USO1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description USO1 vesicle transport factor|The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 8615)
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Genes

354 genes differentially expressed following the USO1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HBA2 hemoglobin, alpha 2 3.13832
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.13832
PDYN prodynorphin 3.13832
ZNF467 zinc finger protein 467 3.13832
CASP5 caspase 5, apoptosis-related cysteine peptidase 3.13832
CLEC19A C-type lectin domain family 19, member A 3.13832
LRRC56 leucine rich repeat containing 56 3.13832
HBA1 hemoglobin, alpha 1 3.13832
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.13832
FETUB fetuin B 3.13832
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.13832
FGL1 fibrinogen-like 1 3.13832
SCGB3A1 secretoglobin, family 3A, member 1 3.13832
USH1G Usher syndrome 1G (autosomal recessive) 3.13832
PLVAP plasmalemma vesicle associated protein 3.13832
TMPRSS11F transmembrane protease, serine 11F 3.13832
RNF17 ring finger protein 17 3.13832
RASL10A RAS-like, family 10, member A 3.13832
MYO7B myosin VIIB 3.13832
UCN urocortin 3.13832
NPAP1 nuclear pore associated protein 1 3.13832
TANGO6 transport and golgi organization 6 homolog (Drosophila) 3.13832
SPINK4 serine peptidase inhibitor, Kazal type 4 3.13832
ASB17 ankyrin repeat and SOCS box containing 17 3.13832
C19ORF67 chromosome 19 open reading frame 67 3.13832
MYOM3 myomesin 3 3.13832
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.13832
ATOH1 atonal homolog 1 (Drosophila) 3.13832
ASGR2 asialoglycoprotein receptor 2 3.13832
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.13832
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.13832
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.13832
CLCF1 cardiotrophin-like cytokine factor 1 3.13832
FGF9 fibroblast growth factor 9 3.13832
PRSS21 protease, serine, 21 (testisin) 3.13832
TMEM184A transmembrane protein 184A 3.13832
KRT78 keratin 78, type II 3.13832
ADAT3 adenosine deaminase, tRNA-specific 3 3.13832
TNIP3 TNFAIP3 interacting protein 3 3.13832
BAAT bile acid CoA:amino acid N-acyltransferase 3.13832
C1ORF146 chromosome 1 open reading frame 146 3.13832
TDRD6 tudor domain containing 6 3.13832
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.13832
KIAA2012 KIAA2012 3.13832
TTPA tocopherol (alpha) transfer protein 3.13832
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.13832
F2 coagulation factor II (thrombin) 3.13832
RIMBP3C RIMS binding protein 3C 3.13832
DSPP dentin sialophosphoprotein 3.13832
FAM3D family with sequence similarity 3, member D 3.13832
LY6S lymphocyte antigen 6 family member S 3.13832
PLAAT2 phospholipase A and acyltransferase 2 3.13832
H3-5 H3.5 histone 3.13832
NECTIN4 nectin cell adhesion molecule 4 3.13832
PTH1R parathyroid hormone 1 receptor 3.13832
SRGN serglycin 3.13832
TBC1D3L TBC1 domain family, member 3L 3.13832
TMPRSS4 transmembrane protease, serine 4 3.13832
IGSF22 immunoglobulin superfamily, member 22 3.13832
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.13832
TMEM40 transmembrane protein 40 3.13832
CLXN calaxin 3.13832
DNAAF8 dynein axonemal assembly factor 8 3.13832
SPDYE8 speedy/RINGO cell cycle regulator family member E8 3.13832
LOC122526780 uncharacterized LOC122526780 3.13832
SMIM31 small integral membrane protein 31 3.13832
ARMH2 armadillo like helical domain containing 2 3.13832
MAJIN membrane anchored junction protein 3.13832
H2BW1 H2B.W histone 1 3.13832
GARIN1A golgi associated RAB2 interactor 1A 3.13832
VXN vexin 3.13832
MSANTD5 Myb/SANT DNA binding domain containing 5 3.13832
RTL9 retrotransposon Gag like 9 3.13832
GPR37L1 G protein-coupled receptor 37 like 1 3.13832
OSTN osteocrin 3.13832
GDF6 growth differentiation factor 6 3.13832
TMEM235 transmembrane protein 235 3.13832
CD79A CD79a molecule, immunoglobulin-associated alpha 3.13832
HPR haptoglobin-related protein 3.13832
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.13832
MBD5 methyl-CpG binding domain protein 5 3.13832
C1ORF87 chromosome 1 open reading frame 87 3.13832
RHOXF2 Rhox homeobox family, member 2 3.13832
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.13832
CDX1 caudal type homeobox 1 3.13832
ATP13A5 ATPase type 13A5 3.13832
SIM2 single-minded family bHLH transcription factor 2 3.13832
