ULK-101_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.132023
CAPRIN2 caprin family member 2 0.0806006
ERRFI1 ERBB receptor feedback inhibitor 1 0.0751509
WWTR1 WW domain containing transcription regulator 1 0.074919
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0705791
TXNRD1 thioredoxin reductase 1 0.0685272
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0647885
TM4SF1 transmembrane 4 L six family member 1 0.0594879
FMNL2 formin-like 2 0.0592191
MACF1 microtubule-actin crosslinking factor 1 0.0588618
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0524894
HOMER1 homer scaffolding protein 1 0.0519527
RAB7A RAB7A, member RAS oncogene family 0.0498007
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0492257
CXCL8 chemokine (C-X-C motif) ligand 8 0.0461796
MT2A metallothionein 2A 0.0445288
ZSWIM6 zinc finger, SWIM-type containing 6 0.0431488
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0429039
JMJD1C jumonji domain containing 1C 0.0419063
ZBTB38 zinc finger and BTB domain containing 38 0.041704
PDE10A phosphodiesterase 10A 0.0415538
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.039788
BCAR3 breast cancer anti-estrogen resistance 3 0.0391764
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0380807
ARHGAP5 Rho GTPase activating protein 5 0.0376018
ZEB1 zinc finger E-box binding homeobox 1 0.0353611
NT5E 5'-nucleotidase, ecto (CD73) 0.0333188
NEK10 NIMA-related kinase 10 0.0331566
BIRC3 baculoviral IAP repeat containing 3 0.0326337
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0324583
BICD1 bicaudal D homolog 1 (Drosophila) 0.0315864
CMIP c-Maf inducing protein 0.0303408
SDCCAG8 serologically defined colon cancer antigen 8 0.0298093
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0292097
MCTP1 multiple C2 domains, transmembrane 1 0.0291495
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0280907
RAP2B RAP2B, member of RAS oncogene family 0.0279773
NAV2 neuron navigator 2 0.0275712
RCOR1 REST corepressor 1 0.0268963
JUN jun proto-oncogene 0.0267357
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0267169
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0266016
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0264575
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0263698
NHSL1 NHS-like 1 0.0263276
KMT2E lysine (K)-specific methyltransferase 2E 0.0261724
NPAS2 neuronal PAS domain protein 2 0.0250906
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0249853
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0248411
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0247815
SPAG9 sperm associated antigen 9 0.0246206
EMP1 epithelial membrane protein 1 0.0245753
SDK1 sidekick cell adhesion molecule 1 0.02442
ZDHHC14 zinc finger, DHHC-type containing 14 0.0243961
CSNK1A1 casein kinase 1, alpha 1 0.0243705
FBXO11 F-box protein 11 0.0236951
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0236041
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231819
SEC24A SEC24 family member A 0.0230516
USP12 ubiquitin specific peptidase 12 0.0229805
UPP1 uridine phosphorylase 1 0.0229028
EREG epiregulin 0.0228837
TRIP12 thyroid hormone receptor interactor 12 0.0223455
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0221275
PYGL phosphorylase, glycogen, liver 0.0219827
RPS8 ribosomal protein S8 0.0218353
ERCC1 excision repair cross-complementation group 1 0.0206735
SGMS2 sphingomyelin synthase 2 0.0201121
VMP1 vacuole membrane protein 1 0.0200282
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0195383
THSD4 thrombospondin, type I, domain containing 4 0.0193493
CD44 CD44 molecule (Indian blood group) 0.0193104
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0189713
ZMIZ1 zinc finger, MIZ-type containing 1 0.0188939
VEGFC vascular endothelial growth factor C 0.0186941
ZCCHC7 zinc finger, CCHC domain containing 7 0.018235
FNDC3B fibronectin type III domain containing 3B 0.018171
RUNX1 runt-related transcription factor 1 0.0179323
USP9X ubiquitin specific peptidase 9, X-linked 0.0178961
DNER delta/notch-like EGF repeat containing 0.0175832
ADARB1 adenosine deaminase, RNA-specific, B1 0.0175462
CDCP1 CUB domain containing protein 1 0.0174092
BZW1 basic leucine zipper and W2 domains 1 0.0173638
TMEM41B transmembrane protein 41B 0.0173423
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0171849
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0171023
USP34 ubiquitin specific peptidase 34 0.0169318
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0164585
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.016358
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0163432
ANGPTL4 angiopoietin-like 4 0.0162382
HBEGF heparin-binding EGF-like growth factor 0.0160141
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0159554
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0159232
GLS2 glutaminase 2 (liver, mitochondrial) 0.0157549
FER fer (fps/fes related) tyrosine kinase 0.0156925
ZFAND3 zinc finger, AN1-type domain 3 0.0155635
