ULK-101_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.138388
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0941608
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0875362
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0716006
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0704943
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.065022
EFNA5 ephrin-A5 0.0616718
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0556897
MCTP1 multiple C2 domains, transmembrane 1 0.055453
ERRFI1 ERBB receptor feedback inhibitor 1 0.0531444
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0493517
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0472924
EXT1 exostosin glycosyltransferase 1 0.0467536
TXNIP thioredoxin interacting protein 0.0444469
HDAC9 histone deacetylase 9 0.0421635
GLS2 glutaminase 2 (liver, mitochondrial) 0.0417646
AHNAK AHNAK nucleoprotein 0.0403333
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.040137
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0389106
DST dystonin 0.0386999
SAMD4A sterile alpha motif domain containing 4A 0.0386092
JMJD1C jumonji domain containing 1C 0.0371977
TMPRSS15 transmembrane protease, serine 15 0.0368262
EEF2 eukaryotic translation elongation factor 2 0.0366955
ELL2 elongation factor, RNA polymerase II, 2 0.0364243
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0361984
RAD21 RAD21 homolog (S. pombe) 0.0353723
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0348499
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0343414
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0341358
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0325815
NAP1L1 nucleosome assembly protein 1-like 1 0.0319682
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0312442
PBX3 pre-B-cell leukemia homeobox 3 0.031216
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0302513
YBX3 Y box binding protein 3 0.0294815
UGCG UDP-glucose ceramide glucosyltransferase 0.0291063
PTPRG protein tyrosine phosphatase, receptor type, G 0.0287299
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0286601
TSC22D2 TSC22 domain family, member 2 0.0284091
STC1 stanniocalcin 1 0.0282787
RUNX1 runt-related transcription factor 1 0.0276412
IPO7 importin 7 0.0276019
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0273804
LIMA1 LIM domain and actin binding 1 0.0260527
RTN4 reticulon 4 0.025908
YBX1 Y box binding protein 1 0.0257626
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256761
WDR26 WD repeat domain 26 0.0253471
PCBP2 poly(rC) binding protein 2 0.0248736
TRIO trio Rho guanine nucleotide exchange factor 0.0246979
NAMPT nicotinamide phosphoribosyltransferase 0.0243681
NCKAP1 NCK-associated protein 1 0.0243516
OSBPL8 oxysterol binding protein-like 8 0.0242813
CDK6 cyclin-dependent kinase 6 0.0242037
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0240426
ASPH aspartate beta-hydroxylase 0.0238853
NUP58 nucleoporin 58 0.0238072
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0235239
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0230671
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0229586
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0228688
IRS2 insulin receptor substrate 2 0.022431
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0220189
PRKCE protein kinase C, epsilon 0.0219744
PNRC1 proline-rich nuclear receptor coactivator 1 0.0219658
ZEB1 zinc finger E-box binding homeobox 1 0.0217826
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0215226
CD163L1 CD163 molecule-like 1 0.0213587
HMGA2 high mobility group AT-hook 2 0.0213404
TFRC transferrin receptor 0.0213196
TLE4 transducin-like enhancer of split 4 0.0212822
ATP13A3 ATPase type 13A3 0.0212571
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0211171
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0210738
LOC112694756 uncharaterized LOC112694756 0.0208868
APP amyloid beta (A4) precursor protein 0.020867
CD44 CD44 molecule (Indian blood group) 0.0204675
FXR1 fragile X mental retardation, autosomal homolog 1 0.020316
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0199718
BRD2 bromodomain containing 2 0.0199036
GPHN gephyrin 0.0195386
ZSWIM6 zinc finger, SWIM-type containing 6 0.018906
KDM3A lysine (K)-specific demethylase 3A 0.0188842
HSPA8 heat shock 70kDa protein 8 0.0179231
RPL4 ribosomal protein L4 0.0178325
NEK7 NIMA-related kinase 7 0.0178211
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.017812
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0176747
CORO1C coronin, actin binding protein, 1C 0.0176567
PEAK1 pseudopodium-enriched atypical kinase 1 0.0175908
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.017547
WDFY2 WD repeat and FYVE domain containing 2 0.0174532
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0168886
TOP1 topoisomerase (DNA) I 0.0166869
