | family with sequence similarity 13, member A | -0.0568092 |
| TMSB10 | thymosin beta 10 | -0.0513724 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0500775 |
| RPL35A | ribosomal protein L35a | -0.0449307 |
| FTL | ferritin, light polypeptide | -0.0437438 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0421914 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0413865 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0358479 |
| GNAS | GNAS complex locus | -0.0356771 |
| ADM | adrenomedullin | -0.0352526 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0351566 |
| COL6A1 | collagen, type VI, alpha 1 | -0.033716 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0331036 |
| WDR45B | WD repeat domain 45B | -0.0300703 |
| CALD1 | caldesmon 1 | -0.029441 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0288162 |
| ZNF292 | zinc finger protein 292 | -0.027676 |
| USP3 | ubiquitin specific peptidase 3 | -0.0274173 |
| ACTG1 | actin gamma 1 | -0.0272051 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0264092 |
| CENPF | centromere protein F, 350/400kDa | -0.025807 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0249625 |
| RLF | rearranged L-myc fusion | -0.0243764 |
| FAM162A | family with sequence similarity 162, member A | -0.0240716 |
| TPX2 | TPX2, microtubule-associated | -0.024001 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0238258 |
| QKI | QKI, KH domain containing, RNA binding | -0.0237799 |
| FLNB | filamin B, beta | -0.0237616 |
| OGA | O-GlcNAcase | -0.0236981 |
| PGK1 | phosphoglycerate kinase 1 | -0.0236717 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0234913 |
| POTEF | POTE ankyrin domain family, member F | -0.0233364 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0231049 |
| TPM1 | tropomyosin 1 (alpha) | -0.0230259 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0226629 |
| TUBB | tubulin, beta class I | -0.0224123 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.022247 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0217941 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0213967 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0210758 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0208069 |
| COL1A1 | collagen, type I, alpha 1 | -0.0207567 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0205888 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0203424 |
| TENM2 | teneurin transmembrane protein 2 | -0.0199575 |
| VCL | vinculin | -0.0197975 |
| TPI1 | triosephosphate isomerase 1 | -0.0196447 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0195106 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0192868 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0192696 |
| CD109 | CD109 molecule | -0.0191832 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0191787 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0191617 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0190655 |
| RBM39 | RNA binding motif protein 39 | -0.0189837 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0188186 |
| DIAPH3 | diaphanous-related formin 3 | -0.0184099 |
| ETV6 | ets variant 6 | -0.0183767 |
| CALR | calreticulin | -0.0183732 |
| RPL37A | ribosomal protein L37a | -0.0182803 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0182803 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0182646 |
| SETD5 | SET domain containing 5 | -0.0181836 |
| RPL9 | ribosomal protein L9 | -0.0181755 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0181521 |
| KIF4A | kinesin family member 4A | -0.0178864 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.017855 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0177286 |
| RPLP2 | ribosomal protein, large, P2 | -0.0176348 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0175993 |
| CENPE | centromere protein E, 312kDa | -0.0175633 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0175282 |
| RPS29 | ribosomal protein S29 | -0.0170726 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0169249 |
| RNF145 | ring finger protein 145 | -0.0169186 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0169113 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0167537 |
| MT2A | metallothionein 2A | -0.0166977 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0165043 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0164589 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0163945 |
| NKTR | natural killer cell triggering receptor | -0.0161387 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0160421 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0160415 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0159818 |
| RIN2 | Ras and Rab interactor 2 | -0.0158759 |
| PRR11 | proline rich 11 | -0.0156748 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0156283 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0155743 |
| COL5A1 | collagen, type V, alpha 1 | -0.0155473 |
| CDC27 | cell division cycle 27 | -0.0154627 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0153928 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0153754 |
