ULK-101_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.277
ERRFI1 ERBB receptor feedback inhibitor 1 0.100934
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0983877
MCL1 myeloid cell leukemia 1 0.0883672
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0801715
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0790498
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0774241
TXNRD1 thioredoxin reductase 1 0.0739047
NIPBL Nipped-B homolog (Drosophila) 0.0728732
ELL2 elongation factor, RNA polymerase II, 2 0.0680525
YBX3 Y box binding protein 3 0.0652603
JMJD1C jumonji domain containing 1C 0.0652482
GRAMD1B GRAM domain containing 1B 0.0602681
VMP1 vacuole membrane protein 1 0.0578132
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0547978
RAB7A RAB7A, member RAS oncogene family 0.051101
EEF2 eukaryotic translation elongation factor 2 0.0509949
PABPC1 poly(A) binding protein, cytoplasmic 1 0.050808
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0482207
SPAG9 sperm associated antigen 9 0.0480023
TM4SF1 transmembrane 4 L six family member 1 0.0468526
FMNL2 formin-like 2 0.0463062
TPM3 tropomyosin 3 0.0448241
ZFAND3 zinc finger, AN1-type domain 3 0.0428334
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0423379
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.040536
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.039996
KDM2A lysine (K)-specific demethylase 2A 0.0393445
HOMER1 homer scaffolding protein 1 0.0392094
FBXO11 F-box protein 11 0.0384301
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0382735
EXT1 exostosin glycosyltransferase 1 0.0375367
OSMR oncostatin M receptor 0.0373414
ZSWIM6 zinc finger, SWIM-type containing 6 0.0365864
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0365386
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.035619
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0345131
CDK17 cyclin-dependent kinase 17 0.0342644
IPO7 importin 7 0.0338449
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0337645
RICTOR RPTOR independent companion of MTOR, complex 2 0.033748
WNK1 WNK lysine deficient protein kinase 1 0.0337246
SNX9 sorting nexin 9 0.0331621
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0331234
PCBP2 poly(rC) binding protein 2 0.0330883
COPA coatomer protein complex, subunit alpha 0.0328752
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0322751
ANO6 anoctamin 6 0.031895
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0305927
TRIO trio Rho guanine nucleotide exchange factor 0.03037
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0299814
NF1 neurofibromin 1 0.0298832
CLTC clathrin, heavy chain (Hc) 0.0296595
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0292578
MORF4L2 mortality factor 4 like 2 0.0290895
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0287867
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0286525
IGF1R insulin-like growth factor 1 receptor 0.0279135
STAU1 staufen double-stranded RNA binding protein 1 0.027401
ZCCHC7 zinc finger, CCHC domain containing 7 0.027261
CTTNBP2NL CTTNBP2 N-terminal like 0.0267936
CSNK1A1 casein kinase 1, alpha 1 0.0263236
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0260782
HBP1 HMG-box transcription factor 1 0.0259586
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0259267
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0258903
USP9X ubiquitin specific peptidase 9, X-linked 0.0257561
R3HDM2 R3H domain containing 2 0.025755
KTN1 kinectin 1 (kinesin receptor) 0.0252897
BIRC3 baculoviral IAP repeat containing 3 0.0250606
SVIL supervillin 0.0250359
MARCHF4 membrane associated ring-CH-type finger 4 0.0249637
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0249591
ANXA5 annexin A5 0.024756
KDM7A lysine (K)-specific demethylase 7A 0.024565
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0244525
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0243152
DOCK5 dedicator of cytokinesis 5 0.0242238
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0240279
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0238564
OGA O-GlcNAcase 0.0238359
TMEM41B transmembrane protein 41B 0.0237734
MYO10 myosin X 0.0235966
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0235812
BZW1 basic leucine zipper and W2 domains 1 0.0235589
SERINC3 serine incorporator 3 0.0233464
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.022557
PTK2 protein tyrosine kinase 2 0.0225241
PUM1 pumilio RNA-binding family member 1 0.0224711
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0223778
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0222249
MACF1 microtubule-actin crosslinking factor 1 0.022101
KIF5B kinesin family member 5B 0.0220982
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0220956
NRG1 neuregulin 1 0.0219318
GLS2 glutaminase 2 (liver, mitochondrial) 0.0219133
