Uridine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.0598618
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0549766
DSPP dentin sialophosphoprotein 0.0490568
LMO7 LIM domain 7 0.0447791
MYH9 myosin, heavy chain 9, non-muscle 0.0445147
CEMIP cell migration inducing protein, hyaluronan binding 0.0438053
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0398407
OGA O-GlcNAcase 0.0351612
RNF43 ring finger protein 43 0.0339918
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0338004
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0329132
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0325973
VCL vinculin 0.0325556
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0302311
PRELID2 PRELI domain containing 2 0.0298999
EREG epiregulin 0.0294965
KDM4C lysine (K)-specific demethylase 4C 0.029391
ATXN1 ataxin 1 0.0291338
KIAA1217 KIAA1217 0.0285092
NFIA nuclear factor I/A 0.0276765
ITPRID2 ITPR interacting domain containing 2 0.0276632
BTBD9 BTB (POZ) domain containing 9 0.0274368
CADPS Ca++-dependent secretion activator 0.027216
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0272023
MBD5 methyl-CpG binding domain protein 5 0.0265568
ABHD2 abhydrolase domain containing 2 0.02569
PDIA4 protein disulfide isomerase family A, member 4 0.0255097
MED13 mediator complex subunit 13 0.024969
MYO1E myosin IE 0.0248489
MON2 MON2 homolog (S. cerevisiae) 0.0246512
KDM7A lysine (K)-specific demethylase 7A 0.0245403
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0235596
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0227152
USP6NL USP6 N-terminal like 0.0221321
CTNND1 catenin (cadherin-associated protein), delta 1 0.0220486
HDLBP high density lipoprotein binding protein 0.0217463
CSNK1A1 casein kinase 1, alpha 1 0.0215239
GOLGB1 golgin B1 0.0212787
METTL15 methyltransferase like 15 0.0202247
AHNAK AHNAK nucleoprotein 0.0201163
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0192407
PATJ PATJ crumbs cell polarity complex component 0.0191178
CAB39 calcium binding protein 39 0.0191127
ASPH aspartate beta-hydroxylase 0.0190867
GDF15 growth differentiation factor 15 0.0189989
SMYD3 SET and MYND domain containing 3 0.018808
TMSB4X thymosin beta 4, X-linked 0.0185425
USO1 USO1 vesicle transport factor 0.0182986
MARF1 meiosis regulator and mRNA stability factor 1 0.018238
KLC1 kinesin light chain 1 0.0182278
LAMA4 laminin, alpha 4 0.0182244
LIPH lipase, member H 0.0181433
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0179834
BAIAP2L1 BAI1-associated protein 2-like 1 0.0179674
SAMD4A sterile alpha motif domain containing 4A 0.0178526
PTPRK protein tyrosine phosphatase, receptor type, K 0.0177106
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.01759
DERA deoxyribose-phosphate aldolase (putative) 0.0172824
MACF1 microtubule-actin crosslinking factor 1 0.0172497
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0172031
KLF5 Kruppel-like factor 5 (intestinal) 0.0171181
PLAUR plasminogen activator, urokinase receptor 0.0170069
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0169737
NEBL nebulette 0.0168762
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0166167
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0165225
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0162522
KMT2C lysine (K)-specific methyltransferase 2C 0.0161542
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.016125
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0160492
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.015993
SRRM2 serine/arginine repetitive matrix 2 0.0159913
ANO6 anoctamin 6 0.015903
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0158162
CEP95 centrosomal protein 95kDa 0.0157784
SHB Src homology 2 domain containing adaptor protein B 0.0157703
TBC1D5 TBC1 domain family, member 5 0.0157133
PCNP PEST proteolytic signal containing nuclear protein 0.0156768
NKD1 naked cuticle homolog 1 (Drosophila) 0.0154125
USP34 ubiquitin specific peptidase 34 0.0151537
ANXA11 annexin A11 0.0151398
GPHN gephyrin 0.0151247
TMF1 TATA element modulatory factor 1 0.0149904
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0147724
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0146849
GAK cyclin G associated kinase 0.0146399
AEBP2 AE binding protein 2 0.0145635
PRRC2C proline-rich coiled-coil 2C 0.0144867
TCF12 transcription factor 12 0.0144125
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0143086
NT5C2 5'-nucleotidase, cytosolic II 0.0142953
BIRC6 baculoviral IAP repeat containing 6 0.0140959
GSK3B glycogen synthase kinase 3 beta 0.0140501
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0140483
TTC17 tetratricopeptide repeat domain 17 0.0139862
