| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ULK-101 perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ULK-101_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.171356 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.12493 |
| ASPH | aspartate beta-hydroxylase | 0.116638 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.11008 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0991196 |
| INTS6 | integrator complex subunit 6 | 0.081595 |
| WWOX | WW domain containing oxidoreductase | 0.0771954 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.068099 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0650957 |
| NAV2 | neuron navigator 2 | 0.0645084 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0641709 |
| SYT1 | synaptotagmin I | 0.0622675 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0577597 |
| DST | dystonin | 0.0556971 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0554061 |
| LMO7 | LIM domain 7 | 0.0535191 |
| SMAD3 | SMAD family member 3 | 0.04972 |
| ENO1 | enolase 1, (alpha) | 0.0491143 |
| CDK6 | cyclin-dependent kinase 6 | 0.0486454 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0485884 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0483611 |
| RPS12 | ribosomal protein S12 | 0.0469789 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0457953 |
| DUSP6 | dual specificity phosphatase 6 | 0.0455348 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0452526 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0449768 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0444188 |
| SPATA13 | spermatogenesis associated 13 | 0.0426933 |
| SLC38A2 | solute carrier family 38, member 2 | 0.041597 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0415761 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0403733 |
| YAP1 | Yes-associated protein 1 | 0.0402211 |
| SERINC5 | serine incorporator 5 | 0.0399744 |
| CCND1 | cyclin D1 | 0.0397083 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0391476 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0391353 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.037756 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0374896 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0374317 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0368531 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0365354 |
| RPS8 | ribosomal protein S8 | 0.0357114 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0354202 |
| FRMD5 | FERM domain containing 5 | 0.0351783 |
| MYO1E | myosin IE | 0.0339872 |
| EZR | ezrin | 0.0338422 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0336547 |
| EGFR | epidermal growth factor receptor | 0.0332133 |
| GSPT1 | G1 to S phase transition 1 | 0.0328321 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0326935 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0325327 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0313427 |
| IPO7 | importin 7 | 0.0308856 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0302872 |
| EHBP1 | EH domain binding protein 1 | 0.0302773 |
| MT2A | metallothionein 2A | 0.0295392 |
| EFNB2 | ephrin-B2 | 0.029393 |
| RCOR1 | REST corepressor 1 | 0.028711 |
| TNS3 | tensin 3 | 0.0286553 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0285314 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0284441 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0280655 |
| MCC | mutated in colorectal cancers | 0.0277254 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0276616 |
| EPHA4 | EPH receptor A4 | 0.0272077 |
| EMP1 | epithelial membrane protein 1 | 0.0268915 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0268705 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0265282 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0262314 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0261236 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0261131 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0260729 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0260058 |
| VCL | vinculin | 0.0259054 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0255403 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0251971 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0251357 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0249869 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0249697 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.024844 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0248155 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0247984 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0243661 |
| SET | SET nuclear proto-oncogene | 0.024334 |
| HOMER1 | homer scaffolding protein 1 | 0.0241253 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0239628 |
| VIM | vimentin | 0.0236107 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0235807 |
| AHNAK | AHNAK nucleoprotein | 0.0235714 |
| TMEM163 | transmembrane protein 163 | 0.0235506 |
| CTSB | cathepsin B | 0.0234001 |
| SKAP1 | src kinase associated phosphoprotein 1 | 0.0233133 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 0.0232879 |
| ATXN7L1 | ataxin 7-like 1 | 0.0232845 |
| ARSG | arylsulfatase G | 0.0232186 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0230542 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0230361 |
| EXOC4 | exocyst complex component 4 | 0.0229707 |
| RPS17 | ribosomal protein S17 | 0.0228409 |
