UNC5B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description unc-5 homolog B (C. elegans)|This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 219699)
Similar Terms
Downloads & Tools

Genes

337 genes differentially expressed following the UNC5B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF436 zinc finger protein 436 2.83447
CAMP cathelicidin antimicrobial peptide 2.83447
MAGEA2 melanoma antigen family A2 2.83447
SNX9 sorting nexin 9 2.83447
FOXA2 forkhead box A2 2.83447
MYRF myelin regulatory factor 2.83447
ATXN7L3 ataxin 7-like 3 2.83447
ERN2 endoplasmic reticulum to nucleus signaling 2 2.83447
UMOD uromodulin 2.83447
ZNF37A zinc finger protein 37A 2.83447
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.83447
ANKRD22 ankyrin repeat domain 22 2.83447
HEATR9 HEAT repeat containing 9 2.83447
RLBP1 retinaldehyde binding protein 1 2.83447
FPR3 formyl peptide receptor 3 2.83447
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.83447
SYCP2 synaptonemal complex protein 2 2.83447
AGTR1 angiotensin II receptor, type 1 2.83447
INHBC inhibin, beta C 2.83447
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.83447
VTN vitronectin 2.83447
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.83447
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.83447
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 2.83447
OLIG3 oligodendrocyte transcription factor 3 2.83447
CRIP1 cysteine-rich protein 1 (intestinal) 2.83447
TMEM140 transmembrane protein 140 2.83447
LGI1 leucine-rich, glioma inactivated 1 2.83447
S100A9 S100 calcium binding protein A9 2.83447
WNT8B wingless-type MMTV integration site family, member 8B 2.83447
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.83447
BFSP2 beaded filament structural protein 2, phakinin 2.83447
ATOH7 atonal homolog 7 (Drosophila) 2.83447
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.83447
CPB2 carboxypeptidase B2 (plasma) 2.83447
CD68 CD68 molecule 2.83447
PCDH8 protocadherin 8 2.83447
ASB17 ankyrin repeat and SOCS box containing 17 2.83447
ASB14 ankyrin repeat and SOCS box containing 14 2.83447
SSTR3 somatostatin receptor 3 2.83447
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.83447
GPR21 G protein-coupled receptor 21 2.83447
MYOM3 myomesin 3 2.83447
ALPK2 alpha-kinase 2 2.83447
RFPL3 ret finger protein-like 3 2.83447
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.83447
LEP leptin 2.83447
RAB41 RAB41, member RAS oncogene family 2.83447
SPMIP9 sperm microtubule inner protein 9 2.83447
SPRR2F small proline-rich protein 2F 2.83447
FMOD fibromodulin 2.83447
ASB9 ankyrin repeat and SOCS box containing 9 2.83447
TMEM190 transmembrane protein 190 2.83447
MYPN myopalladin 2.83447
TSPAN1 tetraspanin 1 2.83447
GPR37L1 G protein-coupled receptor 37 like 1 2.83447
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.83447
DYNLRB2 dynein, light chain, roadblock-type 2 2.83447
SQOR sulfide quinone oxidoreductase 2.83447
STING1 stimulator of interferon response cGAMP interactor 1 2.83447
H3-5 H3.5 histone 2.83447
TEKTL1 tektin like 1 2.83447
LRRC8C-DT LRRC8C divergent transcript 2.83447
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.83447
CIBAR2 CBY1 interacting BAR domain containing 2 2.83447
MUCL3 mucin like 3 2.83447
ARMH2 armadillo like helical domain containing 2 2.83447
NFILZ NFIL3 like basic leucine zipper 2.83447
TERB1 telomere repeat binding bouquet formation protein 1 2.83447
CALHM5 calcium homeostasis modulator family member 5 2.83447
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.83447
GATA2 GATA binding protein 2 2.83447
GATA5 GATA binding protein 5 2.83447
MSX2 msh homeobox 2 2.83447
C10ORF67 chromosome 10 open reading frame 67 2.83447
CBLN2 cerebellin 2 precursor 2.83447
LIX1 Lix1 homolog (chicken) 2.83447
EDAR ectodysplasin A receptor 2.83447
TRIM60 tripartite motif containing 60 2.83447
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.83447
GDA guanine deaminase 2.83447
OASL 2'-5'-oligoadenylate synthetase-like 2.83447
SPMIP1 sperm microtubule inner protein 1 2.83447