PPARA peroxisome proliferator-activated receptor alpha 0.0138906
PKP2 plakophilin 2 0.0138426
CANX calnexin 0.0138271
POF1B premature ovarian failure, 1B 0.0138226
BACE2 beta-site APP-cleaving enzyme 2 0.013811

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175614
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.162485
MUC6 mucin 6, oligomeric mucus/gel-forming -0.145427
PTMA prothymosin, alpha -0.13741
TMSB10 thymosin beta 10 -0.127521
RPS6 ribosomal protein S6 -0.124374
FTL ferritin, light polypeptide -0.0825939
NPSR1 neuropeptide S receptor 1 -0.081024
RPS8 ribosomal protein S8 -0.0730234
FTH1 ferritin, heavy polypeptide 1 -0.0647443
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0638347
RPL35A ribosomal protein L35a -0.0617649
POTEF POTE ankyrin domain family, member F -0.0591241
RPLP1 ribosomal protein, large, P1 -0.0588831
NDRG1 N-myc downstream regulated 1 -0.0577302
S100A6 S100 calcium binding protein A6 -0.0527946
RPS19 ribosomal protein S19 -0.0520774
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0519369
RPL9 ribosomal protein L9 -0.0492095
YBX1 Y box binding protein 1 -0.0490601
HMGA1 high mobility group AT-hook 1 -0.047452
RPLP2 ribosomal protein, large, P2 -0.0464393
RPL12 ribosomal protein L12 -0.0446031
TXNIP thioredoxin interacting protein -0.0425488
RPL23 ribosomal protein L23 -0.0422897
RPL37A ribosomal protein L37a -0.0416713
ALCAM activated leukocyte cell adhesion molecule -0.0414894
TPT1 tumor protein, translationally-controlled 1 -0.0411115
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0400078
LDHA lactate dehydrogenase A -0.0397793
RPS12 ribosomal protein S12 -0.0383827
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0377665
ENO1 enolase 1, (alpha) -0.037476
RPL36 ribosomal protein L36 -0.0373301
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0345806
RPL11 ribosomal protein L11 -0.0344637
ATP5F1B ATP synthase F1 subunit beta -0.03402
HMGB1 high mobility group box 1 -0.033899
ACTG1 actin gamma 1 -0.0337843
RPS23 ribosomal protein S23 -0.0333198
KRT19 keratin 19, type I -0.0331543
RPS29 ribosomal protein S29 -0.0324109
RPS3 ribosomal protein S3 -0.0321747
TPM4 tropomyosin 4 -0.0316941
ANXA1 annexin A1 -0.0312342
PCBP2 poly(rC) binding protein 2 -0.0307456
RPL13A ribosomal protein L13a -0.0305628
RPL37 ribosomal protein L37 -0.0303732
KTN1 kinectin 1 (kinesin receptor) -0.0302694
RPS14 ribosomal protein S14 -0.0302243
RPS25 ribosomal protein S25 -0.0299677
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0295895
RPS17 ribosomal protein S17 -0.0295647
RPL28 ribosomal protein L28 -0.0295363
TUBB4B tubulin, beta 4B class IVb -0.0293084
RNF145 ring finger protein 145 -0.0292185
FOSL1 FOS-like antigen 1 -0.0292154
RPS27A ribosomal protein S27a -0.0291082
ANXA2 annexin A2 -0.0290249
MT2A metallothionein 2A -0.0288751
PFN1 profilin 1 -0.0287439
RPL34 ribosomal protein L34 -0.0279999
PPARG peroxisome proliferator-activated receptor gamma -0.0279376
S100A10 S100 calcium binding protein A10 -0.0273325
RPS27 ribosomal protein S27 -0.0269958
RPLP0 ribosomal protein, large, P0 -0.026825
ATF4 activating transcription factor 4 -0.0267852
ZNF292 zinc finger protein 292 -0.0267803
LDHB lactate dehydrogenase B -0.0264114
RPL5 ribosomal protein L5 -0.0263689
VEGFA vascular endothelial growth factor A -0.0258755
CCND1 cyclin D1 -0.0256746
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0255958
GSTP1 glutathione S-transferase pi 1 -0.0254194
PGK1 phosphoglycerate kinase 1 -0.0252377
DEK DEK proto-oncogene -0.0252176
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0251954
EEF1G eukaryotic translation elongation factor 1 gamma -0.0248976
RPL26 ribosomal protein L26 -0.0246848
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.024479
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.024181
RPL35 ribosomal protein L35 -0.0240172
PKM pyruvate kinase, muscle -0.0239976
RPL7 ribosomal protein L7 -0.0236333
RPL31 ribosomal protein L31 -0.0233438
RPL27A ribosomal protein L27a -0.0231187
RPS4X ribosomal protein S4, X-linked -0.0230587
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0230563
RBM25 RNA binding motif protein 25 -0.022995
KRT18 keratin 18, type I -0.0228164
EIF5B eukaryotic translation initiation factor 5B -0.0228092
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0227984
EEF2 eukaryotic translation elongation factor 2 -0.022735
RPS2 ribosomal protein S2 -0.0226125
DSTN destrin (actin depolymerizing factor) -0.0225906
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0225749
CENPF centromere protein F, 350/400kDa -0.0225351
HDGF hepatoma-derived growth factor -0.0225059
RAB7A RAB7A, member RAS oncogene family -0.0224392
PA2G4 proliferation-associated 2G4, 38kDa -0.0223094