USP28 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ubiquitin specific peptidase 28|The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 57646)
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Genes

324 genes differentially expressed following the USP28 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BTC betacellulin 3.07256
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.07256
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.07256
TAS2R1 taste receptor, type 2, member 1 3.07256
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.07256
SHCBP1L SHC SH2-domain binding protein 1-like 3.07256
HCRTR2 hypocretin (orexin) receptor 2 3.07256
BSX brain-specific homeobox 3.07256
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.07256
SIGLEC5 sialic acid binding Ig-like lectin 5 3.07256
SSMEM1 serine-rich single-pass membrane protein 1 3.07256
TBR1 T-box, brain, 1 3.07256
FABP1 fatty acid binding protein 1, liver 3.07256
PCDHB6 protocadherin beta 6 3.07256
C4A complement component 4A (Rodgers blood group) 3.07256
HORMAD1 HORMA domain containing 1 3.07256
CRISP2 cysteine-rich secretory protein 2 3.07256
BLK BLK proto-oncogene, Src family tyrosine kinase 3.07256
UMOD uromodulin 3.07256
ELSPBP1 epididymal sperm binding protein 1 3.07256
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.07256
CD69 CD69 molecule 3.07256
S100A5 S100 calcium binding protein A5 3.07256
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.07256
ICAM2 intercellular adhesion molecule 2 3.07256
ASCL2 achaete-scute family bHLH transcription factor 2 3.07256
STOML3 stomatin (EPB72)-like 3 3.07256
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.07256
MMP13 matrix metallopeptidase 13 3.07256
MMP10 matrix metallopeptidase 10 3.07256
LHB luteinizing hormone beta polypeptide 3.07256
PITX2 paired-like homeodomain 2 3.07256
GALP galanin-like peptide 3.07256
TPRX1 tetra-peptide repeat homeobox 1 3.07256
BMP5 bone morphogenetic protein 5 3.07256
NMUR2 neuromedin U receptor 2 3.07256
RTP3 receptor (chemosensory) transporter protein 3 3.07256
HIC1 hypermethylated in cancer 1 3.07256
STEAP4 STEAP family member 4 3.07256
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.07256
TYRP1 tyrosinase-related protein 1 3.07256
FGF7 fibroblast growth factor 7 3.07256
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.07256
CAMP cathelicidin antimicrobial peptide 3.07256
SMIM39 small integral membrane protein 39 3.07256
VSIR V-set immunoregulatory receptor 3.07256
TYROBP TYRO protein tyrosine kinase binding protein 3.07256
HBG2 hemoglobin, gamma G 3.07256
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.07256
PDC phosducin 3.07256
ADRB3 adrenoceptor beta 3 3.07256
ASB4 ankyrin repeat and SOCS box containing 4 3.07256
TTR transthyretin 3.07256
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 3.07256
BNIP5 BCL2 interacting protein 5 3.07256
WDR97 WD repeat domain 97 3.07256
SPMIP7 sperm microtubule inner protein 7 3.07256
ANKRD42-DT ANKRD42 divergent transcript 3.07256
SPMIP3 sperm microtubule inner protein 3 3.07256
CIMAP1B ciliary microtubule associated protein 1B 3.07256
CCDC201 coiled-coil domain containing 201 3.07256
SMIM35 small integral membrane protein 35 3.07256
TAFA1 TAFA chemokine like family member 1 3.07256
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.07256
RTL1 retrotransposon-like 1 3.07256
C15ORF62 chromosome 15 open reading frame 62 3.07256
S100G S100 calcium binding protein G 3.07256
MCEMP1 mast cell-expressed membrane protein 1 3.07256
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.07256
NCBP2L nuclear cap binding protein subunit 2-like 3.07256
FOXL1 forkhead box L1 3.07256
HLF hepatic leukemia factor 3.07256
ASB15 ankyrin repeat and SOCS box containing 15 3.07256
SCN2B sodium channel, voltage gated, type II beta subunit 3.07256
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.07256
FOXD1 forkhead box D1 3.07256
COX7B cytochrome c oxidase subunit VIIb 3.07256
PCDHA7 protocadherin alpha 7 3.07256