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0153983
NGLY1 N-glycanase 1 0.0153418
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0153209

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.175191
VIM vimentin -0.108532
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0949916
POTEF POTE ankyrin domain family, member F -0.0683188
DLG1 discs, large homolog 1 (Drosophila) -0.0630338
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0564568
TMSB4X thymosin beta 4, X-linked -0.0509312
HLA-B major histocompatibility complex, class I, B -0.0494483
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0462104
TMSB10 thymosin beta 10 -0.0446811
FTL ferritin, light polypeptide -0.0367433
ACTG1 actin gamma 1 -0.0337269
MYOF myoferlin -0.0335143
LDHA lactate dehydrogenase A -0.0332298
TP63 tumor protein p63 -0.0331745
ZNF292 zinc finger protein 292 -0.0318508
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0317491
IFITM1 interferon induced transmembrane protein 1 -0.0314802
TNS3 tensin 3 -0.0306242
ADAR adenosine deaminase, RNA-specific -0.029778
WSB1 WD repeat and SOCS box containing 1 -0.0289616
PGK1 phosphoglycerate kinase 1 -0.0285742
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0285163
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0282599
TPI1 triosephosphate isomerase 1 -0.0279331
PNISR PNN-interacting serine/arginine-rich protein -0.0272266
RPL37A ribosomal protein L37a -0.0264495
ENO2 enolase 2 (gamma, neuronal) -0.0253842
RPL35A ribosomal protein L35a -0.0249376
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0248498
RBM25 RNA binding motif protein 25 -0.0248023
EPHA4 EPH receptor A4 -0.0243033
RNF213 ring finger protein 213 -0.0229215
OGA O-GlcNAcase -0.0228591
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0223224
EFNA5 ephrin-A5 -0.0220999
IFIH1 interferon induced with helicase C domain 1 -0.0214709
WARS1 tryptophanyl-tRNA synthetase 1 -0.021322
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0212177
NPEPPS aminopeptidase puromycin sensitive -0.0209661
ADGRG6 adhesion G protein-coupled receptor G6 -0.0209129
MKI67 marker of proliferation Ki-67 -0.0208773
CAVIN1 caveolae associated protein 1 -0.0207017
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0206592
DPYD dihydropyrimidine dehydrogenase -0.0205982
H1-0 H1.0 linker histone -0.020516
TSC22D1 TSC22 domain family, member 1 -0.0204234
TUBB tubulin, beta class I -0.0198358
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0197339
FOXK1 forkhead box K1 -0.0190907
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0190611
SEPTIN7 septin 7 -0.0190068
ENO1 enolase 1, (alpha) -0.0189904
PTPRF protein tyrosine phosphatase, receptor type, F -0.0189049
BRWD1 bromodomain and WD repeat domain containing 1 -0.0188747
SMC4 structural maintenance of chromosomes 4 -0.0188006
HLA-A major histocompatibility complex, class I, A -0.0187774
ZNF217 zinc finger protein 217 -0.0187755
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0183898
EIF1 eukaryotic translation initiation factor 1 -0.0183653
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0182812
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0182637
CELF1 CUGBP, Elav-like family member 1 -0.0182073
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0181725
DEK DEK proto-oncogene -0.0181421
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0179654
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0177622
CENPF centromere protein F, 350/400kDa -0.0177267
SLC38A2 solute carrier family 38, member 2 -0.017672
KDM3A lysine (K)-specific demethylase 3A -0.017625
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0175825
RPL11 ribosomal protein L11 -0.0175088
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0173132
RPS27A ribosomal protein S27a -0.0172436
DPH6 diphthamine biosynthesis 6 -0.0170672
RPS23 ribosomal protein S23 -0.0170579
SRGN serglycin -0.0169762
RBM39 RNA binding motif protein 39 -0.0168426
WDR45B WD repeat domain 45B -0.016786
RSF1 remodeling and spacing factor 1 -0.0167753
SMIM44 small integral membrane protein 44 -0.0166389
SRSF11 serine/arginine-rich splicing factor 11 -0.0165583
SDC4 syndecan 4 -0.0165183
MARCHF6 membrane associated ring-CH-type finger 6 -0.0164913
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0164871
CALR calreticulin -0.0164075
RAD51B RAD51 paralog B -0.0164073
PUM2 pumilio RNA-binding family member 2 -0.0162348
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0162262
XPO1 exportin 1 -0.0162009
RPL31 ribosomal protein L31 -0.0160948
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0160689
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0160667
PTBP2 polypyrimidine tract binding protein 2 -0.0160201
FNBP1 formin binding protein 1 -0.0159002
B2M beta-2-microglobulin -0.0158165
PRRC2C proline-rich coiled-coil 2C -0.0158091
EPB41 erythrocyte membrane protein band 4.1 -0.0157216
HMGB1 high mobility group box 1 -0.0155532
RPL13A ribosomal protein L13a -0.0154637