ULK-101_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0557658
ZNF292 zinc finger protein 292 0.0491061
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0398322
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0340622
FRYL FRY-like 0.0329176
EGFR epidermal growth factor receptor 0.0323159
NCOA2 nuclear receptor coactivator 2 0.0311224
COL5A2 collagen, type V, alpha 2 0.0306271
YAP1 Yes-associated protein 1 0.02993
PSPC1 paraspeckle component 1 0.0285109
COL11A1 collagen, type XI, alpha 1 0.0282605
MYO6 myosin VI 0.0267505
MARCHF7 membrane associated ring-CH-type finger 7 0.0265453
PCBP2 poly(rC) binding protein 2 0.0258612
HMGB2 high mobility group box 2 0.0258
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0255518
PDS5B PDS5 cohesin associated factor B 0.0255251
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.02491
PCLO piccolo presynaptic cytomatrix protein 0.0241364
FOXO1 forkhead box O1 0.0238589
TNRC6B trinucleotide repeat containing 6B 0.0232521
ITGAV integrin, alpha V 0.0231846
HMCN1 hemicentin 1 0.0221843
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0221607
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0220648
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0218499
RICTOR RPTOR independent companion of MTOR, complex 2 0.0217863
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0216667
TBC1D12 TBC1 domain family, member 12 0.0213504
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0210028
ERBIN erbb2 interacting protein 0.0209093
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0208484
SLC44A5 solute carrier family 44, member 5 0.0208375
RAD21 RAD21 homolog (S. pombe) 0.0206944
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0206674
MED13L mediator complex subunit 13-like 0.0204603
LCORL ligand dependent nuclear receptor corepressor-like 0.0203571
FRS2 fibroblast growth factor receptor substrate 2 0.0203404
PICALM phosphatidylinositol binding clathrin assembly protein 0.0202626
HBP1 HMG-box transcription factor 1 0.0201258
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0200767
RYBP RING1 and YY1 binding protein 0.0198836
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0198322
CEP85L centrosomal protein 85kDa-like 0.0198099
CDH19 cadherin 19, type 2 0.019669
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0195187
FBXO11 F-box protein 11 0.0194577
PHF3 PHD finger protein 3 0.0192244
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.0192109
RASAL2 RAS protein activator like 2 0.019165
GPC6 glypican 6 0.0191209
FAT1 FAT atypical cadherin 1 0.0189889
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0189244
MMP1 matrix metallopeptidase 1 0.0187094
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0185802
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.0184811
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0183739
FAM193B family with sequence similarity 193, member B 0.0182881
HELZ helicase with zinc finger 0.0182598
SLTM SAFB-like, transcription modulator 0.0182166
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0181482
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.018027
RLF rearranged L-myc fusion 0.0180181
SEC31A SEC31 homolog A (S. cerevisiae) 0.0179621
SETD2 SET domain containing 2 0.0178819
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0178741
RSBN1L round spermatid basic protein 1-like 0.0178703
NUP58 nucleoporin 58 0.0177653
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0177144
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0173161
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0172902
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0171675
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0171229
TOP2B topoisomerase (DNA) II beta 180kDa 0.0170865
AZIN1 antizyme inhibitor 1 0.0170154
KAT6A K(lysine) acetyltransferase 6A 0.0170104
U2SURP U2 snRNP-associated SURP domain containing 0.0169537
RAB30 RAB30, member RAS oncogene family 0.0169172
HBS1L HBS1-like translational GTPase 0.0169158
IFRD1 interferon-related developmental regulator 1 0.0168797
ARRDC3 arrestin domain containing 3 0.0168276
ATF7IP activating transcription factor 7 interacting protein 0.0168248
SAFB scaffold attachment factor B 0.0167537
NPTN neuroplastin 0.0166886
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0166705
CARD16 caspase recruitment domain family, member 16 0.0166069
ACBD6 acyl-CoA binding domain containing 6 0.0165742
CYRIB CYFIP related Rac1 interactor B 0.016487
TAS2R14 taste receptor, type 2, member 14 0.0164215
TMEM39A transmembrane protein 39A 0.0164116
RBM33 RNA binding motif protein 33 0.0164076
ARL5B ADP-ribosylation factor-like 5B 0.0163136
TRIM33 tripartite motif containing 33 0.0163134
TGFB2 transforming growth factor, beta 2 0.0163102
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0162872
NFIB nuclear factor I/B 0.0162714
OXR1 oxidation resistance 1 0.0161763
