ULK-101_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.341253
B2M beta-2-microglobulin 0.17271
AHNAK AHNAK nucleoprotein 0.124341
TRIO trio Rho guanine nucleotide exchange factor 0.115743
EIF1 eukaryotic translation initiation factor 1 0.115368
RPL19 ribosomal protein L19 0.111788
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.108409
IGFBP3 insulin-like growth factor binding protein 3 0.106871
TMSB10 thymosin beta 10 0.103444
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.102818
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0953907
SET SET nuclear proto-oncogene 0.0900357
GOLGB1 golgin B1 0.0884089
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0852396
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0845555
TPT1 tumor protein, translationally-controlled 1 0.0810334
SQSTM1 sequestosome 1 0.0809676
ELL2 elongation factor, RNA polymerase II, 2 0.0798442
RPL37 ribosomal protein L37 0.0778627
EHBP1 EH domain binding protein 1 0.0771004
NAP1L1 nucleosome assembly protein 1-like 1 0.0723691
RPL23 ribosomal protein L23 0.071215
MYO1E myosin IE 0.0694563
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0685434
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0677894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0674963
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0639838
CCNI cyclin I 0.0635234
TPR translocated promoter region, nuclear basket protein 0.0579501
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0575535
AK1 adenylate kinase 1 0.0562322
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0546041
FTH1 ferritin, heavy polypeptide 1 0.0532979
ZSWIM6 zinc finger, SWIM-type containing 6 0.0527609
PKM pyruvate kinase, muscle 0.0516952
PGK1 phosphoglycerate kinase 1 0.0497714
FMNL2 formin-like 2 0.049076
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0487705
RPL5 ribosomal protein L5 0.0479866
IQGAP1 IQ motif containing GTPase activating protein 1 0.0465403
ANXA2 annexin A2 0.0432124
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0429661
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0421123
KMT2C lysine (K)-specific methyltransferase 2C 0.0415057
ITCH itchy E3 ubiquitin protein ligase 0.0396094
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0393644
USP34 ubiquitin specific peptidase 34 0.0380188
RTN4 reticulon 4 0.0374936
RBM39 RNA binding motif protein 39 0.0371356
ANKRD11 ankyrin repeat domain 11 0.0366494
MED13L mediator complex subunit 13-like 0.0364315
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0359742
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0355542
S100A10 S100 calcium binding protein A10 0.0349575
RPL12 ribosomal protein L12 0.0341226
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0335055
NAMPT nicotinamide phosphoribosyltransferase 0.0323037
FTL ferritin, light polypeptide 0.0321205
GNPDA1 glucosamine-6-phosphate deaminase 1 0.031653
FOXP1 forkhead box P1 0.0305685
PCBP2 poly(rC) binding protein 2 0.0305036
MARCHF6 membrane associated ring-CH-type finger 6 0.0303109
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0301691
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0300971
MED13 mediator complex subunit 13 0.0298798
MATR3 matrin 3 0.029633
KDM3A lysine (K)-specific demethylase 3A 0.029154
EPS8 epidermal growth factor receptor pathway substrate 8 0.0282816
KANSL1 KAT8 regulatory NSL complex subunit 1 0.02666
PDE8A phosphodiesterase 8A 0.0265266
PDIA3 protein disulfide isomerase family A, member 3 0.0264828
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0263679
CANX calnexin 0.0261574
RPS12 ribosomal protein S12 0.0257548
RPL37A ribosomal protein L37a 0.0251188
PICALM phosphatidylinositol binding clathrin assembly protein 0.0241107
ZBTB20 zinc finger and BTB domain containing 20 0.0236029
DSPP dentin sialophosphoprotein 0.0223547
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0220778
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0215881
MT2A metallothionein 2A 0.0198466
RPS3 ribosomal protein S3 0.019413
HELZ helicase with zinc finger 0.0184094
CDH13 cadherin 13 0.0170465
RPS6 ribosomal protein S6 0.0166091
AFF4 AF4/FMR2 family, member 4 0.0165893
LPP LIM domain containing preferred translocation partner in lipoma 0.0161533
AKAP13 A kinase (PRKA) anchor protein 13 0.0161449
NPAS2 neuronal PAS domain protein 2 0.0157819
SMAD3 SMAD family member 3 0.0156576
RPL34 ribosomal protein L34 0.0143232
RUNX1 runt-related transcription factor 1 0.0141543
RPLP1 ribosomal protein, large, P1 0.0140985
CXCL8 chemokine (C-X-C motif) ligand 8 0.0127611
ALCAM activated leukocyte cell adhesion molecule 0.0119034
MYOF myoferlin 0.0106691
RAD51B RAD51 paralog B 0.0105022
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0103768
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0103098
RPL26 ribosomal protein L26 0.0101167

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.215476
EFNA5 ephrin-A5 -0.186115
RORA RAR-related orphan receptor A -0.130422
NALF1 NALCN channel auxiliary factor 1 -0.128872
