| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/53315868 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in UNC 0631 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 7.39 |
| ACTN2 | actinin, alpha 2 | 6.64 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 6.47 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 5.72 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 5.13 |
| MYH1 | myosin, heavy chain 1, skeletal muscle, adult | 4.7 |
| APOB | apolipoprotein B | 4.33 |
| PYGM | phosphorylase, glycogen, muscle | 4.22 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | 4.07 |
| NDFIP1 | Nedd4 family interacting protein 1 | 3.1 |
| APOE | apolipoprotein E | 2.87 |
| TTN | titin | 2.65 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 2.47 |
| TPM1 | tropomyosin 1 (alpha) | 2.42 |
| NDFIP2 | Nedd4 family interacting protein 2 | 2.37 |
| ITM2B | integral membrane protein 2B | 2.35 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 2.31 |
| NCOA4 | nuclear receptor coactivator 4 | 2.1 |
| ITM2C | integral membrane protein 2C | 1.97 |
| CKM | creatine kinase, muscle | 1.96 |
| TMEM59 | transmembrane protein 59 | 1.95 |
| GINM1 | glycoprotein integral membrane 1 | 1.85 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 1.81 |
| RNF149 | ring finger protein 149 | 1.77 |
| IFNGR1 | interferon gamma receptor 1 | 1.72 |
| HGFAC | HGF activator | 1.71 |
| NBR1 | neighbor of BRCA1 gene 1 | 1.7 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 1.65 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 1.57 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 1.5 |
| FGFR4 | fibroblast growth factor receptor 4 | 1.5 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 1.41 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.38 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 1.33 |
| APP | amyloid beta (A4) precursor protein | 1.31 |
| TMEM200A | transmembrane protein 200A | 1.29 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.27 |
| GJB3 | gap junction protein, beta 3, 31kDa | 1.26 |
| MFAP3L | microfibrillar-associated protein 3-like | 1.26 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 1.24 |
| TSPAN3 | tetraspanin 3 | 1.21 |
| TMEM248 | transmembrane protein 248 | 1.18 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 1.17 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 1.16 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 1.14 |
| FGG | fibrinogen gamma chain | 1.13 |
| SLC49A4 | solute carrier family 49 member 4 | 1.11 |
| CTSL | cathepsin L | 1.11 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 1.1 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 1.08 |
| SLC38A2 | solute carrier family 38, member 2 | 1.07 |
| F2R | coagulation factor II (thrombin) receptor | 1.05 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 1.05 |
| MSMO1 | methylsterol monooxygenase 1 | 1.04 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 1.03 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 1.03 |
| SQSTM1 | sequestosome 1 | 1.02 |
| TTYH2 | tweety family member 2 | 1.01 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.0 |
| TPM2 | tropomyosin 2 (beta) | 1.0 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.99 |
| MYRF | myelin regulatory factor | 0.99 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.99 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.98 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 0.98 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.98 |
| ADCY3 | adenylate cyclase 3 | 0.98 |
| ACVR1B | activin A receptor, type IB | 0.97 |
| ACVR2A | activin A receptor, type IIA | 0.96 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.94 |
| AREG | amphiregulin | 0.94 |
| SDC4 | syndecan 4 | 0.94 |
| TMEM185B | transmembrane protein 185B | 0.93 |
| CLDND1 | claudin domain containing 1 | 0.92 |
| SERINC3 | serine incorporator 3 | 0.92 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.91 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.91 |
| SGMS2 | sphingomyelin synthase 2 | 0.91 |
| DES | desmin | 0.91 |
| LDLR | low density lipoprotein receptor | 0.9 |
| SQLE | squalene epoxidase | 0.89 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.87 |
| TYRO3 | TYRO3 protein tyrosine kinase | 0.86 |
| CD63 | CD63 molecule | 0.86 |
| BMERB1 | bMERB domain containing 1 | 0.84 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.84 |
| RNF167 | ring finger protein 167 | 0.84 |
| CERK | ceramide kinase | 0.81 |
| HAS3 | hyaluronan synthase 3 | 0.81 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.8 |
| PRF1 | perforin 1 (pore forming protein) | 0.8 |
| RNF13 | ring finger protein 13 | 0.79 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.79 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.79 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.79 |
| PLD3 | phospholipase D family, member 3 | 0.79 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.78 |
| IL6ST | interleukin 6 signal transducer | 0.78 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.78 |
