Uridine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.150828
FN1 fibronectin 1 0.142882
MCL1 myeloid cell leukemia 1 0.110939
IGFBP3 insulin-like growth factor binding protein 3 0.0706492
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.07007
SOD2 superoxide dismutase 2, mitochondrial 0.0584669
MYH9 myosin, heavy chain 9, non-muscle 0.0549795
STC1 stanniocalcin 1 0.0541455
RPL3 ribosomal protein L3 0.0530253
FMNL2 formin-like 2 0.052756
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.05232
MSN moesin 0.0516239
PGK1 phosphoglycerate kinase 1 0.0494683
ITPRID2 ITPR interacting domain containing 2 0.0490948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0487346
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0476728
CANX calnexin 0.0463544
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0459559
BZW1 basic leucine zipper and W2 domains 1 0.0459417
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.044974
PYGL phosphorylase, glycogen, liver 0.0448766
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0435276
ERRFI1 ERBB receptor feedback inhibitor 1 0.042706
FNDC3A fibronectin type III domain containing 3A 0.0414766
TNIP1 TNFAIP3 interacting protein 1 0.0387587
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0380472
EZR ezrin 0.0375593
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0373395
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0372228
SPAG9 sperm associated antigen 9 0.0370476
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0366887
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0359924
ATP13A3 ATPase type 13A3 0.0357822
PDIA6 protein disulfide isomerase family A, member 6 0.0354732
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0350626
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0349909
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0338795
TPM3 tropomyosin 3 0.0335829
AUTS2 autism susceptibility candidate 2 0.0326501
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.032076
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0320556
CTBP2 C-terminal binding protein 2 0.0319328
NFE2L1 nuclear factor, erythroid 2-like 1 0.0316828
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0316426
CUL4B cullin 4B 0.0310145
CTSL cathepsin L 0.0309709
USP9X ubiquitin specific peptidase 9, X-linked 0.0305761
AKAP13 A kinase (PRKA) anchor protein 13 0.0296621
ANXA1 annexin A1 0.02958
SFTPA2 surfactant protein A2 0.0292747
ELL2 elongation factor, RNA polymerase II, 2 0.0291458
CDH13 cadherin 13 0.0290265
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0285678
NCOR2 nuclear receptor corepressor 2 0.0283662
COPA coatomer protein complex, subunit alpha 0.0281663
APP amyloid beta (A4) precursor protein 0.0281106
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0278921
PDIA3 protein disulfide isomerase family A, member 3 0.0278143
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0276542
SMOC1 SPARC related modular calcium binding 1 0.0274561
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0274479
HSPA8 heat shock 70kDa protein 8 0.0274082
HYOU1 hypoxia up-regulated 1 0.0270538
KDM6A lysine (K)-specific demethylase 6A 0.026091
PM20D1 peptidase M20 domain containing 1 0.0256545
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0255056
LAMB1 laminin, beta 1 0.0249981
KDM3A lysine (K)-specific demethylase 3A 0.0249289
PRSS23 protease, serine, 23 0.0247608
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0244371
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.02354
SET SET nuclear proto-oncogene 0.0235062
CAMTA1 calmodulin binding transcription activator 1 0.0229713
NCKAP1 NCK-associated protein 1 0.0225873
TMSB4X thymosin beta 4, X-linked 0.0223935
AKAP12 A kinase (PRKA) anchor protein 12 0.0222549
PDLIM5 PDZ and LIM domain 5 0.0221353
RPS2 ribosomal protein S2 0.0217235
ZC3H11A zinc finger CCCH-type containing 11A 0.0213956
TGFBR1 transforming growth factor, beta receptor 1 0.0213857
SMAD2 SMAD family member 2 0.0212986
SLC38A2 solute carrier family 38, member 2 0.0212435
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0211038
HMG20B high mobility group 20B 0.0208838
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.020812
CXCL5 chemokine (C-X-C motif) ligand 5 0.0208079
DOCK5 dedicator of cytokinesis 5 0.0207982
UBA6 ubiquitin-like modifier activating enzyme 6 0.0202499
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0202171
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0202082
DNER delta/notch-like EGF repeat containing 0.0201848
DDIT4 DNA-damage-inducible transcript 4 0.0198716
GRB10 growth factor receptor-bound protein 10 0.0197967
PDGFA platelet-derived growth factor alpha polypeptide 0.0197386
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0196923
