ULK-101_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.106504
IGFBP3 insulin-like growth factor binding protein 3 0.103724
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0909225
COL6A3 collagen, type VI, alpha 3 0.0904791
FNDC3B fibronectin type III domain containing 3B 0.0883731
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0859419
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0694133
CDH13 cadherin 13 0.0554901
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0548298
PSD3 pleckstrin and Sec7 domain containing 3 0.0515294
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0515129
TRIO trio Rho guanine nucleotide exchange factor 0.0507324
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0504609
STC1 stanniocalcin 1 0.0467752
PDE10A phosphodiesterase 10A 0.04557
ZSWIM6 zinc finger, SWIM-type containing 6 0.0445404
JARID2 jumonji, AT rich interactive domain 2 0.0432806
NAV2 neuron navigator 2 0.0408763
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0402782
CD44 CD44 molecule (Indian blood group) 0.0393589
SOD2 superoxide dismutase 2, mitochondrial 0.0379634
VMP1 vacuole membrane protein 1 0.0378103
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0373714
HMGA2 high mobility group AT-hook 2 0.0370596
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0358392
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0355187
ERRFI1 ERBB receptor feedback inhibitor 1 0.0351148
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0348446
GOLGB1 golgin B1 0.0348304
WWTR1 WW domain containing transcription regulator 1 0.0342078
VEGFA vascular endothelial growth factor A 0.0328208
GLIS3 GLIS family zinc finger 3 0.0327064
RND3 Rho family GTPase 3 0.0319244
ARRDC3 arrestin domain containing 3 0.0315
SDC2 syndecan 2 0.0313037
JUN jun proto-oncogene 0.0311062
ATP13A3 ATPase type 13A3 0.030981
ASPH aspartate beta-hydroxylase 0.0300374
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0300048
IL6 interleukin 6 0.0297417
SON SON DNA binding protein 0.029566
CANX calnexin 0.0293077
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0291801
FBN1 fibrillin 1 0.0289215
PGM3 phosphoglucomutase 3 0.0285183
ZBTB20 zinc finger and BTB domain containing 20 0.0282345
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0277558
MLF1 myeloid leukemia factor 1 0.0276942
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0274693
INHBA inhibin, beta A 0.0270611
MACF1 microtubule-actin crosslinking factor 1 0.0270295
LIMS1 LIM and senescent cell antigen-like domains 1 0.0269657
LOC102724023 ES1 protein homolog, mitochondrial 0.0268929
EGFR epidermal growth factor receptor 0.0266429
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0265704
RASA2 RAS p21 protein activator 2 0.0265575
ZFAND3 zinc finger, AN1-type domain 3 0.026319
IL6ST interleukin 6 signal transducer 0.0261928
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0258908
STK10 serine/threonine kinase 10 0.0255408
COL3A1 collagen, type III, alpha 1 0.025274
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0251094
MYO10 myosin X 0.025073
KDM7A lysine (K)-specific demethylase 7A 0.0250299
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239315
SP100 SP100 nuclear antigen 0.0238957
ZBTB38 zinc finger and BTB domain containing 38 0.0235256
NOTCH2 notch 2 0.0234723
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0228101
RAB2A RAB2A, member RAS oncogene family 0.0224918
PICALM phosphatidylinositol binding clathrin assembly protein 0.0224678
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0219946
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0219124
LTBP1 latent transforming growth factor beta binding protein 1 0.0218805
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0218354
FAM107B family with sequence similarity 107, member B 0.0215995
OSMR oncostatin M receptor 0.021275
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0212181
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0208325
RAB7A RAB7A, member RAS oncogene family 0.0206978
HDAC9 histone deacetylase 9 0.0206744
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0205265
CSPP1 centrosome and spindle pole associated protein 1 0.0204173
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0201641
FMNL2 formin-like 2 0.0201444
COPA coatomer protein complex, subunit alpha 0.0200532
DST dystonin 0.0199622
EXT1 exostosin glycosyltransferase 1 0.0197717
CD109 CD109 molecule 0.0196017
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0193341
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0193229
DUSP6 dual specificity phosphatase 6 0.0190541
NAV1 neuron navigator 1 0.0190461
LPP LIM domain containing preferred translocation partner in lipoma 0.019039
ANKH ANKH inorganic pyrophosphate transport regulator 0.0189217
EGR1 early growth response 1 0.0189099
