ULK-101_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.163277
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.145413
HMGA2 high mobility group AT-hook 2 0.137955
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.107576
SQSTM1 sequestosome 1 0.102891
EFNA5 ephrin-A5 0.0744804
CANX calnexin 0.0650805
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0623648
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0590036
ERRFI1 ERBB receptor feedback inhibitor 1 0.0564653
ZSWIM6 zinc finger, SWIM-type containing 6 0.0524359
PLIN2 perilipin 2 0.0512278
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0484549
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0453931
RAI14 retinoic acid induced 14 0.0423521
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.040913
HIPK2 homeodomain interacting protein kinase 2 0.040677
AKAP12 A kinase (PRKA) anchor protein 12 0.0400782
ZCCHC7 zinc finger, CCHC domain containing 7 0.0391626
SOD2 superoxide dismutase 2, mitochondrial 0.0386697
CXCL8 chemokine (C-X-C motif) ligand 8 0.0384603
NRG1 neuregulin 1 0.0377806
INTS6 integrator complex subunit 6 0.0369038
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367215
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0355356
EGFR epidermal growth factor receptor 0.0348692
FNIP1 folliculin interacting protein 1 0.032613
PDIA4 protein disulfide isomerase family A, member 4 0.0322956
GLIS3 GLIS family zinc finger 3 0.0318829
HDLBP high density lipoprotein binding protein 0.0287725
CTBP2 C-terminal binding protein 2 0.028748
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0283476
RASAL2 RAS protein activator like 2 0.0283077
LIMCH1 LIM and calponin homology domains 1 0.0280071
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.0267103
AEBP2 AE binding protein 2 0.0265082
CLIP2 CAP-GLY domain containing linker protein 2 0.0258403
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0257402
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0255047
TTC3 tetratricopeptide repeat domain 3 0.0254865
KLHL24 kelch-like family member 24 0.0251304
BIRC6 baculoviral IAP repeat containing 6 0.0240632
DENND4C DENN/MADD domain containing 4C 0.0238073
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0235949
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0233432
SLC35F3 solute carrier family 35, member F3 0.0227549
MTSS1 metastasis suppressor 1 0.0227128
ELL2 elongation factor, RNA polymerase II, 2 0.0224661
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0220265
STK10 serine/threonine kinase 10 0.0219924
ZEB2 zinc finger E-box binding homeobox 2 0.0219894
DENND5B DENN/MADD domain containing 5B 0.0219694
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0219418
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0216741
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.021531
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0213645
SIRT1 sirtuin 1 0.0213336
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0212087
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0211605
SPDYA speedy/RINGO cell cycle regulator family member A 0.0211408
SEC31A SEC31 homolog A (S. cerevisiae) 0.0204722
GPC6 glypican 6 0.0203512
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0202615
LTBP1 latent transforming growth factor beta binding protein 1 0.0200409
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.01998
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0198686
AHNAK AHNAK nucleoprotein 0.0197355
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0196943
KDM4C lysine (K)-specific demethylase 4C 0.0195717
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0195629
ANKRD28 ankyrin repeat domain 28 0.0193761
SPIRE1 spire-type actin nucleation factor 1 0.0192495
ARHGAP35 Rho GTPase activating protein 35 0.0187714
GRB10 growth factor receptor-bound protein 10 0.0185557
LYST lysosomal trafficking regulator 0.0180591
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.018031
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0179989
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0178566
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0177474
PIBF1 progesterone immunomodulatory binding factor 1 0.0175149
ARID4B AT rich interactive domain 4B (RBP1-like) 0.017376
TNS3 tensin 3 0.0173442
FBXW11 F-box and WD repeat domain containing 11 0.0173035
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0171182
DOCK5 dedicator of cytokinesis 5 0.0171136
ATXN2 ataxin 2 0.0171085
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0170155
USP34 ubiquitin specific peptidase 34 0.0169622
PICALM phosphatidylinositol binding clathrin assembly protein 0.0169581
MRPS6 mitochondrial ribosomal protein S6 0.0167425
AHI1 Abelson helper integration site 1 0.0167144
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0166361
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0166148
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.0164404
