ULK-101_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0874582
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0869249
FMN1 formin 1 0.0816014
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0743329
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0669312
AKAP12 A kinase (PRKA) anchor protein 12 0.0632295
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0585497
LINGO2 leucine rich repeat and Ig domain containing 2 0.0561144
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.046414
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0455784
TXNRD1 thioredoxin reductase 1 0.0442729
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0403703
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0394243
FMNL2 formin-like 2 0.0368603
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0367473
SPAG9 sperm associated antigen 9 0.0359908
CD44 CD44 molecule (Indian blood group) 0.0342015
GOLGB1 golgin B1 0.0331165
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0324963
DST dystonin 0.0323172
JMJD1C jumonji domain containing 1C 0.0322124
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0321733
LAMP2 lysosomal-associated membrane protein 2 0.0319308
ASPH aspartate beta-hydroxylase 0.0317704
OXSR1 oxidative stress responsive 1 0.0315924
HELZ helicase with zinc finger 0.0304054
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0298891
GOLGA4 golgin A4 0.029715
AKAP13 A kinase (PRKA) anchor protein 13 0.0281988
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0281962
ZCCHC7 zinc finger, CCHC domain containing 7 0.0280492
KDM4C lysine (K)-specific demethylase 4C 0.0280152
BIRC6 baculoviral IAP repeat containing 6 0.0279565
GLS2 glutaminase 2 (liver, mitochondrial) 0.0276831
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0274866
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0274754
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0270415
CHD1 chromodomain helicase DNA binding protein 1 0.0270174
PRELID2 PRELI domain containing 2 0.0265784
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0265018
NAV2 neuron navigator 2 0.0260747
ELL2 elongation factor, RNA polymerase II, 2 0.0258309
FER fer (fps/fes related) tyrosine kinase 0.0256521
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0249594
MSN moesin 0.0245788
ERRFI1 ERBB receptor feedback inhibitor 1 0.0243431
MACF1 microtubule-actin crosslinking factor 1 0.0242145
ZFAND3 zinc finger, AN1-type domain 3 0.0241153
CANX calnexin 0.0241101
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0239413
PTPRG protein tyrosine phosphatase, receptor type, G 0.0236265
KMT2E lysine (K)-specific methyltransferase 2E 0.0235992
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0235955
SEC24A SEC24 family member A 0.0235782
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0234681
FLNB filamin B, beta 0.0232482
USP9X ubiquitin specific peptidase 9, X-linked 0.0230431
PUM1 pumilio RNA-binding family member 1 0.0230401
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0220884
SQSTM1 sequestosome 1 0.0219678
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0216788
CLINT1 clathrin interactor 1 0.0215102
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0213231
VGLL4 vestigial-like family member 4 0.0212667
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0212637
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0208023
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0207655
MED13L mediator complex subunit 13-like 0.0207584
CXCL8 chemokine (C-X-C motif) ligand 8 0.0204479
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0204034
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0198705
POU2F1 POU class 2 homeobox 1 0.0195962
RNF145 ring finger protein 145 0.0194778
NCKAP1 NCK-associated protein 1 0.019379
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0193648
ARB2A ARB2 cotranscriptional regulator A 0.0193388
KTN1 kinectin 1 (kinesin receptor) 0.0193063
RB1CC1 RB1-inducible coiled-coil 1 0.0191767
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0191663
FRMD5 FERM domain containing 5 0.0191558
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.019134
ANXA2 annexin A2 0.0190699
PCBP2 poly(rC) binding protein 2 0.0190411
MYO9B myosin IXB 0.0189012
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0188633
LPP LIM domain containing preferred translocation partner in lipoma 0.0187359
UBA6 ubiquitin-like modifier activating enzyme 6 0.0186672
KDM3A lysine (K)-specific demethylase 3A 0.0186082
SETX senataxin 0.0185699
IQGAP1 IQ motif containing GTPase activating protein 1 0.0185122
TJP1 tight junction protein 1 0.0184786
NCOA3 nuclear receptor coactivator 3 0.0184697
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0183867
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0183219
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.018321
NAMPT nicotinamide phosphoribosyltransferase 0.018268
