| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/46224516 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in UNC 0638 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 5.56 |
| TMEM59 | transmembrane protein 59 | 4.34 |
| NDFIP1 | Nedd4 family interacting protein 1 | 3.81 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 3.48 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 3.43 |
| ITM2B | integral membrane protein 2B | 3.41 |
| APOE | apolipoprotein E | 3.36 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 3.24 |
| ITM2C | integral membrane protein 2C | 3.21 |
| NDFIP2 | Nedd4 family interacting protein 2 | 3.13 |
| NCOA4 | nuclear receptor coactivator 4 | 3.09 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 3.08 |
| APP | amyloid beta (A4) precursor protein | 2.97 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 2.93 |
| CLU | clusterin | 2.76 |
| PSAP | prosaposin | 2.71 |
| TMEM248 | transmembrane protein 248 | 2.69 |
| LDLR | low density lipoprotein receptor | 2.68 |
| NBR1 | neighbor of BRCA1 gene 1 | 2.57 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 2.51 |
| GINM1 | glycoprotein integral membrane 1 | 2.5 |
| SQSTM1 | sequestosome 1 | 2.45 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 2.42 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 2.38 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 2.37 |
| AREG | amphiregulin | 2.35 |
| SDC4 | syndecan 4 | 2.34 |
| IL6ST | interleukin 6 signal transducer | 2.32 |
| IFNGR1 | interferon gamma receptor 1 | 2.3 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 2.29 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.27 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 2.23 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.22 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 2.17 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 2.15 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 2.14 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 2.12 |
| CLDND1 | claudin domain containing 1 | 2.11 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 2.11 |
| RNF149 | ring finger protein 149 | 2.09 |
| RNF130 | ring finger protein 130 | 2.08 |
| CPA4 | carboxypeptidase A4 | 2.07 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 2.06 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 2.05 |
| RELT | RELT tumor necrosis factor receptor | 2.01 |
| OSMR | oncostatin M receptor | 1.98 |
| MSMO1 | methylsterol monooxygenase 1 | 1.96 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 1.94 |
| TMEM200A | transmembrane protein 200A | 1.92 |
| SERINC3 | serine incorporator 3 | 1.92 |
| CTSH | cathepsin H | 1.9 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 1.88 |
| CTSL | cathepsin L | 1.88 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 1.87 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 1.86 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 1.83 |
| SERINC1 | serine incorporator 1 | 1.8 |
| SGMS2 | sphingomyelin synthase 2 | 1.79 |
| SLC38A2 | solute carrier family 38, member 2 | 1.79 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 1.77 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 1.76 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 1.75 |
| MFAP3L | microfibrillar-associated protein 3-like | 1.74 |
| FGFR4 | fibroblast growth factor receptor 4 | 1.72 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 1.7 |
| RNF223 | ring finger protein 223 | 1.67 |
| TSPAN3 | tetraspanin 3 | 1.64 |
| FAT1 | FAT atypical cadherin 1 | 1.63 |
| TMEM185B | transmembrane protein 185B | 1.62 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 1.61 |
| SQLE | squalene epoxidase | 1.59 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.58 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 1.58 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 1.56 |
| UNC5B | unc-5 homolog B (C. elegans) | 1.55 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 1.55 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 1.54 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | 1.51 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 1.51 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 1.5 |
| JAG1 | jagged 1 | 1.5 |
| PLAU | plasminogen activator, urokinase | 1.49 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 1.49 |
| ADIPOR1 | adiponectin receptor 1 | 1.47 |
| CERK | ceramide kinase | 1.45 |
| MVK | mevalonate kinase | 1.43 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 1.43 |
| HAS3 | hyaluronan synthase 3 | 1.43 |
| ANGPTL4 | angiopoietin-like 4 | 1.42 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 1.42 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 1.41 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 1.4 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 1.4 |
| SDCBP | syndecan binding protein (syntenin) | 1.4 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | 1.39 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 1.39 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.38 |
