| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ULK-101 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ULK-101_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.172905 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.100128 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0962354 |
| HMGA2 | high mobility group AT-hook 2 | 0.0896457 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0788831 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0778581 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0742915 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0742682 |
| CD44 | CD44 molecule (Indian blood group) | 0.0724513 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0706517 |
| SFTPA2 | surfactant protein A2 | 0.0703685 |
| INHBA | inhibin, beta A | 0.0692431 |
| RNF149 | ring finger protein 149 | 0.068068 |
| CANX | calnexin | 0.067481 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0662825 |
| CALU | calumenin | 0.0654929 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0631398 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.063062 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0619748 |
| SNX9 | sorting nexin 9 | 0.0617045 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0595326 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0586646 |
| EFNA5 | ephrin-A5 | 0.0585226 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0579477 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0554411 |
| RORA | RAR-related orphan receptor A | 0.0551796 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0519123 |
| ASPH | aspartate beta-hydroxylase | 0.051116 |
| LAMA4 | laminin, alpha 4 | 0.0499589 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0496179 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0482764 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0478498 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0475207 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0474997 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0471539 |
| SLMAP | sarcolemma associated protein | 0.0464395 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0460362 |
| CDK19 | cyclin-dependent kinase 19 | 0.046021 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0458602 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0454571 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0453758 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0450073 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0439183 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0439005 |
| TXNRD1 | thioredoxin reductase 1 | 0.0436528 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0425507 |
| IRS2 | insulin receptor substrate 2 | 0.0425033 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0423475 |
| RIGI | RNA sensor RIG-I | 0.0421761 |
| MYO10 | myosin X | 0.041797 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0415546 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.041535 |
| FN1 | fibronectin 1 | 0.0410621 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0410146 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.040939 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0407269 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0398411 |
| EMP1 | epithelial membrane protein 1 | 0.039386 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0389153 |
| CDC73 | cell division cycle 73 | 0.0386622 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0385265 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0384505 |
| MYO5B | myosin VB | 0.0380371 |
| PRKCA | protein kinase C, alpha | 0.0379028 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0374068 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0373517 |
| VIM | vimentin | 0.036962 |
| MED13 | mediator complex subunit 13 | 0.0369452 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0369194 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0365425 |
| ZNF638 | zinc finger protein 638 | 0.0363938 |
| TMEM165 | transmembrane protein 165 | 0.0360702 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0359864 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0357206 |
| DSPP | dentin sialophosphoprotein | 0.0350672 |
| SBF2 | SET binding factor 2 | 0.0349803 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0348928 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.033911 |
| YEATS2 | YEATS domain containing 2 | 0.0332877 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | 0.0328297 |
| OGA | O-GlcNAcase | 0.0324557 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0324485 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.032014 |
| NUMB | numb homolog (Drosophila) | 0.0319075 |
| KLF6 | Kruppel-like factor 6 | 0.0317144 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0316793 |
| AREG | amphiregulin | 0.0313342 |
| B2M | beta-2-microglobulin | 0.031294 |
| EGFR | epidermal growth factor receptor | 0.0312002 |
| YTHDC1 | YTH domain containing 1 | 0.0311574 |
| COPA | coatomer protein complex, subunit alpha | 0.0310781 |
| RTN4 | reticulon 4 | 0.0309136 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0304005 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0300602 |
| APP | amyloid beta (A4) precursor protein | 0.0300527 |
| RAD51B | RAD51 paralog B | 0.0281465 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0278444 |
| METTL15 | methyltransferase like 15 | 0.0278095 |