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0164919
RPS18 ribosomal protein S18 0.0164298
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0163123
DTNA dystrobrevin, alpha 0.0162955
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0162603

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.135699
VIM vimentin -0.0932279
PTMA prothymosin, alpha -0.0916609
RPL35A ribosomal protein L35a -0.0897682
TPT1 tumor protein, translationally-controlled 1 -0.08948
RPL37A ribosomal protein L37a -0.0798682
RPS6 ribosomal protein S6 -0.0696645
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.066465
NDRG1 N-myc downstream regulated 1 -0.0530312
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0526152
RPS29 ribosomal protein S29 -0.0510435
RPS13 ribosomal protein S13 -0.0500775
RPL31 ribosomal protein L31 -0.0494412
MT2A metallothionein 2A -0.0457165
RPS27A ribosomal protein S27a -0.0453973
PHACTR1 phosphatase and actin regulator 1 -0.044811
FN1 fibronectin 1 -0.044261
RPLP1 ribosomal protein, large, P1 -0.043015
NALF1 NALCN channel auxiliary factor 1 -0.0423876
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0423316
RPS25 ribosomal protein S25 -0.0421155
RPS3 ribosomal protein S3 -0.0420152
AKAP12 A kinase (PRKA) anchor protein 12 -0.0418622
RPS12 ribosomal protein S12 -0.0403261
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0400205
RPLP2 ribosomal protein, large, P2 -0.0379082
CDH13 cadherin 13 -0.037734
RPL37 ribosomal protein L37 -0.0373881
RPS19 ribosomal protein S19 -0.0363416
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0362097
RPL9 ribosomal protein L9 -0.0359837
PDE4D phosphodiesterase 4D, cAMP-specific -0.0355799
POTEF POTE ankyrin domain family, member F -0.033651
RPL11 ribosomal protein L11 -0.0336037
RPL38 ribosomal protein L38 -0.0333564
KIAA1217 KIAA1217 -0.0328624
RPL13A ribosomal protein L13a -0.0326099
PTK2 protein tyrosine kinase 2 -0.0320152
RPS8 ribosomal protein S8 -0.0311027
ENO2 enolase 2 (gamma, neuronal) -0.0298546
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0293797
CUX1 cut-like homeobox 1 -0.0293746
WSB1 WD repeat and SOCS box containing 1 -0.0291242
RPS10 ribosomal protein S10 -0.0288945
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0288672
RPS23 ribosomal protein S23 -0.0287636
NAV1 neuron navigator 1 -0.0286746
RPL36 ribosomal protein L36 -0.0282181
RAD51B RAD51 paralog B -0.0269478
RPS20 ribosomal protein S20 -0.0266497
RPL19 ribosomal protein L19 -0.0265026
RPS16 ribosomal protein S16 -0.0260895
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0252834
RPS17 ribosomal protein S17 -0.0250994
GNAS GNAS complex locus -0.0249999
RPS21 ribosomal protein S21 -0.0244916
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0241694
PTCHD4 patched domain containing 4 -0.0240789
HLA-B major histocompatibility complex, class I, B -0.0233205
FOXP1 forkhead box P1 -0.0229298
RAN RAN, member RAS oncogene family -0.0229149
PDIA3 protein disulfide isomerase family A, member 3 -0.0228248
RPS27 ribosomal protein S27 -0.022813
RPL34 ribosomal protein L34 -0.0225355
IGFBP3 insulin-like growth factor binding protein 3 -0.0223435
RPL36A ribosomal protein L36a -0.0220834
RPL7A ribosomal protein L7a -0.0219103
RPL28 ribosomal protein L28 -0.0218843
SAMD3 sterile alpha motif domain containing 3 -0.0211336
RPL23 ribosomal protein L23 -0.021117
COL6A1 collagen, type VI, alpha 1 -0.021102
RPS11 ribosomal protein S11 -0.0208733
PRSS23 protease, serine, 23 -0.0204341
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0202396
EGFR epidermal growth factor receptor -0.0196043
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0194463
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0184883
VDAC1 voltage-dependent anion channel 1 -0.018359
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0181878
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0178523
COL6A2 collagen, type VI, alpha 2 -0.0176303
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0172913
HLA-A major histocompatibility complex, class I, A -0.0171817
SBF2 SET binding factor 2 -0.017097
ANKRD11 ankyrin repeat domain 11 -0.0170621
NSD2 nuclear receptor binding SET domain protein 2 -0.0169409
PRKG1 protein kinase, cGMP-dependent, type I -0.0163509
RPL5 ribosomal protein L5 -0.0163043
CMIP c-Maf inducing protein -0.0162978
COL27A1 collagen, type XXVII, alpha 1 -0.0161907
RPS15 ribosomal protein S15 -0.0160401
PDIA6 protein disulfide isomerase family A, member 6 -0.0159079
PFN1 profilin 1 -0.0158531
B2M beta-2-microglobulin -0.0156737
KIAA1549L KIAA1549-like -0.0156716
CD109 CD109 molecule -0.0155907
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0155901
C2CD2 C2 calcium-dependent domain containing 2 -0.0153245
TBCA tubulin folding cofactor A -0.015323
S100A9 S100 calcium binding protein A9 -0.0152725