TLR6 toll-like receptor 6 3.13832
HAL histidine ammonia-lyase 3.13832
VCX3A variable charge, X-linked 3A 3.13832
VCX3B variable charge, X-linked 3B 3.13832
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.13832
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.13832
CLDN23 claudin 23 3.13832
S100G S100 calcium binding protein G 3.13832
TMEM179 transmembrane protein 179 3.13832
TBX3 T-box 3 3.13832
MIP major intrinsic protein of lens fiber 3.13832
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.13832
TBC1D28 TBC1 domain family, member 28 3.13832
BCL2L15 BCL2-like 15 3.13832
EBF2 early B-cell factor 2 3.13832
UBXN10 UBX domain protein 10 3.13832
DND1 DND microRNA-mediated repression inhibitor 1 3.13832
RGS13 regulator of G-protein signaling 13 3.13832
CTLA4 cytotoxic T-lymphocyte-associated protein 4 3.13832
TAGAP T-cell activation RhoGTPase activating protein 3.13832
SDS serine dehydratase 3.13832
DYTN dystrotelin 3.13832
SMIM22 small integral membrane protein 22 3.13832
HSF4 heat shock transcription factor 4 3.13832
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.13832
CALML6 calmodulin-like 6 3.13832
RBBP8NL RBBP8 N-terminal like 3.13832
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.13832
KPNA1 karyopherin alpha 1 (importin alpha 5) 3.13832
SH2D1B SH2 domain containing 1B 3.13832
POF1B premature ovarian failure, 1B 3.13832
RORC RAR-related orphan receptor C 3.13832
GP2 glycoprotein 2 (zymogen granule membrane) 3.13832
CST1 cystatin SN 3.13832
DRD3 dopamine receptor D3 3.13832
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.13832
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.13832
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.13832
COMP cartilage oligomeric matrix protein 3.13832
ANKRD55 ankyrin repeat domain 55 3.13832
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.13832
RGCC regulator of cell cycle 3.13832
SMR3B submaxillary gland androgen regulated protein 3B 3.13832
APOC4 apolipoprotein C-IV 3.13832
VAV1 vav 1 guanine nucleotide exchange factor 3.13832
ADGRA1 adhesion G protein-coupled receptor A1 3.13832
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.13832
C11ORF91 chromosome 11 open reading frame 91 3.13832
DPRX divergent-paired related homeobox 3.13832
CDHR5 cadherin-related family member 5 3.13832
C11ORF16 chromosome 11 open reading frame 16 3.13832
PRSS33 protease, serine, 33 3.13832
DLX3 distal-less homeobox 3 3.13832
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.13832
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.13832
OR52I2 olfactory receptor, family 52, subfamily I, member 2 3.13832
NYX nyctalopin 3.13832
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.13832
MEIG1 meiosis/spermiogenesis associated 1 3.13832
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.13832
A1CF APOBEC1 complementation factor 3.13832
C22ORF31 chromosome 22 open reading frame 31 3.13832
PRAP1 proline-rich acidic protein 1 3.13832
CFP complement factor properdin 3.13832
OXER1 oxoeicosanoid (OXE) receptor 1 3.13832
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.13832
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.13832
NRGN neurogranin (protein kinase C substrate, RC3) 3.13832
NEUROD2 neuronal differentiation 2 3.13832
SSTR1 somatostatin receptor 1 3.13832
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.13832
STOML3 stomatin (EPB72)-like 3 3.13832
MZB1 marginal zone B and B1 cell-specific protein 3.13832
CD8B CD8b molecule 3.13832
TTC24 tetratricopeptide repeat domain 24 3.13832
USP32 ubiquitin specific peptidase 32 3.13832
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.13832
RNF224 ring finger protein 224 3.13832
CCDC70 coiled-coil domain containing 70 3.13832
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.13832
C9ORF57 chromosome 9 open reading frame 57 3.13832
ANKRD33 ankyrin repeat domain 33 3.13832
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.13832
EOMES eomesodermin 3.13832
DNAH5 dynein, axonemal, heavy chain 5 3.11768
GDF5 growth differentiation factor 5 3.08927
ETNPPL ethanolamine-phosphate phospho-lyase 3.08927
IL18 interleukin 18 3.08927
GLRA3 glycine receptor, alpha 3 3.08927
VCX variable charge, X-linked 3.08927
MAP2K1 mitogen-activated protein kinase kinase 1 2.9569
GADL1 glutamate decarboxylase-like 1 2.95001
ACP6 acid phosphatase 6, lysophosphatidic 2.94195
