Uridine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSPP dentin sialophosphoprotein 0.131514
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105209
FBF1 Fas (TNFRSF6) binding factor 1 0.0986362
MYH9 myosin, heavy chain 9, non-muscle 0.0712679
ENO1 enolase 1, (alpha) 0.0687358
TF transferrin 0.0682128
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0660498
TRIM26 tripartite motif containing 26 0.0646394
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0645837
KDM3A lysine (K)-specific demethylase 3A 0.0592632
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0569568
PEG3 paternally expressed 3 0.0541755
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0504605
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0426076
EEF2 eukaryotic translation elongation factor 2 0.0418617
RPL3 ribosomal protein L3 0.0408065
RPS2 ribosomal protein S2 0.0378888
DDIT4 DNA-damage-inducible transcript 4 0.0376537
AKAP12 A kinase (PRKA) anchor protein 12 0.0363047
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0361206
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0353047
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0340272
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0328359
GPC3 glypican 3 0.0323356
A2M alpha-2-macroglobulin 0.0319262
EEF1G eukaryotic translation elongation factor 1 gamma 0.0301016
SOD2 superoxide dismutase 2, mitochondrial 0.0299871
MAN1A1 mannosidase, alpha, class 1A, member 1 0.02955
AHSG alpha-2-HS-glycoprotein 0.0294738
RPS27A ribosomal protein S27a 0.0294524
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0293973
NFE2L1 nuclear factor, erythroid 2-like 1 0.0291446
NIPBL Nipped-B homolog (Drosophila) 0.0289467
RPL4 ribosomal protein L4 0.0285548
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0265088
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0264322
AFDN afadin, adherens junction formation factor 0.0255373
OLA1 Obg-like ATPase 1 0.0254244
PTMA prothymosin, alpha 0.0253523
SPAG9 sperm associated antigen 9 0.0252574
PDIA6 protein disulfide isomerase family A, member 6 0.0249538
SDC4 syndecan 4 0.0248684
HDLBP high density lipoprotein binding protein 0.0245985
ANO6 anoctamin 6 0.0237352
NCOA4 nuclear receptor coactivator 4 0.0235701
SERINC1 serine incorporator 1 0.0235521
MTUS1 microtubule associated tumor suppressor 1 0.0232396
MATR3 matrin 3 0.0231649
RLF rearranged L-myc fusion 0.0230434
TPT1 tumor protein, translationally-controlled 1 0.0227321
ZFAND3 zinc finger, AN1-type domain 3 0.0225308
RPL11 ribosomal protein L11 0.0224554
CPE carboxypeptidase E 0.0222281
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0221902
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0221717
KRT8 keratin 8, type II 0.0220874
EIF1 eukaryotic translation initiation factor 1 0.0220741
RPL13A ribosomal protein L13a 0.0215286
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0214811
CALR calreticulin 0.0212143
TPM4 tropomyosin 4 0.02069
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0206259
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0206045
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0204708
YME1L1 YME1-like 1 ATPase 0.0202996
SET SET nuclear proto-oncogene 0.0202876
FXR1 fragile X mental retardation, autosomal homolog 1 0.020269
HELZ helicase with zinc finger 0.0201943
RSL1D1 ribosomal L1 domain containing 1 0.0201415
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.01981
RPL37 ribosomal protein L37 0.0196972
H1-0 H1.0 linker histone 0.0196138
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0194294
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0193384
PUM2 pumilio RNA-binding family member 2 0.0191519
PTPRM protein tyrosine phosphatase, receptor type, M 0.019079
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0189161
HDGF hepatoma-derived growth factor 0.0188777
USP3 ubiquitin specific peptidase 3 0.0188353
IGF2R insulin-like growth factor 2 receptor 0.0187718
RPS3 ribosomal protein S3 0.0186962
APLP2 amyloid beta (A4) precursor-like protein 2 0.0185765
IFRD1 interferon-related developmental regulator 1 0.0185249
PEG10 paternally expressed 10 0.0184682
NAP1L1 nucleosome assembly protein 1-like 1 0.0182908
LYZ lysozyme 0.0181308
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0180752
APOE apolipoprotein E 0.0179558
ZNF292 zinc finger protein 292 0.0178491
QKI QKI, KH domain containing, RNA binding 0.0177944
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0177637
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0177429
ASXL1 additional sex combs like transcriptional regulator 1 0.0176717
ATF3 activating transcription factor 3 0.01742
KRT18 keratin 18, type I 0.0171827
CAMTA1 calmodulin binding transcription activator 1 0.0170716
SDC2 syndecan 2 0.0169162
SELENOP selenoprotein P 0.0167836
GDF15 growth differentiation factor 15 0.016593
CRY1 cryptochrome circadian clock 1 0.0163232

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.310935
