Uridine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

182 genes differentially expressed following the Uridine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.14782
NDRG1 N-myc downstream regulated 1 0.146827
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.144778
MATR3 matrin 3 0.143968
RPS2 ribosomal protein S2 0.122884
FLNB filamin B, beta 0.122559
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.121618
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.121435
XPO1 exportin 1 0.119853
FNDC3B fibronectin type III domain containing 3B 0.117652
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.115497
PCBP2 poly(rC) binding protein 2 0.109505
NAMPT nicotinamide phosphoribosyltransferase 0.108974
HSPH1 heat shock 105kDa/110kDa protein 1 0.101077
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0988994
TPD52 tumor protein D52 0.0980028
SRRM2 serine/arginine repetitive matrix 2 0.0961985
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0943805
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0943067
OGA O-GlcNAcase 0.0923991
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0896873
HELZ helicase with zinc finger 0.0863785
DSCAM Down syndrome cell adhesion molecule 0.0850393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.083431
SPAG9 sperm associated antigen 9 0.0832564
MSI2 musashi RNA-binding protein 2 0.0792176
INHBA inhibin, beta A 0.0788584
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0786117
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0770486
ITGA6 integrin, alpha 6 0.0767717
RICTOR RPTOR independent companion of MTOR, complex 2 0.0766036
KMT2C lysine (K)-specific methyltransferase 2C 0.0758829
JMJD1C jumonji domain containing 1C 0.0748209
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0721411
TMEM123 transmembrane protein 123 0.0710429
ZNF292 zinc finger protein 292 0.0663752
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0614139
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.061013
MED13 mediator complex subunit 13 0.0569739
IGFBP3 insulin-like growth factor binding protein 3 0.0568168
ENO1 enolase 1, (alpha) 0.0568024
PKM pyruvate kinase, muscle 0.0557332
RBM25 RNA binding motif protein 25 0.0550803
PGK1 phosphoglycerate kinase 1 0.0536039
NAV1 neuron navigator 1 0.0531775
FMNL2 formin-like 2 0.0516446
TNRC6B trinucleotide repeat containing 6B 0.0447891
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0422755
OXR1 oxidation resistance 1 0.0401757
HMGA2 high mobility group AT-hook 2 0.040095
GPC6 glypican 6 0.0390402
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0382289
ASPH aspartate beta-hydroxylase 0.037728
RPS8 ribosomal protein S8 0.0358404
LMO7 LIM domain 7 0.0345083
LMNA lamin A/C 0.0334247
SQSTM1 sequestosome 1 0.0325505
RTN4 reticulon 4 0.03113
NAP1L1 nucleosome assembly protein 1-like 1 0.030863
RBM39 RNA binding motif protein 39 0.0302981
ELL2 elongation factor, RNA polymerase II, 2 0.0293262
NKD1 naked cuticle homolog 1 (Drosophila) 0.0290307
ACTG1 actin gamma 1 0.0289844
DST dystonin 0.027477
NALF1 NALCN channel auxiliary factor 1 0.0249384
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0247767
SLIT2 slit homolog 2 (Drosophila) 0.0237378
MYO10 myosin X 0.0229864
PDE8A phosphodiesterase 8A 0.022299
AKAP12 A kinase (PRKA) anchor protein 12 0.0222672
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0222304
MORF4L2 mortality factor 4 like 2 0.0216292
RORA RAR-related orphan receptor A 0.0192167
RAD51B RAD51 paralog B 0.0188473
NF1 neurofibromin 1 0.0177953
STC1 stanniocalcin 1 0.0175171
ATXN1 ataxin 1 0.0145129
PTK2 protein tyrosine kinase 2 0.0143345
PSD3 pleckstrin and Sec7 domain containing 3 0.0138846
SMYD3 SET and MYND domain containing 3 0.0138061
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0130644
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0126675
ARRDC3 arrestin domain containing 3 0.0123758
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0104697
SETD5 SET domain containing 5 0.0086173
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00638739
SND1 staphylococcal nuclease and tudor domain containing 1 0.00625953
CALR calreticulin 0.00535713
RUNX1 runt-related transcription factor 1 0.00308652
GOLGA4 golgin A4 0.00295547
RPL11 ribosomal protein L11 0.00187047

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.242932