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0182553
ATXN1 ataxin 1 0.0182468
DLG1 discs, large homolog 1 (Drosophila) 0.0182237
PTPRM protein tyrosine phosphatase, receptor type, M 0.0181033

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.157342
NLGN1 neuroligin 1 -0.111934
VIM vimentin -0.104974
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0761859
LSAMP limbic system-associated membrane protein -0.0719062
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.064682
RPS3 ribosomal protein S3 -0.0599233
TMSB10 thymosin beta 10 -0.0500757
RPS6 ribosomal protein S6 -0.0485125
PTMA prothymosin, alpha -0.0473967
RPL35A ribosomal protein L35a -0.0466861
FTL ferritin, light polypeptide -0.0461638
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0383923
POTEF POTE ankyrin domain family, member F -0.0369212
IFI6 interferon, alpha-inducible protein 6 -0.0333779
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0333216
RAD51B RAD51 paralog B -0.0287268
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0281493
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0275616
CTSD cathepsin D -0.0271666
FRMD4A FERM domain containing 4A -0.0266192
TPI1 triosephosphate isomerase 1 -0.026003
RPL37A ribosomal protein L37a -0.0259219
PMEL premelanosome protein -0.0251716
ACTG1 actin gamma 1 -0.024303
RPS17 ribosomal protein S17 -0.0237224
VDAC1 voltage-dependent anion channel 1 -0.0235956
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -0.0233084
S100A9 S100 calcium binding protein A9 -0.0228203
PRAME preferentially expressed antigen in melanoma -0.0226766
RPS21 ribosomal protein S21 -0.0226227
LITAF lipopolysaccharide-induced TNF factor -0.0223956
MKI67 marker of proliferation Ki-67 -0.022232
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.022226
RPL23 ribosomal protein L23 -0.0220618
CADM1 cell adhesion molecule 1 -0.0215032
MT2A metallothionein 2A -0.021328
RPL36A ribosomal protein L36a -0.0212595
HLA-B major histocompatibility complex, class I, B -0.0210061
RPL38 ribosomal protein L38 -0.0208285
RPS13 ribosomal protein S13 -0.0205696
S100A10 S100 calcium binding protein A10 -0.0202256
RPS8 ribosomal protein S8 -0.020125
RPL9 ribosomal protein L9 -0.0200996
RPS27A ribosomal protein S27a -0.0197107
SMC4 structural maintenance of chromosomes 4 -0.0190606
TNNC1 troponin C type 1 (slow) -0.017757
TPM4 tropomyosin 4 -0.01743
TRIQK triple QxxK/R motif containing -0.0170263
RPL11 ribosomal protein L11 -0.0169802
RPS12 ribosomal protein S12 -0.0167405
LRMDA leucine rich melanocyte differentiation associated -0.0167001
RPL19 ribosomal protein L19 -0.0164854
DEK DEK proto-oncogene -0.0161975
RPL26 ribosomal protein L26 -0.0161933
WWOX WW domain containing oxidoreductase -0.016125
RPL31 ribosomal protein L31 -0.0160769
RPL37 ribosomal protein L37 -0.0160478
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0159221
RPLP1 ribosomal protein, large, P1 -0.0159193
CCND1 cyclin D1 -0.0157929
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0157718
ENO2 enolase 2 (gamma, neuronal) -0.0155495
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0154479
RPS29 ribosomal protein S29 -0.0152629
EIF5B eukaryotic translation initiation factor 5B -0.015259
HSPB1 heat shock 27kDa protein 1 -0.0152556
SOX5 SRY (sex determining region Y)-box 5 -0.0150703
PGK1 phosphoglycerate kinase 1 -0.0149286
ACLY ATP citrate lyase -0.0145103
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0144234
RPLP2 ribosomal protein, large, P2 -0.0143921
RPL12 ribosomal protein L12 -0.0142854
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0142763
EIF1 eukaryotic translation initiation factor 1 -0.0142646
LDHA lactate dehydrogenase A -0.0141588
S100A6 S100 calcium binding protein A6 -0.0140981
DSTN destrin (actin depolymerizing factor) -0.0139886
RPS19 ribosomal protein S19 -0.0137975
CENPE centromere protein E, 312kDa -0.0137433
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0135797
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0135385
ADGRG1 adhesion G protein-coupled receptor G1 -0.013491
RPL36 ribosomal protein L36 -0.0134797
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.013374
SNU13 small nuclear ribonucleoprotein 13 -0.0133627
PLAT plasminogen activator, tissue -0.0132354
RAN RAN, member RAS oncogene family -0.0131952
UBB ubiquitin B -0.0131437
IFITM3 interferon induced transmembrane protein 3 -0.0130887
TPT1 tumor protein, translationally-controlled 1 -0.0130868
RRBP1 ribosome binding protein 1 -0.0130606
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0127679
RPL35 ribosomal protein L35 -0.0126543
RPS5 ribosomal protein S5 -0.0126127
RPL34 ribosomal protein L34 -0.0124225
TUBB4B tubulin, beta 4B class IVb -0.012277
MFSD12 major facilitator superfamily domain containing 12 -0.0122659
SFTPA2 surfactant protein A2 -0.0122411
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0120571