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.83447
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.83447
PARVG parvin, gamma 2.83447
CNTN5 contactin 5 2.83447
LRRN4CL LRRN4 C-terminal like 2.83447
GPR85 G protein-coupled receptor 85 2.83447
ZAR1L zygote arrest 1-like 2.83447
FGFBP2 fibroblast growth factor binding protein 2 2.83447
VCX3A variable charge, X-linked 3A 2.83447
C9 complement component 9 2.83447
EXOC3L4 exocyst complex component 3-like 4 2.83447
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.83447
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.83447
BTNL2 butyrophilin-like 2 2.83447
GCOM1 GRINL1A complex locus 1 2.83447
HSPA1L heat shock 70kDa protein 1-like 2.83447
NOX3 NADPH oxidase 3 2.83447
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.83447
CDH10 cadherin 10, type 2 (T2-cadherin) 2.83447
PSKH2 protein serine kinase H2 2.83447
SHISA8 shisa family member 8 2.83447
LMOD2 leiomodin 2 (cardiac) 2.83447
GRK7 G protein-coupled receptor kinase 7 2.83447
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.83447
ADGRA1 adhesion G protein-coupled receptor A1 2.83447
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.83447
KRT17 keratin 17, type I 2.83447
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.83447
PMP2 peripheral myelin protein 2 2.83447
SLC25A52 solute carrier family 25, member 52 2.83447
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.83447
ERICH3 glutamate-rich 3 2.83447
GP2 glycoprotein 2 (zymogen granule membrane) 2.83447
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.83447
KLK7 kallikrein-related peptidase 7 2.83447
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.83447
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.83447
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.83447
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.83447
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.83447
LAMB3 laminin, beta 3 2.83447
ZNF831 zinc finger protein 831 2.83447
MB myoglobin 2.83447
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.83447
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.83447
KLHDC1 kelch domain containing 1 2.83447
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.83447
LOXHD1 lipoxygenase homology domains 1 2.83447
PRR35 proline rich 35 2.83447
ITGA10 integrin, alpha 10 2.83447
LY96 lymphocyte antigen 96 2.83447
TH tyrosine hydroxylase 2.83447
AMH anti-Mullerian hormone 2.83447
ANKRD55 ankyrin repeat domain 55 2.83447
ZIM2 zinc finger, imprinted 2 2.83447
PSG3 pregnancy specific beta-1-glycoprotein 3 2.83447
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.83447
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.83447
PXT1 peroxisomal, testis specific 1 2.83447
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.83447
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.83447
MMP13 matrix metallopeptidase 13 2.83447
NPAS4 neuronal PAS domain protein 4 2.83447
GLT6D1 glycosyltransferase 6 domain containing 1 2.83447
CLPSL1 colipase-like 1 2.83447
PGM5 phosphoglucomutase 5 2.83447
PADI1 peptidyl arginine deiminase, type I 2.83447
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.83447
CD8B CD8b molecule 2.83447
TGM4 transglutaminase 4 2.83447
RTN4RL1 reticulon 4 receptor-like 1 2.83447
TEX36 testis expressed 36 2.83447
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.83447
DCST1 DC-STAMP domain containing 1 2.83447
LPAR5 lysophosphatidic acid receptor 5 2.83447
RHOJ ras homolog family member J 2.83447
FAM25C family with sequence similarity 25, member C 2.83447
WFDC12 WAP four-disulfide core domain 12 2.83447
CSPG4 chondroitin sulfate proteoglycan 4 2.83447
TPRX1 tetra-peptide repeat homeobox 1 2.83447
FAM25G family with sequence similarity 25, member G 2.83447
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.83447
FRMPD2 FERM and PDZ domain containing 2 2.83447
PSD2 pleckstrin and Sec7 domain containing 2 2.83447
DAND5 DAN domain family member 5, BMP antagonist 2.83447
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.83447
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.83447
