ULK-101_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.128052
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0707036
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0657207
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0362942
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0359835
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0337432
ELL2 elongation factor, RNA polymerase II, 2 0.0328312
ZSWIM6 zinc finger, SWIM-type containing 6 0.0276339
LAMC2 laminin, gamma 2 0.0260015
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207626
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0207217
VGLL3 vestigial-like family member 3 0.0201853
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0193824
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0189121
HDAC9 histone deacetylase 9 0.018646
INTS6 integrator complex subunit 6 0.0181263
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0158506
SGMS2 sphingomyelin synthase 2 0.0157694
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0154039
ALCAM activated leukocyte cell adhesion molecule 0.0148827
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0144635
MYO5B myosin VB 0.0143841
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0143241
AHNAK AHNAK nucleoprotein 0.0141615
CANX calnexin 0.0136853
DST dystonin 0.0133859
SERINC5 serine incorporator 5 0.0133586
TUFT1 tuftelin 1 0.01332
KIAA1217 KIAA1217 0.0130334
SQSTM1 sequestosome 1 0.0129827
RYBP RING1 and YY1 binding protein 0.0127629
HSPA8 heat shock 70kDa protein 8 0.0124721
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0121192
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.0120569
C3ORF52 chromosome 3 open reading frame 52 0.0114582
ANXA1 annexin A1 0.0112958
MYO10 myosin X 0.0112135
PGBD5 piggyBac transposable element derived 5 0.0109057
MAST4 microtubule associated serine/threonine kinase family member 4 0.0108975
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0107808
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0107499
DTNA dystrobrevin, alpha 0.0106888
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0106834
JUN jun proto-oncogene 0.0106657
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0106496
USP53 ubiquitin specific peptidase 53 0.0105377
OSBPL8 oxysterol binding protein-like 8 0.0102873
DENND4A DENN/MADD domain containing 4A 0.0102602
PEG10 paternally expressed 10 0.0102102
NABP1 nucleic acid binding protein 1 0.0101437
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.010043
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0100036
BIRC3 baculoviral IAP repeat containing 3 0.00995307
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00989181
AFF4 AF4/FMR2 family, member 4 0.00985742
CEMIP2 cell migration inducing hyaluronidase 2 0.00967028
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00965274
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00946629
CRYBG3 beta-gamma crystallin domain containing 3 0.00946555
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00941832
SMAD3 SMAD family member 3 0.00934226
HMGB2 high mobility group box 2 0.0092047
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00920265
USP9X ubiquitin specific peptidase 9, X-linked 0.00900057
FMNL2 formin-like 2 0.00889906
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.00869405
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00862328
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.00857165
SOD2 superoxide dismutase 2, mitochondrial 0.00855026
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00854788
HBP1 HMG-box transcription factor 1 0.00849946
ELOVL7 ELOVL fatty acid elongase 7 0.00841633
FNIP1 folliculin interacting protein 1 0.00839776
RPS3A ribosomal protein S3A 0.00837526
AAMDC adipogenesis associated, Mth938 domain containing 0.00830217
WWC1 WW and C2 domain containing 1 0.0082252
IL6ST interleukin 6 signal transducer 0.00816509
ANXA5 annexin A5 0.00811407
SPAG9 sperm associated antigen 9 0.00805836
ZBTB43 zinc finger and BTB domain containing 43 0.00805467
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.00802077
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.00800805
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00800507
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.00800085
C6ORF62 chromosome 6 open reading frame 62 0.00799781
NIBAN1 niban apoptosis regulator 1 0.00797715
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.00795612
PLK2 polo-like kinase 2 0.00787118
ITPKC inositol-trisphosphate 3-kinase C 0.00782138
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00781923
STEAP4 STEAP family member 4 0.00780614
ATF3 activating transcription factor 3 0.00771014
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.00769609
ERN1 endoplasmic reticulum to nucleus signaling 1 0.00750533
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00746924
MAPK8 mitogen-activated protein kinase 8 0.00740043
