ULK-101_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ULK-101 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ULK-101_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.151489
EGFR epidermal growth factor receptor 0.131726
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.120344
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0849632
LAMA4 laminin, alpha 4 0.0792856
LMO7 LIM domain 7 0.0784436
HMGA2 high mobility group AT-hook 2 0.0737762
BIRC3 baculoviral IAP repeat containing 3 0.0688624
LAMC2 laminin, gamma 2 0.0687018
SNX9 sorting nexin 9 0.0681849
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0590692
RCOR1 REST corepressor 1 0.0580025
PLAUR plasminogen activator, urokinase receptor 0.0548511
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0513817
USP9X ubiquitin specific peptidase 9, X-linked 0.0456959
NCEH1 neutral cholesterol ester hydrolase 1 0.0456591
PDE4B phosphodiesterase 4B, cAMP-specific 0.0442338
AHNAK AHNAK nucleoprotein 0.0434783
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.042385
FAT1 FAT atypical cadherin 1 0.0420146
AREG amphiregulin 0.0406724
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0395091
DSPP dentin sialophosphoprotein 0.0389691
ITPKC inositol-trisphosphate 3-kinase C 0.0381713
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.037792
ATXN1 ataxin 1 0.0371834
FOSL1 FOS-like antigen 1 0.03635
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0361923
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0360797
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0360425
EEF2 eukaryotic translation elongation factor 2 0.0352698
MYO5B myosin VB 0.0347109
EZR ezrin 0.0346847
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0343967
SGMS2 sphingomyelin synthase 2 0.034254
OSBPL10 oxysterol binding protein-like 10 0.033214
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0326111
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.031221
CCSER1 coiled-coil serine-rich protein 1 0.0311023
FHL2 four and a half LIM domains 2 0.0310212
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0308216
SMAD3 SMAD family member 3 0.0305098
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0299154
SMYD3 SET and MYND domain containing 3 0.0295539
KLF6 Kruppel-like factor 6 0.0292768
ARL5B ADP-ribosylation factor-like 5B 0.0291964
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0291248
GCLC glutamate-cysteine ligase, catalytic subunit 0.0286196
NUP50 nucleoporin 50kDa 0.0274748
ITPRID2 ITPR interacting domain containing 2 0.0265186
FERMT1 fermitin family member 1 0.026184
TPM3 tropomyosin 3 0.0258955
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0257672
NAV2 neuron navigator 2 0.02574
CENPF centromere protein F, 350/400kDa 0.0253693
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.0252355
VMP1 vacuole membrane protein 1 0.0247135
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0246513
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0245464
LDHA lactate dehydrogenase A 0.0241581
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0241385
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0241163
ITGA6 integrin, alpha 6 0.0240595
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0239336
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0238606
JARID2 jumonji, AT rich interactive domain 2 0.0233986
ESYT2 extended synaptotagmin-like protein 2 0.0233133
PCBP2 poly(rC) binding protein 2 0.0230352
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0229675
SVIL supervillin 0.0229558
CDCP1 CUB domain containing protein 1 0.0229409
KIAA0040 KIAA0040 0.0228894
RNASEH2A ribonuclease H2, subunit A 0.0223931
SCFD1 sec1 family domain containing 1 0.0223742
ANXA1 annexin A1 0.0223617
SERBP1 SERPINE1 mRNA binding protein 1 0.0219489
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0219267
ABR active BCR-related 0.0218929
SH3RF2 SH3 domain containing ring finger 2 0.0215516
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0213027
FOXO1 forkhead box O1 0.0211658
DPY19L1 dpy-19-like 1 (C. elegans) 0.0210102
OSBPL8 oxysterol binding protein-like 8 0.0207835
AGTPBP1 ATP/GTP binding protein 1 0.020528
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0203443
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0203043
CD83 CD83 molecule 0.0202621
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0201778
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0199094
TSC22D1 TSC22 domain family, member 1 0.019694
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.019595
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.019472
EREG epiregulin 0.019231
PTBP3 polypyrimidine tract binding protein 3 0.0191331
HSPA8 heat shock 70kDa protein 8 0.0191258
DIAPH3 diaphanous-related formin 3 0.0191026
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0189462