ZNF432 zinc finger protein 432 0.0164082
MACF1 microtubule-actin crosslinking factor 1 0.0163735
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0163408
VAC14 Vac14 homolog (S. cerevisiae) 0.0159631
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0159605
FAT1 FAT atypical cadherin 1 0.0159474

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.336172
MT2A metallothionein 2A -0.185423
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.120549
IFI27 interferon, alpha-inducible protein 27 -0.114213
TMSB10 thymosin beta 10 -0.111531
S100A6 S100 calcium binding protein A6 -0.0907833
PTMA prothymosin, alpha -0.0902641
NDRG1 N-myc downstream regulated 1 -0.0892114
NAMPT nicotinamide phosphoribosyltransferase -0.0882242
HLA-B major histocompatibility complex, class I, B -0.0880116
CENPF centromere protein F, 350/400kDa -0.0876611
FTL ferritin, light polypeptide -0.0837716
MAP1B microtubule-associated protein 1B -0.0799018
B2M beta-2-microglobulin -0.0788565
PRRC2C proline-rich coiled-coil 2C -0.0770671
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0657062
RPS6 ribosomal protein S6 -0.0634605
MKI67 marker of proliferation Ki-67 -0.0614157
POTEF POTE ankyrin domain family, member F -0.0613964
VCL vinculin -0.059093
TPI1 triosephosphate isomerase 1 -0.0588846
TMEM156 transmembrane protein 156 -0.0552079
TXNIP thioredoxin interacting protein -0.0550047
VEGFA vascular endothelial growth factor A -0.0537518
TPT1 tumor protein, translationally-controlled 1 -0.052623
LOC102724023 ES1 protein homolog, mitochondrial -0.0525616
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0512458
RPS21 ribosomal protein S21 -0.0507031
PKM pyruvate kinase, muscle -0.0499967
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0491856
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0486476
RPL9 ribosomal protein L9 -0.047629
RTN4 reticulon 4 -0.0474871
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0467571
RPL35A ribosomal protein L35a -0.046531
RPL37A ribosomal protein L37a -0.0447526
HMGA1 high mobility group AT-hook 1 -0.0444824
LMNA lamin A/C -0.043651
RPS19 ribosomal protein S19 -0.0434378
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0428523
RBM39 RNA binding motif protein 39 -0.0424417
LY6E lymphocyte antigen 6 complex, locus E -0.0414165
TOP2A topoisomerase (DNA) II alpha 170kDa -0.041038
RPS12 ribosomal protein S12 -0.040947
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0403219
ETV1 ets variant 1 -0.0399464
IFI6 interferon, alpha-inducible protein 6 -0.0378926
EGR1 early growth response 1 -0.0375704
ENO2 enolase 2 (gamma, neuronal) -0.0370346
VIM vimentin -0.0368359
ZNF292 zinc finger protein 292 -0.0367952
ACTG1 actin gamma 1 -0.0358143
DUSP5 dual specificity phosphatase 5 -0.0351636
RPS29 ribosomal protein S29 -0.034488
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0341109
RPL26 ribosomal protein L26 -0.0340832
NRP1 neuropilin 1 -0.034027
MYH9 myosin, heavy chain 9, non-muscle -0.0337187
RPL11 ribosomal protein L11 -0.0334502
S100A9 S100 calcium binding protein A9 -0.0332996
RPL38 ribosomal protein L38 -0.0332441
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0324365
RPL12 ribosomal protein L12 -0.0324046
RPL19 ribosomal protein L19 -0.0316463
EIF1 eukaryotic translation initiation factor 1 -0.0315597
RPL28 ribosomal protein L28 -0.0314993
MT1X metallothionein 1X -0.031469
ANKRD11 ankyrin repeat domain 11 -0.0313546
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0310467
CAPN2 calpain 2, (m/II) large subunit -0.0310183
KLHL5 kelch-like family member 5 -0.0309845
RPS3 ribosomal protein S3 -0.0308567
HDGF hepatoma-derived growth factor -0.0306051
RPL31 ribosomal protein L31 -0.0305274
EIF5B eukaryotic translation initiation factor 5B -0.0302693
RBM25 RNA binding motif protein 25 -0.0301133
RPS8 ribosomal protein S8 -0.0299316
RPS23 ribosomal protein S23 -0.0298609
ANLN anillin, actin binding protein -0.0297924
PLAUR plasminogen activator, urokinase receptor -0.0289501
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0288172
PTK2 protein tyrosine kinase 2 -0.0284648
MIS18BP1 MIS18 binding protein 1 -0.0283396
PFN1 profilin 1 -0.0282746
RPL8 ribosomal protein L8 -0.0275591
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0272601
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0271872
RPL30 ribosomal protein L30 -0.027157
SEPTIN7 septin 7 -0.0271154
IER3 immediate early response 3 -0.0270842
ACTN4 actinin, alpha 4 -0.0267937
RPS27A ribosomal protein S27a -0.026482
SRRM2 serine/arginine repetitive matrix 2 -0.026394
NAP1L1 nucleosome assembly protein 1-like 1 -0.0263781
UGCG UDP-glucose ceramide glucosyltransferase -0.0263061
CCNL1 cyclin L1 -0.0261893
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0261566
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0258835
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0258665
RNF213 ring finger protein 213 -0.0256691