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0188729
MAML2 mastermind-like 2 (Drosophila) 0.0188661
PLSCR1 phospholipid scramblase 1 0.0188527
GLS2 glutaminase 2 (liver, mitochondrial) 0.0186515

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.201116
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.168868
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.159451
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100832
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0964224
PTMA prothymosin, alpha -0.0934579
VIM vimentin -0.0893292
FTL ferritin, light polypeptide -0.0824528
RPL35A ribosomal protein L35a -0.0704123
NDRG1 N-myc downstream regulated 1 -0.0702239
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0648072
TGFBI transforming growth factor, beta-induced, 68kDa -0.0631107
HLA-B major histocompatibility complex, class I, B -0.0582262
TMSB10 thymosin beta 10 -0.0558644
TPT1 tumor protein, translationally-controlled 1 -0.0545203
COL1A2 collagen, type I, alpha 2 -0.0511803
IER3 immediate early response 3 -0.0489893
MT2A metallothionein 2A -0.0482524
RPL37A ribosomal protein L37a -0.0451749
TM4SF1 transmembrane 4 L six family member 1 -0.0446685
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0428605
RPS6 ribosomal protein S6 -0.0414312
CAVIN1 caveolae associated protein 1 -0.039366
RPLP2 ribosomal protein, large, P2 -0.0364349
WSB1 WD repeat and SOCS box containing 1 -0.0356615
S100A10 S100 calcium binding protein A10 -0.0331715
RPS3 ribosomal protein S3 -0.031995
TPM4 tropomyosin 4 -0.0307272
ACTG1 actin gamma 1 -0.0302782
PLAUR plasminogen activator, urokinase receptor -0.0300753
CALD1 caldesmon 1 -0.0295624
ANXA2 annexin A2 -0.0286639
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0284075
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.028071
RRBP1 ribosome binding protein 1 -0.0274143
RPS8 ribosomal protein S8 -0.027265
EIF1 eukaryotic translation initiation factor 1 -0.02688
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0266407
RPL38 ribosomal protein L38 -0.0266033
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0261389
RPS24 ribosomal protein S24 -0.0254065
RPL9 ribosomal protein L9 -0.0245082
ADM adrenomedullin -0.0241304
RPS29 ribosomal protein S29 -0.0238829
RPS27A ribosomal protein S27a -0.0235901
SETD5 SET domain containing 5 -0.0233454
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0233258
RPL31 ribosomal protein L31 -0.0231164
SLC38A2 solute carrier family 38, member 2 -0.0230241
S100A9 S100 calcium binding protein A9 -0.022989
RPL28 ribosomal protein L28 -0.0229854
RPL30 ribosomal protein L30 -0.0227373
RPL11 ribosomal protein L11 -0.0223124
FAM162A family with sequence similarity 162, member A -0.0222541
RPLP1 ribosomal protein, large, P1 -0.0216507
FKBP10 FK506 binding protein 10, 65 kDa -0.0213998
RPS25 ribosomal protein S25 -0.0213438
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0212289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0205643
SEPTIN7 septin 7 -0.0203955
GNAS GNAS complex locus -0.0203459
BBX bobby sox homolog (Drosophila) -0.019913
USP3 ubiquitin specific peptidase 3 -0.0198245
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0197458
VDAC1 voltage-dependent anion channel 1 -0.0192869
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0191884
RPL13A ribosomal protein L13a -0.0189417
KDM3A lysine (K)-specific demethylase 3A -0.0184275
CALR calreticulin -0.0182268
RPL36 ribosomal protein L36 -0.0181334
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0179168
RPL8 ribosomal protein L8 -0.0178572
HMGB1 high mobility group box 1 -0.0177891
RPS13 ribosomal protein S13 -0.0172113
RPS12 ribosomal protein S12 -0.0170853
RBM39 RNA binding motif protein 39 -0.017069
PGK1 phosphoglycerate kinase 1 -0.0168152
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0166975
RPL7A ribosomal protein L7a -0.0166872
KPNB1 karyopherin (importin) beta 1 -0.0166629
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0166074
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0165567
DSTN destrin (actin depolymerizing factor) -0.0165272
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0165161
RPL26 ribosomal protein L26 -0.0165118
LAMB3 laminin, beta 3 -0.0164865
RPS15 ribosomal protein S15 -0.016429
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0164012
ANKRD10 ankyrin repeat domain 10 -0.0161413
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.016106
MYL12B myosin, light chain 12B, regulatory -0.0160402
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0160069
LMNA lamin A/C -0.0158999
KCTD9 potassium channel tetramerization domain containing 9 -0.015704
PXDN peroxidasin -0.0156976
THY1 Thy-1 cell surface antigen -0.0155138
FSTL1 follistatin-like 1 -0.0154986
RPL37 ribosomal protein L37 -0.0153845
RPS21 ribosomal protein S21 -0.0153127
MTDH metadherin -0.0151467