| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ULK-101 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ULK-101_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.218168 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.125606 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.107519 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103567 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0947805 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0908084 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0757557 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0757111 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0744385 |
| SVIL | supervillin | 0.0719225 |
| MT2A | metallothionein 2A | 0.0672996 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.062716 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0617538 |
| ENO1 | enolase 1, (alpha) | 0.0612137 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0609351 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0572617 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0559565 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0515739 |
| RPS6 | ribosomal protein S6 | 0.0509735 |
| JMJD1C | jumonji domain containing 1C | 0.0504959 |
| TXNRD1 | thioredoxin reductase 1 | 0.0499866 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0490087 |
| VMP1 | vacuole membrane protein 1 | 0.0488742 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0472061 |
| GOLGA4 | golgin A4 | 0.0469967 |
| ITGAV | integrin, alpha V | 0.0461762 |
| FOXP1 | forkhead box P1 | 0.0439712 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0424308 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0418493 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0417372 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0406907 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0399426 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0396083 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0387505 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0386796 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0384163 |
| HM13 | histocompatibility (minor) 13 | 0.0378478 |
| TOP1 | topoisomerase (DNA) I | 0.0374234 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0372974 |
| RPLP0 | ribosomal protein, large, P0 | 0.0372523 |
| PCBP2 | poly(rC) binding protein 2 | 0.0371583 |
| RPS8 | ribosomal protein S8 | 0.0369113 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0366488 |
| SFTPA2 | surfactant protein A2 | 0.0366263 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0366232 |
| AHSG | alpha-2-HS-glycoprotein | 0.0357255 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0352192 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0347066 |
| IGF2 | insulin-like growth factor 2 | 0.0343104 |
| RPLP1 | ribosomal protein, large, P1 | 0.0334338 |
| MYO6 | myosin VI | 0.0331564 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0330738 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0328542 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0327975 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0321598 |
| USP47 | ubiquitin specific peptidase 47 | 0.0318703 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0318069 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0315974 |
| RPL23 | ribosomal protein L23 | 0.0308521 |
| MRTFA | myocardin related transcription factor A | 0.0307221 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0301565 |
| SNX9 | sorting nexin 9 | 0.0301466 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0300292 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0297049 |
| AFF1 | AF4/FMR2 family, member 1 | 0.029512 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.029244 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0290701 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0290073 |
| RASA2 | RAS p21 protein activator 2 | 0.0288741 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.028712 |
| MATR3 | matrin 3 | 0.0285661 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0285497 |
| RPL7 | ribosomal protein L7 | 0.0284532 |
| BCL2L1 | BCL2-like 1 | 0.0282106 |
| DENND4A | DENN/MADD domain containing 4A | 0.0281309 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0278803 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0274797 |
| DIAPH1 | diaphanous-related formin 1 | 0.0274355 |
| RPS12 | ribosomal protein S12 | 0.0273974 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0273886 |
| YME1L1 | YME1-like 1 ATPase | 0.0273842 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0273297 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0273007 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0272691 |
| AAK1 | AP2 associated kinase 1 | 0.0270434 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0270185 |
| RPL5 | ribosomal protein L5 | 0.0269699 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0265959 |
| KIF1B | kinesin family member 1B | 0.0265475 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0265417 |
| RAB10 | RAB10, member RAS oncogene family | 0.0262989 |
| RBM25 | RNA binding motif protein 25 | 0.0262913 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0262563 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0261587 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0261574 |
| SSR1 | signal sequence receptor, alpha | 0.0260455 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0259139 |
| IPO7 | importin 7 | 0.0255435 |
| PTK2 | protein tyrosine kinase 2 | 0.0255073 |
| TPM4 | tropomyosin 4 | 0.0253936 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LRMDA | leucine rich melanocyte differentiation associated | -0.0805737 |
| GPC6 | glypican 6 | -0.0765352 |
| FN1 | fibronectin 1 | -0.0764888 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0751345 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0734725 |
| EHBP1 | EH domain binding protein 1 | -0.0525553 |
| RNF213 | ring finger protein 213 | -0.0475421 |
| CP | ceruloplasmin (ferroxidase) | -0.0427983 |
| RUNX1 | runt-related transcription factor 1 | -0.0413713 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0412488 |
| ATP10A | ATPase, class V, type 10A | -0.0401788 |
| PEG3 | paternally expressed 3 | -0.0371696 |
| TMSB10 | thymosin beta 10 | -0.0344308 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0337842 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0336364 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0326944 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0316317 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0266732 |
| H1-0 | H1.0 linker histone | -0.0258443 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.025792 |
| RIGI | RNA sensor RIG-I | -0.0256065 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0250312 |
| GNAS | GNAS complex locus | -0.0248028 |
| PLXDC2 | plexin domain containing 2 | -0.0236719 |
| RNASET2 | ribonuclease T2 | -0.0236322 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.022917 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0222715 |
| A2M | alpha-2-macroglobulin | -0.0221459 |
| INTS6 | integrator complex subunit 6 | -0.021935 |
| PTCHD4 | patched domain containing 4 | -0.0218396 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0217658 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0217473 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0199601 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0199187 |
| GPC3 | glypican 3 | -0.0198861 |
| KIZ | kizuna centrosomal protein | -0.0198167 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0192715 |
| STK39 | serine threonine kinase 39 | -0.0192587 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0188334 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0188017 |
| NREP | neuronal regeneration related protein | -0.0183982 |
| HMGA2 | high mobility group AT-hook 2 | -0.0183783 |
| MX2 | MX dynamin-like GTPase 2 | -0.018224 |
| EGR1 | early growth response 1 | -0.0180665 |
| TMEM123 | transmembrane protein 123 | -0.0179105 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0177963 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0173066 |
| SLC2A14 | solute carrier family 2 (facilitated glucose transporter), member 14 | -0.0171938 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0170494 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0161067 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0160998 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0158105 |
| DOK6 | docking protein 6 | -0.0157938 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0152092 |
| TNS1 | tensin 1 | -0.0147286 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0146581 |
| CCDC146 | coiled-coil domain containing 146 | -0.0146183 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0144361 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0144281 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0142295 |
| RAD51B | RAD51 paralog B | -0.0141622 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0141565 |
| RNF220 | ring finger protein 220 | -0.0140538 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0138646 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0137218 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0133651 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0132874 |
| RPL28 | ribosomal protein L28 | -0.0132279 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0132025 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0131281 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0130173 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.012949 |
| SP100 | SP100 nuclear antigen | -0.0128449 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0128362 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0127813 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0127703 |
| PFN1 | profilin 1 | -0.0127471 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0126754 |
| DCDC2 | doublecortin domain containing 2 | -0.0124856 |
| LCN2 | lipocalin 2 | -0.0124721 |
| LAP3 | leucine aminopeptidase 3 | -0.0124598 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0123602 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0123589 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0123244 |
| CDK6 | cyclin-dependent kinase 6 | -0.0122551 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0121924 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0121491 |
| CCNL2 | cyclin L2 | -0.0120741 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.012066 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.0119701 |
| LMNA | lamin A/C | -0.011876 |
| FRMD5 | FERM domain containing 5 | -0.0118747 |
| GSN | gelsolin | -0.0118117 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0118112 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0116933 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0116589 |
| TAFA5 | TAFA chemokine like family member 5 | -0.0114685 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.0114299 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.011395 |
| EXOC6 | exocyst complex component 6 | -0.0113012 |
