Ulipristal Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/13559281
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Genes

200 proteins with high or low expression in Ulipristal relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ALPK3 alpha-kinase 3 1.96
PIP prolactin-induced protein 1.79
AASDH aminoadipate-semialdehyde dehydrogenase 1.61
ANGPTL4 angiopoietin-like 4 1.54
ZER1 zyg-11 related, cell cycle regulator 1.32
H3C1 H3 clustered histone 1 1.23
MCOLN2 mucolipin 2 1.2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.1
NLGN2 neuroligin 2 1.09
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.09
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.08
MT1F metallothionein 1F 0.86
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.81
EED embryonic ectoderm development 0.81
C1ORF43 chromosome 1 open reading frame 43 0.75
TMEM135 transmembrane protein 135 0.7
TLE5 TLE family member 5, transcriptional modulator 0.7
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.66
RCOR1 REST corepressor 1 0.66
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.57
KMT2C lysine (K)-specific methyltransferase 2C 0.57
TECPR1 tectonin beta-propeller repeat containing 1 0.57
JPT1 Jupiter microtubule associated homolog 1 0.54
PITX2 paired-like homeodomain 2 0.52
KLHL23 kelch-like family member 23 0.52
PCSK9 proprotein convertase subtilisin/kexin type 9 0.51
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.51
CLTA clathrin, light chain A 0.51
FGFBP1 fibroblast growth factor binding protein 1 0.51
TPM4 tropomyosin 4 0.5
CREG1 cellular repressor of E1A-stimulated genes 1 0.5
HIST2H2BF histone cluster 2, H2bf 0.5
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 0.49
ASB3 ankyrin repeat and SOCS box containing 3 0.48
BAG4 BCL2-associated athanogene 4 0.48
DERPC DERPC proline and glycine rich nuclear protein 0.47
STMN2 stathmin 2 0.46
GLRX glutaredoxin (thioltransferase) 0.46
TMEM98 transmembrane protein 98 0.46
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.44
COMMD8 COMM domain containing 8 0.43
FAR1 fatty acyl CoA reductase 1 0.43
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.43
MED29 mediator complex subunit 29 0.43
EHF ets homologous factor 0.42
ABHD2 abhydrolase domain containing 2 0.42
BCO2 beta-carotene oxygenase 2 0.42
ZNF28 zinc finger protein 28 0.42
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.42
CLIC3 chloride intracellular channel 3 0.42
RPE ribulose-5-phosphate-3-epimerase 0.41
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 0.41
TESC tescalcin 0.4
ARL4C ADP-ribosylation factor-like 4C 0.4
ATP5PF ATP synthase peripheral stalk subunit F6 0.4
KMT2B lysine (K)-specific methyltransferase 2B 0.4
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.39
WNT16 wingless-type MMTV integration site family, member 16 0.39
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.39
TRIM2 tripartite motif containing 2 0.39
EIF5A eukaryotic translation initiation factor 5A 0.39
IL10RB interleukin 10 receptor, beta 0.38
C15ORF41 chromosome 15 open reading frame 41 0.38
NPTXR neuronal pentraxin receptor 0.38
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 0.38
JAK1 Janus kinase 1 0.38
ANTXR1 anthrax toxin receptor 1 0.38
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.37
CHKA choline kinase alpha 0.37
AKAP6 A kinase (PRKA) anchor protein 6 0.37
RILPL2 Rab interacting lysosomal protein-like 2 0.37
BOLA1 bolA family member 1 0.37
NPM3 nucleophosmin/nucleoplasmin 3 0.37
RPL31 ribosomal protein L31 0.37
COPRS coordinator of PRMT5, differentiation stimulator 0.36
C12ORF73 chromosome 12 open reading frame 73 0.36
TNNC2 troponin C type 2 (fast) 0.36
LAMA3 laminin, alpha 3 0.36
ITGA7 integrin, alpha 7 0.36
MT2A metallothionein 2A 0.35
LIME1 Lck interacting transmembrane adaptor 1 0.35
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.35
TSPOAP1 TSPO associated protein 1 0.35
PET100 PET100 homolog (S. cerevisiae) 0.35
HLA-F major histocompatibility complex, class I, F 0.35
RPL13A ribosomal protein L13a 0.35
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.34
P4HB prolyl 4-hydroxylase, beta polypeptide 0.34
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 0.34
EIF5A2 eukaryotic translation initiation factor 5A2 0.34
SNTA1 syntrophin, alpha 1 0.33
LOXL2 lysyl oxidase-like 2 0.33
COX5A cytochrome c oxidase subunit Va 0.33
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.33
DENND5B DENN/MADD domain containing 5B 0.33
IL6ST interleukin 6 signal transducer 0.33
RHOBTB3 Rho-related BTB domain containing 3 0.33
CYB5A cytochrome b5 type A (microsomal) 0.33
MSX1 msh homeobox 1 0.33
LGALSL lectin, galactoside-binding-like 0.33

