Uremia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D014511
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Genes

274 genes/proteins associated with the disease Uremia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
KDR kinase insert domain receptor 2.88009
RUNX2 runt-related transcription factor 2 2.88009
TGFBR1 transforming growth factor, beta receptor 1 2.88009
SPP1 secreted phosphoprotein 1 2.88009
TGFB1 transforming growth factor, beta 1 2.88009
BMP2 bone morphogenetic protein 2 2.88009
VCAM1 vascular cell adhesion molecule 1 2.88009
FLT1 fms-related tyrosine kinase 1 2.88009
NOS3 nitric oxide synthase 3 (endothelial cell) 2.88009
SGK1 serum/glucocorticoid regulated kinase 1 2.88009
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.88009
ICAM1 intercellular adhesion molecule 1 2.88009
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.88009
MGP matrix Gla protein 2.88009
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.88009
PTH parathyroid hormone 2.88009
BCL2 B-cell CLL/lymphoma 2 1.92658
BAX BCL2-associated X protein 1.91368
IL1B interleukin 1, beta 1.84622
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.80491
HMOX1 heme oxygenase 1 1.8
CAT catalase 1.79579
DDIT3 DNA-damage-inducible transcript 3 1.78682
TNF tumor necrosis factor 1.76013
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.75182
BCL2L1 BCL2-like 1 1.72426
CCL2 chemokine (C-C motif) ligand 2 1.71524
VEGFA vascular endothelial growth factor A 1.70906
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.6934
IL6 interleukin 6 1.67761
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.65599
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.65204
EGR1 early growth response 1 1.64685
FAS Fas cell surface death receptor 1.64528
NOS2 nitric oxide synthase 2, inducible 1.64168
EDN1 endothelin 1 1.63272
CLU clusterin 1.62468
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.62268
FASLG Fas ligand (TNF superfamily, member 6) 1.62222
AQP2 aquaporin 2 (collecting duct) 1.62013
SOD2 superoxide dismutase 2, mitochondrial 1.61851
GADD45A growth arrest and DNA-damage-inducible, alpha 1.60105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.58701
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.58255
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.57546
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.57186
REN renin 1.56923
FOS FBJ murine osteosarcoma viral oncogene homolog 1.5641
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.55255
SOD1 superoxide dismutase 1, soluble 1.55035
THBS1 thrombospondin 1 1.54475
IL10 interleukin 10 1.54354
NPPB natriuretic peptide B 1.53579
PPARA peroxisome proliferator-activated receptor alpha 1.52262
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.52187
NPPA natriuretic peptide A 1.52061
TIMP1 TIMP metallopeptidase inhibitor 1 1.51734
TP53 tumor protein p53 1.49558
GSR glutathione reductase 1.49457
MGMT O-6-methylguanine-DNA methyltransferase 1.49407
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.48222
TIMP2 TIMP metallopeptidase inhibitor 2 1.48119
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.47762
GSTM1 glutathione S-transferase mu 1 1.47141
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.45962
JUN jun proto-oncogene 1.45352
GSTP1 glutathione S-transferase pi 1 1.44927
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.44572
CALR calreticulin 1.43946
PARP1 poly (ADP-ribose) polymerase 1 1.43809
IGF1 insulin-like growth factor 1 (somatomedin C) 1.4332
MKI67 marker of proliferation Ki-67 1.4294
EPO erythropoietin 1.4275
NFE2L2 nuclear factor, erythroid 2-like 2 1.42669
ANXA5 annexin A5 1.4202
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.41586
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.41368
IFNG interferon, gamma 1.41174
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.39785
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.39226
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.3903
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.38156
HSPA1A heat shock 70kDa protein 1A 1.38156
COL1A1 collagen, type I, alpha 1 1.37987
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.35676
NRP1 neuropilin 1 1.35444
HSPE1 heat shock 10kDa protein 1 1.34782
IL1A interleukin 1, alpha 1.34489