| ANO6 | anoctamin 6 | 0.027781 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0273974 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT17 | keratin 17, type I | -0.121225 |
| MUC16 | mucin 16, cell surface associated | -0.112364 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.101209 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0996368 |
| PTMA | prothymosin, alpha | -0.0939544 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0936765 |
| POTEF | POTE ankyrin domain family, member F | -0.085431 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0851574 |
| NDRG1 | N-myc downstream regulated 1 | -0.0839117 |
| RPL37A | ribosomal protein L37a | -0.0828315 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0825012 |
| TPM4 | tropomyosin 4 | -0.0779019 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0777467 |
| USP34 | ubiquitin specific peptidase 34 | -0.0773097 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.075252 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0752075 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0745522 |
| RPS12 | ribosomal protein S12 | -0.072552 |
| RPS6 | ribosomal protein S6 | -0.0697298 |
| RPL15 | ribosomal protein L15 | -0.0690381 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0680164 |
| LDHA | lactate dehydrogenase A | -0.0676933 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0661168 |
| AHNAK | AHNAK nucleoprotein | -0.0649771 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0646942 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0645216 |
| TMSB10 | thymosin beta 10 | -0.0597845 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0593899 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0573002 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0557214 |
| RPL31 | ribosomal protein L31 | -0.0547763 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0541925 |
| RPLP0 | ribosomal protein, large, P0 | -0.0529886 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0524031 |
| SEPTIN7 | septin 7 | -0.0510691 |
| RPS25 | ribosomal protein S25 | -0.0506983 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.049765 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0495162 |
| RPS3 | ribosomal protein S3 | -0.0488287 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0479889 |
| CALR | calreticulin | -0.0470658 |
| ABHD17C | abhydrolase domain containing 17C | -0.0469479 |
| RPL12 | ribosomal protein L12 | -0.0467921 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0462214 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0453167 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0445655 |
| RPS16 | ribosomal protein S16 | -0.044098 |
| TJP1 | tight junction protein 1 | -0.0437425 |
| S100A6 | S100 calcium binding protein A6 | -0.0434122 |
| CDC42SE2 | CDC42 small effector 2 | -0.0429562 |
| PARD3 | par-3 family cell polarity regulator | -0.0425908 |
| SVIL | supervillin | -0.0415969 |
| RPL35A | ribosomal protein L35a | -0.0414943 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0414222 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0410914 |
| INTS6 | integrator complex subunit 6 | -0.0408265 |
| MEF2A | myocyte enhancer factor 2A | -0.0402161 |
| RPL28 | ribosomal protein L28 | -0.040023 |
| RPS29 | ribosomal protein S29 | -0.0398207 |
| FTL | ferritin, light polypeptide | -0.0390793 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0380378 |
| RPS17 | ribosomal protein S17 | -0.037693 |
| VCL | vinculin | -0.0370145 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0369732 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0366718 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0364915 |
| SEPTIN2 | septin 2 | -0.0363513 |
| ATXN1 | ataxin 1 | -0.0362937 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0362876 |
| S100A9 | S100 calcium binding protein A9 | -0.0353206 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0350596 |
| SETD5 | SET domain containing 5 | -0.0339863 |
| RPS20 | ribosomal protein S20 | -0.0338699 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0338159 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0337995 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0331663 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0330424 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0327964 |
| RUNX1 | runt-related transcription factor 1 | -0.0326294 |
| AHI1 | Abelson helper integration site 1 | -0.0323072 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0316445 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0312369 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0312096 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0308805 |
| RPL26 | ribosomal protein L26 | -0.0304931 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0304311 |
| RPS27A | ribosomal protein S27a | -0.0303056 |
| SEPTIN9 | septin 9 | -0.0302915 |
| HDAC9 | histone deacetylase 9 | -0.03002 |
| ACTG1 | actin gamma 1 | -0.0298011 |
| CNKSR3 | CNKSR family member 3 | -0.0294961 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0293211 |
| SET | SET nuclear proto-oncogene | -0.0291532 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0290052 |
| RPL37 | ribosomal protein L37 | -0.0286017 |
| SRPK2 | SRSF protein kinase 2 | -0.0277154 |
| RRBP1 | ribosome binding protein 1 | -0.0273884 |
| RNF145 | ring finger protein 145 | -0.0271419 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0267274 |
| MED13L | mediator complex subunit 13-like | -0.026295 |