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0161602
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0160836
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0159268

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.202115
PTMA prothymosin, alpha -0.171454
TMSB10 thymosin beta 10 -0.157308
RPS16 ribosomal protein S16 -0.134306
RPL35A ribosomal protein L35a -0.0939815
RPS8 ribosomal protein S8 -0.0918207
MDK midkine (neurite growth-promoting factor 2) -0.0877723
RPS6 ribosomal protein S6 -0.0810863
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0803524
TPT1 tumor protein, translationally-controlled 1 -0.0706469
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0702513
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0698822
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0663622
COL1A2 collagen, type I, alpha 2 -0.0648387
RPL11 ribosomal protein L11 -0.0646486
RPLP1 ribosomal protein, large, P1 -0.0642141
GNAS GNAS complex locus -0.0627659
CADM2 cell adhesion molecule 2 -0.058306
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0574443
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0546774
PLPP1 phospholipid phosphatase 1 -0.0545461
RPS12 ribosomal protein S12 -0.0535265
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0523846
RPL12 ribosomal protein L12 -0.0513941
RPL37A ribosomal protein L37a -0.0508742
RPS19 ribosomal protein S19 -0.0493246
WSB1 WD repeat and SOCS box containing 1 -0.0484589
S100A10 S100 calcium binding protein A10 -0.0484067
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0481434
RPL23 ribosomal protein L23 -0.0474806
RPL19 ribosomal protein L19 -0.0472176
CNRIP1 cannabinoid receptor interacting protein 1 -0.0464797
GPC3 glypican 3 -0.0461741
PGK1 phosphoglycerate kinase 1 -0.0459037
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0457615
EIF1 eukaryotic translation initiation factor 1 -0.044967
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0446153
RPS25 ribosomal protein S25 -0.0445437
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0444297
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0430431
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0428952
B2M beta-2-microglobulin -0.0427887
RPL37 ribosomal protein L37 -0.0427886
AKAP9 A kinase (PRKA) anchor protein 9 -0.0426026
RPL31 ribosomal protein L31 -0.0421413
ACTG1 actin gamma 1 -0.0415267
RPS27A ribosomal protein S27a -0.0407553
PEG10 paternally expressed 10 -0.0405395
MEIS2 Meis homeobox 2 -0.0405152
RPL26 ribosomal protein L26 -0.0395238
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0390902
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0390719
ATP5F1B ATP synthase F1 subunit beta -0.038217
MAP4 microtubule-associated protein 4 -0.0376604
RPLP2 ribosomal protein, large, P2 -0.0375668
RPS24 ribosomal protein S24 -0.0373607
FTL ferritin, light polypeptide -0.037231
HSPB1 heat shock 27kDa protein 1 -0.037098
GSE1 Gse1 coiled-coil protein -0.0369108
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0368727
RPL34 ribosomal protein L34 -0.0366928
PARD3B par-3 family cell polarity regulator beta -0.0352928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0348021
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0342136
ENO1 enolase 1, (alpha) -0.0340812
RPS13 ribosomal protein S13 -0.033956
RPL7A ribosomal protein L7a -0.0333342
PBX3 pre-B-cell leukemia homeobox 3 -0.0332913
LRRC4C leucine rich repeat containing 4C -0.0331476
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0327816
SERF2 small EDRK-rich factor 2 -0.0327111
PHIP pleckstrin homology domain interacting protein -0.0319821
SLC38A1 solute carrier family 38, member 1 -0.0314132
PFN1 profilin 1 -0.0313425
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0312593
ISG15 ISG15 ubiquitin-like modifier -0.0309998
RPS29 ribosomal protein S29 -0.030598
NRG1 neuregulin 1 -0.0303044
RPS21 ribosomal protein S21 -0.0300907
PDIA3 protein disulfide isomerase family A, member 3 -0.0299285
RPS10 ribosomal protein S10 -0.0298655
RPL9 ribosomal protein L9 -0.0297012
MYL12B myosin, light chain 12B, regulatory -0.0296919
RPL36A ribosomal protein L36a -0.0295422
NEBL nebulette -0.0293501
RACK1 receptor for activated C kinase 1 -0.0293255
CAVIN1 caveolae associated protein 1 -0.0289361
NPAS3 neuronal PAS domain protein 3 -0.0288997
RBM39 RNA binding motif protein 39 -0.0288544
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0287551
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0286972
TBCA tubulin folding cofactor A -0.0285338
NACA nascent polypeptide-associated complex alpha subunit -0.0283833
RPS23 ribosomal protein S23 -0.0283521
ARHGAP15 Rho GTPase activating protein 15 -0.0282849
RAB6A RAB6A, member RAS oncogene family -0.0282669
FBXO17 F-box protein 17 -0.0281106
SRRM2 serine/arginine repetitive matrix 2 -0.027945
PKM pyruvate kinase, muscle -0.0275153
ZBTB20 zinc finger and BTB domain containing 20 -0.0271939