ULK-101_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in LoVo cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ULK-101_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.102705
LMO7 LIM domain 7 0.0579371
ZSWIM6 zinc finger, SWIM-type containing 6 0.0565584
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0449433
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0445666
MYO1E myosin IE 0.0359573
INTS6 integrator complex subunit 6 0.0317273
EXT1 exostosin glycosyltransferase 1 0.0268936
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0265333
EGFR epidermal growth factor receptor 0.026177
ASPH aspartate beta-hydroxylase 0.0257609
EEF2 eukaryotic translation elongation factor 2 0.025218
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0250857
CANX calnexin 0.0249629
SEC31A SEC31 homolog A (S. cerevisiae) 0.0248543
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0245899
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0241121
PGM3 phosphoglucomutase 3 0.0239315
PDIA3 protein disulfide isomerase family A, member 3 0.0233955
FNDC3B fibronectin type III domain containing 3B 0.0231385
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0225292
PTPRB protein tyrosine phosphatase, receptor type, B 0.0224818
GOLGB1 golgin B1 0.0223797
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0223085
SQSTM1 sequestosome 1 0.0220212
FAT1 FAT atypical cadherin 1 0.0208867
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0207671
GOLGA4 golgin A4 0.0206964
SLC38A2 solute carrier family 38, member 2 0.0204686
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0203582
AKAP9 A kinase (PRKA) anchor protein 9 0.0203578
FNIP1 folliculin interacting protein 1 0.0202912
SEC24A SEC24 family member A 0.0200677
PDLIM5 PDZ and LIM domain 5 0.0199775
CADPS2 Ca++-dependent secretion activator 2 0.0199586
TTC3 tetratricopeptide repeat domain 3 0.0198957
VMP1 vacuole membrane protein 1 0.0198289
SEC24D SEC24 family member D 0.0196974
ERRFI1 ERBB receptor feedback inhibitor 1 0.0196394
HM13 histocompatibility (minor) 13 0.0191215
LRRC23 leucine rich repeat containing 23 0.0178334
COG6 component of oligomeric golgi complex 6 0.0169456
COPA coatomer protein complex, subunit alpha 0.0169354
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0168649
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0166799
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0166296
AGR2 anterior gradient 2 0.0164719
MORF4L2 mortality factor 4 like 2 0.0160219
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0159885
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0156321
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0154865
CATSPERB catsper channel auxiliary subunit beta 0.015243
ARF4 ADP-ribosylation factor 4 0.0151786
RPS18 ribosomal protein S18 0.0149758
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0149257
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0148295
PCBP2 poly(rC) binding protein 2 0.0147604
NABP1 nucleic acid binding protein 1 0.0146991
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0142549
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0142473
TRAM1 translocation associated membrane protein 1 0.0142263
CEMIP2 cell migration inducing hyaluronidase 2 0.0138972
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0138047
COPB1 coatomer protein complex, subunit beta 1 0.0136716
ZCCHC7 zinc finger, CCHC domain containing 7 0.0136437
TBC1D15 TBC1 domain family, member 15 0.0134211
SND1 staphylococcal nuclease and tudor domain containing 1 0.0133804
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0132642
N4BP2L2 NEDD4 binding protein 2-like 2 0.0130546
LARP1B La ribonucleoprotein domain family, member 1B 0.0130172
APLP2 amyloid beta (A4) precursor-like protein 2 0.013015
CALU calumenin 0.0129524
TMF1 TATA element modulatory factor 1 0.0129246
HYOU1 hypoxia up-regulated 1 0.0128995
UTRN utrophin 0.0127281
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.012687
SETX senataxin 0.0126782
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0126089
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0124048
AGO3 argonaute RISC catalytic component 3 0.0122698
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0120286
SRP54 signal recognition particle 54kDa 0.0119697
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0117864
PTGES2 prostaglandin E synthase 2 0.0116758
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0116629
GCLC glutamate-cysteine ligase, catalytic subunit 0.0116611
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0115431
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0115312
HDLBP high density lipoprotein binding protein 0.0114837
DST dystonin 0.0114529
SCFD1 sec1 family domain containing 1 0.0114006
PARD3B par-3 family cell polarity regulator beta 0.0113697
RPL21 ribosomal protein L21 0.0113674
