UNC-1999 Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

75 genes differentially expressed following the UNC-1999 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
INSIG1 insulin induced gene 1 7.47766
ALDOC aldolase C, fructose-bisphosphate 7.09536
MSMO1 methylsterol monooxygenase 1 5.9672
FDPS farnesyl diphosphate synthase 5.7143
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 5.65443
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 5.54844
FDFT1 farnesyl-diphosphate farnesyltransferase 1 5.4652
DHCR7 7-dehydrocholesterol reductase 5.40604
SCD stearoyl-CoA desaturase (delta-9-desaturase) 5.28332
NSDHL NAD(P) dependent steroid dehydrogenase-like 5.11453
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 4.94267
FADS1 fatty acid desaturase 1 4.90908
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 4.8412
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 4.71864
IDI1 isopentenyl-diphosphate delta isomerase 1 4.66554
DHCR24 24-dehydrocholesterol reductase 4.61808
SQLE squalene epoxidase 4.57682
SC5D sterol-C5-desaturase 4.54937
MVD mevalonate (diphospho) decarboxylase 4.54315
PNPLA3 patatin-like phospholipase domain containing 3 4.53514
DHRS7 dehydrogenase/reductase (SDR family) member 7 4.52628
ACAT2 acetyl-CoA acetyltransferase 2 4.23091
SREBF2 sterol regulatory element binding transcription factor 2 4.13219
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 4.11278
ERG28 ergosterol biosynthesis 28 homolog 4.09241
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 4.08683
PANK3 pantothenate kinase 3 3.91517
INSIG2 insulin induced gene 2 3.88652
LPIN1 lipin 1 3.84419
LPCAT1 lysophosphatidylcholine acyltransferase 1 3.79713
LDLR low density lipoprotein receptor 3.79557
AK4 adenylate kinase 4 3.70319
HK2 hexokinase 2 3.69321
FAF2 Fas associated factor family member 2 3.67277
SQSTM1 sequestosome 1 3.55728
TCTA T-cell leukemia translocation altered 3.50763
MVK mevalonate kinase 3.45974
MFSD10 major facilitator superfamily domain containing 10 3.45417
TRIB3 tribbles pseudokinase 3 3.41626
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.41365
MXI1 MAX interactor 1, dimerization protein 3.40337
FGFBP1 fibroblast growth factor binding protein 1 3.37492
ABHD6 abhydrolase domain containing 6 3.35845
PHLDA2 pleckstrin homology-like domain, family A, member 2 3.31984
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 3.31713
PGK1 phosphoglycerate kinase 1 3.25905
MYO1B myosin IB 3.17257
RAB8A RAB8A, member RAS oncogene family 3.17115
HILPDA hypoxia inducible lipid droplet-associated 3.16158
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 3.13594
SCARB1 scavenger receptor class B, member 1 3.1148
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3.09208
TSPO translocator protein (18kDa) 3.09082
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 3.08981
NPC1 Niemann-Pick disease, type C1 3.08562
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 3.08247
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.07041
TXNRD1 thioredoxin reductase 1 3.04462
MAMLD1 mastermind-like domain containing 1 3.02718
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 3.02709

decreased expression

Symbol Name Standardized Value
COPS7A COP9 signalosome subunit 7A -3.9444
EFHC1 EF-hand domain (C-terminal) containing 1 -3.85071
CEP290 centrosomal protein 290kDa -3.81379
PLCL2 phospholipase C-like 2 -3.79047
DDB2 damage-specific DNA binding protein 2, 48kDa -3.4523
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -3.31813
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -3.28715
CEP83 centrosomal protein 83kDa -3.28366
STX18 syntaxin 18 -3.27271
JADE1 jade family PHD finger 1 -3.25843
AARSD1 alanyl-tRNA synthetase domain containing 1 -3.20414
TRIT1 tRNA isopentenyltransferase 1 -3.13334
DPH5 diphthamide biosynthesis 5 -3.06332
RPL37A ribosomal protein L37a -3.04315
ARL3 ADP-ribosylation factor-like 3 -3.01348