low expression

Symbol Name Standardized Value
WLS wntless Wnt ligand secretion mediator -0.97
ZNF410 zinc finger protein 410 -0.75
MYBPC1 myosin binding protein C, slow type -0.67
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.67
NRP1 neuropilin 1 -0.64
RNF13 ring finger protein 13 -0.62
LYST lysosomal trafficking regulator -0.62
ANKRD20A4 ankyrin repeat domain 20 family, member A4 -0.62
LMLN leishmanolysin-like (metallopeptidase M8 family) -0.58
SYN1 synapsin I -0.58
MYOM3 myomesin 3 -0.56
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -0.56
COL1A1 collagen, type I, alpha 1 -0.55
LTBP4 latent transforming growth factor beta binding protein 4 -0.55
COL11A1 collagen, type XI, alpha 1 -0.53
ACTN4 actinin, alpha 4 -0.5
LTO1 LTO1 maturation factor of ABCE1 -0.47
SPHK2 sphingosine kinase 2 -0.46
PLIN2 perilipin 2 -0.45
SGSH N-sulfoglucosamine sulfohydrolase -0.45
FN1 fibronectin 1 -0.45
UBE2A ubiquitin-conjugating enzyme E2A -0.44
C9ORF40 chromosome 9 open reading frame 40 -0.43
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -0.43
SESN1 sestrin 1 -0.41
ZNF276 zinc finger protein 276 -0.41
SESN2 sestrin 2 -0.41
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) -0.4
UPP1 uridine phosphorylase 1 -0.4
FGB fibrinogen beta chain -0.4
PCGF1 polycomb group ring finger 1 -0.39
KIF27 kinesin family member 27 -0.39
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.38
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 -0.38
PYGM phosphorylase, glycogen, muscle -0.37
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.37
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.37
PDIK1L PDLIM1 interacting kinase 1 like -0.36
TSPAN5 tetraspanin 5 -0.36
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.36
ACTL8 actin-like 8 -0.36
PTPDC1 protein tyrosine phosphatase domain containing 1 -0.35
ZNF675 zinc finger protein 675 -0.35
LRRC8B leucine rich repeat containing 8 family, member B -0.35
ESPN espin -0.35
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -0.34
MROH6 maestro heat-like repeat family member 6 -0.34
ZXDB zinc finger, X-linked, duplicated B -0.34
CBWD1 COBW domain containing 1 -0.34
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.34
MKRN4P makorin ring finger protein 4, pseudogene -0.33
TMEM143 transmembrane protein 143 -0.33
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -0.33
DTWD1 DTW domain containing 1 -0.33
TOR3A torsin family 3, member A -0.32
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) -0.32
MEST mesoderm specific transcript -0.32
SLC38A7 solute carrier family 38, member 7 -0.32
WDR5B WD repeat domain 5B -0.32
TCEA2 transcription elongation factor A (SII), 2 -0.32
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -0.32
RNASE4 ribonuclease, RNase A family, 4 -0.31
SCAND1 SCAN domain containing 1 -0.31
B9D1 B9 protein domain 1 -0.31
PDE4B phosphodiesterase 4B, cAMP-specific -0.3
UXT ubiquitously-expressed, prefoldin-like chaperone -0.3
ZBED2 zinc finger, BED-type containing 2 -0.3
ACVR1B activin A receptor, type IB -0.3
RAD51D RAD51 paralog D -0.29
CAPRIN2 caprin family member 2 -0.29
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.29
ARSD arylsulfatase D -0.29
WDR13 WD repeat domain 13 -0.29
FSTL3 follistatin-like 3 (secreted glycoprotein) -0.28
STAB1 stabilin 1 -0.28
PBX3 pre-B-cell leukemia homeobox 3 -0.28
PLAAT3 phospholipase A and acyltransferase 3 -0.28
ZNF669 zinc finger protein 669 -0.28
CCPG1 cell cycle progression 1 -0.28
TMC4 transmembrane channel-like 4 -0.28
SENP8 SUMO/sentrin specific peptidase family member 8 -0.28
EGR1 early growth response 1 -0.28
KCTD17 potassium channel tetramerization domain containing 17 -0.27
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.27
ZNF431 zinc finger protein 431 -0.27
HDAC5 histone deacetylase 5 -0.27
MKS1 Meckel syndrome, type 1 -0.27
NABP2 nucleic acid binding protein 2 -0.27
CCNDBP1 cyclin D-type binding-protein 1 -0.26
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -0.26
JMJD4 jumonji domain containing 4 -0.26
HOXB9 homeobox B9 -0.26
DNAH6 dynein, axonemal, heavy chain 6 -0.26
PAQR7 progestin and adipoQ receptor family member VII -0.26
ABHD5 abhydrolase domain containing 5 -0.26
ARL16 ADP-ribosylation factor-like 16 -0.26
VGF VGF nerve growth factor inducible -0.26
AMZ2 archaelysin family metallopeptidase 2 -0.26
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -0.25
CCDC90B coiled-coil domain containing 90B -0.25