SPDYC speedy/RINGO cell cycle regulator family member C 3.07256
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.07256
TLR8 toll-like receptor 8 3.07256
TLR1 toll-like receptor 1 3.07256
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 3.07256
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.07256
HPR haptoglobin-related protein 3.07256
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.07256
SPATA31A6 SPATA31 subfamily A, member 6 3.07256
TMEM156 transmembrane protein 156 3.07256
FNDC9 fibronectin type III domain containing 9 3.07256
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.07256
WFDC1 WAP four-disulfide core domain 1 3.07256
WFDC9 WAP four-disulfide core domain 9 3.07256
PKDREJ polycystin (PKD) family receptor for egg jelly 3.07256
C16ORF78 chromosome 16 open reading frame 78 3.07256
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.07256
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 3.07256
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.07256
KLF1 Kruppel-like factor 1 (erythroid) 3.07256
TAS2R50 taste receptor, type 2, member 50 3.07256
ZSCAN4 zinc finger and SCAN domain containing 4 3.07256
POF1B premature ovarian failure, 1B 3.07256
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.07256
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.07256
FATE1 fetal and adult testis expressed 1 3.07256
THTPA thiamine triphosphatase 3.07256
CLRN3 clarin 3 3.07256
DUOX2 dual oxidase 2 3.07256
IL19 interleukin 19 3.07256
HRCT1 histidine rich carboxyl terminus 1 3.07256
HOPX HOP homeobox 3.07256
CSF1R colony stimulating factor 1 receptor 3.07256
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.07256
MOBP myelin-associated oligodendrocyte basic protein 3.07256
LDLRAD1 low density lipoprotein receptor class A domain containing 1 3.07256
GAS2L2 growth arrest-specific 2 like 2 3.07256
C1ORF185 chromosome 1 open reading frame 185 3.07256
DRC7 dynein regulatory complex subunit 7 3.07256
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.07256
SH2D1B SH2 domain containing 1B 3.07256
DMRT2 doublesex and mab-3 related transcription factor 2 3.07256
C8ORF89 chromosome 8 open reading frame 89 3.07256
KLK15 kallikrein-related peptidase 15 3.07256
FBXO40 F-box protein 40 3.07256
ZNF335 zinc finger protein 335 3.07256
IGF2 insulin-like growth factor 2 3.07256
LENEP lens epithelial protein 3.07256
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.07256
DMRT3 doublesex and mab-3 related transcription factor 3 3.07256
RGSL1 regulator of G-protein signaling like 1 3.07256
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.07256
CCDC166 coiled-coil domain containing 166 3.07256
PLA2G4E phospholipase A2, group IVE 3.07256
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.07256
CIDEA cell death-inducing DFFA-like effector a 3.07256
ZMYND10 zinc finger, MYND-type containing 10 3.07256
PRSS54 protease, serine, 54 3.07256
SLFN12L schlafen family member 12-like 3.07256
IHH indian hedgehog 3.07256
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.07256
CHRM4 cholinergic receptor, muscarinic 4 3.07256
AMER3 APC membrane recruitment protein 3 3.07256
HHIPL2 HHIP-like 2 3.07256
CETP cholesteryl ester transfer protein, plasma 3.07256
HP haptoglobin 3.07256
NGB neuroglobin 3.07256
APOD apolipoprotein D 3.07256
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.07256
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.07256
FAM221B family with sequence similarity 221, member B 3.06622
MYRIP myosin VIIA and Rab interacting protein 3.05545
DYNLT2B dynein light chain Tctex-type 2B 3.05545
CNOT10 CCR4-NOT transcription complex, subunit 10 3.05002
DMC1 DNA meiotic recombinase 1 3.01544
SBNO1 strawberry notch homolog 1 (Drosophila) 2.99935
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.79274
PDIA5 protein disulfide isomerase family A, member 5 2.77038
FNDC10 fibronectin type III domain containing 10 2.70542
CXXC5 CXXC finger protein 5 2.68596
PITPNB phosphatidylinositol transfer protein, beta 2.63152
