Uridine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.161662
FLNB filamin B, beta 0.137446
CLU clusterin 0.0971634
KRT17 keratin 17, type I 0.0826661
CUL4B cullin 4B 0.072326
LMNA lamin A/C 0.0673934
FOXO1 forkhead box O1 0.0662202
BCL2L1 BCL2-like 1 0.063397
MSN moesin 0.0633531
CEMIP cell migration inducing protein, hyaluronan binding 0.0630987
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0621077
TMSB4X thymosin beta 4, X-linked 0.0616681
PLEC plectin 0.0581506
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.056764
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0552811
ITGA6 integrin, alpha 6 0.0551341
AHNAK AHNAK nucleoprotein 0.0541617
NAMPT nicotinamide phosphoribosyltransferase 0.0485264
CTNND1 catenin (cadherin-associated protein), delta 1 0.0480245
OGA O-GlcNAcase 0.0474501
EZR ezrin 0.0462089
STC1 stanniocalcin 1 0.0458447
NCOA3 nuclear receptor coactivator 3 0.0457101
FN1 fibronectin 1 0.0444319
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0415477
ANLN anillin, actin binding protein 0.0409389
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0409091
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0407452
KDM3A lysine (K)-specific demethylase 3A 0.0404901
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0403138
ANKRD33B ankyrin repeat domain 33B 0.0401521
ENO1 enolase 1, (alpha) 0.0392164
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0390558
PGK1 phosphoglycerate kinase 1 0.0389747
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0388662
TRIO trio Rho guanine nucleotide exchange factor 0.0388083
SLC45A4 solute carrier family 45, member 4 0.037563
RPL3 ribosomal protein L3 0.0366451
EMP1 epithelial membrane protein 1 0.0354777
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0353036
H1-0 H1.0 linker histone 0.0341229
EPHA2 EPH receptor A2 0.0336645
CPNE1 copine I 0.0334114
CALR calreticulin 0.0332548
VCL vinculin 0.0329543
PRELID2 PRELI domain containing 2 0.0326734
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0326357
YBX3 Y box binding protein 3 0.0324861
COPB1 coatomer protein complex, subunit beta 1 0.0317017
NRG1 neuregulin 1 0.0315097
SMAD3 SMAD family member 3 0.0311045
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0310814
CAVIN1 caveolae associated protein 1 0.0309535
ARHGAP29 Rho GTPase activating protein 29 0.0302186
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.030195
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0291539
LNPEP leucyl/cystinyl aminopeptidase 0.0285989
NDE1 nudE neurodevelopment protein 1 0.0284944
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0279832
GOLGA4 golgin A4 0.027973
CAPRIN2 caprin family member 2 0.0278163
RNF19B ring finger protein 19B 0.0274873
SEC31A SEC31 homolog A (S. cerevisiae) 0.0274066
SEPTIN9 septin 9 0.0273189
SERINC3 serine incorporator 3 0.0270201
KRT6A keratin 6A, type II 0.0267841
LIMA1 LIM domain and actin binding 1 0.0267137
GOLGA2 golgin A2 0.0265624
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0265135
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0264486
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026297
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0260952
TNIP1 TNFAIP3 interacting protein 1 0.0260499
FLNA filamin A, alpha 0.0258185
EIF1 eukaryotic translation initiation factor 1 0.0257981
TPM3 tropomyosin 3 0.0257812
KTN1 kinectin 1 (kinesin receptor) 0.02569
TPX2 TPX2, microtubule-associated 0.0254522
SDC4 syndecan 4 0.0252524
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0252162
EFHD2 EF-hand domain family, member D2 0.0249549
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0247984
WASF2 WAS protein family, member 2 0.0246659
COPA coatomer protein complex, subunit alpha 0.0243121
RIOK3 RIO kinase 3 0.0238463
DOCK5 dedicator of cytokinesis 5 0.0238252
TMF1 TATA element modulatory factor 1 0.0235945
PDLIM1 PDZ and LIM domain 1 0.0234744
NCEH1 neutral cholesterol ester hydrolase 1 0.0234557
LUZP1 leucine zipper protein 1 0.0232307
ACBD3 acyl-CoA binding domain containing 3 0.0229755
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0229544
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0228691
BIRC2 baculoviral IAP repeat containing 2 0.0227134
ARRDC3 arrestin domain containing 3 0.0226149
PLK2 polo-like kinase 2 0.0225499
RAB6A RAB6A, member RAS oncogene family 0.0225424
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022516
BZW2 basic leucine zipper and W2 domains 2 0.0221908
EHBP1L1 EH domain binding protein 1-like 1 0.0220417

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.343504
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.182863
MTSS1 metastasis suppressor 1 -0.134991
SLC35F3 solute carrier family 35, member F3 -0.125058