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0998525
DOCK4 dedicator of cytokinesis 4 -0.0974558
FNDC3B fibronectin type III domain containing 3B -0.0791139
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0749996
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0728173
FNDC3A fibronectin type III domain containing 3A -0.0694558
PTPRM protein tyrosine phosphatase, receptor type, M -0.0686256
FLNB filamin B, beta -0.06824
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0653111
POTEF POTE ankyrin domain family, member F -0.0626827
BPTF bromodomain PHD finger transcription factor -0.0626454
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0623738
MAML3 mastermind-like 3 (Drosophila) -0.0599721
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0576728
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0576115
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0560361
NHSL1 NHS-like 1 -0.0556982
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0553196
TBC1D5 TBC1 domain family, member 5 -0.0545594
MBD5 methyl-CpG binding domain protein 5 -0.0536549
FAM13A family with sequence similarity 13, member A -0.0534683
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0533137
ARB2A ARB2 cotranscriptional regulator A -0.0533128
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0521943
RPS27A ribosomal protein S27a -0.0520788
RAB7A RAB7A, member RAS oncogene family -0.0519231
TBC1D22A TBC1 domain family, member 22A -0.0507399
WSB1 WD repeat and SOCS box containing 1 -0.0505244
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0503208
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.049639
EXT1 exostosin glycosyltransferase 1 -0.047996
HMGA2 high mobility group AT-hook 2 -0.0472125
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0450389
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0444107
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0433632
GRB10 growth factor receptor-bound protein 10 -0.043329
NBEAL1 neurobeachin-like 1 -0.0429581
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0425736
PRKCA protein kinase C, alpha -0.0424158
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0420952
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0419351
GOLGA4 golgin A4 -0.041888
MBNL2 muscleblind-like splicing regulator 2 -0.0403231
PARD3 par-3 family cell polarity regulator -0.0395921
PTK2 protein tyrosine kinase 2 -0.0393228
COG5 component of oligomeric golgi complex 5 -0.0392462
SMYD3 SET and MYND domain containing 3 -0.0373192
RPL9 ribosomal protein L9 -0.0355779
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0355707
NIPBL Nipped-B homolog (Drosophila) -0.0326908
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0326844
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0322366
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0319165
NAV2 neuron navigator 2 -0.0313483
USP15 ubiquitin specific peptidase 15 -0.0312422
PSD3 pleckstrin and Sec7 domain containing 3 -0.0307851
RPS13 ribosomal protein S13 -0.0304624
NCOR1 nuclear receptor corepressor 1 -0.0304456
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0301266
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.030024
ASPH aspartate beta-hydroxylase -0.0298557
DGKD diacylglycerol kinase, delta 130kDa -0.0298444
TTC3 tetratricopeptide repeat domain 3 -0.0286856
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0286171
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0285103
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0285027
SETD5 SET domain containing 5 -0.0266948
CD44 CD44 molecule (Indian blood group) -0.0266852
SEC31A SEC31 homolog A (S. cerevisiae) -0.0256129
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.025043
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0230171
GMDS GDP-mannose 4,6-dehydratase -0.0229303
RBM25 RNA binding motif protein 25 -0.0228178
INTS6 integrator complex subunit 6 -0.0225183
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0212541
RPS19 ribosomal protein S19 -0.0211911
PDLIM5 PDZ and LIM domain 5 -0.0211447
S100A6 S100 calcium binding protein A6 -0.021121
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0204044
GPC6 glypican 6 -0.0202294
RPS23 ribosomal protein S23 -0.0200627
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0189282
MAML2 mastermind-like 2 (Drosophila) -0.0187657
NKD1 naked cuticle homolog 1 (Drosophila) -0.0186741
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0186531
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.01863
ACTG1 actin gamma 1 -0.018574
RPLP0 ribosomal protein, large, P0 -0.0183912
BABAM2 BRISC and BRCA1 A complex member 2 -0.0179669
MACF1 microtubule-actin crosslinking factor 1 -0.0172004
PDE4D phosphodiesterase 4D, cAMP-specific -0.0162729
HOOK2 hook microtubule-tethering protein 2 -0.0160165
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0150922
KLF12 Kruppel-like factor 12 -0.0146762
RPS16 ribosomal protein S16 -0.0140594
VCL vinculin -0.0127389