VIM vimentin -0.104574
VCL vinculin -0.100479
POTEF POTE ankyrin domain family, member F -0.097141
TMSB10 thymosin beta 10 -0.0952891
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0906588
CD44 CD44 molecule (Indian blood group) -0.0817209
FTL ferritin, light polypeptide -0.0806751
FN1 fibronectin 1 -0.0801394
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0778654
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0757291
RPL35A ribosomal protein L35a -0.0738912
EFNA5 ephrin-A5 -0.0734807
EGFR epidermal growth factor receptor -0.068854
TPM4 tropomyosin 4 -0.0679662
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0677493
RPS12 ribosomal protein S12 -0.0662191
MYO1E myosin IE -0.0633761
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0601033
MT2A metallothionein 2A -0.0581127
MCL1 myeloid cell leukemia 1 -0.0569291
EXT1 exostosin glycosyltransferase 1 -0.0552269
RPS3 ribosomal protein S3 -0.0550635
FTH1 ferritin, heavy polypeptide 1 -0.0540882
RAB7A RAB7A, member RAS oncogene family -0.0504892
USP34 ubiquitin specific peptidase 34 -0.0500261
RPL26 ribosomal protein L26 -0.0486478
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0464493
LOC102724023 ES1 protein homolog, mitochondrial -0.0451912
HLA-B major histocompatibility complex, class I, B -0.0440516
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0434034
SLC38A2 solute carrier family 38, member 2 -0.0419543
YBX3 Y box binding protein 3 -0.0419428
TXNRD1 thioredoxin reductase 1 -0.0395742
SP100 SP100 nuclear antigen -0.0364829
KIF5B kinesin family member 5B -0.03583
RPLP1 ribosomal protein, large, P1 -0.0356359
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.035419
NIPBL Nipped-B homolog (Drosophila) -0.0353937
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0351146
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.034526
MYO6 myosin VI -0.0341469
PRRC2C proline-rich coiled-coil 2C -0.033837
PDE4D phosphodiesterase 4D, cAMP-specific -0.0327653
TRIO trio Rho guanine nucleotide exchange factor -0.0316125
IGF2 insulin-like growth factor 2 -0.0314609
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0298034
CANX calnexin -0.0298023
MAP4 microtubule-associated protein 4 -0.0288343
LDHA lactate dehydrogenase A -0.0281558
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0276949
KMT2E lysine (K)-specific methyltransferase 2E -0.0271742
CCNI cyclin I -0.0256171
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0254383
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0250254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0244751
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0234342
NCOA3 nuclear receptor coactivator 3 -0.0231975
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0230571
RPS6 ribosomal protein S6 -0.0221349
RPL19 ribosomal protein L19 -0.0210203
SBF2 SET binding factor 2 -0.0200625
RPL31 ribosomal protein L31 -0.0196317
B2M beta-2-microglobulin -0.0186624
PRKCA protein kinase C, alpha -0.0185067
PDE10A phosphodiesterase 10A -0.0174969
COL6A3 collagen, type VI, alpha 3 -0.016378
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0162486
RPS24 ribosomal protein S24 -0.0162465
TPT1 tumor protein, translationally-controlled 1 -0.0152827
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0152581
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0152069
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0151463
RPL37A ribosomal protein L37a -0.0137465
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0123126
H3-3B H3.3 histone B -0.0094217
PIAS1 protein inhibitor of activated STAT, 1 -0.00850919
ARB2A ARB2 cotranscriptional regulator A -0.00798633
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.00751594
TXNIP thioredoxin interacting protein -0.00715157
EIF1 eukaryotic translation initiation factor 1 -0.00694837
EEF2 eukaryotic translation elongation factor 2 -0.00687198
SLTM SAFB-like, transcription modulator -0.00651132
PTMA prothymosin, alpha -0.00583196
HDAC9 histone deacetylase 9 -0.00531889
MYOF myoferlin -0.00241612
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00195238
MACF1 microtubule-actin crosslinking factor 1 -0.0014023
HDLBP high density lipoprotein binding protein -0.00132786
KTN1 kinectin 1 (kinesin receptor) -0.00104344
AKAP9 A kinase (PRKA) anchor protein 9 -1.42914E-4