HBP1 HMG-box transcription factor 1 0.0113147
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0112708
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0112239
BBS9 Bardet-Biedl syndrome 9 0.0111807
STX5 syntaxin 5 0.01099
KDM4C lysine (K)-specific demethylase 4C 0.0108915
EEF1G eukaryotic translation elongation factor 1 gamma 0.0105959

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.117469
TMSB10 thymosin beta 10 -0.116422
TPT1 tumor protein, translationally-controlled 1 -0.114967
FLNB filamin B, beta -0.0804878
RPLP1 ribosomal protein, large, P1 -0.0746599
PTMA prothymosin, alpha -0.0718537
MSI2 musashi RNA-binding protein 2 -0.0670671
RPL35A ribosomal protein L35a -0.0645198
RPS12 ribosomal protein S12 -0.0611285
CALB1 calbindin 1, 28kDa -0.060048
RPS3 ribosomal protein S3 -0.052916
PDE4D phosphodiesterase 4D, cAMP-specific -0.0507627
RPLP2 ribosomal protein, large, P2 -0.0495467
RPS19 ribosomal protein S19 -0.0492022
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0455551
PLAC8 placenta-specific 8 -0.0449391
MX1 MX dynamin-like GTPase 1 -0.0447852
RPL26 ribosomal protein L26 -0.0437672
IFI6 interferon, alpha-inducible protein 6 -0.0431646
KRT18 keratin 18, type I -0.0431229
RPL37A ribosomal protein L37a -0.0427095
RIGI RNA sensor RIG-I -0.0426953
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0415774
P3H2 prolyl 3-hydroxylase 2 -0.0411158
EZR ezrin -0.040537
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0402764
ITGA6 integrin, alpha 6 -0.0395636
RPL12 ribosomal protein L12 -0.0393933
RPS27A ribosomal protein S27a -0.0391944
RPL11 ribosomal protein L11 -0.0388377
RPL19 ribosomal protein L19 -0.038735
HLA-B major histocompatibility complex, class I, B -0.0386218
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0386196
RPS21 ribosomal protein S21 -0.0385142
ANXA2 annexin A2 -0.0379221
ACTN4 actinin, alpha 4 -0.0366675
RPL13A ribosomal protein L13a -0.0364611
STAT1 signal transducer and activator of transcription 1, 91kDa -0.036174
RPL36 ribosomal protein L36 -0.035465
RPL34 ribosomal protein L34 -0.0354085
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0352374
RPS29 ribosomal protein S29 -0.0351822
PRSS3 protease, serine, 3 -0.0344961
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0344017
AOPEP aminopeptidase O (putative) -0.0342693
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0337508
RPS24 ribosomal protein S24 -0.0336217
VCL vinculin -0.0324767
RPL38 ribosomal protein L38 -0.0316795
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0312464
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0311119
PRRC2C proline-rich coiled-coil 2C -0.0310733
MYOF myoferlin -0.0310299
ANXA11 annexin A11 -0.0307928
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0302666
KRT8 keratin 8, type II -0.0302625
LAMB3 laminin, beta 3 -0.0301586
TRIM2 tripartite motif containing 2 -0.029499
FERMT1 fermitin family member 1 -0.0291489
RBM25 RNA binding motif protein 25 -0.0290951
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0288601
RPL37 ribosomal protein L37 -0.0287641
RNF213 ring finger protein 213 -0.0285912
MX2 MX dynamin-like GTPase 2 -0.0284366
COBL cordon-bleu WH2 repeat protein -0.0283789
S100P S100 calcium binding protein P -0.0281655
RPS13 ribosomal protein S13 -0.0280258
RPL9 ribosomal protein L9 -0.027805
RPL30 ribosomal protein L30 -0.0276961
ATP5F1B ATP synthase F1 subunit beta -0.027671
MKI67 marker of proliferation Ki-67 -0.0276627
PTPRG protein tyrosine phosphatase, receptor type, G -0.0274716
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0268474
XAF1 XIAP associated factor 1 -0.0267072
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.026379
UBE2H ubiquitin-conjugating enzyme E2H -0.026277
RPL28 ribosomal protein L28 -0.026248
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0259896
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0259644
PTPRK protein tyrosine phosphatase, receptor type, K -0.025879
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.025725
S100A6 S100 calcium binding protein A6 -0.0255458
RRBP1 ribosome binding protein 1 -0.0255147
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0253793
SPATS2L spermatogenesis associated, serine-rich 2-like -0.025315
YBX3 Y box binding protein 3 -0.0252995
RPS6 ribosomal protein S6 -0.0249783
TPI1 triosephosphate isomerase 1 -0.0248639
SP100 SP100 nuclear antigen -0.0248114
LOC102724023 ES1 protein homolog, mitochondrial -0.0246949
DSG3 desmoglein 3 -0.0246412
EPCAM epithelial cell adhesion molecule -0.0245344
ACTG1 actin gamma 1 -0.0245226
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0244285
RPL18 ribosomal protein L18 -0.0244018
LAMA4 laminin, alpha 4 -0.0243333
EIF1 eukaryotic translation initiation factor 1 -0.0242946
RPL32 ribosomal protein L32 -0.0242254
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0241545
WWC1 WW and C2 domain containing 1 -0.0238636