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.118899
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.114264
NDRG1 N-myc downstream regulated 1 -0.0918987
ALCAM activated leukocyte cell adhesion molecule -0.0889159
PDE4D phosphodiesterase 4D, cAMP-specific -0.0886703
DPYD dihydropyrimidine dehydrogenase -0.0886597
PODXL podocalyxin-like -0.0772594
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0736971
GRB10 growth factor receptor-bound protein 10 -0.0723731
ABI3BP ABI family, member 3 (NESH) binding protein -0.071324
ANO1 anoctamin 1, calcium activated chloride channel -0.0694039
FTH1 ferritin, heavy polypeptide 1 -0.0665931
HSPG2 heparan sulfate proteoglycan 2 -0.0653098
HMGA2 high mobility group AT-hook 2 -0.0636902
SULF2 sulfatase 2 -0.0636406
RAI14 retinoic acid induced 14 -0.0636182
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0599979
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0584643
RPS6 ribosomal protein S6 -0.0571851
PDLIM5 PDZ and LIM domain 5 -0.0557541
PLS3 plastin 3 -0.0550983
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0549336
MEF2A myocyte enhancer factor 2A -0.0538474
RASAL2 RAS protein activator like 2 -0.0509607
TPT1 tumor protein, translationally-controlled 1 -0.0508021
RPS8 ribosomal protein S8 -0.0498412
LMO7 LIM domain 7 -0.049165
CDK6 cyclin-dependent kinase 6 -0.048406
PSD3 pleckstrin and Sec7 domain containing 3 -0.0483087
PTK2 protein tyrosine kinase 2 -0.048236
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.046472
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0446956
RIGI RNA sensor RIG-I -0.0426824
RAD51B RAD51 paralog B -0.0416023
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.040417
RNF217 ring finger protein 217 -0.0401667
RABGAP1L RAB GTPase activating protein 1-like -0.0400375
NAV2 neuron navigator 2 -0.0394515
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0391162
POTEF POTE ankyrin domain family, member F -0.0387094
EFNA5 ephrin-A5 -0.0380715
IFI44L interferon-induced protein 44-like -0.0380113
INTS6 integrator complex subunit 6 -0.0379263
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0374658
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.037443
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0366482
HMGA1 high mobility group AT-hook 1 -0.0365674
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0364785
CALB1 calbindin 1, 28kDa -0.0364684
ANKRD11 ankyrin repeat domain 11 -0.0362587
RPL37 ribosomal protein L37 -0.0360364
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0353603
HLA-B major histocompatibility complex, class I, B -0.0350708
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0348864
EGFR epidermal growth factor receptor -0.0345217
LAMA5 laminin, alpha 5 -0.0323147
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0319326
ABLIM3 actin binding LIM protein family, member 3 -0.0316801
THSD4 thrombospondin, type I, domain containing 4 -0.031449
RPL35A ribosomal protein L35a -0.0314055
RAB7A RAB7A, member RAS oncogene family -0.0313428
WARS1 tryptophanyl-tRNA synthetase 1 -0.0309955
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0307315
AKAP13 A kinase (PRKA) anchor protein 13 -0.0305664
CSMD2 CUB and Sushi multiple domains 2 -0.0303243
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0301916
TNS3 tensin 3 -0.0301471
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0293834
SAMD9 sterile alpha motif domain containing 9 -0.0293808
CUX1 cut-like homeobox 1 -0.0289468
F3 coagulation factor III (thromboplastin, tissue factor) -0.0287908
RPS24 ribosomal protein S24 -0.0286309
RPL34 ribosomal protein L34 -0.0282003
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.028017
RPL37A ribosomal protein L37a -0.0275994
FRMD6 FERM domain containing 6 -0.0275496
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0275147
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0272606
MT1E metallothionein 1E -0.0272362
RPL39 ribosomal protein L39 -0.0272231
LDHA lactate dehydrogenase A -0.0271698
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0270873
LRP1B low density lipoprotein receptor-related protein 1B -0.0268456
FRMD4B FERM domain containing 4B -0.0267937
RPS25 ribosomal protein S25 -0.0266574
RPS13 ribosomal protein S13 -0.0266151
RPLP1 ribosomal protein, large, P1 -0.0265921
RPL9 ribosomal protein L9 -0.0263064
IGF2 insulin-like growth factor 2 -0.026072
MT2A metallothionein 2A -0.0260357
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0259471
LAMC2 laminin, gamma 2 -0.0254875
FTL ferritin, light polypeptide -0.0254778
VEGFA vascular endothelial growth factor A -0.0251902
EXOC4 exocyst complex component 4 -0.0250485
RPL30 ribosomal protein L30 -0.0248602