| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ULK-101 perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ULK-101_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.132647 |
| KYNU | kynureninase | 0.0960011 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0728883 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0721502 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0714507 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0703012 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0672973 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0650971 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0637643 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0623458 |
| FMNL2 | formin-like 2 | 0.0580377 |
| MCL1 | myeloid cell leukemia 1 | 0.0578184 |
| PCBP2 | poly(rC) binding protein 2 | 0.0547403 |
| POTEF | POTE ankyrin domain family, member F | 0.0522001 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0518417 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0507312 |
| ASPH | aspartate beta-hydroxylase | 0.0496432 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0487572 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0474512 |
| GRAMD1B | GRAM domain containing 1B | 0.047252 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0468403 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0466891 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0451116 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0438211 |
| SQSTM1 | sequestosome 1 | 0.0415522 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0414653 |
| DST | dystonin | 0.040635 |
| PTEN | phosphatase and tensin homolog | 0.04054 |
| FNIP1 | folliculin interacting protein 1 | 0.0404064 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0395398 |
| RPS6 | ribosomal protein S6 | 0.0394617 |
| VIM | vimentin | 0.0393558 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0393337 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0392597 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.038869 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0384194 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0358448 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0354195 |
| RPS23 | ribosomal protein S23 | 0.0347489 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0344033 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0343853 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0337121 |
| RPL23 | ribosomal protein L23 | 0.0334203 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0333789 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0332937 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.033045 |
| MYOF | myoferlin | 0.0326692 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0324534 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0322103 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0303354 |
| USP34 | ubiquitin specific peptidase 34 | 0.0298301 |
| VMP1 | vacuole membrane protein 1 | 0.0288612 |
| VCL | vinculin | 0.0284282 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0284029 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0283345 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0282547 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0281263 |
| PKM | pyruvate kinase, muscle | 0.0278301 |
| MED13 | mediator complex subunit 13 | 0.027151 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0270089 |
| RPS8 | ribosomal protein S8 | 0.0264377 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0262384 |
| RPL12 | ribosomal protein L12 | 0.0260919 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0259661 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0255525 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0253272 |
| ASTN2 | astrotactin 2 | 0.0246786 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0246748 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0246287 |
| B2M | beta-2-microglobulin | 0.0245343 |
| BPTF | bromodomain PHD finger transcription factor | 0.0239103 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0238718 |
| TPM3 | tropomyosin 3 | 0.0236892 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0231819 |
| MSN | moesin | 0.022788 |
| SFTPA2 | surfactant protein A2 | 0.0221381 |
| BMP6 | bone morphogenetic protein 6 | 0.0221024 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0220738 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0219814 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0218876 |
| SMAD2 | SMAD family member 2 | 0.0217566 |
| NBEAL1 | neurobeachin-like 1 | 0.021671 |
| CENPF | centromere protein F, 350/400kDa | 0.0213548 |
| RPL36A | ribosomal protein L36a | 0.0212567 |
| GPC6 | glypican 6 | 0.0211593 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0209065 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0207688 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0207437 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0205869 |
| RASAL2 | RAS protein activator like 2 | 0.0205866 |
| GOLGA4 | golgin A4 | 0.0205645 |
| RPS14 | ribosomal protein S14 | 0.0205324 |
| RPS4X | ribosomal protein S4, X-linked | 0.0205209 |
| ENO1 | enolase 1, (alpha) | 0.0202619 |
| UBC | ubiquitin C | 0.0201931 |
| RPS12 | ribosomal protein S12 | 0.0201059 |
| SPAG9 | sperm associated antigen 9 | 0.0200983 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0200407 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0200309 |
| DNER | delta/notch-like EGF repeat containing | 0.0199671 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.313166 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.104761 |
| PCBP3 | poly(rC) binding protein 3 | -0.0701616 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0589088 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0440888 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0403606 |
| PDE10A | phosphodiesterase 10A | -0.0391086 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0384254 |
| SMYD3 | SET and MYND domain containing 3 | -0.0363186 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0336808 |
| TENM3 | teneurin transmembrane protein 3 | -0.032835 |
| NCKAP5 | NCK-associated protein 5 | -0.0315679 |
| TBXT | T-box transcription factor T | -0.0292904 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0289468 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0284726 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0280739 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0278251 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0272661 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.027239 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0268883 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0268492 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0238356 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0232969 |
| RPL38 | ribosomal protein L38 | -0.0225537 |
| IER3 | immediate early response 3 | -0.022281 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0216203 |
| AOPEP | aminopeptidase O (putative) | -0.021568 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0211824 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0210167 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0198191 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0197875 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0197297 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0195681 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0194955 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0192794 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0192343 |
| PYGL | phosphorylase, glycogen, liver | -0.0190778 |
| HLA-B | major histocompatibility complex, class I, B | -0.018386 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0177935 |
| RANBP17 | RAN binding protein 17 | -0.0176859 |
| GNAS | GNAS complex locus | -0.017643 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0174435 |
| RPL13A | ribosomal protein L13a | -0.0172884 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0170347 |
| ALPK2 | alpha-kinase 2 | -0.0170194 |
| GDA | guanine deaminase | -0.0170162 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0169986 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0166844 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0165126 |
| OSMR | oncostatin M receptor | -0.0160448 |
| CRLF2 | cytokine receptor-like factor 2 | -0.0159644 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0155465 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0154962 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0154791 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0151171 |
| TMSB4X | thymosin beta 4, X-linked | -0.0148304 |
| CUL1 | cullin 1 | -0.0147899 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0146025 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0144701 |
| RHOB | ras homolog family member B | -0.0142561 |
| STC2 | stanniocalcin 2 | -0.0140867 |
| CDH13 | cadherin 13 | -0.0140393 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0138032 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0137847 |
| RPL35A | ribosomal protein L35a | -0.0137502 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0136012 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0133219 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0132706 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.013008 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0128632 |
| RPS3 | ribosomal protein S3 | -0.0127309 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0126983 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0125973 |
| ANXA2 | annexin A2 | -0.0125953 |
| DYNC2I1 | dynein 2 intermediate chain 1 | -0.0125646 |
| PTGR1 | prostaglandin reductase 1 | -0.0123758 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.012299 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.0121049 |
| RAI14 | retinoic acid induced 14 | -0.0118344 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0117156 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0116869 |
| RASA3 | RAS p21 protein activator 3 | -0.0116743 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0116513 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0116221 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0115825 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0115217 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0114826 |
| RPL6 | ribosomal protein L6 | -0.01143 |
| OGA | O-GlcNAcase | -0.0111882 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0110945 |
| ABLIM1 | actin binding LIM protein 1 | -0.0110788 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0110777 |
| TBC1D19 | TBC1 domain family, member 19 | -0.010714 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0106231 |
| MAP4 | microtubule-associated protein 4 | -0.0104995 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0104959 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0103138 |
| NTN4 | netrin 4 | -0.0102292 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0101648 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.00998749 |