CFL2 cofilin 2 (muscle) 2.61546
ILDR1 immunoglobulin-like domain containing receptor 1 2.57672
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.50852
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.48878
BCAS2 breast carcinoma amplified sequence 2 2.48696
TM2D3 TM2 domain containing 3 2.4758
C1RL complement component 1, r subcomponent-like 2.43784
ISYNA1 inositol-3-phosphate synthase 1 2.43784
IGSF5 immunoglobulin superfamily, member 5 2.42482
CMIP c-Maf inducing protein 2.40093
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 2.38312
EVL Enah/Vasp-like 2.36934
SDC2 syndecan 2 2.36934
GFM2 G elongation factor, mitochondrial 2 2.35818
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.33812
SPATA21 spermatogenesis associated 21 2.33494
LOXL4 lysyl oxidase-like 4 2.33486
MIP major intrinsic protein of lens fiber 2.33486
VMAC vimentin-type intermediate filament associated coiled-coil protein 2.32925
ACTL10 actin-like 10 2.32414
NEO1 neogenin 1 2.29849
TLK1 tousled-like kinase 1 2.29364
TSPAN7 tetraspanin 7 2.2846
BAG5 BCL2-associated athanogene 5 2.25669
DPY19L1 dpy-19-like 1 (C. elegans) 2.24256
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.22494
PDZD7 PDZ domain containing 7 2.22071
NLRP6 NLR family, pyrin domain containing 6 2.21709
ACY3 aminoacylase 3 2.21709
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.21709
TMEM132A transmembrane protein 132A 2.20597
OXLD1 oxidoreductase-like domain containing 1 2.19884
SNX33 sorting nexin 33 2.19173
CAPNS1 calpain, small subunit 1 2.19173
BSG basigin (Ok blood group) 2.17903
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.17014
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.15854
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.15445
ACSM6 acyl-CoA synthetase medium-chain family member 6 2.15233
MXD1 MAX dimerization protein 1 2.1353
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.13145
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.12783
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.12454
LMOD3 leiomodin 3 (fetal) 2.12137
ACOT12 acyl-CoA thioesterase 12 2.12137
JSRP1 junctional sarcoplasmic reticulum protein 1 2.12137
MYADML2 myeloid-associated differentiation marker-like 2 2.12137
VSTM1 V-set and transmembrane domain containing 1 2.12137
SLC7A14 solute carrier family 7, member 14 2.10302
XPOT exportin, tRNA 2.09612
CCDC88C coiled-coil domain containing 88C 2.08431
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.08124
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.07759
CALM2 calmodulin 2 (phosphorylase kinase, delta) 2.07759
SLC35H1 solute carrier family 35 member H1 2.07192
LASP1NB LASP1 neighbor 2.04945
MYO19 myosin XIX 2.01933
DCLK1 doublecortin-like kinase 1 2.01246
DONSON downstream neighbor of SON 2.01071
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.00753

decreased expression

Symbol Name Standardized Value
FBXL20 F-box and leucine-rich repeat protein 20 -3.07256
S100B S100 calcium binding protein B -3.07256
CTAGE9 CTAGE family, member 9 -3.07256
CRYBB2 crystallin, beta B2 -3.07256
IZUMO4 IZUMO family member 4 -3.07256
GMFG glia maturation factor, gamma -3.07256
PLIN1 perilipin 1 -3.07256
TPTE transmembrane phosphatase with tensin homology -3.07256
HEATR9 HEAT repeat containing 9 -3.07256
BBS9 Bardet-Biedl syndrome 9 -3.07256
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -3.07256
EPHB3 EPH receptor B3 -3.07256
ADGRE3 adhesion G protein-coupled receptor E3 -3.07256
USP28 ubiquitin specific peptidase 28 -3.07256
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -3.07256
SESN3 sestrin 3 -3.07256
SAMD11 sterile alpha motif domain containing 11 -3.07256
CGB7 chorionic gonadotropin, beta polypeptide 7 -3.07256
NOTCH2NLB notch 2 N-terminal like B -3.07256
MB myoglobin -3.07256
PPP1R27 protein phosphatase 1, regulatory subunit 27 -3.07256
FCMR Fc fragment of IgM receptor -3.07256
C1ORF105 chromosome 1 open reading frame 105 -3.07256
DMRTC1 DMRT-like family C1 -3.07256