| CPA4 | carboxypeptidase A4 | 0.78 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RNF111 | ring finger protein 111 | -2.04 |
| ZNF644 | zinc finger protein 644 | -1.05 |
| ZNF189 | zinc finger protein 189 | -0.81 |
| GLA | galactosidase, alpha | -0.77 |
| NMRK1 | nicotinamide riboside kinase 1 | -0.75 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.67 |
| ZNF28 | zinc finger protein 28 | -0.66 |
| ZNF551 | zinc finger protein 551 | -0.64 |
| CRCP | CGRP receptor component | -0.62 |
| FUCA2 | fucosidase, alpha-L- 2, plasma | -0.62 |
| CTSZ | cathepsin Z | -0.61 |
| ACTL8 | actin-like 8 | -0.6 |
| BAG4 | BCL2-associated athanogene 4 | -0.57 |
| ZNF268 | zinc finger protein 268 | -0.55 |
| SELENOS | selenoprotein S | -0.55 |
| ZNF845 | zinc finger protein 845 | -0.54 |
| HEXA | hexosaminidase A (alpha polypeptide) | -0.54 |
| ZNF7 | zinc finger protein 7 | -0.54 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.53 |
| ABHD18 | abhydrolase domain containing 18 | -0.52 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.5 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | -0.5 |
| ZNF57 | zinc finger protein 57 | -0.49 |
| SCPEP1 | serine carboxypeptidase 1 | -0.49 |
| PDGFC | platelet derived growth factor C | -0.49 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -0.48 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.47 |
| ZNF362 | zinc finger protein 362 | -0.47 |
| TMEM160 | transmembrane protein 160 | -0.47 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -0.46 |
| GID8 | GID complex subunit 8 | -0.46 |
| GBA | glucosidase, beta, acid | -0.45 |
| ZNF525 | zinc finger protein 525 | -0.45 |
| ZNF354B | zinc finger protein 354B | -0.44 |
| PPME1 | protein phosphatase methylesterase 1 | -0.44 |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | -0.43 |
| SH2D5 | SH2 domain containing 5 | -0.43 |
| RABEP1 | rabaptin, RAB GTPase binding effector protein 1 | -0.43 |
| ZNF724 | zinc finger protein 724 | -0.42 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.42 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -0.42 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.42 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.41 |
| RIBC2 | RIB43A domain with coiled-coils 2 | -0.41 |
| ZNF600 | zinc finger protein 600 | -0.41 |
| C12ORF60 | chromosome 12 open reading frame 60 | -0.41 |
| ZNF544 | zinc finger protein 544 | -0.41 |
| ZNF729 | zinc finger protein 729 | -0.4 |
| ZIC5 | Zic family member 5 | -0.4 |
| ZNF14 | zinc finger protein 14 | -0.4 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | -0.4 |
| PTMA | prothymosin, alpha | -0.4 |
| ZNF417 | zinc finger protein 417 | -0.39 |
| ZNF91 | zinc finger protein 91 | -0.39 |
| SELENOK | selenoprotein K | -0.39 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.39 |
| ZNF564 | zinc finger protein 564 | -0.39 |
| PRX | periaxin | -0.38 |
| ZNF721 | zinc finger protein 721 | -0.38 |
| UBAP1 | ubiquitin associated protein 1 | -0.38 |
| MXRA7 | matrix-remodelling associated 7 | -0.38 |
| ISL2 | ISL LIM homeobox 2 | -0.38 |
| GLRX | glutaredoxin (thioltransferase) | -0.38 |
| TPP1 | tripeptidyl peptidase I | -0.38 |
| MEGF8 | multiple EGF-like-domains 8 | -0.38 |
| ETV5 | ets variant 5 | -0.38 |
| HELQ | helicase, POLQ-like | -0.37 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | -0.37 |
| HMGXB4 | HMG box domain containing 4 | -0.37 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -0.36 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.36 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.36 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.36 |
| ZNF627 | zinc finger protein 627 | -0.36 |
| GANC | glucosidase, alpha; neutral C | -0.36 |
| CALU | calumenin | -0.36 |
| PWWP3B | PWWP domain containing 3B | -0.36 |
| DPY30 | dpy-30 homolog (C. elegans) | -0.35 |
| ZNF611 | zinc finger protein 611 | -0.35 |
| FAM126B | family with sequence similarity 126, member B | -0.35 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.35 |
| ZNF8 | zinc finger protein 8 | -0.35 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | -0.35 |
| PPP1R2B | PPP1R2 family member B | -0.34 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -0.34 |
| DST | dystonin | -0.34 |
| XTBD1 | XRN2 binding domain containing 1 | -0.34 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.34 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.34 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | -0.34 |
| ATMIN | ATM interactor | -0.34 |
| HINT2 | histidine triad nucleotide binding protein 2 | -0.34 |
| ZNF557 | zinc finger protein 557 | -0.33 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.33 |
| DENND4A | DENN/MADD domain containing 4A | -0.33 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -0.33 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.33 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.33 |
| CABLES2 | Cdk5 and Abl enzyme substrate 2 | -0.32 |
| CDC34 | cell division cycle 34 | -0.32 |
