Uridine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0832437
TMSB4X thymosin beta 4, X-linked 0.0811616
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0707001
MYH9 myosin, heavy chain 9, non-muscle 0.0662569
SLC38A2 solute carrier family 38, member 2 0.060119
MACF1 microtubule-actin crosslinking factor 1 0.0567709
TXNRD1 thioredoxin reductase 1 0.0531342
EZR ezrin 0.0483148
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0473217
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0467638
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0400555
CENPF centromere protein F, 350/400kDa 0.0393458
SRRM2 serine/arginine repetitive matrix 2 0.0369038
EEF2 eukaryotic translation elongation factor 2 0.0355328
BCAR3 breast cancer anti-estrogen resistance 3 0.0353938
ARHGAP5 Rho GTPase activating protein 5 0.0351434
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0345486
APP amyloid beta (A4) precursor protein 0.0342991
FMNL2 formin-like 2 0.0331494
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0327771
SET SET nuclear proto-oncogene 0.0323551
RPL3 ribosomal protein L3 0.0321308
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0321248
PYGL phosphorylase, glycogen, liver 0.0320536
WWTR1 WW domain containing transcription regulator 1 0.0319371
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0313613
AHNAK AHNAK nucleoprotein 0.031214
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0310727
PLK2 polo-like kinase 2 0.0307605
CAPRIN2 caprin family member 2 0.0307255
RAI1 retinoic acid induced 1 0.0301129
MSN moesin 0.0280565
ANGPTL4 angiopoietin-like 4 0.027897
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0272519
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0272439
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0269363
EREG epiregulin 0.0256601
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0254674
JMJD1C jumonji domain containing 1C 0.0252763
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.024706
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0243122
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0242652
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0237913
RUNX1 runt-related transcription factor 1 0.0236211
EIF1 eukaryotic translation initiation factor 1 0.0234025
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233988
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0231292
JUN jun proto-oncogene 0.0229823
PLEC plectin 0.022978
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0227889
HSPA8 heat shock 70kDa protein 8 0.0227361
TPM3 tropomyosin 3 0.0221044
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0220421
MKI67 marker of proliferation Ki-67 0.0218524
CSNK1A1 casein kinase 1, alpha 1 0.021075
DST dystonin 0.0203529
ADAM17 ADAM metallopeptidase domain 17 0.0202909
SGK1 serum/glucocorticoid regulated kinase 1 0.0195721
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0195
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0194915
MCL1 myeloid cell leukemia 1 0.0190908
CKAP5 cytoskeleton associated protein 5 0.0190679
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0188997
CSDE1 cold shock domain containing E1, RNA-binding 0.0185583
NCEH1 neutral cholesterol ester hydrolase 1 0.0184357
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0183895
CANX calnexin 0.0183175
SDCCAG8 serologically defined colon cancer antigen 8 0.0179313
FLNB filamin B, beta 0.0178573
BIRC3 baculoviral IAP repeat containing 3 0.0177685
KTN1 kinectin 1 (kinesin receptor) 0.0173861
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0173258
ATP13A3 ATPase type 13A3 0.017167
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0169515
ZEB1 zinc finger E-box binding homeobox 1 0.0169409
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0167627
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0167498
USP9X ubiquitin specific peptidase 9, X-linked 0.0167279
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0165771
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0162817
XPO1 exportin 1 0.0161768
YME1L1 YME1-like 1 ATPase 0.0160982
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0157728
KMT2E lysine (K)-specific methyltransferase 2E 0.0157259
CEP250 centrosomal protein 250kDa 0.0157067
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0156323
UPP1 uridine phosphorylase 1 0.0151551
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0148596
PRRC2C proline-rich coiled-coil 2C 0.0148346
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0146794
YEATS2 YEATS domain containing 2 0.0146745
RAP2B RAP2B, member of RAS oncogene family 0.0145247
BIRC2 baculoviral IAP repeat containing 2 0.0144849
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0143493
IER2 immediate early response 2 0.0143448