VTCN1 V-set domain containing T cell activation inhibitor 1 2.83447
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.77317
TMEM192 transmembrane protein 192 2.76491
RANBP2 RAN binding protein 2 2.68586
EFCAB7 EF-hand calcium binding domain 7 2.61238
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.59884
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.59704
TXNL4A thioredoxin-like 4A 2.58156
LRRC8B leucine rich repeat containing 8 family, member B 2.52001
NOXO1 NADPH oxidase organizer 1 2.51905
ATP5MJ ATP synthase membrane subunit j 2.50293
GPR107 G protein-coupled receptor 107 2.4371
WDR62 WD repeat domain 62 2.43633
SMC2 structural maintenance of chromosomes 2 2.4335
H1-3 H1.3 linker histone, cluster member 2.42097
FGF18 fibroblast growth factor 18 2.38192
RANBP10 RAN binding protein 10 2.37418
TRIM5 tripartite motif containing 5 2.374
C20ORF96 chromosome 20 open reading frame 96 2.3269
CAPN2 calpain 2, (m/II) large subunit 2.31782
PYGB phosphorylase, glycogen; brain 2.27675
CERT1 ceramide transporter 1 2.25278
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 2.23625
MCM8 minichromosome maintenance complex component 8 2.23044
ACP6 acid phosphatase 6, lysophosphatidic 2.18739
KCTD2 potassium channel tetramerization domain containing 2 2.18246
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2.16619
HOOK3 hook microtubule-tethering protein 3 2.16333
TPRA1 transmembrane protein, adipocyte asscociated 1 2.16292
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 2.15864
RPTOR regulatory associated protein of MTOR, complex 1 2.15864
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.1451
GTPBP2 GTP binding protein 2 2.13516
NEK3 NIMA-related kinase 3 2.13465
H2AC21 H2A clustered histone 21 2.11272
C12ORF56 chromosome 12 open reading frame 56 2.10149
PCDHA10 protocadherin alpha 10 2.09545
RIGI RNA sensor RIG-I 2.08522
CD320 CD320 molecule 2.08226
PTMS parathymosin 2.06679
MED18 mediator complex subunit 18 2.06622
RAB3C RAB3C, member RAS oncogene family 2.06358
SQLE squalene epoxidase 2.06358
RNF181 ring finger protein 181 2.06358
SRPRB signal recognition particle receptor, B subunit 2.05906
RPS13 ribosomal protein S13 2.05022
LTN1 listerin E3 ubiquitin protein ligase 1 2.04542
COL4A4 collagen, type IV, alpha 4 2.0446
SMIM7 small integral membrane protein 7 2.02834
CLCN6 chloride channel, voltage-sensitive 6 2.02834
TATDN3 TatD DNase domain containing 3 2.02624
MTA1 metastasis associated 1 2.02445
H2AC11 H2A clustered histone 11 2.01509
MOB1A MOB kinase activator 1A 2.01509
DARS1 aspartyl-tRNA synthetase 1 2.00777
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.00584

decreased expression

Symbol Name Standardized Value
ZFP36 ZFP36 ring finger protein -2.83447
TMEM74 transmembrane protein 74 -2.83447
ARSB arylsulfatase B -2.83447
RPP25L ribonuclease P/MRP 25kDa subunit-like -2.83447
TMEM50A transmembrane protein 50A -2.83447
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -2.83447
ZNF544 zinc finger protein 544 -2.83447
FAM229A family with sequence similarity 229, member A -2.83447
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.83447
SSUH2 ssu-2 homolog (C. elegans) -2.83447
IL32 interleukin 32 -2.83447
METTL24 methyltransferase like 24 -2.83447
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.83447
LYPD1 LY6/PLAUR domain containing 1 -2.83447
FLT3 fms-related tyrosine kinase 3 -2.83447
LIPI lipase, member I -2.83447
BBS12 Bardet-Biedl syndrome 12 -2.83447
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -2.83447
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.83447
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.83447
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.79918
IL23A interleukin 23, alpha subunit p19 -2.79918
FAM151A family with sequence similarity 151, member A -2.79918
FRS3 fibroblast growth factor receptor substrate 3 -2.79918
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -2.79918
ARL11 ADP-ribosylation factor-like 11 -2.79918
ACKR3 atypical chemokine receptor 3 -2.79918