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0219001
ADAM17 ADAM metallopeptidase domain 17 0.0217946
GPHN gephyrin 0.0217495
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0217324

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0945635
PTMA prothymosin, alpha -0.0893411
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0781704
RPL35A ribosomal protein L35a -0.0693311
HLA-B major histocompatibility complex, class I, B -0.0460625
RPL37A ribosomal protein L37a -0.0434019
FTL ferritin, light polypeptide -0.0416382
RAD51B RAD51 paralog B -0.0375753
RPL31 ribosomal protein L31 -0.0350476
RPS3 ribosomal protein S3 -0.0326536
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0315243
PFN1 profilin 1 -0.0296452
RPS29 ribosomal protein S29 -0.0295286
TPT1 tumor protein, translationally-controlled 1 -0.0290783
IFI6 interferon, alpha-inducible protein 6 -0.0287391
TPI1 triosephosphate isomerase 1 -0.0282318
RPS12 ribosomal protein S12 -0.0280767
RPS19 ribosomal protein S19 -0.0268801
RPL37 ribosomal protein L37 -0.0268023
EIF5B eukaryotic translation initiation factor 5B -0.0262821
RPS21 ribosomal protein S21 -0.0259192
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0256122
IGF2 insulin-like growth factor 2 -0.0254555
RPLP2 ribosomal protein, large, P2 -0.0252593
RYR3 ryanodine receptor 3 -0.0248876
MT2A metallothionein 2A -0.0244229
RPL19 ribosomal protein L19 -0.023731
RPL11 ribosomal protein L11 -0.0233581
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0226368
ATP5F1B ATP synthase F1 subunit beta -0.0215774
RPL26 ribosomal protein L26 -0.0211992
RPS27A ribosomal protein S27a -0.0211334
GNAS GNAS complex locus -0.0204532
RPS25 ribosomal protein S25 -0.020176
RPS17 ribosomal protein S17 -0.0198711
RPS13 ribosomal protein S13 -0.0198622
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0196961
RPL9 ribosomal protein L9 -0.0195989
RPL13A ribosomal protein L13a -0.0194041
RPL36 ribosomal protein L36 -0.0192676
RPS15 ribosomal protein S15 -0.019201
RNF213 ring finger protein 213 -0.019166
WSB1 WD repeat and SOCS box containing 1 -0.0189848
RPLP1 ribosomal protein, large, P1 -0.0181634
NCOA7 nuclear receptor coactivator 7 -0.018116
ATXN1 ataxin 1 -0.0180281
HDGF hepatoma-derived growth factor -0.0172671
RPS10 ribosomal protein S10 -0.01706
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0167413
RPS23 ribosomal protein S23 -0.0166682
TPM2 tropomyosin 2 (beta) -0.0163864
CBX5 chromobox homolog 5 -0.0162527
POTEF POTE ankyrin domain family, member F -0.0156845
RPL23 ribosomal protein L23 -0.0155479
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0154072
SMIM44 small integral membrane protein 44 -0.0152635
PDE10A phosphodiesterase 10A -0.0151061
RPS6 ribosomal protein S6 -0.0150649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0150207
ITSN1 intersectin 1 (SH3 domain protein) -0.0147311
HSPB1 heat shock 27kDa protein 1 -0.0146188
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0143768
LDHB lactate dehydrogenase B -0.0142508
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0138815
PDCD5 programmed cell death 5 -0.0138769
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0138454
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -0.013751
RPL38 ribosomal protein L38 -0.0137487
FMN1 formin 1 -0.0137459
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0136396
RPS8 ribosomal protein S8 -0.0136203
RPS24 ribosomal protein S24 -0.0135414
GSTP1 glutathione S-transferase pi 1 -0.0134986
PA2G4 proliferation-associated 2G4, 38kDa -0.0134029
XPOT exportin, tRNA -0.0131772
S100A10 S100 calcium binding protein A10 -0.0131689
RPL12 ribosomal protein L12 -0.0129336
SRRM2 serine/arginine repetitive matrix 2 -0.0128733
RPL30 ribosomal protein L30 -0.0128377
DCAF7 DDB1 and CUL4 associated factor 7 -0.0127759
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0126749
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0124609
NCOR2 nuclear receptor corepressor 2 -0.0124407
DENND5B DENN/MADD domain containing 5B -0.0122957
KIAA1328 KIAA1328 -0.0121322
DEK DEK proto-oncogene -0.0120649
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0120637
TP53 tumor protein p53 -0.0119161
MAP4 microtubule-associated protein 4 -0.0117631
CCND1 cyclin D1 -0.0116555
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0116554
RPS14 ribosomal protein S14 -0.0116362
PTPRF protein tyrosine phosphatase, receptor type, F -0.011558
PABPN1 poly(A) binding protein, nuclear 1 -0.0115399
MKI67 marker of proliferation Ki-67 -0.0115186
SMC4 structural maintenance of chromosomes 4 -0.0114564
SERF2 small EDRK-rich factor 2 -0.0113851
PNISR PNN-interacting serine/arginine-rich protein -0.011306
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0112512
BABAM2 BRISC and BRCA1 A complex member 2 -0.0111959