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.33701
CASP12 caspase 12 (gene/pseudogene) 1.33701
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.33257
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.32964
MPO myeloperoxidase 1.32964
BIRC3 baculoviral IAP repeat containing 3 1.32696
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.32577
KLF6 Kruppel-like factor 6 1.32428
CREBBP CREB binding protein 1.32015
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.31208
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.30819
GDF15 growth differentiation factor 15 1.29875
G6PD glucose-6-phosphate dehydrogenase 1.2975
KNG1 kininogen 1 1.29256
VIM vimentin 1.2895
APOB apolipoprotein B 1.28889
BIRC2 baculoviral IAP repeat containing 2 1.28518
MCL1 myeloid cell leukemia 1 1.28303
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.28149
MAPK1 mitogen-activated protein kinase 1 1.27905
TXNIP thioredoxin interacting protein 1.27782
CCNB2 cyclin B2 1.27595
CHEK2 checkpoint kinase 2 1.26886
EDNRB endothelin receptor type B 1.26886
HSPA1B heat shock 70kDa protein 1B 1.26732
TGFB2 transforming growth factor, beta 2 1.26732
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.26732
F3 coagulation factor III (thromboplastin, tissue factor) 1.25369
XBP1 X-box binding protein 1 1.25214
PTH1R parathyroid hormone 1 receptor 1.25183
APP amyloid beta (A4) precursor protein 1.24781
STK39 serine threonine kinase 39 1.2475
PCNA proliferating cell nuclear antigen 1.24687
CHEK1 checkpoint kinase 1 1.2456
BTG2 BTG family, member 2 1.2456
EGF epidermal growth factor 1.24401
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.24181
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.23743
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.23712
CD44 CD44 molecule (Indian blood group) 1.23584
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.23488
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.23265
FN1 fibronectin 1 1.22599
ATF3 activating transcription factor 3 1.22599
BTG1 B-cell translocation gene 1, anti-proliferative 1.22534
KLF4 Kruppel-like factor 4 (gut) 1.22534
BCL2L2 BCL2-like 2 1.21951
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.21887
UBE2C ubiquitin-conjugating enzyme E2C 1.21402
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.21271
NOS1 nitric oxide synthase 1 (neuronal) 1.20816
CCL5 chemokine (C-C motif) ligand 5 1.20295
AURKB aurora kinase B 1.20295
ALB albumin 1.20229
ADRB2 adrenoceptor beta 2, surface 1.20229
MAPK3 mitogen-activated protein kinase 3 1.1977
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.19445
PPARG peroxisome proliferator-activated receptor gamma 1.19213
BDKRB1 bradykinin receptor B1 1.1908
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.18816
LEP leptin 1.18751
NGF nerve growth factor (beta polypeptide) 1.18259
S100A9 S100 calcium binding protein A9 1.18226
CTGF connective tissue growth factor 1.17728
TOP2A topoisomerase (DNA) II alpha 170kDa 1.17067
CD40 CD40 molecule, TNF receptor superfamily member 5 1.16633
AGTR2 angiotensin II receptor, type 2 1.165
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.16401
TTK TTK protein kinase 1.16203
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.15899
CYBA cytochrome b-245, alpha polypeptide 1.15526
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 1.14678
GLS glutaminase 1.14678
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.1461
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.1461
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.13895
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.13484
CYCS cytochrome c, somatic 1.13449
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.13415
HSPB1 heat shock 27kDa protein 1 1.13279
PDIA4 protein disulfide isomerase family A, member 4 1.13007
NPY neuropeptide Y 1.13007
STIP1 stress-induced phosphoprotein 1 1.13007
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.13007
IL1RN interleukin 1 receptor antagonist 1.13007
CXCL10 chemokine (C-X-C motif) ligand 10 1.12805
SMAD7 SMAD family member 7 1.12737
BAK1 BCL2-antagonist/killer 1 1.12703
FADS1 fatty acid desaturase 1 1.12461
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 1.12461
NTF3 neurotrophin 3 1.12219
BDKRB2 bradykinin receptor B2 1.12219
MAPK9 mitogen-activated protein kinase 9 1.11775
