ULK-101_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105031
ZSWIM6 zinc finger, SWIM-type containing 6 0.0818175
DTNA dystrobrevin, alpha 0.0708376
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0684753
AKAP12 A kinase (PRKA) anchor protein 12 0.0625241
SQSTM1 sequestosome 1 0.061315
MT2A metallothionein 2A 0.0591604
BIRC3 baculoviral IAP repeat containing 3 0.0540662
INTS6 integrator complex subunit 6 0.0527091
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0524114
CD44 CD44 molecule (Indian blood group) 0.0479819
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0470606
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.044955
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.04469
GLS2 glutaminase 2 (liver, mitochondrial) 0.0430168
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.042564
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0425131
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0423872
HDAC9 histone deacetylase 9 0.0406685
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0401352
RPLP1 ribosomal protein, large, P1 0.0383721
UBAP2 ubiquitin associated protein 2 0.0377913
VMP1 vacuole membrane protein 1 0.0363497
FMNL2 formin-like 2 0.0362624
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347251
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0344431
SH3KBP1 SH3-domain kinase binding protein 1 0.0343707
TUT7 terminal uridylyl transferase 7 0.034019
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0323562
SPIDR scaffolding protein involved in DNA repair 0.0314871
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0313976
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0309846
C6ORF62 chromosome 6 open reading frame 62 0.0304665
FNIP1 folliculin interacting protein 1 0.0304284
MYO10 myosin X 0.0303993
MCTP1 multiple C2 domains, transmembrane 1 0.0302816
AFF4 AF4/FMR2 family, member 4 0.0298585
CEMIP2 cell migration inducing hyaluronidase 2 0.0296703
NGLY1 N-glycanase 1 0.0293098
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0291885
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0288854
PCNX4 pecanex 4 0.0282165
YAP1 Yes-associated protein 1 0.0281967
PSEN1 presenilin 1 0.0281848
MYO9A myosin IXA 0.0280702
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0280437
HOMER1 homer scaffolding protein 1 0.0276268
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271686
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0271412
AHNAK AHNAK nucleoprotein 0.0270605
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0268816
TTC3 tetratricopeptide repeat domain 3 0.0266534
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0262937
UBE4B ubiquitination factor E4B 0.0259635
IRAK2 interleukin-1 receptor-associated kinase 2 0.0259275
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0259038
MCL1 myeloid cell leukemia 1 0.0257384
NPR2 natriuretic peptide receptor 2 0.0257081
GOLGB1 golgin B1 0.0256715
TRAPPC9 trafficking protein particle complex 9 0.0256337
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0255704
TPST1 tyrosylprotein sulfotransferase 1 0.0255331
TRA2A transformer 2 alpha homolog (Drosophila) 0.025481
FBXL20 F-box and leucine-rich repeat protein 20 0.0254611
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0251626
ARL13B ADP-ribosylation factor-like 13B 0.0251617
OXSR1 oxidative stress responsive 1 0.0249448
DMXL1 Dmx-like 1 0.0247178
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0246988
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0246796
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0245332
TTC17 tetratricopeptide repeat domain 17 0.024512
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0243356
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0242081
HEATR5A HEAT repeat containing 5A 0.0241385
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0237664
MACF1 microtubule-actin crosslinking factor 1 0.0236804
HSPA1A heat shock 70kDa protein 1A 0.0236594
S100A9 S100 calcium binding protein A9 0.0234942
ALCAM activated leukocyte cell adhesion molecule 0.0233343
MAST4 microtubule associated serine/threonine kinase family member 4 0.0232713
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0231736
HMGA2 high mobility group AT-hook 2 0.0228075
ELL2 elongation factor, RNA polymerase II, 2 0.0227404
AOPEP aminopeptidase O (putative) 0.0227041
DNER delta/notch-like EGF repeat containing 0.0226669
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0226556
PNN pinin, desmosome associated protein 0.0225841
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0224662
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.022455
RAI14 retinoic acid induced 14 0.022351
ZEB1 zinc finger E-box binding homeobox 1 0.0223382
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.0223286
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.022326
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0221158
ZSWIM4 zinc finger, SWIM-type containing 4 0.0221125
RASA2 RAS p21 protein activator 2 0.0221037
