ULK-101_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.14179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.120542
FRMD6 FERM domain containing 6 0.11936
EXT1 exostosin glycosyltransferase 1 0.113509
NAV3 neuron navigator 3 0.108947
JMJD1C jumonji domain containing 1C 0.103102
HDAC9 histone deacetylase 9 0.103082
PABPC1 poly(A) binding protein, cytoplasmic 1 0.100991
ZNF438 zinc finger protein 438 0.0828475
FRMD4A FERM domain containing 4A 0.0777103
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0767436
ARHGAP22 Rho GTPase activating protein 22 0.074392
ZEB1 zinc finger E-box binding homeobox 1 0.0743236
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0703772
MCTP1 multiple C2 domains, transmembrane 1 0.0677456
ELL2 elongation factor, RNA polymerase II, 2 0.0666899
AGO2 argonaute RISC catalytic component 2 0.0558493
SAMD4A sterile alpha motif domain containing 4A 0.050877
ZSWIM6 zinc finger, SWIM-type containing 6 0.0482596
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0481005
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0462127
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0461121
SGMS2 sphingomyelin synthase 2 0.0456926
EEF2 eukaryotic translation elongation factor 2 0.042599
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0419519
MAST4 microtubule associated serine/threonine kinase family member 4 0.0405779
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0391789
RASA2 RAS p21 protein activator 2 0.0380775
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0376274
GLS2 glutaminase 2 (liver, mitochondrial) 0.0366985
CANX calnexin 0.035357
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0353042
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0350471
IARS1 isoleucyl-tRNA synthetase 1 0.0339409
RCOR1 REST corepressor 1 0.0338031
ZFAND3 zinc finger, AN1-type domain 3 0.0334651
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0334066
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.033183
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0330543
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.031272
TUT7 terminal uridylyl transferase 7 0.0309992
JUN jun proto-oncogene 0.0304029
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0301112
ERBIN erbb2 interacting protein 0.0298623
DGKI diacylglycerol kinase, iota 0.029048
CREB5 cAMP responsive element binding protein 5 0.0290172
NABP1 nucleic acid binding protein 1 0.0289406
PARD3 par-3 family cell polarity regulator 0.0289
CALU calumenin 0.0287776
VMP1 vacuole membrane protein 1 0.0286762
EFL1 elongation factor like GTPase 1 0.0282942
SETX senataxin 0.0281987
CAPRIN2 caprin family member 2 0.0280656
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.027589
TJP1 tight junction protein 1 0.0275232
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0272941
USP34 ubiquitin specific peptidase 34 0.0267407
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0265151
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.026195
AKAP12 A kinase (PRKA) anchor protein 12 0.02606
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0259736
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0259309
RB1CC1 RB1-inducible coiled-coil 1 0.0259094
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0255769
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0254998
WDFY2 WD repeat and FYVE domain containing 2 0.0254358
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0253982
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0247786
CD44 CD44 molecule (Indian blood group) 0.0244382
ANXA5 annexin A5 0.02432
ACTG1 actin gamma 1 0.0239361
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0239169
USP9X ubiquitin specific peptidase 9, X-linked 0.023858
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0233771
ZBTB43 zinc finger and BTB domain containing 43 0.0230491
RAP1B RAP1B, member of RAS oncogene family 0.0230489
ADTRP androgen-dependent TFPI-regulating protein 0.0230043
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.022779
NAV2 neuron navigator 2 0.0227177
IL6ST interleukin 6 signal transducer 0.022613
INTS6 integrator complex subunit 6 0.0225949
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0225107
MED13L mediator complex subunit 13-like 0.0223925
RAB7A RAB7A, member RAS oncogene family 0.0221002
TM4SF19 transmembrane 4 L six family member 19 0.0220178
TMEM41B transmembrane protein 41B 0.0218773
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0216983
OSBPL8 oxysterol binding protein-like 8 0.021518
ZBTB38 zinc finger and BTB domain containing 38 0.0212866
PUM1 pumilio RNA-binding family member 1 0.0212833
KMT2E lysine (K)-specific methyltransferase 2E 0.0211287
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0210606
CORO1C coronin, actin binding protein, 1C 0.0210547
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0210017
PTK2 protein tyrosine kinase 2 0.0209406