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0143232
RAD23B RAD23 homolog B (S. cerevisiae) 0.0143084
TRIP12 thyroid hormone receptor interactor 12 0.0141251
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0140579
NUMA1 nuclear mitotic apparatus protein 1 0.0139181

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172551
MT2A metallothionein 2A -0.11218
TMSB10 thymosin beta 10 -0.0707647
VIM vimentin -0.0547211
FTL ferritin, light polypeptide -0.051353
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0439369
CADM2 cell adhesion molecule 2 -0.0385857
RPL35A ribosomal protein L35a -0.035727
TP63 tumor protein p63 -0.0354143
RPS8 ribosomal protein S8 -0.0336758
RPLP1 ribosomal protein, large, P1 -0.0327301
RPS6 ribosomal protein S6 -0.0309905
HLA-B major histocompatibility complex, class I, B -0.0307018
RPS19 ribosomal protein S19 -0.0296184
HMGA1 high mobility group AT-hook 1 -0.0271205
MT1E metallothionein 1E -0.0258786
RAB7A RAB7A, member RAS oncogene family -0.0257489
TPT1 tumor protein, translationally-controlled 1 -0.025021
RPLP2 ribosomal protein, large, P2 -0.0240129
RPL28 ribosomal protein L28 -0.023127
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0230801
RPS23 ribosomal protein S23 -0.0227352
RPL36 ribosomal protein L36 -0.0211934
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.020663
WSB1 WD repeat and SOCS box containing 1 -0.0206502
RPS24 ribosomal protein S24 -0.0204647
RPL12 ribosomal protein L12 -0.0202084
WARS1 tryptophanyl-tRNA synthetase 1 -0.0194791
RPL5 ribosomal protein L5 -0.0190976
RPL31 ribosomal protein L31 -0.019095
RPL38 ribosomal protein L38 -0.0181975
RPL37A ribosomal protein L37a -0.0181023
RPL19 ribosomal protein L19 -0.0164117
RPS29 ribosomal protein S29 -0.0163748
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0161186
SP100 SP100 nuclear antigen -0.0160223
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0156035
YBX1 Y box binding protein 1 -0.0152864
ANXA2 annexin A2 -0.0148041
ACTG1 actin gamma 1 -0.0147291
IFITM1 interferon induced transmembrane protein 1 -0.0145972
RPL39 ribosomal protein L39 -0.014516
RPL23 ribosomal protein L23 -0.0145085
EFNA5 ephrin-A5 -0.0144856
RPL34 ribosomal protein L34 -0.014281
S100A9 S100 calcium binding protein A9 -0.0142248
RPS15 ribosomal protein S15 -0.0140449
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0138496
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0138311
RPL27 ribosomal protein L27 -0.0137068
RPS21 ribosomal protein S21 -0.0135907
RPL9 ribosomal protein L9 -0.0133242
RPS20 ribosomal protein S20 -0.0133117
HMGB1 high mobility group box 1 -0.0132619
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0132472
RPS14 ribosomal protein S14 -0.0132231
CFAP299 cilia and flagella associated protein 299 -0.0130858
DPYD dihydropyrimidine dehydrogenase -0.012886
FTH1 ferritin, heavy polypeptide 1 -0.0127284
FUS FUS RNA binding protein -0.0125698
MT1X metallothionein 1X -0.0125281
RPL36A ribosomal protein L36a -0.0124794
S100A10 S100 calcium binding protein A10 -0.0123223
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0122417
PLSCR1 phospholipid scramblase 1 -0.0119678
RPL11 ribosomal protein L11 -0.0119542
RACK1 receptor for activated C kinase 1 -0.0116784
RPS16 ribosomal protein S16 -0.0116658
TNS3 tensin 3 -0.0115142
RPL32 ribosomal protein L32 -0.0114291
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.01131
RPS25 ribosomal protein S25 -0.0111583
RPS4X ribosomal protein S4, X-linked -0.0110914
IFIH1 interferon induced with helicase C domain 1 -0.0110858
RPS10 ribosomal protein S10 -0.0110212
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0109839
RPS28 ribosomal protein S28 -0.0109798
RPS27 ribosomal protein S27 -0.0106188
RPL37 ribosomal protein L37 -0.0105513
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0104963
S100A6 S100 calcium binding protein A6 -0.0103399
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.00999611
TIMP1 TIMP metallopeptidase inhibitor 1 -0.00997035
RPS13 ribosomal protein S13 -0.00993257
GNAS GNAS complex locus -0.00964093
ISG15 ISG15 ubiquitin-like modifier -0.00954698
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00952066
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.00949965
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00945666
DPH6 diphthamine biosynthesis 6 -0.00933551
NDRG1 N-myc downstream regulated 1 -0.00933401
RPL26 ribosomal protein L26 -0.00912973
UBE2B ubiquitin-conjugating enzyme E2B -0.00912479
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.00904017
RPL35 ribosomal protein L35 -0.00890798
TBCA tubulin folding cofactor A -0.00887323
SEPTIN2 septin 2 -0.00884477
RPL27A ribosomal protein L27a -0.00879847
INTS6 integrator complex subunit 6 -0.00859342
POTEF POTE ankyrin domain family, member F -0.00858134