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196271
FAM107B family with sequence similarity 107, member B 0.0196105
CHL1 cell adhesion molecule L1-like 0.0195299
FAM13A family with sequence similarity 13, member A 0.0194371
MXI1 MAX interactor 1, dimerization protein 0.0192862

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.330229
FTL ferritin, light polypeptide -0.137492
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.129895
TMSB10 thymosin beta 10 -0.115068
RPLP1 ribosomal protein, large, P1 -0.111935
MT2A metallothionein 2A -0.0995896
RPS6 ribosomal protein S6 -0.0952215
TXNRD1 thioredoxin reductase 1 -0.0851898
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0803266
RPL12 ribosomal protein L12 -0.0796758
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.077496
RPS24 ribosomal protein S24 -0.0721005
EFNA5 ephrin-A5 -0.0715315
RPL19 ribosomal protein L19 -0.0650397
RPL9 ribosomal protein L9 -0.0635598
RPS23 ribosomal protein S23 -0.0629036
RPL35A ribosomal protein L35a -0.0622803
RPS8 ribosomal protein S8 -0.0608814
RPL31 ribosomal protein L31 -0.0599192
VIM vimentin -0.0579444
RPS19 ribosomal protein S19 -0.0563768
TFPI2 tissue factor pathway inhibitor 2 -0.0557311
RPL23 ribosomal protein L23 -0.0530428
RPL37A ribosomal protein L37a -0.0523474
ACTG1 actin gamma 1 -0.050998
ATP5F1B ATP synthase F1 subunit beta -0.05081
RPLP0 ribosomal protein, large, P0 -0.0489331
PSD3 pleckstrin and Sec7 domain containing 3 -0.0473638
NRCAM neuronal cell adhesion molecule -0.0459107
RPL26 ribosomal protein L26 -0.0451804
PRDX1 peroxiredoxin 1 -0.0450116
RPS29 ribosomal protein S29 -0.0448135
RPS21 ribosomal protein S21 -0.0447947
RPLP2 ribosomal protein, large, P2 -0.0442449
PDE10A phosphodiesterase 10A -0.0425145
FTH1 ferritin, heavy polypeptide 1 -0.0422773
RPL38 ribosomal protein L38 -0.0421556
SMYD3 SET and MYND domain containing 3 -0.040919
RPL34 ribosomal protein L34 -0.0408492
GRAMD1B GRAM domain containing 1B -0.0408404
RPS13 ribosomal protein S13 -0.0408181
RPL36 ribosomal protein L36 -0.0405349
RPL37 ribosomal protein L37 -0.0385167
AKR1C1 aldo-keto reductase family 1, member C1 -0.0382516
RPL11 ribosomal protein L11 -0.0374316
RPS14 ribosomal protein S14 -0.0370043
COL4A5 collagen, type IV, alpha 5 -0.0365154
RPL13A ribosomal protein L13a -0.0363081
RPS4X ribosomal protein S4, X-linked -0.0358959
S100A10 S100 calcium binding protein A10 -0.0356225
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0354674
NALF1 NALCN channel auxiliary factor 1 -0.0352068
RPL32 ribosomal protein L32 -0.0351716
RPL36A ribosomal protein L36a -0.0349664
POTEF POTE ankyrin domain family, member F -0.0343711
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0340255
NCOA7 nuclear receptor coactivator 7 -0.0339565
RPS16 ribosomal protein S16 -0.033898
RPL5 ribosomal protein L5 -0.0337343
OSMR oncostatin M receptor -0.0333139
NDRG1 N-myc downstream regulated 1 -0.0330871
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0329166
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0326234
RPS12 ribosomal protein S12 -0.0324958
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0323166
VDAC1 voltage-dependent anion channel 1 -0.0317079
EIF5B eukaryotic translation initiation factor 5B -0.0316544
RPS27 ribosomal protein S27 -0.031546
TBCA tubulin folding cofactor A -0.0313345
PDE4D phosphodiesterase 4D, cAMP-specific -0.0298103
TM4SF1 transmembrane 4 L six family member 1 -0.0294512
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0293645
RPL30 ribosomal protein L30 -0.0288217
RPL28 ribosomal protein L28 -0.0286554
RPS25 ribosomal protein S25 -0.0284272
RTN4 reticulon 4 -0.0278594
TUBA1B tubulin, alpha 1b -0.027697
HMGB1 high mobility group box 1 -0.0274317
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0272581
PHF14 PHD finger protein 14 -0.0270051
RPS28 ribosomal protein S28 -0.0269458
RPL27 ribosomal protein L27 -0.0266522
RPL7A ribosomal protein L7a -0.0265175
TPT1 tumor protein, translationally-controlled 1 -0.0260454
ATP5F1E ATP synthase F1 subunit epsilon -0.0258795
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0257981
RPL39 ribosomal protein L39 -0.0255687
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0253325
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0253042
RPS15 ribosomal protein S15 -0.0252546
MORF4L2 mortality factor 4 like 2 -0.0248732
RPL27A ribosomal protein L27a -0.0248327
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0247917
MAP1B microtubule-associated protein 1B -0.0241393
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0240534
SLF1 SMC5-SMC6 complex localization factor 1 -0.0238679
CENPF centromere protein F, 350/400kDa -0.0238422
PTGR1 prostaglandin reductase 1 -0.0238104
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0237092
GNAS GNAS complex locus -0.0236469