ULK-101_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.0905251
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0855044
LMO7 LIM domain 7 0.0806336
PDLIM5 PDZ and LIM domain 5 0.0724599
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0719144
PDE4D phosphodiesterase 4D, cAMP-specific 0.0656172
RAI14 retinoic acid induced 14 0.0649882
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0594263
NAV2 neuron navigator 2 0.0505086
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0433539
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0418894
SQSTM1 sequestosome 1 0.039787
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0396759
CD44 CD44 molecule (Indian blood group) 0.039318
SMAD3 SMAD family member 3 0.0391943
DSCAM Down syndrome cell adhesion molecule 0.0381118
RASAL2 RAS protein activator like 2 0.0376543
CEMIP cell migration inducing protein, hyaluronan binding 0.0374573
JMJD1C jumonji domain containing 1C 0.0362216
BCAR3 breast cancer anti-estrogen resistance 3 0.0353901
OSMR oncostatin M receptor 0.0347712
ZSWIM6 zinc finger, SWIM-type containing 6 0.0337645
AKAP13 A kinase (PRKA) anchor protein 13 0.0326008
NRIP1 nuclear receptor interacting protein 1 0.0321676
MYOF myoferlin 0.0309112
PICALM phosphatidylinositol binding clathrin assembly protein 0.0308557
FNIP1 folliculin interacting protein 1 0.0299311
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0297627
HLA-E major histocompatibility complex, class I, E 0.0281878
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0280952
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0277272
EXT1 exostosin glycosyltransferase 1 0.0269486
RUNX1 runt-related transcription factor 1 0.0268647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0265332
FAM107B family with sequence similarity 107, member B 0.0261604
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0259091
MACF1 microtubule-actin crosslinking factor 1 0.0249615
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.024765
PLS3 plastin 3 0.024597
EFNA5 ephrin-A5 0.0243121
DOCK5 dedicator of cytokinesis 5 0.0241916
BMAL2 basic helix-loop-helix ARNT like 2 0.023894
INTS6 integrator complex subunit 6 0.023791
UBE2H ubiquitin-conjugating enzyme E2H 0.0236092
HMGA2 high mobility group AT-hook 2 0.0230366
FNDC3B fibronectin type III domain containing 3B 0.0230053
SOD2 superoxide dismutase 2, mitochondrial 0.0226623
DOK5 docking protein 5 0.0226497
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0226123
FN1 fibronectin 1 0.022555
ARHGAP21 Rho GTPase activating protein 21 0.0222964
FRMD6 FERM domain containing 6 0.0221523
CNTNAP3 contactin associated protein-like 3 0.0220841
UTRN utrophin 0.0216642
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0212775
ZC3H12C zinc finger CCCH-type containing 12C 0.0212771
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0211751
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0210964
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0210656
LAMC2 laminin, gamma 2 0.0206637
LUZP1 leucine zipper protein 1 0.0204651
ABI3BP ABI family, member 3 (NESH) binding protein 0.020405
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0203429
TOP1 topoisomerase (DNA) I 0.0199619
SVIL supervillin 0.0198231
DST dystonin 0.0196662
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0193216
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0187218
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0185576
SMYD3 SET and MYND domain containing 3 0.0185088
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0184164
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0183235
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0181461
SEC31A SEC31 homolog A (S. cerevisiae) 0.017877
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0178112
ERRFI1 ERBB receptor feedback inhibitor 1 0.0177955
ANKHD1 ankyrin repeat and KH domain containing 1 0.0177922
BARX2 BARX homeobox 2 0.017766
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0176699
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0175636
ARHGAP29 Rho GTPase activating protein 29 0.0172139
THSD4 thrombospondin, type I, domain containing 4 0.017189
EGFR epidermal growth factor receptor 0.0168682
MYH9 myosin, heavy chain 9, non-muscle 0.0168376
IRAK2 interleukin-1 receptor-associated kinase 2 0.0166965
PRSS23 protease, serine, 23 0.0166246
MT1E metallothionein 1E 0.0165856
KAT6A K(lysine) acetyltransferase 6A 0.0165676
APP amyloid beta (A4) precursor protein 0.0165397
OSBPL6 oxysterol binding protein-like 6 0.0165169
ASPH aspartate beta-hydroxylase 0.0163777
VCL vinculin 0.016083
SIK3 SIK family kinase 3 0.0159012
KLHL24 kelch-like family member 24 0.0158316
EFCAB13 EF-hand calcium binding domain 13 0.0158246
ANKRD12 ankyrin repeat domain 12 0.0158187
CDK13 cyclin-dependent kinase 13 0.015485
