ULK-101_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ULK-101_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.348017
THSD4 thrombospondin, type I, domain containing 4 0.0888805
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0665017
SLTM SAFB-like, transcription modulator 0.0592629
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0493465
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0479211
MCTP1 multiple C2 domains, transmembrane 1 0.0473132
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0403889
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0387992
EFNA5 ephrin-A5 0.0380472
INTS6 integrator complex subunit 6 0.0375703
MYO1E myosin IE 0.0369679
PTPRM protein tyrosine phosphatase, receptor type, M 0.0365875
LPP LIM domain containing preferred translocation partner in lipoma 0.0357285
PDLIM5 PDZ and LIM domain 5 0.035355
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0343325
ZSWIM6 zinc finger, SWIM-type containing 6 0.0333997
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0328535
RAD51B RAD51 paralog B 0.0324439
CEMIP cell migration inducing protein, hyaluronan binding 0.0317901
ERRFI1 ERBB receptor feedback inhibitor 1 0.0317863
NSUN6 NOP2/Sun domain family, member 6 0.0315144
CXCL8 chemokine (C-X-C motif) ligand 8 0.0310939
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0299111
HOMER1 homer scaffolding protein 1 0.0290941
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0288113
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.028202
SAMD4A sterile alpha motif domain containing 4A 0.0281313
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0277369
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0277155
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.027048
SMYD3 SET and MYND domain containing 3 0.0263382
EGR1 early growth response 1 0.0263259
DOCK5 dedicator of cytokinesis 5 0.0261965
DOCK1 dedicator of cytokinesis 1 0.0260513
RNF213 ring finger protein 213 0.0260185
BCAR3 breast cancer anti-estrogen resistance 3 0.0258006
FNDC3B fibronectin type III domain containing 3B 0.0256169
TJP1 tight junction protein 1 0.0251495
EXT1 exostosin glycosyltransferase 1 0.0249388
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0247706
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0243912
SIK3 SIK family kinase 3 0.0232585
MYOF myoferlin 0.0228702
DOCK4 dedicator of cytokinesis 4 0.0226758
HDAC9 histone deacetylase 9 0.0223415
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.022096
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0216073
AKAP13 A kinase (PRKA) anchor protein 13 0.0215868
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0215819
FOXP1 forkhead box P1 0.0214187
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0213448
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.021333
FNIP1 folliculin interacting protein 1 0.0209725
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0206796
GOLGB1 golgin B1 0.020405
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0203878
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0203058
AGO3 argonaute RISC catalytic component 3 0.019658
BMP6 bone morphogenetic protein 6 0.0196399
LMO7 LIM domain 7 0.0196123
CUX1 cut-like homeobox 1 0.0194609
SP100 SP100 nuclear antigen 0.0194417
LGALS12 lectin, galactoside-binding, soluble, 12 0.019182
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0190579
KYNU kynureninase 0.0187681
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.018662
TPM4 tropomyosin 4 0.0183462
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0180005
SVIL supervillin 0.0179775
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0177213
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0175162
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0173051
ELL2 elongation factor, RNA polymerase II, 2 0.0170004
RASAL2 RAS protein activator like 2 0.0169441
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0168027
FNDC3A fibronectin type III domain containing 3A 0.016741
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0166628
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0165434
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0162925
MCL1 myeloid cell leukemia 1 0.0162662
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0162473
RABGAP1L RAB GTPase activating protein 1-like 0.0160829
PDE4D phosphodiesterase 4D, cAMP-specific 0.0158727
SMOC1 SPARC related modular calcium binding 1 0.0157149
VMP1 vacuole membrane protein 1 0.0157019
MYO9A myosin IXA 0.0156492
CD163L1 CD163 molecule-like 1 0.0154826
CYSTM1 cysteine-rich transmembrane module containing 1 0.0154579
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.01535
ATF6 activating transcription factor 6 0.015131
SLC38A2 solute carrier family 38, member 2 0.0151309
EHBP1 EH domain binding protein 1 0.0150746
SPIRE1 spire-type actin nucleation factor 1 0.0150037
CCSER1 coiled-coil serine-rich protein 1 0.0149884
TRAPPC9 trafficking protein particle complex 9 0.0145494
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0145469
LYST lysosomal trafficking regulator 0.0145276
