ULK-101_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.162629
DOCK4 dedicator of cytokinesis 4 0.0953706
PDE4D phosphodiesterase 4D, cAMP-specific 0.0816338
SAMD4A sterile alpha motif domain containing 4A 0.0710004
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0700187
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.060429
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0598749
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0584407
GRAMD1B GRAM domain containing 1B 0.0566567
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.052444
AKAP12 A kinase (PRKA) anchor protein 12 0.0516686
FAM107B family with sequence similarity 107, member B 0.0511274
MACF1 microtubule-actin crosslinking factor 1 0.0499932
FMNL2 formin-like 2 0.0497639
SOD2 superoxide dismutase 2, mitochondrial 0.0480868
FNDC3B fibronectin type III domain containing 3B 0.0437656
EGFR epidermal growth factor receptor 0.0426126
ELL2 elongation factor, RNA polymerase II, 2 0.041983
ZFAND3 zinc finger, AN1-type domain 3 0.0416979
ZSWIM6 zinc finger, SWIM-type containing 6 0.0409328
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0391297
NRG1 neuregulin 1 0.0381734
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0375209
RICTOR RPTOR independent companion of MTOR, complex 2 0.037263
CXCL8 chemokine (C-X-C motif) ligand 8 0.0370208
RB1CC1 RB1-inducible coiled-coil 1 0.0363554
ZEB1 zinc finger E-box binding homeobox 1 0.0362025
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0348625
TRIO trio Rho guanine nucleotide exchange factor 0.0346002
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.034012
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0337533
SMOC1 SPARC related modular calcium binding 1 0.0334244
ATXN1 ataxin 1 0.0328249
TIMP1 TIMP metallopeptidase inhibitor 1 0.0327343
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0325802
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0324587
AGO2 argonaute RISC catalytic component 2 0.0323113
MCL1 myeloid cell leukemia 1 0.0318544
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0317042
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0310948
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0292224
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0291349
BIRC6 baculoviral IAP repeat containing 6 0.0288346
DSCAM Down syndrome cell adhesion molecule 0.028424
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0279057
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0277874
NUMB numb homolog (Drosophila) 0.0272606
SVIL supervillin 0.026886
THSD4 thrombospondin, type I, domain containing 4 0.0265202
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0263647
BMP6 bone morphogenetic protein 6 0.0254462
IL6 interleukin 6 0.0253499
NAV3 neuron navigator 3 0.0251356
CCL5 chemokine (C-C motif) ligand 5 0.0238218
ERRFI1 ERBB receptor feedback inhibitor 1 0.023753
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0237354
CTBP2 C-terminal binding protein 2 0.0226242
KYNU kynureninase 0.0226153
SFPQ splicing factor proline/glutamine-rich 0.0226008
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0225959
DOCK5 dedicator of cytokinesis 5 0.0223031
GOLGB1 golgin B1 0.0221335
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220231
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218604
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0218517
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0216436
SPIRE1 spire-type actin nucleation factor 1 0.0216171
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.021588
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0215028
USP34 ubiquitin specific peptidase 34 0.0214814
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0210318
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0209534
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0207978
C15ORF48 chromosome 15 open reading frame 48 0.020178
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0201776
AHNAK AHNAK nucleoprotein 0.0201462
FLNB filamin B, beta 0.0200831
PCBP2 poly(rC) binding protein 2 0.0200795
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0200347
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0200287
YAP1 Yes-associated protein 1 0.0199847
PSEN1 presenilin 1 0.0199209
RUNX1 runt-related transcription factor 1 0.0198813
CD44 CD44 molecule (Indian blood group) 0.0196668
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0195437
COPA coatomer protein complex, subunit alpha 0.0194927
PUM2 pumilio RNA-binding family member 2 0.0194004
AGO3 argonaute RISC catalytic component 3 0.0193909
JMJD1C jumonji domain containing 1C 0.0192919
SON SON DNA binding protein 0.0190784
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0189856
HELZ helicase with zinc finger 0.018823
CYTH1 cytohesin 1 0.0187691
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0186015
NEK7 NIMA-related kinase 7 0.018542