| PCDH1 | protocadherin 1 | 1.38 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -5.91 |
| MIEF1 | mitochondrial elongation factor 1 | -2.18 |
| ZNF2 | zinc finger protein 2 | -1.99 |
| ZNF644 | zinc finger protein 644 | -1.58 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -1.56 |
| MTERF2 | mitochondrial transcription termination factor 2 | -1.34 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -1.29 |
| JPT1 | Jupiter microtubule associated homolog 1 | -1.28 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -1.22 |
| POC1B | POC1 centriolar protein B | -1.18 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -1.16 |
| IVNS1ABP | influenza virus NS1A binding protein | -1.13 |
| DNAL4 | dynein, axonemal, light chain 4 | -1.1 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -1.1 |
| ZNF543 | zinc finger protein 543 | -1.1 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -1.08 |
| OGG1 | 8-oxoguanine DNA glycosylase | -1.06 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -1.06 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -1.05 |
| GLA | galactosidase, alpha | -1.05 |
| DCLRE1B | DNA cross-link repair 1B | -1.04 |
| PTTG1 | pituitary tumor-transforming 1 | -1.04 |
| MUTYH | mutY homolog | -0.95 |
| TYMS | thymidylate synthetase | -0.94 |
| CTSZ | cathepsin Z | -0.94 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.94 |
| MTERF3 | mitochondrial transcription termination factor 3 | -0.92 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.9 |
| HEXA | hexosaminidase A (alpha polypeptide) | -0.9 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | -0.89 |
| ZNF189 | zinc finger protein 189 | -0.89 |
| PPT2 | palmitoyl-protein thioesterase 2 | -0.89 |
| SMAD1 | SMAD family member 1 | -0.88 |
| TCTEX1D2 | Tctex1 domain containing 2 | -0.87 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -0.86 |
| GLB1 | galactosidase, beta 1 | -0.84 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | -0.84 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.83 |
| CDCA2 | cell division cycle associated 2 | -0.83 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.82 |
| OBI1 | ORC ubiquitin ligase 1 | -0.82 |
| RFLNB | refilin B | -0.82 |
| ZWINT | ZW10 interacting kinetochore protein | -0.81 |
| DEPDC1 | DEP domain containing 1 | -0.81 |
| RANBP17 | RAN binding protein 17 | -0.81 |
| KIF22 | kinesin family member 22 | -0.81 |
| ZNRD2 | zinc ribbon domain containing 2 | -0.8 |
| NAAA | N-acylethanolamine acid amidase | -0.8 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | -0.79 |
| GTF3A | general transcription factor IIIA | -0.79 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.79 |
| HPSE | heparanase | -0.79 |
| ZNF584 | zinc finger protein 584 | -0.78 |
| ZNF142 | zinc finger protein 142 | -0.78 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | -0.77 |
| CDC7 | cell division cycle 7 | -0.77 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.77 |
| ZNF616 | zinc finger protein 616 | -0.77 |
| COMMD5 | COMM domain containing 5 | -0.77 |
| COX15 | cytochrome c oxidase assembly homolog 15 (yeast) | -0.77 |
| ZFP1 | ZFP1 zinc finger protein | -0.76 |
| KNL1 | kinetochore scaffold 1 | -0.76 |
| DIXDC1 | DIX domain containing 1 | -0.75 |
| SCPEP1 | serine carboxypeptidase 1 | -0.75 |
| LIAS | lipoic acid synthetase | -0.75 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.75 |
| MKX | mohawk homeobox | -0.75 |
| MIS18A | MIS18 kinetochore protein A | -0.75 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.74 |
| NEK2 | NIMA-related kinase 2 | -0.74 |
| EXO1 | exonuclease 1 | -0.74 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.74 |
| CDC20 | cell division cycle 20 | -0.74 |
| KIF18A | kinesin family member 18A | -0.74 |
| USP1 | ubiquitin specific peptidase 1 | -0.73 |
| RAD51AP1 | RAD51 associated protein 1 | -0.73 |
| SPAG5 | sperm associated antigen 5 | -0.73 |
| MRPL54 | mitochondrial ribosomal protein L54 | -0.73 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.73 |
| CISD3 | CDGSH iron sulfur domain 3 | -0.73 |
| WDR76 | WD repeat domain 76 | -0.72 |
| ZFPM1 | zinc finger protein, FOG family member 1 | -0.72 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -0.72 |
| CDK5RAP1 | CDK5 regulatory subunit associated protein 1 | -0.72 |
| SGO2 | shugoshin 2 | -0.72 |
| RBFA | ribosome binding factor A (putative) | -0.72 |
| FUCA2 | fucosidase, alpha-L- 2, plasma | -0.72 |
| KIAA0586 | KIAA0586 | -0.72 |
| DMAC2L | distal membrane arm assembly component 2 like | -0.71 |
| CCDC138 | coiled-coil domain containing 138 | -0.71 |
| ZNF286B | zinc finger protein 286B | -0.71 |
| CEP95 | centrosomal protein 95kDa | -0.71 |
| EML1 | echinoderm microtubule associated protein like 1 | -0.71 |
| ADI1 | acireductone dioxygenase 1 | -0.71 |
| NDUFAF2 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 | -0.71 |
| CENPF | centromere protein F, 350/400kDa | -0.71 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.71 |
| MRPL3 | mitochondrial ribosomal protein L3 | -0.71 |
| MRPL41 | mitochondrial ribosomal protein L41 | -0.71 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | -0.71 |