AKAP9 A kinase (PRKA) anchor protein 9 0.0145096
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0144889

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.177938
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154622
TXNRD1 thioredoxin reductase 1 -0.104375
UBC ubiquitin C -0.097773
MT2A metallothionein 2A -0.0826773
NDRG1 N-myc downstream regulated 1 -0.0812241
NAMPT nicotinamide phosphoribosyltransferase -0.0786342
TMSB10 thymosin beta 10 -0.0778933
FAM13A family with sequence similarity 13, member A -0.0602631
FTL ferritin, light polypeptide -0.0579649
PRRC2C proline-rich coiled-coil 2C -0.0573494
PTMA prothymosin, alpha -0.0514559
RPS3 ribosomal protein S3 -0.0488736
RPS27A ribosomal protein S27a -0.048456
TPT1 tumor protein, translationally-controlled 1 -0.0477576
SEC61G Sec61 gamma subunit -0.045356
H1-0 H1.0 linker histone -0.0439933
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0413314
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0403572
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0400138
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0372692
TMEM165 transmembrane protein 165 -0.037103
OGA O-GlcNAcase -0.0360024
MKI67 marker of proliferation Ki-67 -0.0340631
PKM pyruvate kinase, muscle -0.0337025
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0335265
KCMF1 potassium channel modulatory factor 1 -0.033352
WDR45B WD repeat domain 45B -0.0330367
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0327376
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0320848
NGLY1 N-glycanase 1 -0.0316495
LDHA lactate dehydrogenase A -0.031391
RUNX1 runt-related transcription factor 1 -0.0312518
KDM3A lysine (K)-specific demethylase 3A -0.0308045
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0308036
CES1 carboxylesterase 1 -0.0300229
RPL37A ribosomal protein L37a -0.0299363
EIF1 eukaryotic translation initiation factor 1 -0.0291026
GCLC glutamate-cysteine ligase, catalytic subunit -0.0287238
BRWD3 bromodomain and WD repeat domain containing 3 -0.0279932
KMT2E lysine (K)-specific methyltransferase 2E -0.0275399
RNF145 ring finger protein 145 -0.0272859
RPL35A ribosomal protein L35a -0.0269275
GSK3B glycogen synthase kinase 3 beta -0.0268222
ZFC3H1 zinc finger, C3H1-type containing -0.0265126
CSNK1A1 casein kinase 1, alpha 1 -0.0263019
CAV1 caveolin 1, caveolae protein, 22kDa -0.0261678
PGK1 phosphoglycerate kinase 1 -0.025983
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0257836
TPD52 tumor protein D52 -0.0257109
LOC112694756 uncharaterized LOC112694756 -0.025312
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0252375
ARRDC3 arrestin domain containing 3 -0.02497
ADAM17 ADAM metallopeptidase domain 17 -0.0248633
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0242332
MT1X metallothionein 1X -0.0240508
ENO1 enolase 1, (alpha) -0.023972
HELZ helicase with zinc finger -0.0238548
BRWD1 bromodomain and WD repeat domain containing 1 -0.0236493
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0234853
RTN4 reticulon 4 -0.0234598
FTH1 ferritin, heavy polypeptide 1 -0.0232423
PDE8A phosphodiesterase 8A -0.0230625
SLC38A1 solute carrier family 38, member 1 -0.0224979
ZMYND8 zinc finger, MYND-type containing 8 -0.0224038
TOP1 topoisomerase (DNA) I -0.0223669
RNMT RNA (guanine-7-) methyltransferase -0.0220144
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0218454
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0212653
AKR1C1 aldo-keto reductase family 1, member C1 -0.0210408
CAMTA1 calmodulin binding transcription activator 1 -0.020948
KDM2A lysine (K)-specific demethylase 2A -0.0207302
IER3 immediate early response 3 -0.0204514
RBM39 RNA binding motif protein 39 -0.0204258
LAMB3 laminin, beta 3 -0.0203724
MYH9 myosin, heavy chain 9, non-muscle -0.0202735
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0202585
PCBP2 poly(rC) binding protein 2 -0.0201209
ADAM9 ADAM metallopeptidase domain 9 -0.0199406
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0198329
EEF2 eukaryotic translation elongation factor 2 -0.0197933
PNISR PNN-interacting serine/arginine-rich protein -0.0196444
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0193247
SLMAP sarcolemma associated protein -0.0192706
MARF1 meiosis regulator and mRNA stability factor 1 -0.0192319
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0192289
RPLP1 ribosomal protein, large, P1 -0.0191089
RAP1B RAP1B, member of RAS oncogene family -0.0189413
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0187263
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0186995
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0185883
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0183651
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0182078
CSTB cystatin B (stefin B) -0.0180456
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0179971
ANKRD37 ankyrin repeat domain 37 -0.0179098
NDE1 nudE neurodevelopment protein 1 -0.0178528
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0177828
NUP58 nucleoporin 58 -0.0177387
ANKRD12 ankyrin repeat domain 12 -0.0175492