IFRD1 interferon-related developmental regulator 1 0.0220279
AHR aryl hydrocarbon receptor 0.0218912
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0217372

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209446
LDHA lactate dehydrogenase A -0.0827695
IGFBP3 insulin-like growth factor binding protein 3 -0.0718945
TMSB10 thymosin beta 10 -0.0670494
TPT1 tumor protein, translationally-controlled 1 -0.0664459
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0558227
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0503035
CENPF centromere protein F, 350/400kDa -0.0489655
TAS2R14 taste receptor, type 2, member 14 -0.0462931
RTN4 reticulon 4 -0.0457388
RBM39 RNA binding motif protein 39 -0.0453456
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0447891
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0445908
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0431196
ZBTB20 zinc finger and BTB domain containing 20 -0.0415675
ATF7IP activating transcription factor 7 interacting protein -0.0412178
RORA RAR-related orphan receptor A -0.0412124
GNAS GNAS complex locus -0.0404619
ANKRD28 ankyrin repeat domain 28 -0.0386878
DST dystonin -0.0381883
MKI67 marker of proliferation Ki-67 -0.0378887
PFN1 profilin 1 -0.037104
NCOR1 nuclear receptor corepressor 1 -0.0362845
OSMR oncostatin M receptor -0.0362828
GOLGA4 golgin A4 -0.0362138
TPX2 TPX2, microtubule-associated -0.0361737
CSDE1 cold shock domain containing E1, RNA-binding -0.0360919
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0355702
TPM4 tropomyosin 4 -0.0350062
DEK DEK proto-oncogene -0.0344256
BIRC6 baculoviral IAP repeat containing 6 -0.0335003
DIAPH3 diaphanous-related formin 3 -0.0332777
YBX3 Y box binding protein 3 -0.0332726
VIM vimentin -0.0329727
SMC4 structural maintenance of chromosomes 4 -0.0327979
ANXA2 annexin A2 -0.0326188
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0322488
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0321887
ACTG1 actin gamma 1 -0.032109
ATXN1 ataxin 1 -0.0317097
FMN1 formin 1 -0.0306091
POTEF POTE ankyrin domain family, member F -0.0303993
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0302216
TCF12 transcription factor 12 -0.0298673
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0294598
FBXL17 F-box and leucine-rich repeat protein 17 -0.0293284
TMEM14B transmembrane protein 14B -0.0290492
BHLHE40 basic helix-loop-helix family, member e40 -0.0290209
PRH1 proline-rich protein HaeIII subfamily 1 -0.0289409
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0288332
RBM25 RNA binding motif protein 25 -0.0287488
FTH1 ferritin, heavy polypeptide 1 -0.02853
NALCN sodium leak channel, non selective -0.0281121
DERA deoxyribose-phosphate aldolase (putative) -0.028068
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0280493
H3-3B H3.3 histone B -0.0280174
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0277652
IER3 immediate early response 3 -0.0276474
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0275158
KDM5A lysine (K)-specific demethylase 5A -0.0273696
PKM pyruvate kinase, muscle -0.0270824
NUP58 nucleoporin 58 -0.0264513
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0252208
NF1 neurofibromin 1 -0.0251666
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0251386
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.024972
RAB5A RAB5A, member RAS oncogene family -0.02493
RPL9 ribosomal protein L9 -0.024337
SETD5 SET domain containing 5 -0.0241862
RAD51B RAD51 paralog B -0.0240842
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0238548
ZFHX3 zinc finger homeobox 3 -0.0237453
RNF213 ring finger protein 213 -0.0236761
BCAR3 breast cancer anti-estrogen resistance 3 -0.0236372
ENO1 enolase 1, (alpha) -0.0233374
PTPRG protein tyrosine phosphatase, receptor type, G -0.0231758
EP400 E1A binding protein p400 -0.023172
EXOC4 exocyst complex component 4 -0.0231332
UBAC2 UBA domain containing 2 -0.0230917
TMEM123 transmembrane protein 123 -0.023003
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.022936
DLG1 discs, large homolog 1 (Drosophila) -0.0227587
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0227058
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0226627
SCLT1 sodium channel and clathrin linker 1 -0.0226497
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0226297
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0225934
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0225767
CKAP5 cytoskeleton associated protein 5 -0.0225541
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0225101
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0224836
CCAR1 cell division cycle and apoptosis regulator 1 -0.0224449
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.022403
UBB ubiquitin B -0.022221
TPI1 triosephosphate isomerase 1 -0.0222048
NDRG1 N-myc downstream regulated 1 -0.0221369
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0220541
RPS25 ribosomal protein S25 -0.0219691
NSD1 nuclear receptor binding SET domain protein 1 -0.0217871
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0217631