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.07256
RPS27L ribosomal protein S27-like -3.07256
C8ORF88 chromosome 8 open reading frame 88 -3.07256
CNTNAP4 contactin associated protein-like 4 -3.07256
BAX BCL2-associated X protein -3.07256
CNTN6 contactin 6 -3.07256
SPEF1 sperm flagellar 1 -3.07256
GJB3 gap junction protein, beta 3, 31kDa -3.07256
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -3.06947
MED26 mediator complex subunit 26 -3.05002
CNTNAP5 contactin associated protein-like 5 -2.99585
IGFBP4 insulin-like growth factor binding protein 4 -2.9373
DEPDC7 DEP domain containing 7 -2.89474
CYB5D1 cytochrome b5 domain containing 1 -2.86121
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.85742
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) -2.78512
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.74873
RABGAP1 RAB GTPase activating protein 1 -2.71615
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -2.63152
IRF1 interferon regulatory factor 1 -2.63152
CNTN5 contactin 5 -2.54358
N4BP1 NEDD4 binding protein 1 -2.53622
BMP2 bone morphogenetic protein 2 -2.50834
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -2.48878
MLXIPL MLX interacting protein-like -2.48514
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -2.47384
HEPH hephaestin -2.45897
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.45384
DNAH5 dynein, axonemal, heavy chain 5 -2.43925
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.42025
CEP68 centrosomal protein 68kDa -2.40009
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -2.37867
ZNF564 zinc finger protein 564 -2.36828
DCP1B decapping mRNA 1B -2.36058
ZMAT3 zinc finger, matrin-type 3 -2.32414
GSDMA gasdermin A -2.32414
COL7A1 collagen, type VII, alpha 1 -2.30209
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.29364
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.28229
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled -2.27877
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.24593
GET3 guided entry of tail-anchored proteins factor 3, ATPase -2.23122
ZNF324 zinc finger protein 324 -2.23122
ZFP1 ZFP1 zinc finger protein -2.21035
DRAM1 DNA-damage regulated autophagy modulator 1 -2.20871
PRR19 proline rich 19 -2.20871
ZFAND6 zinc finger, AN1-type domain 6 -2.16913
HPCAL1 hippocalcin-like 1 -2.15972
SCIN scinderin -2.14911
KCTD19 potassium channel tetramerization domain containing 19 -2.14037
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.12454
NTPCR nucleoside-triphosphatase, cancer-related -2.12364
STAB1 stabilin 1 -2.10775
CFAP61 cilia and flagella associated protein 61 -2.10775
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.10775
ANKRD13A ankyrin repeat domain 13A -2.10723
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.1051
WASF2 WAS protein family, member 2 -2.10302
SET SET nuclear proto-oncogene -2.10302
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.10148
REN renin -2.10148
GPR150 G protein-coupled receptor 150 -2.10148
GOLGA6L7 golgin A6 family like 7 -2.10148
NSG2 neuronal vesicle trafficking associated 2 -2.10148
HORMAD2 HORMA domain containing 2 -2.10148
RRM2B ribonucleotide reductase M2 B (TP53 inducible) -2.09612
RP2 retinitis pigmentosa 2 (X-linked recessive) -2.09356
RBMX2 RNA binding motif protein, X-linked 2 -2.09244
PIAS2 protein inhibitor of activated STAT, 2 -2.07685
L3MBTL3 l(3)mbt-like 3 (Drosophila) -2.05415
PRKD2 protein kinase D2 -2.05415
C5ORF34 chromosome 5 open reading frame 34 -2.05415
DNAI3 dynein axonemal intermediate chain 3 -2.05295
TP53I3 tumor protein p53 inducible protein 3 -2.05213
NT5C 5', 3'-nucleotidase, cytosolic -2.05213
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.04544
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 -2.04263
RERG RAS-like, estrogen-regulated, growth inhibitor -2.03497
PCNP PEST proteolytic signal containing nuclear protein -2.03322
LTO1 LTO1 maturation factor of ABCE1 -2.03086
FBXL5 F-box and leucine-rich repeat protein 5 -2.01148