PTHLH parathyroid hormone-like hormone 1.11707
CCL3 chemokine (C-C motif) ligand 3 1.11571
BCL2A1 BCL2-related protein A1 1.11186
IL2 interleukin 2 1.11116
POLM polymerase (DNA directed), mu 1.11081
COL4A1 collagen, type IV, alpha 1 1.10942
IGFBP1 insulin-like growth factor binding protein 1 1.10872
SAT1 spermidine/spermine N1-acetyltransferase 1 1.10665
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 1.10665
PZP pregnancy-zone protein 1.10596
CDK2 cyclin-dependent kinase 2 1.10317
ATM ATM serine/threonine kinase 1.10246
VDAC1 voltage-dependent anion channel 1 1.1014
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 1.10104
IL12B interleukin 12B 1.09998
CD14 CD14 molecule 1.09927
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.09927
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.09927
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.09857
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.09716
PDCD5 programmed cell death 5 1.09681
DCN decorin 1.09681
MMP3 matrix metallopeptidase 3 1.09297
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.09226
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.08549
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.08442
RUNX3 runt-related transcription factor 3 1.08442
GHR growth hormone receptor 1.08231
CDC25B cell division cycle 25B 1.08231
MXI1 MAX interactor 1, dimerization protein 1.07983
PLAU plasminogen activator, urokinase 1.07804
SMAD2 SMAD family member 2 1.07589
EGFR epidermal growth factor receptor 1.07589
IL4 interleukin 4 1.07411
MMP2 matrix metallopeptidase 2 1.07411
TYMS thymidylate synthetase 1.07234
HRK harakiri, BCL2 interacting protein 1.06808
GSK3B glycogen synthase kinase 3 beta 1.06442
IFRD1 interferon-related developmental regulator 1 1.06442
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.06333
PRDX6 peroxiredoxin 6 1.06225
NME2 NME/NM23 nucleoside diphosphate kinase 2 1.06008
MAPK8 mitogen-activated protein kinase 8 1.05828
FOXQ1 forkhead box Q1 1.05648
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.05386
GPR176 G protein-coupled receptor 176 1.05349
EPOR erythropoietin receptor 1.05274
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.05237
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.04941
TPD52L1 tumor protein D52-like 1 1.04904
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.04904
TMSB4X thymosin beta 4, X-linked 1.04868
ZFP36L2 ZFP36 ring finger protein-like 2 1.04868
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.04757
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.04201
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1.04201
HSPA8 heat shock 70kDa protein 8 1.04163
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.04126
ALAD aminolevulinate dehydratase 1.04126
LAMB3 laminin, beta 3 1.03789
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 1.03789
BTG3 BTG family, member 3 1.03789
CCND1 cyclin D1 1.03752
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.03493
EGR2 early growth response 2 1.03493
TJP1 tight junction protein 1 1.03308
BAD BCL2-associated agonist of cell death 1.03235
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 1.03122
SRM spermidine synthase 1.03122
G6PC glucose-6-phosphatase, catalytic subunit 1.03122
DONSON downstream neighbor of SON 1.03084
CKAP2 cytoskeleton associated protein 2 1.03084
TLR4 toll-like receptor 4 1.02971
APOE apolipoprotein E 1.02971
EDNRA endothelin receptor type A 1.02933
CLIC4 chloride intracellular channel 4 1.02783
STAT1 signal transducer and activator of transcription 1, 91kDa 1.02708
GJA1 gap junction protein, alpha 1, 43kDa 1.02708
PPARD peroxisome proliferator-activated receptor delta 1.02708
LGALS3 lectin, galactoside-binding, soluble, 3 1.02522
CCNB1 cyclin B1 1.02485
ATG3 autophagy related 3 1.02373
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.02336
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.01966
TFRC transferrin receptor 1.01966
RBM17 RNA binding motif protein 17 1.01739
NT5C2 5'-nucleotidase, cytosolic II 1.01701
USP36 ubiquitin specific peptidase 36 1.01701
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.01587
MVP major vault protein 1.01437
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 1.01437
CA2 carbonic anhydrase II 1.01212
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 1.01137