FNDC3B fibronectin type III domain containing 3B 0.0209343
STC1 stanniocalcin 1 0.0207978
DSCAM Down syndrome cell adhesion molecule 0.0206909
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0206448
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0205909

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.162584
RPL35A ribosomal protein L35a -0.0539666
PFN1 profilin 1 -0.0380859
TMSB10 thymosin beta 10 -0.0376684
RPS6 ribosomal protein S6 -0.0355559
FTL ferritin, light polypeptide -0.0346281
RPL37A ribosomal protein L37a -0.0342112
POTEF POTE ankyrin domain family, member F -0.0332914
RPS3 ribosomal protein S3 -0.0304767
RPL9 ribosomal protein L9 -0.0291594
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0269806
PTMA prothymosin, alpha -0.0266423
RPLP2 ribosomal protein, large, P2 -0.025603
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0249656
RPS13 ribosomal protein S13 -0.0245734
RPS19 ribosomal protein S19 -0.0245242
RPL36 ribosomal protein L36 -0.0233061
RPL11 ribosomal protein L11 -0.0225274
RPL26 ribosomal protein L26 -0.0219818
HMGA1 high mobility group AT-hook 1 -0.0214988
RPS12 ribosomal protein S12 -0.021059
MT1X metallothionein 1X -0.0202699
RPL19 ribosomal protein L19 -0.0195207
RPS21 ribosomal protein S21 -0.0194042
CALD1 caldesmon 1 -0.0189422
IFITM2 interferon induced transmembrane protein 2 -0.0188851
RPL30 ribosomal protein L30 -0.0184884
RPS10 ribosomal protein S10 -0.018034
IFI6 interferon, alpha-inducible protein 6 -0.0178795
SMC4 structural maintenance of chromosomes 4 -0.0178474
S100A9 S100 calcium binding protein A9 -0.017791
RPL23 ribosomal protein L23 -0.0177145
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0172804
TPT1 tumor protein, translationally-controlled 1 -0.0171319
RPL13A ribosomal protein L13a -0.016728
RPLP1 ribosomal protein, large, P1 -0.0166357
RPS27A ribosomal protein S27a -0.0162378
ATAD2 ATPase family, AAA domain containing 2 -0.0160972
GNAS GNAS complex locus -0.0160956
RBM25 RNA binding motif protein 25 -0.0157815
LDHB lactate dehydrogenase B -0.0156652
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0153984
PNISR PNN-interacting serine/arginine-rich protein -0.0153119
RPS17 ribosomal protein S17 -0.0152505
NOP56 NOP56 ribonucleoprotein -0.0152005
ATP5F1B ATP synthase F1 subunit beta -0.0147856
DEK DEK proto-oncogene -0.0146639
DIAPH3 diaphanous-related formin 3 -0.0145257
IFITM3 interferon induced transmembrane protein 3 -0.0139176
RPS5 ribosomal protein S5 -0.0138466
ISG15 ISG15 ubiquitin-like modifier -0.0136423
MKI67 marker of proliferation Ki-67 -0.0135782
MTAP methylthioadenosine phosphorylase -0.0134241
RPL31 ribosomal protein L31 -0.0130149
RAB3IP RAB3A interacting protein -0.0129435
B2M beta-2-microglobulin -0.0128864
PABPN1 poly(A) binding protein, nuclear 1 -0.0127803
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0126311
RPL36AL ribosomal protein L36a-like -0.0125564
TTR transthyretin -0.0121936
CBX3 chromobox homolog 3 -0.0121473
PKM pyruvate kinase, muscle -0.0120679
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0119842
HMGB1 high mobility group box 1 -0.0119761
CENPF centromere protein F, 350/400kDa -0.0119051
TPI1 triosephosphate isomerase 1 -0.0118772
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0116091
IFITM1 interferon induced transmembrane protein 1 -0.0115846
PNN pinin, desmosome associated protein -0.0115141
RPS29 ribosomal protein S29 -0.0115028
HLA-C major histocompatibility complex, class I, C -0.0114822
NACA nascent polypeptide-associated complex alpha subunit -0.0114657
RPL35 ribosomal protein L35 -0.0112603
COX5A cytochrome c oxidase subunit Va -0.011185
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0111597
RPL37 ribosomal protein L37 -0.0111099
RPL7A ribosomal protein L7a -0.0111075
RPL22L1 ribosomal protein L22-like 1 -0.0109453
S100A2 S100 calcium binding protein A2 -0.0108935
ENO2 enolase 2 (gamma, neuronal) -0.0108297
RPS26 ribosomal protein S26 -0.010712
RPL38 ribosomal protein L38 -0.0106665
ADAR adenosine deaminase, RNA-specific -0.0106549
RPL28 ribosomal protein L28 -0.0106124
RRM1 ribonucleotide reductase M1 -0.010534
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0103836
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0103648
NFIA nuclear factor I/A -0.0103024
G0S2 G0/G1 switch 2 -0.0101319
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0100852
KIF20B kinesin family member 20B -0.0100543
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0100041
TUBA1B tubulin, alpha 1b -0.00995428
SNRPF small nuclear ribonucleoprotein polypeptide F -0.00992605
RPL7 ribosomal protein L7 -0.00989368
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.00981125
COX6C cytochrome c oxidase subunit VIc -0.00980823
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.00975992
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.00971576
UBL5 ubiquitin-like 5 -0.00958094