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0154695
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.0154127
DOCK4 dedicator of cytokinesis 4 0.0153969

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.0804317
CLU clusterin -0.0769425
TMSB10 thymosin beta 10 -0.0738387
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0689633
FLNB filamin B, beta -0.066771
PTMA prothymosin, alpha -0.0637866
POTEF POTE ankyrin domain family, member F -0.0587783
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0488148
TPT1 tumor protein, translationally-controlled 1 -0.04862
RPS21 ribosomal protein S21 -0.0482948
B2M beta-2-microglobulin -0.0462933
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0403546
ITGA6 integrin, alpha 6 -0.040104
LMNA lamin A/C -0.0388052
GNAS GNAS complex locus -0.0375772
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0374703
SULF1 sulfatase 1 -0.037394
S100A6 S100 calcium binding protein A6 -0.0367012
RPS6 ribosomal protein S6 -0.036604
RPS3 ribosomal protein S3 -0.0363074
MT2A metallothionein 2A -0.0358547
PGK1 phosphoglycerate kinase 1 -0.0356661
MEF2A myocyte enhancer factor 2A -0.0345632
DSTN destrin (actin depolymerizing factor) -0.0335606
S100A10 S100 calcium binding protein A10 -0.0329559
LDHA lactate dehydrogenase A -0.0328476
RPL35A ribosomal protein L35a -0.03281
CAV1 caveolin 1, caveolae protein, 22kDa -0.0324139
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0319032
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0311455
IFITM3 interferon induced transmembrane protein 3 -0.030464
RPL11 ribosomal protein L11 -0.0304404
ANLN anillin, actin binding protein -0.0294967
RPLP2 ribosomal protein, large, P2 -0.0291268
IFITM1 interferon induced transmembrane protein 1 -0.0290343
PODXL podocalyxin-like -0.0287232
MT1X metallothionein 1X -0.0284646
HLA-B major histocompatibility complex, class I, B -0.0283623
TMSB4X thymosin beta 4, X-linked -0.0280731
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0275215
PDIA3 protein disulfide isomerase family A, member 3 -0.0269236
NAMPT nicotinamide phosphoribosyltransferase -0.0268973
RPS13 ribosomal protein S13 -0.0263557
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.025689
PKM pyruvate kinase, muscle -0.0255851
RPS19 ribosomal protein S19 -0.0249926
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0249544
RPLP1 ribosomal protein, large, P1 -0.0244712
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0241379
RPL19 ribosomal protein L19 -0.0237852
RPL37A ribosomal protein L37a -0.0236811
EZR ezrin -0.0236174
PFN1 profilin 1 -0.0235326
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0227484
EMP1 epithelial membrane protein 1 -0.0224501
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0221797
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0215371
H1-0 H1.0 linker histone -0.0215235
RPL5 ribosomal protein L5 -0.0214058
IFI6 interferon, alpha-inducible protein 6 -0.021356
RPS12 ribosomal protein S12 -0.0212995
UQCRB ubiquinol-cytochrome c reductase binding protein -0.020981
IFI27 interferon, alpha-inducible protein 27 -0.0209683
S100A11 S100 calcium binding protein A11 -0.0209395
S100A9 S100 calcium binding protein A9 -0.0206064
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0205117
RPL35 ribosomal protein L35 -0.0203871
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0202379
RPL12 ribosomal protein L12 -0.0200986
KRT17 keratin 17, type I -0.0200863
CALR calreticulin -0.0198848
POMP proteasome maturation protein -0.0198809
S100A4 S100 calcium binding protein A4 -0.0198302
VDAC1 voltage-dependent anion channel 1 -0.019577
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.019499
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.019424
CNRIP1 cannabinoid receptor interacting protein 1 -0.0194109
MYO10 myosin X -0.0191097
PRRC2C proline-rich coiled-coil 2C -0.0188991
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0185718
YBX1 Y box binding protein 1 -0.0185711
SYPL1 synaptophysin-like 1 -0.0181412
MKI67 marker of proliferation Ki-67 -0.018119
RPS23 ribosomal protein S23 -0.0180619
S100A2 S100 calcium binding protein A2 -0.0176764
RPL36 ribosomal protein L36 -0.0176308
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0175203
EFHD2 EF-hand domain family, member D2 -0.0174841
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0173978
SQLE squalene epoxidase -0.0172883
RPS27A ribosomal protein S27a -0.0172591
RPS11 ribosomal protein S11 -0.0171303
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0171185
TPX2 TPX2, microtubule-associated -0.0170548
SAMD9 sterile alpha motif domain containing 9 -0.0169519
RPS4X ribosomal protein S4, X-linked -0.0167567
RPS16 ribosomal protein S16 -0.0166444
TPI1 triosephosphate isomerase 1 -0.0165743
KRT19 keratin 19, type I -0.0165269
KRT6A keratin 6A, type II -0.0165087