LGI2 leucine-rich repeat LGI family, member 2 2.92233
SMC2 structural maintenance of chromosomes 2 2.89361
ZNF892 zinc finger protein 892 2.83762
TACC1 transforming, acidic coiled-coil containing protein 1 2.79881
EFCAB11 EF-hand calcium binding domain 11 2.74212
EDC3 enhancer of mRNA decapping 3 2.7235
C11ORF71 chromosome 11 open reading frame 71 2.7208
IQCK IQ motif containing K 2.65675
LEKR1 leucine, glutamate and lysine rich 1 2.63254
SASH1 SAM and SH3 domain containing 1 2.62997
ZNF227 zinc finger protein 227 2.62997
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.61294
INTU inturned planar cell polarity protein 2.59457
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 2.57744
NXF1 nuclear RNA export factor 1 2.54291
CAMK4 calcium/calmodulin-dependent protein kinase IV 2.53075
AMBRA1 autophagy/beclin-1 regulator 1 2.52307
MKRN2OS MKRN2 opposite strand 2.51104
SGK3 serum/glucocorticoid regulated kinase family, member 3 2.47291
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.45207
C16ORF46 chromosome 16 open reading frame 46 2.39044
BASP1 brain abundant, membrane attached signal protein 1 2.38439
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.34888
CHL1 cell adhesion molecule L1-like 2.34672
LURAP1L leucine rich adaptor protein 1-like 2.34672
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.33273
ZNF451 zinc finger protein 451 2.32902
ADGRG1 adhesion G protein-coupled receptor G1 2.31482
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.30852
ADGRD2 adhesion G protein-coupled receptor D2 2.29429
ANO10 anoctamin 10 2.26911
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 2.26181
PLXNA1 plexin A1 2.25036
BAIAP2L2 BAI1-associated protein 2-like 2 2.23524
LMLN leishmanolysin-like (metallopeptidase M8 family) 2.23336
CSMD1 CUB and Sushi multiple domains 1 2.18412
SLC12A9 solute carrier family 12, member 9 2.18412
ARHGAP9 Rho GTPase activating protein 9 2.15998
TMEM171 transmembrane protein 171 2.15998
NLRP7 NLR family, pyrin domain containing 7 2.15998
ATXN7L2 ataxin 7-like 2 2.15998
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.15998
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.15998
CPB2 carboxypeptidase B2 (plasma) 2.15998
ADRA2A adrenoceptor alpha 2A 2.15998
DIPK2A divergent protein kinase domain 2A 2.15663
OSBPL1A oxysterol binding protein-like 1A 2.15572
SLC48A1 solute carrier family 48 (heme transporter), member 1 2.15548
RRAGA Ras-related GTP binding A 2.14163
PLPPR4 phospholipid phosphatase related 4 2.12175
SRP54 signal recognition particle 54kDa 2.11622
LPAR1 lysophosphatidic acid receptor 1 2.1035
MAVS mitochondrial antiviral signaling protein 2.07155
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.05047
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 2.04939
ANKLE2 ankyrin repeat and LEM domain containing 2 2.04061
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 2.03537
FKBP11 FK506 binding protein 11, 19 kDa 2.03537
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.03537
GTF2H2C GTF2H2 family member C 2.02862
CENPI centromere protein I 2.02862
GUK1 guanylate kinase 1 2.02774
SOX13 SRY (sex determining region Y)-box 13 2.02774
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.01287

decreased expression

Symbol Name Standardized Value
UPK1B uroplakin 1B -3.13832
XXYLT1 xyloside xylosyltransferase 1 -3.13832
SCAMP4 secretory carrier membrane protein 4 -3.13832
RABIF RAB interacting factor -3.13832
C16ORF54 chromosome 16 open reading frame 54 -3.13832
CCDC22 coiled-coil domain containing 22 -3.13832
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -3.13832
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -3.13832
FANCM Fanconi anemia, complementation group M -3.13832
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -3.13832
NICN1 nicolin 1 -3.13832
SMIM47 small integral membrane protein 47 -3.08927
C1QTNF2 C1q and tumor necrosis factor related protein 2 -3.08927
FOSB FBJ murine osteosarcoma viral oncogene homolog B -3.08927
FZD1 frizzled class receptor 1 -3.08927
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -3.08927
C3ORF80 chromosome 3 open reading frame 80 -3.08927
CFAP99 cilia and flagella associated protein 99 -3.08927
OXT oxytocin/neurophysin I prepropeptide -3.08927
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -3.08927
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -3.08927