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187695
USP47 ubiquitin specific peptidase 47 0.0187263
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0186649

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.232035
TPT1 tumor protein, translationally-controlled 1 -0.14596
RPL35A ribosomal protein L35a -0.139686
RPL37A ribosomal protein L37a -0.117711
RPS6 ribosomal protein S6 -0.103761
RPS29 ribosomal protein S29 -0.0823196
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0742527
RPL34 ribosomal protein L34 -0.0726529
TMSB10 thymosin beta 10 -0.0639128
RPS8 ribosomal protein S8 -0.063355
RPLP2 ribosomal protein, large, P2 -0.0632814
ACTG1 actin gamma 1 -0.0621341
RPL31 ribosomal protein L31 -0.0619234
RPL9 ribosomal protein L9 -0.0602718
RPS12 ribosomal protein S12 -0.0601257
RPS25 ribosomal protein S25 -0.0570078
RPLP1 ribosomal protein, large, P1 -0.0554983
RPS24 ribosomal protein S24 -0.0542139
RPS27A ribosomal protein S27a -0.0528543
RPL7A ribosomal protein L7a -0.0520928
VCL vinculin -0.0512782
RPL13A ribosomal protein L13a -0.0481799
RPS3 ribosomal protein S3 -0.0466612
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0466301
RPL38 ribosomal protein L38 -0.0466076
FTL ferritin, light polypeptide -0.0450334
HLA-B major histocompatibility complex, class I, B -0.0449354
RPL11 ribosomal protein L11 -0.0447049
HDAC2 histone deacetylase 2 -0.041981
RPS13 ribosomal protein S13 -0.0414656
FHIT fragile histidine triad -0.0399201
RPS17 ribosomal protein S17 -0.0391448
IER3 immediate early response 3 -0.0384549
VIM vimentin -0.0377048
RPS21 ribosomal protein S21 -0.0371291
RPS14 ribosomal protein S14 -0.0359189
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0352239
RPL26 ribosomal protein L26 -0.0342835
NAP1L1 nucleosome assembly protein 1-like 1 -0.0340366
SETD5 SET domain containing 5 -0.0328289
RPL36 ribosomal protein L36 -0.0324439
EIF1 eukaryotic translation initiation factor 1 -0.0321186
RPS19 ribosomal protein S19 -0.0306648
CUX1 cut-like homeobox 1 -0.0306434
RPL23 ribosomal protein L23 -0.0299135
RPL36A ribosomal protein L36a -0.0298366
RPS23 ribosomal protein S23 -0.0281144
ANKRD11 ankyrin repeat domain 11 -0.0273047
RPS15 ribosomal protein S15 -0.0267201
CALR calreticulin -0.0266432
RPL28 ribosomal protein L28 -0.0266062
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0262357
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0261779
RPS10 ribosomal protein S10 -0.0260433
HLA-A major histocompatibility complex, class I, A -0.0258336
NACA nascent polypeptide-associated complex alpha subunit -0.0258145
SRSF11 serine/arginine-rich splicing factor 11 -0.0256437
RPS11 ribosomal protein S11 -0.025569
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0248803
H3-3B H3.3 histone B -0.0245973
RPL27A ribosomal protein L27a -0.0244374
RPS16 ribosomal protein S16 -0.0241348
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0238353
PNISR PNN-interacting serine/arginine-rich protein -0.023596
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0231624
RPL37 ribosomal protein L37 -0.023045
RPL32 ribosomal protein L32 -0.0230278
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0228292
S100A6 S100 calcium binding protein A6 -0.0227421
RPS5 ribosomal protein S5 -0.0226997
EIF5B eukaryotic translation initiation factor 5B -0.0225816
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0223588
RPS27 ribosomal protein S27 -0.0222876
RPS20 ribosomal protein S20 -0.0222226
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0220062
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0212625
RAB1A RAB1A, member RAS oncogene family -0.0211736
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0208656
LAMB3 laminin, beta 3 -0.0208076
OFD1 oral-facial-digital syndrome 1 -0.0205592
RAD51B RAD51 paralog B -0.0205575
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0205463
CD36 CD36 molecule (thrombospondin receptor) -0.0203636
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0201712
RPL19 ribosomal protein L19 -0.0201178
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0199314
GARS1 glycyl-tRNA synthetase 1 -0.0195484
AOPEP aminopeptidase O (putative) -0.0194485
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0193187
NKTR natural killer cell triggering receptor -0.0192674
RPL12 ribosomal protein L12 -0.0188737
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0186919
RBM39 RNA binding motif protein 39 -0.0183509
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0183267
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0181194
RPL15 ribosomal protein L15 -0.0180943
KPNB1 karyopherin (importin) beta 1 -0.0180259
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0178563
TBC1D22A TBC1 domain family, member 22A -0.0176765
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0176289