SPAG9 sperm associated antigen 9 0.0185375
COG5 component of oligomeric golgi complex 5 0.0185003
ATP11A ATPase, class VI, type 11A 0.0184051
RNF216 ring finger protein 216 0.0183478
BCAR3 breast cancer anti-estrogen resistance 3 0.0182885

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203873
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.136496
FTL ferritin, light polypeptide -0.109116
PTMA prothymosin, alpha -0.0849055
TMSB10 thymosin beta 10 -0.0848762
ACTG1 actin gamma 1 -0.0836805
IGF2 insulin-like growth factor 2 -0.0736333
PM20D1 peptidase M20 domain containing 1 -0.0650486
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0615336
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0611028
TFPI2 tissue factor pathway inhibitor 2 -0.0543665
POTEF POTE ankyrin domain family, member F -0.0513227
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.050103
FGB fibrinogen beta chain -0.0488492
BASP1 brain abundant, membrane attached signal protein 1 -0.0484812
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0423461
RPL35A ribosomal protein L35a -0.041525
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0409115
CAVIN1 caveolae associated protein 1 -0.0390248
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.038759
PFN1 profilin 1 -0.0368998
HMGA1 high mobility group AT-hook 1 -0.0349275
IGFBP4 insulin-like growth factor binding protein 4 -0.0347565
TPT1 tumor protein, translationally-controlled 1 -0.0323032
TPM4 tropomyosin 4 -0.0321992
RTN4 reticulon 4 -0.0306941
PDIA3 protein disulfide isomerase family A, member 3 -0.0304884
VIM vimentin -0.0300755
SERF2 small EDRK-rich factor 2 -0.0295895
PDE8A phosphodiesterase 8A -0.0293268
EGR1 early growth response 1 -0.0288744
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.02856
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0283238
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0277582
GNAS GNAS complex locus -0.0262923
RPS29 ribosomal protein S29 -0.0261802
PLS3 plastin 3 -0.0261269
SRGN serglycin -0.0258839
RPS21 ribosomal protein S21 -0.0258816
RPL8 ribosomal protein L8 -0.0255119
PABPN1 poly(A) binding protein, nuclear 1 -0.0243009
DEK DEK proto-oncogene -0.0240372
TUBB tubulin, beta class I -0.023751
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0235163
RBM25 RNA binding motif protein 25 -0.0234962
MKI67 marker of proliferation Ki-67 -0.0234347
KPNB1 karyopherin (importin) beta 1 -0.0233434
HMGB1 high mobility group box 1 -0.0232923
VDAC1 voltage-dependent anion channel 1 -0.0227179
RPL19 ribosomal protein L19 -0.0226268
TM4SF1 transmembrane 4 L six family member 1 -0.0223918
NTN4 netrin 4 -0.022129
RPS23 ribosomal protein S23 -0.0221214
RHOA ras homolog family member A -0.0219995
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0219089
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0216475
TPI1 triosephosphate isomerase 1 -0.02156
TAGLN2 transgelin 2 -0.02082
PKM pyruvate kinase, muscle -0.0206593
PA2G4 proliferation-associated 2G4, 38kDa -0.0205847
FGG fibrinogen gamma chain -0.0205739
MYL12B myosin, light chain 12B, regulatory -0.0205577
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0198716
YY1 YY1 transcription factor -0.0198288
FKBP10 FK506 binding protein 10, 65 kDa -0.0197637
LMNA lamin A/C -0.0195602
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.019547
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0186472
S100A10 S100 calcium binding protein A10 -0.0184611
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0183913
ZFHX3 zinc finger homeobox 3 -0.018057
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0178482
NEGR1 neuronal growth regulator 1 -0.0178473
CALR calreticulin -0.0174316
TMEM123 transmembrane protein 123 -0.0173804
ATP5F1B ATP synthase F1 subunit beta -0.0171195
CCNL1 cyclin L1 -0.017087
ZMYND8 zinc finger, MYND-type containing 8 -0.0170485
LAMB1 laminin, beta 1 -0.017014
RPL38 ribosomal protein L38 -0.0169331
RSL1D1 ribosomal L1 domain containing 1 -0.0167398
BICC1 BicC family RNA binding protein 1 -0.0166749
SLC38A2 solute carrier family 38, member 2 -0.0166397
ANLN anillin, actin binding protein -0.0165795
MIS18BP1 MIS18 binding protein 1 -0.0165394
ENAH enabled homolog (Drosophila) -0.0165161
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0165141
RAN RAN, member RAS oncogene family -0.0164702
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0163732
RPL13A ribosomal protein L13a -0.0163561
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0161867
RPL11 ribosomal protein L11 -0.0160605
LDHB lactate dehydrogenase B -0.0159499
ATP5F1E ATP synthase F1 subunit epsilon -0.0158715
RPS24 ribosomal protein S24 -0.0157797
TPM1 tropomyosin 1 (alpha) -0.0157271
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0156727
ANKRD28 ankyrin repeat domain 28 -0.0155483
RPS6 ribosomal protein S6 -0.0155148
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0153717