LRRC63 leucine rich repeat containing 63 -3.08927
KRTAP13-4 keratin associated protein 13-4 -3.08927
GDNF glial cell derived neurotrophic factor -3.08927
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -3.08927
HAS1 hyaluronan synthase 1 -3.08927
KIF19 kinesin family member 19 -3.08927
TGM6 transglutaminase 6 -3.08927
LIF leukemia inhibitory factor -3.08927
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -3.08927
KY kyphoscoliosis peptidase -3.08927
FRG2C FSHD region gene 2 family, member C -3.08927
CCDC154 coiled-coil domain containing 154 -3.08927
EXD1 exonuclease 3'-5' domain containing 1 -3.08927
CEND1 cell cycle exit and neuronal differentiation 1 -3.08927
FAM177B family with sequence similarity 177, member B -3.08927
IFT70A intraflagellar transport 70A -3.08927
TDRD10 tudor domain containing 10 -3.08927
F11 coagulation factor XI -3.08927
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -3.08927
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 -3.08927
SMKR1 small lysine-rich protein 1 -3.08927
CCL25 chemokine (C-C motif) ligand 25 -3.08927
WNT9B wingless-type MMTV integration site family, member 9B -3.08927
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -3.08927
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -3.05351
MANSC1 MANSC domain containing 1 -3.03403
CLASRP CLK4-associating serine/arginine rich protein -2.98745
ICA1 islet cell autoantigen 1, 69kDa -2.91151
TMEM242 transmembrane protein 242 -2.76899
SCO2 SCO2 cytochrome c oxidase assembly protein -2.62642
RASIP1 Ras interacting protein 1 -2.58037
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -2.57936
FLOT2 flotillin 2 -2.49322
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.45582
CRABP2 cellular retinoic acid binding protein 2 -2.45413
STAG2 stromal antigen 2 -2.41657
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -2.40334
ZSWIM8 zinc finger, SWIM-type containing 8 -2.39773
TMEM184B transmembrane protein 184B -2.39533
ZNF524 zinc finger protein 524 -2.38277
CDV3 CDV3 homolog (mouse) -2.36223
SRCAP Snf2-related CREBBP activator protein -2.31482
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -2.30885
RAP2C RAP2C, member of RAS oncogene family -2.30885
HYAL2 hyaluronoglucosaminidase 2 -2.30885
GRK4 G protein-coupled receptor kinase 4 -2.30583
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.30583
MRPS26 mitochondrial ribosomal protein S26 -2.30583
M6PR mannose-6-phosphate receptor (cation dependent) -2.30583
C5 complement component 5 -2.28848
SGF29 SAGA complex associated factor 29 -2.25799
SYCP2L synaptonemal complex protein 2-like -2.25164
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -2.2417
SCAND1 SCAN domain containing 1 -2.23505
HPS4 Hermansky-Pudlak syndrome 4 -2.23424
NXT1 nuclear transport factor 2-like export factor 1 -2.23336
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing -2.22829
KLK8 kallikrein-related peptidase 8 -2.22511
DCDC2 doublecortin domain containing 2 -2.21071
ACER3 alkaline ceramidase 3 -2.18412
MRM3 mitochondrial rRNA methyltransferase 3 -2.1643
ZNF750 zinc finger protein 750 -2.15835
GFY golgi-associated, olfactory signaling regulator -2.15835
CRIP1 cysteine-rich protein 1 (intestinal) -2.15835
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.14784
RASL11B RAS-like, family 11, member B -2.14163
ZNF225 zinc finger protein 225 -2.14163
GLCCI1 glucocorticoid induced 1 -2.13903
ZNF154 zinc finger protein 154 -2.11707
GPR139 G protein-coupled receptor 139 -2.1035
DOLPP1 dolichyldiphosphatase 1 -2.08618
NEK4 NIMA-related kinase 4 -2.08618
GPM6A glycoprotein M6A -2.0684
USO1 USO1 vesicle transport factor -2.06562
SMAD9 SMAD family member 9 -2.05527
RBM11 RNA binding motif protein 11 -2.05527
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -2.04939
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.04166
MRPL30 mitochondrial ribosomal protein L30 -2.03537
DCTN6 dynactin 6 -2.03537
TSLIG3C tRNA splicing ligase complex subunit 3C -2.02862
CCDC71 coiled-coil domain containing 71 -2.02774
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.02774
ZNF324 zinc finger protein 324 -2.02774
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.02774
TMEM120A transmembrane protein 120A -2.02774
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -2.02578
IGSF21 immunoglobin superfamily, member 21 -2.02236
LAMP2 lysosomal-associated membrane protein 2 -2.00776