ULK-101_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.0428239
STC1 stanniocalcin 1 0.0379938
RORA RAR-related orphan receptor A 0.0370909
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0336936
SMOC1 SPARC related modular calcium binding 1 0.0316148
DOCK5 dedicator of cytokinesis 5 0.0315746
ST18 suppression of tumorigenicity 18, zinc finger 0.0295508
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0292557
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290592
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288846
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0258732
GRB10 growth factor receptor-bound protein 10 0.0256123
MCTP1 multiple C2 domains, transmembrane 1 0.0242081
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0231018
LCOR ligand dependent nuclear receptor corepressor 0.0229161
EGFR epidermal growth factor receptor 0.0226749
ZSWIM6 zinc finger, SWIM-type containing 6 0.0221838
DGKD diacylglycerol kinase, delta 130kDa 0.0215524
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0209788
APP amyloid beta (A4) precursor protein 0.0196981
AKAP13 A kinase (PRKA) anchor protein 13 0.0195257
ANKRD36C ankyrin repeat domain 36C 0.0193339
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0191321
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0190562
RNF144A ring finger protein 144A 0.0187704
USP34 ubiquitin specific peptidase 34 0.018712
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0184585
FNDC3A fibronectin type III domain containing 3A 0.018079
SETX senataxin 0.0179346
KIF26B kinesin family member 26B 0.0176624
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0175957
NBAS neuroblastoma amplified sequence 0.0175654
EFNA5 ephrin-A5 0.0175398
MSN moesin 0.0172009
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0171967
ASPH aspartate beta-hydroxylase 0.0169793
AHR aryl hydrocarbon receptor 0.0169357
BIRC6 baculoviral IAP repeat containing 6 0.0167822
HOMER1 homer scaffolding protein 1 0.0157523
TOP1 topoisomerase (DNA) I 0.0157233
EP300 E1A binding protein p300 0.0154806
GON4L gon-4-like (C. elegans) 0.0152849
CHD1 chromodomain helicase DNA binding protein 1 0.0150652
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0150289
TRIO trio Rho guanine nucleotide exchange factor 0.0147668
AGO2 argonaute RISC catalytic component 2 0.0147283
SNAP25 synaptosomal-associated protein, 25kDa 0.0147153
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0147011
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0145326
SVIL supervillin 0.0144834
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0143274
ARHGAP21 Rho GTPase activating protein 21 0.0143237
FBXO32 F-box protein 32 0.0139487
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.0139143
COPA coatomer protein complex, subunit alpha 0.0138797
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0138775
MBNL2 muscleblind-like splicing regulator 2 0.013729
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0137098
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0137055
SIK3 SIK family kinase 3 0.0136548
ARFGEF3 ARFGEF family member 3 0.0136404
CTBP2 C-terminal binding protein 2 0.0136242
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0136048
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0135573
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0134895
ZC3H11A zinc finger CCCH-type containing 11A 0.0134339
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0133135
SMC5 structural maintenance of chromosomes 5 0.0130606
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0129972
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0129431
NANOS1 nanos homolog 1 (Drosophila) 0.012929
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0129198
CERT1 ceramide transporter 1 0.0128393
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0128013
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0127891
SIK2 salt-inducible kinase 2 0.0126162
MPRIP myosin phosphatase Rho interacting protein 0.0125362
FNDC3B fibronectin type III domain containing 3B 0.0125067
CREBRF CREB3 regulatory factor 0.0124947
MYO6 myosin VI 0.0124735
SKI SKI proto-oncogene 0.0124729
CLTC clathrin, heavy chain (Hc) 0.0124376
FAM13A family with sequence similarity 13, member A 0.0123668
SCAF8 SR-related CTD-associated factor 8 0.0121393
FOCAD focadhesin 0.012105
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0120854
NF1 neurofibromin 1 0.0120043
TENT5A terminal nucleotidyltransferase 5A 0.0119077
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0118984
ETV6 ets variant 6 0.0118397
CHGB chromogranin B 0.0116504
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.011635
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0116104
ZNF451 zinc finger protein 451 0.0114568
RAB5A RAB5A, member RAS oncogene family 0.0114111
CYRIB CYFIP related Rac1 interactor B 0.0113559