GREB1L growth regulation by estrogen in breast cancer-like -2.79918
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.79918
LAMP3 lysosomal-associated membrane protein 3 -2.79918
EPN3 epsin 3 -2.79918
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.79918
FRMPD1 FERM and PDZ domain containing 1 -2.79918
RNF112 ring finger protein 112 -2.79918
FGF7 fibroblast growth factor 7 -2.79918
PRR22 proline rich 22 -2.79918
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.79918
PTX3 pentraxin 3, long -2.79918
BEAN1 brain expressed, associated with NEDD4, 1 -2.79918
MRPL53 mitochondrial ribosomal protein L53 -2.79918
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -2.79918
NFAM1 NFAT activating protein with ITAM motif 1 -2.79918
PCDHB14 protocadherin beta 14 -2.79918
ZNF556 zinc finger protein 556 -2.79918
TSPAN16 tetraspanin 16 -2.79918
RASA4 RAS p21 protein activator 4 -2.79918
IL21R interleukin 21 receptor -2.79918
SPNS2 spinster homolog 2 (Drosophila) -2.79918
HAL histidine ammonia-lyase -2.79918
GDF6 growth differentiation factor 6 -2.79918
NLRC3 NLR family, CARD domain containing 3 -2.79918
RBP4 retinol binding protein 4, plasma -2.79918
ZNF207 zinc finger protein 207 -2.76491
ATF7IP activating transcription factor 7 interacting protein -2.74476
SSC4D scavenger receptor cysteine rich family, 4 domains -2.725
ZFHX2 zinc finger homeobox 2 -2.70255
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.65513
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.65513
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase -2.65092
ERVMER34-1 endogenous retrovirus group MER34, member 1 -2.64369
SOWAHD sosondowah ankyrin repeat domain family member D -2.61849
TMEM191C transmembrane protein 191C -2.61849
KLF9 Kruppel-like factor 9 -2.61849
ATG101 autophagy related 101 -2.59857
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -2.50293
TMEM167B transmembrane protein 167B -2.49604
ERLIN2 ER lipid raft associated 2 -2.45257
GASK1A golgi associated kinase 1A -2.43633
PDLIM4 PDZ and LIM domain 4 -2.40709
GTSE1 G-2 and S-phase expressed 1 -2.39367
COX5B cytochrome c oxidase subunit Vb -2.32954
KLHL7 kelch-like family member 7 -2.31782
MACROD2 MACRO domain containing 2 -2.30959
RBM15 RNA binding motif protein 15 -2.30959
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -2.29587
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -2.29587
TMEM187 transmembrane protein 187 -2.29587
RECQL4 RecQ protein-like 4 -2.2728
DTNB dystrobrevin, beta -2.26737
C16ORF46 chromosome 16 open reading frame 46 -2.24756
DCP1A decapping mRNA 1A -2.23625
SPRYD7 SPRY domain containing 7 -2.23044
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.21602
MBTPS1 membrane-bound transcription factor peptidase, site 1 -2.16388
TBC1D10A TBC1 domain family, member 10A -2.16292
MCOLN3 mucolipin 3 -2.15864
CPN1 carboxypeptidase N, polypeptide 1 -2.15864
CCDC86 coiled-coil domain containing 86 -2.14671
FAM8A1 family with sequence similarity 8, member A1 -2.14631
NBPF14 neuroblastoma breakpoint family, member 14 -2.1451
RCSD1 RCSD domain containing 1 -2.1451
MYADM myeloid-associated differentiation marker -2.1406
SDHAF4 succinate dehydrogenase complex assembly factor 4 -2.13465
USP27X ubiquitin specific peptidase 27, X-linked -2.13415
ARL8A ADP-ribosylation factor-like 8A -2.13038
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.11059
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.09556
GLDN gliomedin -2.09545
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 -2.09545
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.09545
M6PR mannose-6-phosphate receptor (cation dependent) -2.09479
ZNF343 zinc finger protein 343 -2.08522
RPL37A ribosomal protein L37a -2.06715
DNHD1 dynein heavy chain domain 1 -2.06358
LINGO2 leucine rich repeat and Ig domain containing 2 -2.06358
NALCN sodium leak channel, non selective -2.06107
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -2.04494
NTN4 netrin 4 -2.04494
FHIP1A FHF complex subunit HOOK interacting protein 1A -2.02624
ASTN2 astrotactin 2 -2.02445
CEP68 centrosomal protein 68kDa -2.01509