| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Uridine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Uridine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.179015 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.128147 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0978988 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0955412 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0718062 |
| TPI1 | triosephosphate isomerase 1 | 0.0598352 |
| RTN4 | reticulon 4 | 0.0480549 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0474003 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0453614 |
| TPM3 | tropomyosin 3 | 0.0430968 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0419275 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.041744 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0403439 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0395378 |
| PHIP | pleckstrin homology domain interacting protein | 0.0373937 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.036808 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0361995 |
| MKI67 | marker of proliferation Ki-67 | 0.0342562 |
| XPO1 | exportin 1 | 0.0339352 |
| MSN | moesin | 0.0325977 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0323974 |
| PCBP2 | poly(rC) binding protein 2 | 0.0310789 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0309802 |
| RPL3 | ribosomal protein L3 | 0.030623 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0297928 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0283198 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.027615 |
| PGK1 | phosphoglycerate kinase 1 | 0.0273938 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0249155 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0245889 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0241283 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0228643 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0227636 |
| SET | SET nuclear proto-oncogene | 0.0226209 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0225408 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0225295 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.02244 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0223833 |
| OGA | O-GlcNAcase | 0.0219766 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0214415 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0212147 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0211104 |
| CKAP5 | cytoskeleton associated protein 5 | 0.020931 |
| PLEC | plectin | 0.0207992 |
| PTMA | prothymosin, alpha | 0.0207774 |
| MED13L | mediator complex subunit 13-like | 0.0207341 |
| MYPN | myopalladin | 0.0207205 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0203074 |
| NCKAP1 | NCK-associated protein 1 | 0.0198588 |
| EZR | ezrin | 0.0196618 |
| RASAL2 | RAS protein activator like 2 | 0.0196042 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0195911 |
| CENPF | centromere protein F, 350/400kDa | 0.01958 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0193875 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0193236 |
| TMEM41B | transmembrane protein 41B | 0.0192126 |
| PNN | pinin, desmosome associated protein | 0.0190769 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0190271 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.019005 |
| TPM2 | tropomyosin 2 (beta) | 0.0190036 |
| WBP11 | WW domain binding protein 11 | 0.0189969 |
| PFN1 | profilin 1 | 0.018926 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0188569 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0188159 |
| SRPK1 | SRSF protein kinase 1 | 0.0186436 |
| IPO7 | importin 7 | 0.0184086 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0181498 |
| RNF145 | ring finger protein 145 | 0.0180438 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0180352 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0180325 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.0179981 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0179354 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0178814 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0178569 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0177723 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0177302 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0177164 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.017611 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0173856 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0172519 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0172297 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0171205 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0170852 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0170777 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0170423 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0169715 |
| PCM1 | pericentriolar material 1 | 0.0169367 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0168543 |
| MSH6 | mutS homolog 6 | 0.0167449 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0167135 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0167041 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0163669 |
| LDHB | lactate dehydrogenase B | 0.0163503 |
| RRM2 | ribonucleotide reductase M2 | 0.0161199 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.016072 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0160473 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0160465 |
| RPS3 | ribosomal protein S3 | 0.0159704 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0159163 |
| TPX2 | TPX2, microtubule-associated | 0.0159099 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.178408 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.149451 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13204 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.111803 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0892616 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0865428 |
| HMGA2 | high mobility group AT-hook 2 | -0.0854022 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0824864 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0797901 |
| OSMR | oncostatin M receptor | -0.0737877 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.073774 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.070891 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0703978 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.068558 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0654112 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0653627 |
| PDE10A | phosphodiesterase 10A | -0.0617831 |
| RAD51B | RAD51 paralog B | -0.0599649 |
| RYR3 | ryanodine receptor 3 | -0.0542182 |
| ATXN1 | ataxin 1 | -0.0533695 |
| WWOX | WW domain containing oxidoreductase | -0.0519205 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0517506 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0515494 |
| AEBP2 | AE binding protein 2 | -0.0510788 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0495061 |
| MCL1 | myeloid cell leukemia 1 | -0.0477786 |
| FMNL2 | formin-like 2 | -0.0469274 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0457708 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.044939 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0439948 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0438038 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.043413 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0430019 |
| VCL | vinculin | -0.0425089 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0418665 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0413849 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0396859 |
| PRELID2 | PRELI domain containing 2 | -0.0391197 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0391052 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.038785 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0384727 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0380334 |
| INTS6 | integrator complex subunit 6 | -0.0376698 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.036927 |
| NF1 | neurofibromin 1 | -0.0361833 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0358475 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0356096 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0341021 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0338418 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0337175 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0335734 |
| ATG7 | autophagy related 7 | -0.0332618 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0329037 |
| EHBP1 | EH domain binding protein 1 | -0.0322794 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0320315 |
| CUX1 | cut-like homeobox 1 | -0.0317848 |
| USP34 | ubiquitin specific peptidase 34 | -0.031689 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0312518 |
| RBM39 | RNA binding motif protein 39 | -0.0311776 |
| LOXL2 | lysyl oxidase-like 2 | -0.0310424 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0308498 |
| EXOC4 | exocyst complex component 4 | -0.0305076 |
| HLA-B | major histocompatibility complex, class I, B | -0.0296734 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.029671 |
| EGFR | epidermal growth factor receptor | -0.0294805 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0294218 |
| PRKCE | protein kinase C, epsilon | -0.0291704 |
| RNF213 | ring finger protein 213 | -0.0290025 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.028943 |
| TMSB10 | thymosin beta 10 | -0.0287944 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0285083 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0284883 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0283803 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0279928 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0270846 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0268755 |
| ATP11A | ATPase, class VI, type 11A | -0.0262289 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0261685 |
| GPATCH2L | G patch domain containing 2-like | -0.025352 |
| FMN1 | formin 1 | -0.0251963 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0251446 |
| SVIL | supervillin | -0.0243459 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0242874 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0242537 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0241813 |
| NEK10 | NIMA-related kinase 10 | -0.0241582 |
| TBC1D22A | TBC1 domain family, member 22A | -0.023944 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0239004 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0232823 |
| DENND5B | DENN/MADD domain containing 5B | -0.0231861 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0231612 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0228955 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0228329 |
| DIAPH2 | diaphanous-related formin 2 | -0.0226662 |
| FBXO11 | F-box protein 11 | -0.0223906 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0222777 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0219067 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0217493 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0214681 |
| PCDH7 | protocadherin 7 | -0.0213821 |