| RPS18 | ribosomal protein S18 | 0.0225919 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.176925 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.153331 |
| PTMA | prothymosin, alpha | -0.13072 |
| RPL35A | ribosomal protein L35a | -0.0951807 |
| GOLGA4 | golgin A4 | -0.0695164 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0657209 |
| RPS6 | ribosomal protein S6 | -0.0641171 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0619496 |
| TMSB10 | thymosin beta 10 | -0.0605707 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0600421 |
| H1-0 | H1.0 linker histone | -0.0599317 |
| RBM39 | RNA binding motif protein 39 | -0.0596286 |
| OXR1 | oxidation resistance 1 | -0.0572655 |
| ANLN | anillin, actin binding protein | -0.0571809 |
| THOC2 | THO complex 2 | -0.0562332 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0552244 |
| KRT18 | keratin 18, type I | -0.0552051 |
| RPS24 | ribosomal protein S24 | -0.053983 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0534726 |
| OGA | O-GlcNAcase | -0.052121 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0520613 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0519149 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0502225 |
| MKI67 | marker of proliferation Ki-67 | -0.0496404 |
| DIAPH3 | diaphanous-related formin 3 | -0.0477968 |
| FTL | ferritin, light polypeptide | -0.0476913 |
| ZNF292 | zinc finger protein 292 | -0.0472866 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0468359 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0462503 |
| NKTR | natural killer cell triggering receptor | -0.0456902 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0448945 |
| SETD5 | SET domain containing 5 | -0.0444041 |
| RPL11 | ribosomal protein L11 | -0.0443831 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0436203 |
| KPNB1 | karyopherin (importin) beta 1 | -0.043419 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.042143 |
| RAB6A | RAB6A, member RAS oncogene family | -0.041816 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0413893 |
| MORF4L2 | mortality factor 4 like 2 | -0.041257 |
| SRPK2 | SRSF protein kinase 2 | -0.0412127 |
| RPLP2 | ribosomal protein, large, P2 | -0.0406335 |
| TPI1 | triosephosphate isomerase 1 | -0.0403563 |
| DEK | DEK proto-oncogene | -0.0403326 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0402744 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.038978 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0387468 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0386259 |
| RBM25 | RNA binding motif protein 25 | -0.0384815 |
| RPL13A | ribosomal protein L13a | -0.0379661 |
| RPS21 | ribosomal protein S21 | -0.0379474 |
| COG5 | component of oligomeric golgi complex 5 | -0.0369722 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0363542 |
| TMEM41B | transmembrane protein 41B | -0.0363046 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0360087 |
| NF1 | neurofibromin 1 | -0.0360045 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0359619 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.035732 |
| ACTG1 | actin gamma 1 | -0.0355672 |
| KRT8 | keratin 8, type II | -0.0354484 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0353928 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.03478 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0346742 |
| GNAS | GNAS complex locus | -0.034648 |
| RPL37A | ribosomal protein L37a | -0.0344851 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0341623 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0341263 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0337981 |
| CDK8 | cyclin-dependent kinase 8 | -0.0337246 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0336731 |
| TXNIP | thioredoxin interacting protein | -0.0336043 |
| RPL34 | ribosomal protein L34 | -0.0334072 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0331329 |
| CENPF | centromere protein F, 350/400kDa | -0.0328482 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0327195 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0326452 |
| RPL38 | ribosomal protein L38 | -0.0323007 |
| RPL9 | ribosomal protein L9 | -0.0322324 |
| CEP95 | centrosomal protein 95kDa | -0.0320262 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0319858 |
| RPS25 | ribosomal protein S25 | -0.0319582 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0318038 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0317705 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0316599 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0312629 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0311495 |
| MYO1D | myosin ID | -0.0307347 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0303886 |
| SBF2 | SET binding factor 2 | -0.0302815 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0300327 |
| RPL36A | ribosomal protein L36a | -0.0292884 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0291408 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0290612 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0290548 |
| PDE8A | phosphodiesterase 8A | -0.0288923 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0288309 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0288162 |
| HMGB1 | high mobility group box 1 | -0.0286693 |
| RPL8 | ribosomal protein L8 | -0.028621 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0285771 |
| RBMX | RNA binding motif protein, X-linked | -0.0284972 |