ANKRD17 ankyrin repeat domain 17 0.0112852
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0112295
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0111122
LIN52 lin-52 DREAM MuvB core complex component 0.0111069

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.218952
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.148374
CALCA calcitonin-related polypeptide alpha -0.139773
FTL ferritin, light polypeptide -0.112689
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111538
RPS21 ribosomal protein S21 -0.0818635
NALF1 NALCN channel auxiliary factor 1 -0.0800927
PDE10A phosphodiesterase 10A -0.0759427
MT2A metallothionein 2A -0.0719195
ENO1 enolase 1, (alpha) -0.064357
RPS3 ribosomal protein S3 -0.0640122
RPL26 ribosomal protein L26 -0.0591932
RIMS2 regulating synaptic membrane exocytosis 2 -0.0574885
RPL8 ribosomal protein L8 -0.0568666
S100A9 S100 calcium binding protein A9 -0.0556066
IFI6 interferon, alpha-inducible protein 6 -0.0551258
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.055074
RPS6 ribosomal protein S6 -0.0550031
RPL37A ribosomal protein L37a -0.0546089
SNTG1 syntrophin, gamma 1 -0.054552
TMSB10 thymosin beta 10 -0.0543815
ATP5F1E ATP synthase F1 subunit epsilon -0.0531568
RPLP1 ribosomal protein, large, P1 -0.0521342
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0518008
PEG10 paternally expressed 10 -0.0500412
ISG15 ISG15 ubiquitin-like modifier -0.0498517
RPS8 ribosomal protein S8 -0.0482671
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0478798
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0478589
RPL23 ribosomal protein L23 -0.0465396
RPS19 ribosomal protein S19 -0.0456708
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0447938
TENM1 teneurin transmembrane protein 1 -0.0438209
ACTG1 actin gamma 1 -0.0437493
SYT1 synaptotagmin I -0.0430121
RPL37 ribosomal protein L37 -0.0425692
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0419942
RPL38 ribosomal protein L38 -0.0419086
VGF VGF nerve growth factor inducible -0.0415178
RPS16 ribosomal protein S16 -0.0400943
GNAS GNAS complex locus -0.0399781
RPL36 ribosomal protein L36 -0.0394851
CENPF centromere protein F, 350/400kDa -0.0391086
RPL32 ribosomal protein L32 -0.0388887
RPS5 ribosomal protein S5 -0.0388709
RPL11 ribosomal protein L11 -0.0383952
RPL35 ribosomal protein L35 -0.0380228
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0373026
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0371628
RPL7 ribosomal protein L7 -0.0368676
TPT1 tumor protein, translationally-controlled 1 -0.0360343
RPL30 ribosomal protein L30 -0.0357923
RPL19 ribosomal protein L19 -0.0357572
RPLP2 ribosomal protein, large, P2 -0.0349314
RNF213 ring finger protein 213 -0.0348867
H1-0 H1.0 linker histone -0.0347374
RPL36AL ribosomal protein L36a-like -0.0345782
B2M beta-2-microglobulin -0.0343709
LOC112694756 uncharaterized LOC112694756 -0.0343212
RPS29 ribosomal protein S29 -0.0340088
SASH1 SAM and SH3 domain containing 1 -0.0338896
RPS11 ribosomal protein S11 -0.0333649
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0333408
HMGB1 high mobility group box 1 -0.0332978
RBM25 RNA binding motif protein 25 -0.0330141
RPS27A ribosomal protein S27a -0.0328691
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0327816
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0327477
RPS12 ribosomal protein S12 -0.0323243
PFN1 profilin 1 -0.0321915
CNTNAP2 contactin associated protein-like 2 -0.0321318
RPS25 ribosomal protein S25 -0.0319716
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0317192
NAP1L1 nucleosome assembly protein 1-like 1 -0.0311063
COX6C cytochrome c oxidase subunit VIc -0.0307535
UBB ubiquitin B -0.0306438
RPL31 ribosomal protein L31 -0.0306135
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0303472
RPL12 ribosomal protein L12 -0.029764
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0297586
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0296868
RPL35A ribosomal protein L35a -0.0296234
EIF5B eukaryotic translation initiation factor 5B -0.0294182
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0293713
PKM pyruvate kinase, muscle -0.0292621
MKI67 marker of proliferation Ki-67 -0.0292488
TMSB4X thymosin beta 4, X-linked -0.0290074
RPLP0 ribosomal protein, large, P0 -0.028455
PABPN1 poly(A) binding protein, nuclear 1 -0.0284137
DEK DEK proto-oncogene -0.0282199
RPL34 ribosomal protein L34 -0.0279612
RPL7A ribosomal protein L7a -0.0279569
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0277085
IGFBP5 insulin-like growth factor binding protein 5 -0.0275452
PRRC2C proline-rich coiled-coil 2C -0.0275314
RPS23 ribosomal protein S23 -0.0273742
TUBB4B tubulin, beta 4B class IVb -0.0271687
SCG2 secretogranin II -0.0271001
TXNRD1 thioredoxin reductase 1 -0.0267945
RAD21 RAD21 homolog (S. pombe) -0.0262938