IGF2 insulin-like growth factor 2 -0.233567
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.140474
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.108326
MT2A metallothionein 2A -0.104431
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0897961
FNDC3B fibronectin type III domain containing 3B -0.0725576
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0706024
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0694035
SLC38A2 solute carrier family 38, member 2 -0.066148
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.065159
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0633472
EHBP1 EH domain binding protein 1 -0.0557807
GPC6 glypican 6 -0.0554879
ITGAV integrin, alpha V -0.0490156
MAML2 mastermind-like 2 (Drosophila) -0.0466479
IGFBP1 insulin-like growth factor binding protein 1 -0.0465271
DLC1 DLC1 Rho GTPase activating protein -0.0401623
MRTFA myocardin related transcription factor A -0.039247
FOXP1 forkhead box P1 -0.0335425
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0328223
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0326099
FHIT fragile histidine triad -0.0317315
MALT1 MALT1 paracaspase -0.0307967
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0305877
ATXN1 ataxin 1 -0.0303233
LRMDA leucine rich melanocyte differentiation associated -0.0294792
HMGA1 high mobility group AT-hook 1 -0.0290087
SVIL supervillin -0.0288991
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0287001
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0283509
PARD3 par-3 family cell polarity regulator -0.0275318
VCL vinculin -0.0266463
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0258465
ZMYND8 zinc finger, MYND-type containing 8 -0.0257627
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0254482
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0253007
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0252665
VMP1 vacuole membrane protein 1 -0.0251787
BCL2L1 BCL2-like 1 -0.0249122
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0247796
FTL ferritin, light polypeptide -0.0246193
JAG1 jagged 1 -0.0244726
FOXO1 forkhead box O1 -0.0243501
APOB apolipoprotein B -0.0241377
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0237987
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0226867
AHR aryl hydrocarbon receptor -0.0225007
NPAS2 neuronal PAS domain protein 2 -0.0224048
ZFP36L1 ZFP36 ring finger protein-like 1 -0.022112
RPL9 ribosomal protein L9 -0.0219894
RPS13 ribosomal protein S13 -0.0219027
LOC112694756 uncharaterized LOC112694756 -0.0214007
TMEM123 transmembrane protein 123 -0.020911
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0208446
EML4 echinoderm microtubule associated protein like 4 -0.0208403
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0206249
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0202891
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0202063
GRB10 growth factor receptor-bound protein 10 -0.0202008
NHSL1 NHS-like 1 -0.0197796
UBASH3B ubiquitin associated and SH3 domain containing B -0.0195444
EGR1 early growth response 1 -0.0194487
ATP10A ATPase, class V, type 10A -0.0192203
PTBP3 polypyrimidine tract binding protein 3 -0.0191582
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0190668
CCN2 cellular communication network factor 2 -0.0186083
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.018131
LMCD1 LIM and cysteine-rich domains 1 -0.017716
PLAC8 placenta-specific 8 -0.0176283
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0170277
PDE4D phosphodiesterase 4D, cAMP-specific -0.0168912
STK39 serine threonine kinase 39 -0.0168527
OSMR oncostatin M receptor -0.0167288
ANKRD12 ankyrin repeat domain 12 -0.0165672
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0164671
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0159932
ELL2 elongation factor, RNA polymerase II, 2 -0.0159866
AK1 adenylate kinase 1 -0.0159644
KLF6 Kruppel-like factor 6 -0.0159432
RDX radixin -0.0158907
ACYP2 acylphosphatase 2, muscle type -0.0158805
NKTR natural killer cell triggering receptor -0.0155944
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0153426
SOX4 SRY (sex determining region Y)-box 4 -0.0153089
GLRX glutaredoxin (thioltransferase) -0.0152344
BLTP1 bridge-like lipid transfer protein family member 1 -0.0152287
ITGB5 integrin, beta 5 -0.0152254
TMEM51 transmembrane protein 51 -0.0152025
SYNJ2 synaptojanin 2 -0.0149614
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0149566
SMYD3 SET and MYND domain containing 3 -0.0148705
CENPF centromere protein F, 350/400kDa -0.0148428
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0146284
DOCK4 dedicator of cytokinesis 4 -0.0145711
TTC28 tetratricopeptide repeat domain 28 -0.014557
BIRC6 baculoviral IAP repeat containing 6 -0.0145513
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0144141
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0142941
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0142304