TMED2 transmembrane emp24 domain trafficking protein 2 0.00739868
PHACTR4 phosphatase and actin regulator 4 0.00738555
DSPP dentin sialophosphoprotein 0.00738423
JAK1 Janus kinase 1 0.00736597

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.211865
FTL ferritin, light polypeptide -0.199419
PTMA prothymosin, alpha -0.191037
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143454
POTEF POTE ankyrin domain family, member F -0.132409
ACTG1 actin gamma 1 -0.128005
NDRG1 N-myc downstream regulated 1 -0.123746
IFI27 interferon, alpha-inducible protein 27 -0.0941081
FN1 fibronectin 1 -0.0885632
RPL35A ribosomal protein L35a -0.0823248
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0808836
S100A6 S100 calcium binding protein A6 -0.0788365
LIMCH1 LIM and calponin homology domains 1 -0.078698
ISG15 ISG15 ubiquitin-like modifier -0.074202
LPP LIM domain containing preferred translocation partner in lipoma -0.0684724
EIF1 eukaryotic translation initiation factor 1 -0.0666988
IGFBP3 insulin-like growth factor binding protein 3 -0.0644708
SOX4 SRY (sex determining region Y)-box 4 -0.0614984
HLA-B major histocompatibility complex, class I, B -0.0590672
CSTB cystatin B (stefin B) -0.0582588
IFITM1 interferon induced transmembrane protein 1 -0.058127
RPLP2 ribosomal protein, large, P2 -0.0580155
S100A10 S100 calcium binding protein A10 -0.0578477
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0576455
IFI6 interferon, alpha-inducible protein 6 -0.0564885
RPLP1 ribosomal protein, large, P1 -0.0547868
BASP1 brain abundant, membrane attached signal protein 1 -0.0546189
TPT1 tumor protein, translationally-controlled 1 -0.0544166
NPEPPS aminopeptidase puromycin sensitive -0.0539428
RPS6 ribosomal protein S6 -0.0538686
RPS19 ribosomal protein S19 -0.0536398
RPL8 ribosomal protein L8 -0.0520204
MDK midkine (neurite growth-promoting factor 2) -0.051711
IFITM3 interferon induced transmembrane protein 3 -0.0516614
RPL34 ribosomal protein L34 -0.0509136
VEGFA vascular endothelial growth factor A -0.0504731
LY6E lymphocyte antigen 6 complex, locus E -0.0501459
HLA-A major histocompatibility complex, class I, A -0.0487106
RBM25 RNA binding motif protein 25 -0.0473124
TMSB4X thymosin beta 4, X-linked -0.0472761
RPS23 ribosomal protein S23 -0.0471649
GOLGA4 golgin A4 -0.0468014
TMEM165 transmembrane protein 165 -0.0462194
RPS29 ribosomal protein S29 -0.0462045
GNAS GNAS complex locus -0.0450032
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0446794
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0445199
TOP1 topoisomerase (DNA) I -0.0444188
TPI1 triosephosphate isomerase 1 -0.0443078
WSB1 WD repeat and SOCS box containing 1 -0.043937
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0439367
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0432086
FTH1 ferritin, heavy polypeptide 1 -0.0431037
LMNA lamin A/C -0.0428564
RPL23 ribosomal protein L23 -0.0425383
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0417582
TSC22D2 TSC22 domain family, member 2 -0.0416117
PRRC2C proline-rich coiled-coil 2C -0.0413698
RPS13 ribosomal protein S13 -0.0399112
HSPB1 heat shock 27kDa protein 1 -0.0391455
TM4SF1 transmembrane 4 L six family member 1 -0.0386537
CD2AP CD2-associated protein -0.0384879
ITCH itchy E3 ubiquitin protein ligase -0.0375307
RPS21 ribosomal protein S21 -0.0372038
RNF145 ring finger protein 145 -0.0361454
ACBD3 acyl-CoA binding domain containing 3 -0.0355107
F3 coagulation factor III (thromboplastin, tissue factor) -0.0351388
CCND1 cyclin D1 -0.0349807
RPS8 ribosomal protein S8 -0.0346213
STRN3 striatin, calmodulin binding protein 3 -0.0346155
YY1 YY1 transcription factor -0.0346084
LMO7 LIM domain 7 -0.033895
PKM pyruvate kinase, muscle -0.0338746
ENO2 enolase 2 (gamma, neuronal) -0.0334838
KMT2E lysine (K)-specific methyltransferase 2E -0.0333421
RRBP1 ribosome binding protein 1 -0.0333079
PGK1 phosphoglycerate kinase 1 -0.0324299
SETD5 SET domain containing 5 -0.0323463
KDM5B lysine (K)-specific demethylase 5B -0.0322447
RPL32 ribosomal protein L32 -0.0320532
RPL19 ribosomal protein L19 -0.0319365
EFNA5 ephrin-A5 -0.0318191
UBC ubiquitin C -0.0315507
SACK1A scaffolding CK1 anchoring protein A -0.0313374
FBXO32 F-box protein 32 -0.0309882
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0308883
KMT2C lysine (K)-specific methyltransferase 2C -0.0308369
LAMB3 laminin, beta 3 -0.0307181
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0306234
SLC38A1 solute carrier family 38, member 1 -0.030578
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0304201
RPS14 ribosomal protein S14 -0.0300957
HMGA1 high mobility group AT-hook 1 -0.0299411
RPL9 ribosomal protein L9 -0.0298348
ADAR adenosine deaminase, RNA-specific -0.0297088
RBM39 RNA binding motif protein 39 -0.0296845
RPL31 ribosomal protein L31 -0.0294416
RPL28 ribosomal protein L28 -0.0292423
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0287996
RPS27 ribosomal protein S27 -0.0284775